JP2022522007A5 - - Google Patents

Info

Publication number
JP2022522007A5
JP2022522007A5 JP2021550149A JP2021550149A JP2022522007A5 JP 2022522007 A5 JP2022522007 A5 JP 2022522007A5 JP 2021550149 A JP2021550149 A JP 2021550149A JP 2021550149 A JP2021550149 A JP 2021550149A JP 2022522007 A5 JP2022522007 A5 JP 2022522007A5
Authority
JP
Japan
Prior art keywords
antibody
drug conjugate
conjugate according
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021550149A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022522007A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/020207 external-priority patent/WO2020176794A1/en
Publication of JP2022522007A publication Critical patent/JP2022522007A/ja
Publication of JP2022522007A5 publication Critical patent/JP2022522007A5/ja
Priority to JP2025001193A priority Critical patent/JP2025061007A/ja
Pending legal-status Critical Current

Links

JP2021550149A 2019-02-27 2020-02-27 抗tm4sf1抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法 Pending JP2022522007A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025001193A JP2025061007A (ja) 2019-02-27 2025-01-06 抗tm4sf1抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962811411P 2019-02-27 2019-02-27
US62/811,411 2019-02-27
US202062967377P 2020-01-29 2020-01-29
US62/967,377 2020-01-29
PCT/US2020/020207 WO2020176794A1 (en) 2019-02-27 2020-02-27 Antibody-drug conjugates comprising anti-tm4sf1 antibodies and methods of using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025001193A Division JP2025061007A (ja) 2019-02-27 2025-01-06 抗tm4sf1抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法

Publications (2)

Publication Number Publication Date
JP2022522007A JP2022522007A (ja) 2022-04-13
JP2022522007A5 true JP2022522007A5 (enExample) 2023-02-21

Family

ID=72238523

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021550149A Pending JP2022522007A (ja) 2019-02-27 2020-02-27 抗tm4sf1抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法
JP2025001193A Pending JP2025061007A (ja) 2019-02-27 2025-01-06 抗tm4sf1抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025001193A Pending JP2025061007A (ja) 2019-02-27 2025-01-06 抗tm4sf1抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法

Country Status (8)

Country Link
US (1) US12428477B2 (enExample)
EP (1) EP3930767A4 (enExample)
JP (2) JP2022522007A (enExample)
CN (1) CN113874051A (enExample)
AU (1) AU2020228060A1 (enExample)
CA (1) CA3131391A1 (enExample)
MX (1) MX2021010254A (enExample)
WO (1) WO2020176794A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024511479A (ja) * 2021-03-26 2024-03-13 アンジーエックス・インコーポレーテッド メイタンシン抗体コンジュゲートおよびそれを使用する方法
AU2022242927A1 (en) * 2021-03-26 2023-10-05 Angiex, Inc. Combinations comprising anti-tm4sf1 antibodies and immunotherapeutic agents and methods of using the same
WO2023056069A1 (en) * 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
US20250011428A1 (en) * 2021-10-28 2025-01-09 Novartis Ag Engineered fc variants
WO2025059546A1 (en) * 2023-09-13 2025-03-20 Trustees Of Tufts College Proteolysis-targeting chimera tumor vaccine

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
CA2372813A1 (en) 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
WO1999029888A1 (en) 1997-12-05 1999-06-17 The Scripps Research Institute Humanization of murine antibody
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
CA2323757C (en) 1998-04-02 2011-08-02 Genentech, Inc. Antibody variants and fragments thereof
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20040214872A1 (en) 2002-09-26 2004-10-28 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
HUE035898T2 (en) 2002-12-16 2018-05-28 Genentech Inc Immunoglobulin variants and their applications
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
CN1961003B (zh) 2004-03-31 2013-03-27 健泰科生物技术公司 人源化抗TGF-β抗体
WO2005100402A1 (en) 2004-04-13 2005-10-27 F.Hoffmann-La Roche Ag Anti-p-selectin antibodies
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
US9200079B2 (en) 2004-11-12 2015-12-01 Xencor, Inc. Fc variants with altered binding to FcRn
EP1951890A4 (en) 2005-11-16 2009-06-24 Ambrx Inc PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
KR101423898B1 (ko) 2005-12-14 2014-07-28 암브룩스, 인코포레이티드 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도
AU2006332809A1 (en) 2005-12-30 2007-07-12 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
AU2007215566A1 (en) 2006-01-19 2007-08-23 Ambrx, Inc. Non-natural amino acid polypeptides having modulated immunogenicity
AU2007333737A1 (en) 2006-12-18 2008-06-26 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
US20100098630A1 (en) 2006-12-28 2010-04-22 Ambrx, Inc. Phenazine and Quinoxaline Substituted Amino Acids and Polypeptides
PT2175884T (pt) 2007-07-12 2016-09-21 Gitr Inc Terapias de combinação empregando moléculas de ligação a gitr
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2230300A4 (en) * 2007-10-24 2012-08-08 Otsuka Chemical Holdings Co Ltd POLYPEPTIDE WITH IMPROVED EFFECTOR FUNCTION
KR101616758B1 (ko) 2007-12-26 2016-04-29 젠코어 인코포레이티드 FcRn에 대한 변경된 결합성을 갖는 Fc 변이체
MX2010008578A (es) 2008-02-08 2010-11-10 Medimmune Llc Anticuerpos anti-receptor 1 de interferon alfa con afinidad reducida al ligando fc.
PE20110480A1 (es) 2008-09-26 2011-07-01 Ambrx Inc Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales
EP2385114A4 (en) 2008-12-25 2012-08-08 Univ Tokyo CANCER TREATMENT DIAGNOSIS WITH ANTI-TM4SF20 ANTIBODY
BRPI1015234A2 (en) * 2009-06-22 2018-02-20 Medimmune Llc fc regions designed for site specific conjugation.
LT2691417T (lt) 2011-03-29 2018-10-25 Roche Glycart Ag Antikūno fc variantai
EP2699256B1 (en) 2011-04-21 2017-09-27 The Regents of the University of Colorado, a body corporate Compositions and methods for the treatment of neuromyelitis optica
KR20200128601A (ko) 2011-05-27 2020-11-13 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
DK2714685T3 (en) 2011-05-27 2017-01-09 Ambrx Inc FORMATIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID BOUND dolastatin
AR088513A1 (es) * 2011-10-24 2014-06-18 Abbvie Inc Inmunoenlazantes dirigidos contra esclerostina
EP3004174B1 (en) 2013-05-31 2019-04-17 Zymeworks Inc. Heteromultimers with reduced or silenced effector function
WO2015054427A1 (en) * 2013-10-10 2015-04-16 Beth Israel Deaconess Medical Center, Inc. Tm4sf1 binding proteins and methods of using same
PE20160654A1 (es) 2013-11-22 2016-07-15 Pharmakea Inc Compuestos de inhibidor de autotaxina
LT3148579T (lt) 2014-05-28 2021-05-25 Agenus Inc. Anti-gitr antikūnai ir jų panaudojimo būdai
DK3268047T3 (da) * 2015-03-09 2024-01-02 Heidelberg Pharma Res Gmbh Amatoxin/antistof-konjugater
TWI812873B (zh) 2015-11-30 2023-08-21 美商輝瑞股份有限公司 用於部位專一性接合之抗體和抗體片段
AU2017215350A1 (en) * 2016-02-02 2018-08-09 Meditope Biosciences, Inc. Anti-EGFR antibody drug conjugate
MX2020002241A (es) * 2017-08-28 2020-09-03 Angiex Inc Anticuerpos anti-tm4sf y métodos de uso de los mismos.
EP3807644A4 (en) * 2018-06-12 2022-07-06 Angiex, Inc. ANTIBODY-OLIGONUCLEOTIDE CONJUGATES
MX2022011958A (es) 2020-03-27 2023-01-11 Angiex Inc Conjugados de anticuerpo degradador y métodos de uso de los mismos.
WO2021222783A1 (en) 2020-05-01 2021-11-04 Angiex, Inc. Anti-tm4sf1 antibody drug conjugates and methods of using same
EP4188449A4 (en) 2020-07-31 2025-12-17 Angiex Inc ANTI-TM4SF1 ANTIBODY AGENT CONJUGATES WITH CRISPABLE LINKERS AND METHOD FOR USE THEREMISH
WO2022046941A1 (en) 2020-08-26 2022-03-03 Angiex, Inc. Antimitotic tetrapeptide-antibody conjugates and methods of using same

Similar Documents

Publication Publication Date Title
JP7585230B2 (ja) バイパラトピックFR-α抗体及びイムノコンジュゲート
JP7785669B2 (ja) N末端scFv多重特異性結合分子
CN105585630B (zh) 具有修改的等电点的抗体
JP6454269B2 (ja) Cd33抗体及び癌を処置するためのその使用
JP2017518304A (ja) 抗体−薬物コンジュゲート、それらの製造、及びそれらの治療用途
JP2016518332A5 (enExample)
JP2018134080A (ja) イムノコンジュゲートを作製する抗体を修飾するための特定部位
JP2018501781A5 (enExample)
JP2020534351A5 (enExample)
CN107207564A (zh) 靶向xten缀合物组合物及其制备方法
KR20110050753A (ko) 칼리치아미신 유도체-운반체 접합체
US20260042847A1 (en) Cysteine engineered antibody constructs, conjugates and methods of use
JP2025061007A5 (enExample)
WO2024145398A1 (en) Antibody drug conjugates
CN114502593A (zh) 生物药物组合物和相关方法
TW202430570A (zh) 抗cmet抗體及使用方法
JP2024511479A5 (enExample)
JP2025511002A (ja) 活性化可能な二重特異性抗cd3および抗pd-l1タンパク質ならびにその使用
RU2832083C2 (ru) Бипаратопные fr-альфа антитела и иммуноконъюгаты
CN113329769A (zh) 具有反应性精氨酸的抗体化合物及相关的抗体药物缀合物
RU2824761C2 (ru) Биофармацевтические композиции и связанные с ними способы
WO2026035986A1 (en) Humanized anti-cdh17 antibodies and use of the same
HK40130188A (en) Cd38 and icam1 antibodies and uses thereof
TW202411249A (zh) 抗體-藥物偶聯物的製備方法
RU2023100251A (ru) Антитело против клаудина 18.2 и его конъюгат антитело-лекарственное средство