JP2005507076A5 - - Google Patents
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- Publication number
- JP2005507076A5 JP2005507076A5 JP2003538707A JP2003538707A JP2005507076A5 JP 2005507076 A5 JP2005507076 A5 JP 2005507076A5 JP 2003538707 A JP2003538707 A JP 2003538707A JP 2003538707 A JP2003538707 A JP 2003538707A JP 2005507076 A5 JP2005507076 A5 JP 2005507076A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- solid support
- biological molecule
- groups
- available amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 21
- 239000007787 solid Substances 0.000 claims 17
- 125000003277 amino group Chemical group 0.000 claims 7
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 5
- 230000003213 activating effect Effects 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229920000936 Agarose Polymers 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 229920000620 organic polymer Polymers 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- -1 polypropylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/033,308 US20030092062A1 (en) | 2001-10-24 | 2001-10-24 | Immobilizing biological molecules |
| PCT/US2002/033059 WO2003036257A2 (en) | 2001-10-24 | 2002-10-17 | Immobilizing biological molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005507076A JP2005507076A (ja) | 2005-03-10 |
| JP2005507076A5 true JP2005507076A5 (https=) | 2005-12-22 |
Family
ID=21869661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003538707A Pending JP2005507076A (ja) | 2001-10-24 | 2002-10-17 | 生物学的分子の固定化 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20030092062A1 (https=) |
| EP (1) | EP1454139A2 (https=) |
| JP (1) | JP2005507076A (https=) |
| WO (1) | WO2003036257A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005017155A (ja) * | 2003-06-27 | 2005-01-20 | Toyobo Co Ltd | 金属基板上のアレイの作製方法 |
| US7776567B2 (en) | 2005-03-17 | 2010-08-17 | Biotium, Inc. | Dimeric and trimeric nucleic acid dyes, and associated systems and methods |
| US7601498B2 (en) * | 2005-03-17 | 2009-10-13 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection and associated technology |
| US7494776B2 (en) * | 2005-07-07 | 2009-02-24 | Beckman Coulter, Inc. | Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands |
| US20070043510A1 (en) * | 2005-08-19 | 2007-02-22 | Beckman Coulter, Inc. | Assay system |
| BRPI1011753B8 (pt) * | 2009-06-22 | 2021-05-25 | Wyeth Llc | conjugados imunogênicos de polissacarídeo capsular de staphylococcus aureus de sorotipos 5 e 8, seu uso e composições que os compreendem |
| US8877437B1 (en) | 2009-12-23 | 2014-11-04 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4330440A (en) * | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| US5240602A (en) * | 1987-06-08 | 1993-08-31 | Chromatochem, Inc. | Chromatographic material |
| GB2275270A (en) * | 1993-02-11 | 1994-08-24 | Pall Corp | Membranes for use in affinity separation |
| US6689370B1 (en) * | 1995-04-20 | 2004-02-10 | Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) | Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence |
| WO1997023497A1 (en) * | 1995-12-22 | 1997-07-03 | University Technologies International Inc. | Linker arm for solid support oligonucleotide synthesis and process for production thereof |
| JP4313861B2 (ja) * | 1997-08-01 | 2009-08-12 | キヤノン株式会社 | プローブアレイの製造方法 |
| US6268141B1 (en) * | 1999-05-12 | 2001-07-31 | Beckman Coulter, Inc. | Immobilization of unmodified biopolymers to acyl fluoride activated substrates |
| WO2001002452A1 (en) * | 1999-07-02 | 2001-01-11 | Symyx Technologies, Inc. | Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto |
| EP1255996B1 (en) * | 2000-02-16 | 2010-05-26 | Wisconsin Alumni Research Foundation | Biochemical blocking layer for liquid crystal assay |
| US6413722B1 (en) * | 2000-03-22 | 2002-07-02 | Incyte Genomics, Inc. | Polymer coated surfaces for microarray applications |
| US6500921B1 (en) * | 2000-11-07 | 2002-12-31 | Amersham Biosciences Ab | Schiff base reductant co-dispense process |
| CA2461661A1 (en) * | 2001-10-19 | 2003-05-01 | Maxim Pharmaceuticals, Inc. | Use of histamine to treat liver disease |
-
2001
- 2001-10-24 US US10/033,308 patent/US20030092062A1/en not_active Abandoned
-
2002
- 2002-10-17 JP JP2003538707A patent/JP2005507076A/ja active Pending
- 2002-10-17 WO PCT/US2002/033059 patent/WO2003036257A2/en not_active Ceased
- 2002-10-17 EP EP02773775A patent/EP1454139A2/en not_active Withdrawn
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