JP2022515193A - アミロイド前駆体タンパク質(APP)RNAi薬剤組成物およびその使用方法 - Google Patents
アミロイド前駆体タンパク質(APP)RNAi薬剤組成物およびその使用方法 Download PDFInfo
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- JP2022515193A JP2022515193A JP2021536024A JP2021536024A JP2022515193A JP 2022515193 A JP2022515193 A JP 2022515193A JP 2021536024 A JP2021536024 A JP 2021536024A JP 2021536024 A JP2021536024 A JP 2021536024A JP 2022515193 A JP2022515193 A JP 2022515193A
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- 0 COC[C@](C1)N(*)CC1OC Chemical compound COC[C@](C1)N(*)CC1OC 0.000 description 10
- HXJJFAFABXEKLD-SSDOTTSWSA-N B[C@@H](C1)OC(COC)=C1OC Chemical compound B[C@@H](C1)OC(COC)=C1OC HXJJFAFABXEKLD-SSDOTTSWSA-N 0.000 description 1
- XOJVXYVKUFVBQE-UHFFFAOYSA-N CC[n](cc1)c(cc2)c1cc2[N+]([O-])=O Chemical compound CC[n](cc1)c(cc2)c1cc2[N+]([O-])=O XOJVXYVKUFVBQE-UHFFFAOYSA-N 0.000 description 1
- ORZQZDFOABYORG-UHFFFAOYSA-N COCC(OCC1)=C1OC Chemical compound COCC(OCC1)=C1OC ORZQZDFOABYORG-UHFFFAOYSA-N 0.000 description 1
- AUIBUIVVOOFMLT-UHFFFAOYSA-N COCC(OCC1OC)=C1OC Chemical compound COCC(OCC1OC)=C1OC AUIBUIVVOOFMLT-UHFFFAOYSA-N 0.000 description 1
- AVCGGVFMLBZIGD-JGVFFNPUSA-N COC[C@H]1OCCC[C@@H]1OC Chemical compound COC[C@H]1OCCC[C@@H]1OC AVCGGVFMLBZIGD-JGVFFNPUSA-N 0.000 description 1
- LSKCTDOPSVEIPU-UHFFFAOYSA-N C[n]1c(nc(N)nc2)c2nc1 Chemical compound C[n]1c(nc(N)nc2)c2nc1 LSKCTDOPSVEIPU-UHFFFAOYSA-N 0.000 description 1
- CQYLGSKQLBWLHF-UHFFFAOYSA-N Cc(c(F)c1)cc(C)c1F Chemical compound Cc(c(F)c1)cc(C)c1F CQYLGSKQLBWLHF-UHFFFAOYSA-N 0.000 description 1
- DRJSEGTWOQNMSY-UHFFFAOYSA-N Cc1cccc2c1nc[n]2C Chemical compound Cc1cccc2c1nc[n]2C DRJSEGTWOQNMSY-UHFFFAOYSA-N 0.000 description 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024090554A JP2024113043A (ja) | 2018-12-19 | 2024-06-04 | アミロイド前駆体タンパク質(APP)RNAi薬剤組成物およびその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862781774P | 2018-12-19 | 2018-12-19 | |
| US62/781,774 | 2018-12-19 | ||
| US201962862472P | 2019-06-17 | 2019-06-17 | |
| US62/862,472 | 2019-06-17 | ||
| US201962928795P | 2019-10-31 | 2019-10-31 | |
| US62/928,795 | 2019-10-31 | ||
| PCT/US2019/067449 WO2020132227A2 (en) | 2018-12-19 | 2019-12-19 | AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024090554A Division JP2024113043A (ja) | 2018-12-19 | 2024-06-04 | アミロイド前駆体タンパク質(APP)RNAi薬剤組成物およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022515193A true JP2022515193A (ja) | 2022-02-17 |
| JP2022515193A5 JP2022515193A5 (https=) | 2022-12-26 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536024A Pending JP2022515193A (ja) | 2018-12-19 | 2019-12-19 | アミロイド前駆体タンパク質(APP)RNAi薬剤組成物およびその使用方法 |
| JP2024090554A Pending JP2024113043A (ja) | 2018-12-19 | 2024-06-04 | アミロイド前駆体タンパク質(APP)RNAi薬剤組成物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024090554A Pending JP2024113043A (ja) | 2018-12-19 | 2024-06-04 | アミロイド前駆体タンパク質(APP)RNAi薬剤組成物およびその使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11034957B2 (https=) |
| EP (1) | EP3898979A4 (https=) |
| JP (2) | JP2022515193A (https=) |
| KR (1) | KR20210111780A (https=) |
| CN (2) | CN113454222B (https=) |
| AU (1) | AU2019405783B2 (https=) |
| BR (1) | BR112021011895A2 (https=) |
| CA (1) | CA3124090A1 (https=) |
| CL (1) | CL2021001605A1 (https=) |
| CO (1) | CO2021009163A2 (https=) |
| CR (1) | CR20210393A (https=) |
| DO (2) | DOP2021000126A (https=) |
| IL (1) | IL283852A (https=) |
| MX (1) | MX2021007570A (https=) |
| MY (1) | MY206230A (https=) |
| PE (1) | PE20211420A1 (https=) |
| PH (1) | PH12021551482A1 (https=) |
| SG (1) | SG11202105886QA (https=) |
| TW (1) | TW202039844A (https=) |
| WO (1) | WO2020132227A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024518564A (ja) * | 2021-05-11 | 2024-05-01 | ディセルナ ファーマシューティカルズ インコーポレイテッド | 中枢神経系のニューロンを標的とするための脂質コンジュゲーション |
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| JP6382800B2 (ja) | 2012-05-29 | 2018-08-29 | スリーエム イノベイティブ プロパティズ カンパニー | ポリマー発泡体及び中間体を含む吸収性物品 |
| US11732260B2 (en) | 2018-03-02 | 2023-08-22 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-β precursor protein |
| US20220275037A1 (en) * | 2019-07-19 | 2022-09-01 | Dingding MO | ß-AMYLOID CYCLIC RIBONUCLEIC ACID, POLYPEPTIDE, AND APPLICATION THEREOF |
| JP2019213978A (ja) * | 2019-09-30 | 2019-12-19 | 株式会社三洋物産 | 遊技機 |
| CA3189922A1 (en) * | 2020-07-28 | 2022-02-03 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
| WO2022026531A1 (en) * | 2020-07-29 | 2022-02-03 | Alnylam Pharmaceuticals, Inc. | Atxn2 irna compositions and methods of use thereof for treating or preventing atxn2-associated neurodegenerative diseases |
| US20240117349A1 (en) * | 2021-01-29 | 2024-04-11 | Alnylam Pharmaceuticals, Inc. | iRNA COMPOSITIONS AND METHODS FOR SILENCING AMYLOID PRECURSOR PROTEIN (APP) |
| US20240175028A1 (en) * | 2021-03-05 | 2024-05-30 | Alnylam Pharmaceuticals, Inc | DOSING OF siRNA COMPOUNDS TO THE CISTERNA MAGNA |
| EP4399311A4 (en) * | 2021-09-10 | 2025-11-26 | Alnylam Pharmaceuticals Inc | APP ARNI COMPOSITIONS AND THEIR METHODS OF USE FOR TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ENLARGED ENDOSOMES |
| TW202328449A (zh) | 2021-09-24 | 2023-07-16 | 美商艾拉倫製藥公司 | 微管相關蛋白TAU(MAPT)iRNA試劑組合物及其使用方法 |
| EP4422699A4 (en) * | 2021-10-28 | 2026-02-11 | Univ Hong Kong Science & Tech | CRISPR-MEDIATED MANIPULATION OF APP EXPRESSION AS A THERAPEUTIC APPROACH FOR AMYLOID PATHOLOGIES |
| WO2023081500A2 (en) * | 2021-11-08 | 2023-05-11 | Dicerna Pharmaceuticals, Inc. | RNAi OLIGONUCLEOTIDE CONJUGATES |
| TW202335674A (zh) * | 2021-11-05 | 2023-09-16 | 美商黛瑟納製藥公司 | 靶定中樞神經系統的星狀細胞之脂質結合物 |
| WO2023173061A2 (en) * | 2022-03-11 | 2023-09-14 | University Of Massachusetts | Oligonucleotides for app modulation |
| WO2023207615A1 (zh) * | 2022-04-26 | 2023-11-02 | 南京明德新药研发有限公司 | 一类含由天然核苷酸组成突出端的双链RNAi化合物 |
| WO2023224979A1 (en) * | 2022-05-16 | 2023-11-23 | University Of Massachusetts | Optimized sirna scaffolds |
| WO2023230465A1 (en) * | 2022-05-23 | 2023-11-30 | Switch Therapeutics Inc. | Antisense oligonucleotides |
| WO2025007961A1 (zh) | 2023-07-06 | 2025-01-09 | 大睿生物 | 调控AGT表达的dsRNA分子 |
| US20250064958A1 (en) * | 2023-08-22 | 2025-02-27 | Eli Lilly And Company | AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENTS |
| WO2025045195A1 (zh) * | 2023-08-31 | 2025-03-06 | 上海拓界生物医药科技有限公司 | 靶向APP的RNAi剂及其医药用途 |
| AU2024354107A1 (en) * | 2023-09-28 | 2026-04-16 | Bebetter Med Inc. | Sirna inhibiting expression of amyloid precursor protein (app) gene, drug, and use |
| TW202516009A (zh) * | 2023-10-10 | 2025-04-16 | 大陸商上海舶望製藥有限公司 | 抑制澱粉樣前體蛋白(app)表達的組合物和方法 |
| WO2025228429A1 (zh) * | 2024-04-30 | 2025-11-06 | 北京安龙生物医药有限公司 | 靶向淀粉样前体蛋白基因的寡核苷酸及其用途 |
| CN118979036B (zh) * | 2024-08-01 | 2025-08-19 | 北京尧景基因技术有限公司 | 抑制APP基因表达的siRNA及其缀合物和应用 |
| WO2026085164A2 (en) | 2024-10-16 | 2026-04-23 | Alnylam Pharmaceuticals, Inc. | Snca irna formulations and methods of use thereof |
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| WO2005003350A2 (en) * | 2003-06-27 | 2005-01-13 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER’S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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| US20080032942A1 (en) * | 2000-08-30 | 2008-02-07 | Mcswiggen James | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
| US20050209179A1 (en) * | 2000-08-30 | 2005-09-22 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
| US8101348B2 (en) | 2002-07-10 | 2012-01-24 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | RNA-interference by single-stranded RNA molecules |
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