JP2022515193A - アミロイド前駆体タンパク質（ＡＰＰ）ＲＮＡｉ薬剤組成物およびその使用方法 - Google Patents

アミロイド前駆体タンパク質（ＡＰＰ）ＲＮＡｉ薬剤組成物およびその使用方法 Download PDF

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JP2022515193A
JP2022515193A JP2021536024A JP2021536024A JP2022515193A JP 2022515193 A JP2022515193 A JP 2022515193A JP 2021536024 A JP2021536024 A JP 2021536024A JP 2021536024 A JP2021536024 A JP 2021536024A JP 2022515193 A JP2022515193 A JP 2022515193A
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double
nucleotides
rnai agent
app
strand
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JP2022515193A5 (https=
JPWO2020132227A5 (https=
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スチュアート ミルスタイン，
カーク ブラウン，
ジャヤプラカーシュ ナイヤー，
マーティン マイヤー，
ヴァサント ジャダーヴ，
マーク キーティング，
アダム カストレーノ，
パトリック ハスレット，
マンガラ， ミーナクシー サウンダラパンディアン，
ケヴィン フィッツジェラルド，
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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JP2021536024A 2018-12-19 2019-12-19 アミロイド前駆体タンパク質（ＡＰＰ）ＲＮＡｉ薬剤組成物およびその使用方法 Pending JP2022515193A (ja)

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JP2024090554A JP2024113043A (ja) 2018-12-19 2024-06-04 アミロイド前駆体タンパク質（ＡＰＰ）ＲＮＡｉ薬剤組成物およびその使用方法

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US201862781774P 2018-12-19 2018-12-19
US62/781,774 2018-12-19
US201962862472P 2019-06-17 2019-06-17
US62/862,472 2019-06-17
US201962928795P 2019-10-31 2019-10-31
US62/928,795 2019-10-31
PCT/US2019/067449 WO2020132227A2 (en) 2018-12-19 2019-12-19 AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF

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JP2022515193A5 JP2022515193A5 (https=) 2022-12-26
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JP2024090554A Pending JP2024113043A (ja) 2018-12-19 2024-06-04 アミロイド前駆体タンパク質（ＡＰＰ）ＲＮＡｉ薬剤組成物およびその使用方法

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EP (1) EP3898979A4 (https=)
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KR (1) KR20210111780A (https=)
CN (2) CN113454222B (https=)
AU (1) AU2019405783B2 (https=)
BR (1) BR112021011895A2 (https=)
CA (1) CA3124090A1 (https=)
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KR20240067943A (ko) 2021-09-24 2024-05-17 알닐람 파마슈티칼스 인코포레이티드 미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법
JP2024542125A (ja) * 2021-10-28 2024-11-13 ザ・ホンコン・ユニバーシティー・オブ・サイエンス・アンド・テクノロジー アミロイド病変に対する治療アプローチとしてのａｐｐ発現のｃｒｉｓｐｒ媒介性操作
TW202335674A (zh) * 2021-11-05 2023-09-16 美商黛瑟納製藥公司 靶定中樞神經系統的星狀細胞之脂質結合物
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WO2023207615A1 (zh) * 2022-04-26 2023-11-02 南京明德新药研发有限公司 一类含由天然核苷酸组成突出端的双链RNAi化合物
WO2023224979A1 (en) * 2022-05-16 2023-11-23 University Of Massachusetts Optimized sirna scaffolds
WO2023230465A1 (en) * 2022-05-23 2023-11-30 Switch Therapeutics Inc. Antisense oligonucleotides
CN121399258A (zh) 2023-07-06 2026-01-23 大睿生物医药科技(上海)有限公司 调控AGT表达的dsRNA分子
AU2024326438A1 (en) * 2023-08-22 2026-04-02 Eli Lilly And Company AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENTS
WO2025045195A1 (zh) * 2023-08-31 2025-03-06 上海拓界生物医药科技有限公司 靶向APP的RNAi剂及其医药用途
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CN118979036B (zh) * 2024-08-01 2025-08-19 北京尧景基因技术有限公司 抑制APP基因表达的siRNA及其缀合物和应用

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