MX2022011958A - Conjugados de anticuerpo degradador y métodos de uso de los mismos. - Google Patents
Conjugados de anticuerpo degradador y métodos de uso de los mismos.Info
- Publication number
- MX2022011958A MX2022011958A MX2022011958A MX2022011958A MX2022011958A MX 2022011958 A MX2022011958 A MX 2022011958A MX 2022011958 A MX2022011958 A MX 2022011958A MX 2022011958 A MX2022011958 A MX 2022011958A MX 2022011958 A MX2022011958 A MX 2022011958A
- Authority
- MX
- Mexico
- Prior art keywords
- degrader
- methods
- antibody conjugates
- same
- binding group
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000001064 degrader Substances 0.000 abstract 3
- 102000044159 Ubiquitin Human genes 0.000 abstract 2
- 108090000848 Ubiquitin Proteins 0.000 abstract 2
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 abstract 2
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen conjugados de anticuerpo-degradador (DAC), que comprenden anticuerpos anti TM4SF1 y fragmentos de unión a antígeno de los mismos. Las moléculas degradadoras tal como se describen comprenden un grupo de unión a ubiquitina ligasa E3 (E3LB) y un grupo de unión a proteína (PB). Pueden utilizarse enlazadores entre los anticuerpos y las moléculas degradadoras (L1) y entre el grupo de unión a ubiquitina ligasa E3 (E3LB) y el grupo de unión a proteínas (PB) de la molécula degradadora (L2). También se describen métodos de uso de dichos DAC.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063000991P | 2020-03-27 | 2020-03-27 | |
US202063044699P | 2020-06-26 | 2020-06-26 | |
PCT/US2021/024535 WO2021195598A2 (en) | 2020-03-27 | 2021-03-26 | Degrader-antibody conjugates and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011958A true MX2022011958A (es) | 2023-01-11 |
Family
ID=77890749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011958A MX2022011958A (es) | 2020-03-27 | 2021-03-26 | Conjugados de anticuerpo degradador y métodos de uso de los mismos. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20230126271A1 (es) |
EP (1) | EP4126042A2 (es) |
JP (1) | JP2023520371A (es) |
CN (1) | CN115734789A (es) |
AU (1) | AU2021244621A1 (es) |
CA (1) | CA3172516A1 (es) |
MX (1) | MX2022011958A (es) |
WO (1) | WO2021195598A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11535607B2 (en) | 2018-04-20 | 2022-12-27 | Valo Health, Inc. | Isoindolines as HDAC inhibitors |
WO2023056069A1 (en) * | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
WO2024006252A1 (en) * | 2022-06-28 | 2024-01-04 | The Regents Of The University Of Colorado, A Body Corporate | Dual inhibition of mdm2 and eif2-alpha induces cell death in multiple cancer cell types |
-
2021
- 2021-03-26 AU AU2021244621A patent/AU2021244621A1/en active Pending
- 2021-03-26 EP EP21775463.9A patent/EP4126042A2/en active Pending
- 2021-03-26 CA CA3172516A patent/CA3172516A1/en active Pending
- 2021-03-26 WO PCT/US2021/024535 patent/WO2021195598A2/en active Application Filing
- 2021-03-26 MX MX2022011958A patent/MX2022011958A/es unknown
- 2021-03-26 JP JP2022558403A patent/JP2023520371A/ja active Pending
- 2021-03-26 CN CN202180038813.8A patent/CN115734789A/zh active Pending
-
2022
- 2022-09-27 US US17/935,690 patent/US20230126271A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021195598A2 (en) | 2021-09-30 |
EP4126042A2 (en) | 2023-02-08 |
CN115734789A (zh) | 2023-03-03 |
WO2021195598A3 (en) | 2021-12-16 |
AU2021244621A1 (en) | 2022-10-20 |
JP2023520371A (ja) | 2023-05-17 |
US20230126271A1 (en) | 2023-04-27 |
CA3172516A1 (en) | 2021-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022011958A (es) | Conjugados de anticuerpo degradador y métodos de uso de los mismos. | |
CY1119416T1 (el) | Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ' αυτων | |
WO2021163064A3 (en) | Antibodies and fusion proteins that bind to ccr8 and uses thereof | |
NO20083053L (no) | Humane monoklonale antistoffer mot O8E | |
WO2006089230A3 (en) | Human monoclonal antibodies to prostate specific membrane antigen (psma) | |
WO2019241430A3 (en) | Antibody-oligonucleotide conjugates | |
TNSN08255A1 (en) | Anti-mn antibodies and methods of using same | |
GEP20094829B (en) | Fully human antibodies against human 4-1bb (cd137) | |
WO2007116360A3 (en) | Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof | |
MX2022015847A (es) | Proteinas de union a cd123 y composiciones y metodos relacionados. | |
MX2021011997A (es) | Enlazadores de conjugacion mejorados. | |
DK1692158T3 (da) | VEGF-binding og understøttede peptider til behandling af hudsygdomme | |
WO2006068975A3 (en) | Binding proteins specific for human matriptase | |
MY194997A (en) | Anti-ccr7 antibody drug conjugates | |
AU2018338322A1 (en) | A33 antibody compositions and methods of using the same in radioimmunotherapy | |
WO2008098917A3 (en) | Novel antibodies against igf-ir | |
WO2008085878A3 (en) | High affinity antibodies that neutralize staphylcoccus enterotoxin b | |
AU2019433019A8 (en) | Antibodies binding CD40 and uses thereof | |
EP4253959A3 (en) | Anti-idiotypic antibodies directed to the antigen-binding portion of an bcma-binding molecule | |
ATE517340T1 (de) | Sätze gegen kurze epitope gerichteter digitaler antikörper sowie diese verwendende verfahren | |
ZA202201464B (en) | Anti-tigit antibodies and application thereof | |
MX2021010254A (es) | Conjugados de anticuerpo-farmaco que comprenden anticuerpos anti-tm4sf1 y metodos de uso de los mismos. | |
WO2005059131A3 (en) | Protein binding miniature proteins and uses thereof | |
WO2004052932A3 (en) | Antibody (“11c7”) anti nogo a and its pharmaceutical use | |
MX2022015966A (es) | Anticuerpos y metodos para tratar enfermedades asociadas a claudina. |