JP2022524866A5 - - Google Patents

Info

Publication number
JP2022524866A5
JP2022524866A5 JP2021555368A JP2021555368A JP2022524866A5 JP 2022524866 A5 JP2022524866 A5 JP 2022524866A5 JP 2021555368 A JP2021555368 A JP 2021555368A JP 2021555368 A JP2021555368 A JP 2021555368A JP 2022524866 A5 JP2022524866 A5 JP 2022524866A5
Authority
JP
Japan
Prior art keywords
rna
rna molecule
molecule
nucleic acid
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021555368A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022524866A (ja
Filing date
Publication date
Priority claimed from GBGB1903519.5A external-priority patent/GB201903519D0/en
Application filed filed Critical
Publication of JP2022524866A publication Critical patent/JP2022524866A/ja
Publication of JP2022524866A5 publication Critical patent/JP2022524866A5/ja
Priority to JP2025189181A priority Critical patent/JP2026041744A/ja
Pending legal-status Critical Current

Links

JP2021555368A 2019-03-14 2020-03-12 機能不全rna分子へのサイレンシング活性の導入、及び関心遺伝子に対する特異性の改変 Pending JP2022524866A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025189181A JP2026041744A (ja) 2019-03-14 2025-11-10 機能不全rna分子へのサイレンシング活性の導入、及び関心遺伝子に対する特異性の改変

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1903519.5 2019-03-14
GBGB1903519.5A GB201903519D0 (en) 2019-03-14 2019-03-14 Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
PCT/IB2020/052248 WO2020183419A1 (en) 2019-03-14 2020-03-12 Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025189181A Division JP2026041744A (ja) 2019-03-14 2025-11-10 機能不全rna分子へのサイレンシング活性の導入、及び関心遺伝子に対する特異性の改変

Publications (2)

Publication Number Publication Date
JP2022524866A JP2022524866A (ja) 2022-05-10
JP2022524866A5 true JP2022524866A5 (https=) 2023-03-22

Family

ID=66381105

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021555368A Pending JP2022524866A (ja) 2019-03-14 2020-03-12 機能不全rna分子へのサイレンシング活性の導入、及び関心遺伝子に対する特異性の改変
JP2025189181A Pending JP2026041744A (ja) 2019-03-14 2025-11-10 機能不全rna分子へのサイレンシング活性の導入、及び関心遺伝子に対する特異性の改変

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025189181A Pending JP2026041744A (ja) 2019-03-14 2025-11-10 機能不全rna分子へのサイレンシング活性の導入、及び関心遺伝子に対する特異性の改変

Country Status (12)

Country Link
US (1) US20220154187A1 (https=)
EP (1) EP3938512A1 (https=)
JP (2) JP2022524866A (https=)
KR (1) KR20210148187A (https=)
CN (1) CN113906138A (https=)
AU (1) AU2020237667B2 (https=)
BR (1) BR112021018159A2 (https=)
CA (1) CA3133198A1 (https=)
GB (1) GB201903519D0 (https=)
IL (1) IL286380A (https=)
SG (1) SG11202109469VA (https=)
WO (1) WO2020183419A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202002481RA (en) 2017-09-19 2020-04-29 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
AU2021353004A1 (en) 2020-09-30 2023-04-13 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same
CN113430194B (zh) * 2020-11-30 2023-04-07 东北林业大学 一种基于CRISPR/Cas9的白桦基因编辑方法
GB202103256D0 (en) 2021-03-09 2021-04-21 Tropic Biosciences Uk Ltd Method for silencing genes
WO2022232054A1 (en) * 2021-04-26 2022-11-03 Gordian Biotechnology, Inc. Compositions and methods for in vivo screening of therapeutics
CN113502351B (zh) * 2021-06-29 2023-11-21 中国人民解放军疾病预防控制中心 一种crRNA及用于CRISPR-Cas12a检测人腺病毒核酸的方法
GB202112866D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to fusarium wilt in a banana
GB202112865D0 (en) 2021-09-09 2021-10-27 Tropic Biosciences Uk Ltd Resistance to black sigatoka disease in banana
CN115029378B (zh) * 2022-06-23 2023-09-15 河北北方学院 一种利用PtrDJ1C基因创制花斑观赏杨树的方法
CN115250913B (zh) * 2022-07-25 2023-06-20 三峡大学 一种盐肤木体细胞胚胎发生与植株再生方法
CN116218882A (zh) * 2022-10-11 2023-06-06 江苏省农业科学院 PI4KIIa在控制灰飞虱传播水稻黑条矮缩病毒中的应用
EP4649150A1 (en) 2023-01-13 2025-11-19 Laverock Therapeutics Limited Cell context-specific gene regulation using inhibitory rnas
GB202305021D0 (en) 2023-04-04 2023-05-17 Tropic Biosciences Uk Ltd Methods for generating breaks in a genome
CN116640196B (zh) * 2023-05-10 2024-02-06 山东农业大学 囊泡相关膜蛋白的相关蛋白vap1在抗马铃薯y病毒中的应用
CN120555500A (zh) * 2025-05-13 2025-08-29 中国农业大学 核糖核酸酶MdRNS3a在苹果综合抗性育种中的应用

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
CA1192510A (en) 1981-05-27 1985-08-27 Lawrence E. Pelcher Rna plant virus vector or portion thereof, a method of construction thereof, and a method of producing a gene derived product therefrom
JPS6054684A (ja) 1983-09-05 1985-03-29 Teijin Ltd 新規dνa及びハイブリツドdνa
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
CA1288073C (en) 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
GB8608850D0 (en) 1986-04-11 1986-05-14 Diatech Ltd Packaging system
JPS6314693A (ja) 1986-07-04 1988-01-21 Sumitomo Chem Co Ltd 植物ウイルスrnaベクタ−
ATE87032T1 (de) 1986-12-05 1993-04-15 Ciba Geigy Ag Verbessertes verfahren zur transformation von pflanzlichen protoplasten.
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
DE3850683T2 (de) 1987-02-09 1994-10-27 Lubrizol Genetics Inc Hybrides RNS-Virus.
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5316931A (en) 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US5416011A (en) 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
US5693507A (en) 1988-09-26 1997-12-02 Auburn University Genetic engineering of plant chloroplasts
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5302523A (en) 1989-06-21 1994-04-12 Zeneca Limited Transformation of plant cells
US5550318A (en) 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
WO1991010725A1 (en) 1990-01-22 1991-07-25 Dekalb Plant Genetics Fertile transgenic corn plants
US6403865B1 (en) 1990-08-24 2002-06-11 Syngenta Investment Corp. Method of producing transgenic maize using direct transformation of commercially important genotypes
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
ATE398679T1 (de) 1992-07-07 2008-07-15 Japan Tobacco Inc Verfahren zur transformation einer monokotyledon pflanze
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
JP2952041B2 (ja) 1992-07-27 1999-09-20 パイオニア ハイ−ブレッド インターナショナル,インコーポレイテッド 培養ダイズ細胞のagrobacterium媒介形質転換の改良法
US5693512A (en) 1996-03-01 1997-12-02 The Ohio State Research Foundation Method for transforming plant tissue by sonication
US5981840A (en) 1997-01-24 1999-11-09 Pioneer Hi-Bred International, Inc. Methods for agrobacterium-mediated transformation
WO2000042207A2 (en) 1999-01-14 2000-07-20 Monsanto Technology Llc Soybean transformation method
JP5697297B2 (ja) * 2004-05-14 2015-04-08 ロゼッタ ジノミクス リミテッド マイクロnasおよびその使用
US20060236427A1 (en) * 2004-09-20 2006-10-19 North Carolina State University MicroRNAs (miRNAs) for plant growth and development
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
ES2582091T3 (es) 2005-10-18 2016-09-09 Precision Biosciences Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
US20080280848A1 (en) * 2005-10-28 2008-11-13 Volker Patzel Structures of Active Guide Rna Molecules and Method of Selection
RU2485180C2 (ru) 2007-06-07 2013-06-20 Эгрикалча Энд Эгри-Фуд Кэнэда Способ трансфекции и трансдукции растительных клеток
EP2195438B1 (en) 2007-10-05 2013-01-23 Dow AgroSciences LLC Methods for transferring molecular substances into plant cells
EP2292176B1 (en) 2009-09-07 2019-01-09 Nobel Biocare Services AG Implantation set
WO2013126963A1 (en) 2012-02-29 2013-09-06 Benitec Biopharma Limited Pain treatment
KR20150103280A (ko) 2013-01-08 2015-09-09 베니텍 바이오파마 리미티드 연령-관련 황반 변성 치료
AU2014273082B2 (en) * 2013-05-29 2018-11-08 Cellectis A method for producing precise DNA cleavage using Cas9 nickase activity
CN120574876A (zh) 2013-08-22 2025-09-02 纳幕尔杜邦公司 使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法
JP6723230B2 (ja) * 2014-10-09 2020-07-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 神経障害性疼痛を治療するためのcsf1−dap12経路のメンバー遺伝子の標的破壊
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
WO2016100333A1 (en) * 2014-12-15 2016-06-23 Syngenta Participations Ag Pesticidal microrna carriers and use thereof
US20170101642A1 (en) * 2015-10-08 2017-04-13 Washington University Methods of inhibiting viral replication comprising the signal peptidase complex
US12404514B2 (en) * 2016-12-09 2025-09-02 The Broad Institute, Inc. CRISPR-systems for modifying a trait of interest in a plant
WO2019005886A1 (en) * 2017-06-26 2019-01-03 The Broad Institute, Inc. CRISPR / CAS-CYTIDINE DEAMINASE COMPOSITIONS, SYSTEMS AND METHODS FOR TARGETED EDITING OF NUCLEIC ACIDS
CN107519492B (zh) * 2017-09-06 2019-01-25 武汉迈特维尔生物科技有限公司 使用CRISPR技术敲除miR-3187-3p在冠状动脉粥样硬化性心脏病中的应用
SG11202002481RA (en) * 2017-09-19 2020-04-29 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells
GB201903520D0 (en) * 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
GB201903521D0 (en) * 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd No title
GB202103256D0 (en) * 2021-03-09 2021-04-21 Tropic Biosciences Uk Ltd Method for silencing genes

Similar Documents

Publication Publication Date Title
JP2022524866A5 (https=)
JP2020533988A5 (https=)
JP2020534826A5 (https=)
US20150291969A1 (en) Compositions for reduced lignin content in sorghum and improving cell wall digestibility, and methods of making the same
JP2022524864A5 (https=)
CN112707956B (zh) 一种玉米穗行数相关蛋白及其编码基因和应用
CN108048486A (zh) 一种基因敲除选育fhl1b基因缺失型斑马鱼的方法
CN111206047B (zh) OsSWEET13基因突变体及其在提高水稻产量中的应用
AU2020225594A1 (en) Powdery mildew resistant cannabis plants
JP2019520807A5 (https=)
CN110066323B (zh) 微藻捕光蛋白NoHLR1基因及其应用
CN107805632B (zh) OsMKK6蛋白及编码基因在调控植物种子发育中的应用
CN104711259B (zh) 一种双miRNA抑制表达载体及其构建方法和应用
BR112020015964A2 (pt) Composições e métodos para aprimorar os rendimentos de cultura através do empilhamento de traços
CN107805633B (zh) OsMPK4蛋白及编码基因在调控植物种子发育中的应用
CN118240872B (zh) Hlr基因在提高植物高光耐受性中的应用
JP6012016B2 (ja) 単為結果制御遺伝子およびその利用
CN117946996A (zh) 粒型相关水稻蛋白OsCSLC2及其生物材料和应用
CN118440980B (zh) 玉米miRNA172及其前体序列Zma-MIR172c在改变玉米株高中的应用
CN118813626B (zh) 一种抗寒Lnc RNA及其应用
CN111705077A (zh) 番茄miR156e-3p基因在提高番茄低温抗性中的应用和植物过表达载体
WO2025092484A1 (zh) 一种靶向抑制基因表达的方法及应用
CN101139386B (zh) 一种具有RNaseIII酶活性的dicer蛋白及其编码基因与应用
WO2025228120A1 (zh) 一种鱼类mstn1a、mstn1b和mstn2a基因的敲除与应用
WO2026026630A1 (zh) 一种提高鱼类生长速度的方法