JP2022525186A5 - - Google Patents
Info
- Publication number
- JP2022525186A5 JP2022525186A5 JP2021555405A JP2021555405A JP2022525186A5 JP 2022525186 A5 JP2022525186 A5 JP 2022525186A5 JP 2021555405 A JP2021555405 A JP 2021555405A JP 2021555405 A JP2021555405 A JP 2021555405A JP 2022525186 A5 JP2022525186 A5 JP 2022525186A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylenyl
- haloalkyl
- halogen
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023076091A JP7605892B2 (ja) | 2019-03-15 | 2023-05-02 | Ｔｅａｄ転写因子の新規小分子阻害剤 |
| JP2024218270A JP2025038074A (ja) | 2019-03-15 | 2024-12-12 | Ｔｅａｄ転写因子の新規小分子阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962819347P | 2019-03-15 | 2019-03-15 | |
| US62/819,347 | 2019-03-15 | ||
| PCT/US2020/022757 WO2020190774A1 (en) | 2019-03-15 | 2020-03-13 | Novel small molecule inhibitors of tead transcription factors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076091A Division JP7605892B2 (ja) | 2019-03-15 | 2023-05-02 | Ｔｅａｄ転写因子の新規小分子阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022525186A JP2022525186A (ja) | 2022-05-11 |
| JP2022525186A5 true JP2022525186A5 (https=) | 2023-05-22 |
Family
ID=72520559
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021555405A Pending JP2022525186A (ja) | 2019-03-15 | 2020-03-13 | Ｔｅａｄ転写因子新規小分子阻害剤 |
| JP2023076091A Active JP7605892B2 (ja) | 2019-03-15 | 2023-05-02 | Ｔｅａｄ転写因子の新規小分子阻害剤 |
| JP2024218270A Pending JP2025038074A (ja) | 2019-03-15 | 2024-12-12 | Ｔｅａｄ転写因子の新規小分子阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076091A Active JP7605892B2 (ja) | 2019-03-15 | 2023-05-02 | Ｔｅａｄ転写因子の新規小分子阻害剤 |
| JP2024218270A Pending JP2025038074A (ja) | 2019-03-15 | 2024-12-12 | Ｔｅａｄ転写因子の新規小分子阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12187722B2 (https=) |
| EP (1) | EP3937943A4 (https=) |
| JP (3) | JP2022525186A (https=) |
| KR (1) | KR102866499B1 (https=) |
| CN (2) | CN119490431A (https=) |
| AU (2) | AU2020241258B2 (https=) |
| CA (1) | CA3133753A1 (https=) |
| IL (1) | IL286352B2 (https=) |
| MA (1) | MA55322A (https=) |
| MX (2) | MX2021011209A (https=) |
| WO (1) | WO2020190774A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018300150A1 (en) | 2017-07-11 | 2020-01-30 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| BR112021020226A2 (pt) * | 2019-04-10 | 2021-12-07 | Cellestia Biotech Ag | Inibidores de via de sinalização notch e uso dos mesmos no tratamento de cânceres |
| CA3142351A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3141826A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| US11787775B2 (en) | 2020-07-24 | 2023-10-17 | Genentech, Inc. | Therapeutic compounds and methods of use |
| WO2022120355A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead degraders and uses thereof |
| WO2022120353A1 (en) * | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3205726A1 (en) | 2021-01-25 | 2022-07-28 | Alfredo C. Castro | Combination of a 3-(imidazol-4-yl)-4-(amino)-benzenesulfonamide tead inhibitor with an egfr inhibitor and/or mek inhibitor for use in the treatment of lung cancer |
| WO2022221866A1 (en) | 2021-04-16 | 2022-10-20 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| WO2023060227A1 (en) | 2021-10-07 | 2023-04-13 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| US12378202B2 (en) | 2021-12-23 | 2025-08-05 | Springworks Therapeutics, Inc. | Tetrahydrobenzoazepinones and related analogs for inhibiting YAP/TAZ-TEAD |
| WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
| CN115181756B (zh) * | 2022-08-03 | 2023-06-16 | 四川省医学科学院·四川省人民医院 | 一种重组慢病毒载体、重组慢病毒质粒、细胞模型及相关应用 |
| CN119968359A (zh) | 2022-09-29 | 2025-05-09 | 英矽智能科技知识产权有限公司 | Tead抑制剂及其使用方法 |
| WO2024092116A1 (en) | 2022-10-26 | 2024-05-02 | Ikena Oncology, Inc. | Combination of tead inhibitors and egfr inhibitors and uses thereof |
| CN117986195A (zh) * | 2023-01-10 | 2024-05-07 | 四川大学 | 一种新型杂环化合物及其制备方法和用途 |
| CN115850190B (zh) * | 2023-01-10 | 2024-09-10 | 四川大学 | 一种5-氟尿嘧啶衍生物及其抗肿瘤用途 |
| WO2024173761A1 (en) | 2023-02-17 | 2024-08-22 | Ikena Oncology, Inc. | Combinations comprising mek inhibitors for use in the treatment of cancer |
| WO2025083563A1 (en) * | 2023-10-18 | 2025-04-24 | Pillai Universal Llc | Effective therapeutic small-molecule inhibitors for metastatic cancer |
| CN117736100B (zh) * | 2023-12-20 | 2025-09-26 | 维思普新材料（苏州）有限公司 | 一种二苯胺类金刚烷取代基化合物的制备方法 |
| CN118146146B (zh) * | 2024-05-11 | 2024-07-05 | 北京勤邦科技股份有限公司 | 氟尼辛葡甲胺含量检测用半抗原及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2649977B1 (fr) | 1989-07-18 | 1991-10-04 | Cird | Esters bi-aromatiques, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| CN1187185A (zh) * | 1995-06-07 | 1998-07-08 | 中国医学科学院药物研究所 | 查尔酮维甲类化合物及其应用方法 |
| FR2741876B1 (fr) | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| TR199900684T2 (xx) * | 1996-07-08 | 1999-07-21 | Galderma Research & Development, S.N.C. | Apoptoz uyar�c� adamantil t�revleri ve bunlar�n kansere kar�� maddeler olarak kullan�m�. |
| WO1998035957A1 (en) | 1997-02-14 | 1998-08-20 | Bayer Corporation | Amide derivatives as selective neuropeptide y receptor antagonists |
| ATE266639T1 (de) | 1997-10-17 | 2004-05-15 | Yamanouchi Pharma Co Ltd | Amidderivate oder deren salze |
| US20030220402A1 (en) | 2000-02-15 | 2003-11-27 | Naoki Tsuchiya | Cancer remedy comprising anthranilic acid derivatives as active ingredients |
| KR100786927B1 (ko) | 2000-06-28 | 2007-12-17 | 스미스클라인비이참피이엘시이 | 습식 분쇄방법 |
| US7132546B2 (en) * | 2000-12-22 | 2006-11-07 | Ishihara Sangyo Kaisha, Ltd. | Aniline derivatives or salts thereof and cytokine production inhibitors containing the same |
| JP4083422B2 (ja) | 2000-12-22 | 2008-04-30 | 石原産業株式会社 | アニリン誘導体またはその塩ならびにそれらを含有するサイトカイン産生抑制剤 |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| GB0226583D0 (en) | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
| PT1660458E (pt) | 2003-08-15 | 2012-04-27 | Novartis Ag | 2,4-pirimidinodiaminas úteis no tratamento de doenças neoplásicas, desordens inflamatórias e do sistema imunitário |
| US7754714B2 (en) * | 2004-05-18 | 2010-07-13 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
| JP5191391B2 (ja) | 2005-11-01 | 2013-05-08 | ターゲジェン インコーポレーティッド | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| NZ569329A (en) | 2006-01-30 | 2011-09-30 | Transtech Pharma Inc | Substituted imidazole derivatives and their use as PTPase inhibitors |
| JP2010514672A (ja) | 2006-12-29 | 2010-05-06 | 武田薬品工業株式会社 | Ｃｒｆアンタゴニスト活性を有する縮合複素環化合物 |
| WO2008147831A1 (en) | 2007-05-23 | 2008-12-04 | Smithkline Beecham Corporation | Anthranilamides |
| EA017252B1 (ru) | 2007-08-28 | 2012-11-30 | Айрм Ллк | Производные 2-бифениламино-4-аминопиримидина в качестве ингибиторов киназ |
| WO2009105498A1 (en) | 2008-02-19 | 2009-08-27 | Smithkline Beecham Corporation | Anilinopyridines as inhibitors of fak |
| WO2009153589A1 (en) | 2008-06-17 | 2009-12-23 | Astrazeneca Ab | Pyridine compounds |
| JO3067B1 (ar) | 2008-10-27 | 2017-03-15 | Glaxosmithkline Llc | بيرميدينات بيرازولو امينو كمثبطات ل fak |
| EP2415755A4 (en) * | 2009-03-31 | 2012-09-19 | Renascience Co Ltd | INHIBITOR AGENT OF PLASMINOGEN ACTIVATOR INHIBITOR 1 |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| CN102471261B (zh) | 2009-06-30 | 2014-10-29 | 日本瑞翁株式会社 | 二芳基胺化合物、以及抗老化剂、聚合物组合物、橡胶交联物及其成型品、以及二芳基胺化合物的制备方法 |
| US20110053916A1 (en) | 2009-08-14 | 2011-03-03 | Vertex Pharmaceuticals Incorporated | Pyrimidine compounds as tuberculosis inhibitors |
| WO2012135641A2 (en) * | 2011-03-30 | 2012-10-04 | H. Lee Moffitt Cancer Center And Research Institute | Aurora kinase inhibitors and methods of making and using thereof |
| CN102718702B (zh) * | 2011-03-31 | 2015-01-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 氨基吡啶类衍生物及其用途 |
| EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| JP5840324B2 (ja) * | 2013-04-15 | 2016-01-06 | 株式会社レナサイエンス | Ｐａｉ−１阻害剤の新規用途 |
| JP6486353B2 (ja) | 2013-07-31 | 2019-03-20 | ユー・ディー・シー アイルランド リミテッド | 発光性ジアザベンゾイミダゾールカルベン金属錯体 |
| WO2015026990A2 (en) * | 2013-08-20 | 2015-02-26 | University Of Washington Through Its Center For Commercialization | Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydrolase |
| WO2015051149A1 (en) | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
| WO2017053706A1 (en) * | 2015-09-23 | 2017-03-30 | The General Hospital Corporation | Tead transcription factor autopalmitoylation inhibitors |
| AU2017232391C1 (en) * | 2016-03-17 | 2022-12-22 | Xeniopro GmbH | Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch |
| WO2018154118A2 (en) * | 2017-02-24 | 2018-08-30 | Reinmueller Viktoria | Novel aromatic compounds |
| TW201834649A (zh) * | 2017-03-02 | 2018-10-01 | 新加坡商亞獅康私人有限公司 | 癌症療法 |
| US11555009B2 (en) | 2017-03-02 | 2023-01-17 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | 2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof |
| JP6978251B2 (ja) * | 2017-03-03 | 2021-12-08 | アスラン ファーマシューティカルズ ピーティーイー リミテッド | がん治療 |
| WO2018204532A1 (en) * | 2017-05-03 | 2018-11-08 | Vivace Therapeutics, Inc. | Non-fused tricyclic compounds |
| WO2019027855A1 (en) | 2017-08-02 | 2019-02-07 | Merck Sharp & Dohme Corp. | NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO) |
| WO2019165032A1 (en) * | 2018-02-21 | 2019-08-29 | The Scripps Research Institute | Agonists of stimulator of interferon genes sting |
-
2020
- 2020-03-13 KR KR1020217032688A patent/KR102866499B1/ko active Active
- 2020-03-13 EP EP20773621.6A patent/EP3937943A4/en active Pending
- 2020-03-13 CN CN202411510567.3A patent/CN119490431A/zh active Pending
- 2020-03-13 MX MX2021011209A patent/MX2021011209A/es unknown
- 2020-03-13 MA MA055322A patent/MA55322A/fr unknown
- 2020-03-13 AU AU2020241258A patent/AU2020241258B2/en active Active
- 2020-03-13 WO PCT/US2020/022757 patent/WO2020190774A1/en not_active Ceased
- 2020-03-13 IL IL286352A patent/IL286352B2/en unknown
- 2020-03-13 CA CA3133753A patent/CA3133753A1/en active Pending
- 2020-03-13 JP JP2021555405A patent/JP2022525186A/ja active Pending
- 2020-03-13 US US17/439,735 patent/US12187722B2/en active Active
- 2020-03-13 CN CN202080035177.9A patent/CN113811300B/zh active Active
-
2021
- 2021-09-14 MX MX2024014142A patent/MX2024014142A/es unknown
-
2023
- 2023-05-02 JP JP2023076091A patent/JP7605892B2/ja active Active
-
2024
- 2024-08-21 US US18/810,625 patent/US20250122194A1/en active Pending
- 2024-12-12 JP JP2024218270A patent/JP2025038074A/ja active Pending
-
2025
- 2025-12-09 AU AU2025275335A patent/AU2025275335A1/en active Pending
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