|
US2592668A
(en)
|
1948-09-08 |
1952-04-15 |
Dufour Leon |
Locking mechanism for a differential
|
|
US5292668A
(en)
|
1981-12-21 |
1994-03-08 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
|
ATE87659T1
(de)
|
1986-09-02 |
1993-04-15 |
Enzon Lab Inc |
Bindungsmolekuele mit einzelpolypeptidkette.
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
SE9201331D0
(sv)
|
1992-04-28 |
1992-04-28 |
Hightech Receptor C O Active |
Protein l och hybridproteiner daerav
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
AUPO591797A0
(en)
|
1997-03-27 |
1997-04-24 |
Commonwealth Scientific And Industrial Research Organisation |
High avidity polyvalent and polyspecific reagents
|
|
JP3266276B2
(ja)
|
1996-07-25 |
2002-03-18 |
ゲーエスエフ―フォルシュングスツェントゥルム・フューア・ウムヴェルト・ウント・ゲズントハイト・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
二重特異性抗体断片の簡易化した製造
|
|
US20040038894A1
(en)
|
1996-12-31 |
2004-02-26 |
Institut National De La Sante Et De La Recherche Medicale (I.N.S.E.R.M.) |
Compounds for modulating cell negative regulations and biological applications thereof
|
|
JP4213224B2
(ja)
|
1997-05-02 |
2009-01-21 |
ジェネンテック,インコーポレーテッド |
ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
|
|
WO1999055369A1
(en)
|
1998-04-28 |
1999-11-04 |
Smithkline Beecham Corporation |
Monoclonal antibodies with reduced immunogenicity
|
|
US6528286B1
(en)
|
1998-05-29 |
2003-03-04 |
Genentech, Inc. |
Mammalian cell culture process for producing glycoproteins
|
|
DE19859110A1
(de)
|
1998-09-25 |
2000-04-13 |
Horst Lindhofer |
Bispezifische und trispezifische Antikörper, die spezifisch mit induzierbaren Oberflächenantigenen als operationelle Zielstrukturen reagieren
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
NZ530212A
(en)
|
2001-06-13 |
2006-09-29 |
Genmab As |
An isolated human monoclonal antibody that binds to human epidermal growth factor receptor (EGFR)
|
|
CN101928344B
(zh)
|
2002-10-17 |
2014-08-13 |
根马布股份公司 |
抗cd20的人单克隆抗体
|
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
JP2006524039A
(ja)
|
2003-01-09 |
2006-10-26 |
マクロジェニクス,インコーポレーテッド |
変異型Fc領域を含む抗体の同定および作製ならびにその利用法
|
|
CA2529945A1
(en)
|
2003-06-27 |
2005-01-06 |
Biogen Idec Ma Inc. |
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
|
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
|
AU2003280713A1
(en)
|
2003-11-04 |
2005-05-19 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibody
|
|
US20050136051A1
(en)
|
2003-12-22 |
2005-06-23 |
Bernard Scallon |
Methods for generating multimeric molecules
|
|
US8772013B2
(en)
|
2004-02-02 |
2014-07-08 |
Engeneic Molecular Delivery Pty Ltd |
Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
|
|
US20050208519A1
(en)
|
2004-03-12 |
2005-09-22 |
Genenews Inc. |
Biomarkers for diagnosing schizophrenia and bipolar disorder
|
|
US7537930B2
(en)
|
2004-07-23 |
2009-05-26 |
Immunomedics, Inc. |
Mammalian cell lines for increasing longevity and protein yield from a cell culture
|
|
US20060074225A1
(en)
|
2004-09-14 |
2006-04-06 |
Xencor, Inc. |
Monomeric immunoglobulin Fc domains
|
|
US8911726B2
(en)
|
2004-09-22 |
2014-12-16 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human Igg4 antibodies
|
|
JP5553963B2
(ja)
|
2004-10-22 |
2014-07-23 |
アムジエン・インコーポレーテツド |
組換え抗体をリフォールディングする方法
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
DE102005028778A1
(de)
|
2005-06-22 |
2006-12-28 |
SUNJÜT Deutschland GmbH |
Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
|
|
US10155816B2
(en)
|
2005-11-28 |
2018-12-18 |
Genmab A/S |
Recombinant monovalent antibodies and methods for production thereof
|
|
WO2007103112A2
(en)
|
2006-03-03 |
2007-09-13 |
Elan Pharmaceuticals, Inc. |
Methods of treating inflammatory and autoimmune diseases with natalizumab
|
|
US8871912B2
(en)
|
2006-03-24 |
2014-10-28 |
Merck Patent Gmbh |
Engineered heterodimeric protein domains
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
GB0621513D0
(en)
|
2006-10-30 |
2006-12-06 |
Domantis Ltd |
Novel polypeptides and uses thereof
|
|
WO2008119353A1
(en)
|
2007-03-29 |
2008-10-09 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
|
EP2144628B1
(en)
|
2007-05-08 |
2012-10-17 |
Genentech, Inc. |
Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
|
|
AU2008255352B2
(en)
|
2007-05-31 |
2014-05-22 |
Genmab A/S |
Stable IgG4 antibodies
|
|
AU2008255350B2
(en)
|
2007-05-31 |
2014-07-10 |
Genmab A/S |
Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
|
|
UA107557C2
(xx)
|
2007-07-06 |
2015-01-26 |
|
Композиція антитіла офатумумабу
|
|
WO2009023562A2
(en)
|
2007-08-09 |
2009-02-19 |
Wyeth |
Use of perfusion to enhance production of fed-batch cell culture in bioreactors
|
|
JP2011507519A
(ja)
|
2007-12-19 |
2011-03-10 |
セントコア・オーソ・バイオテツク・インコーポレーテツド |
pIX又はpVIIへの融合を介したヒトデノボpIXファージディスプレイライブラリの設計及び作製、ベクター、抗体、及び方法
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
ES2563027T3
(es)
|
2008-01-07 |
2016-03-10 |
Amgen Inc. |
Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
|
GB2461546B
(en)
|
2008-07-02 |
2010-07-07 |
Argen X Bv |
Antigen binding polypeptides
|
|
JP5746040B2
(ja)
|
2008-12-03 |
2015-07-08 |
ゲンマブ エー/エス |
定常領域の中に改変を有する抗体変種
|
|
JP2012525149A
(ja)
|
2009-04-27 |
2012-10-22 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
ヘテロ多量体分子を作製するための方法
|
|
JP5816170B2
(ja)
|
2009-06-26 |
2015-11-18 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体
|
|
DK2560993T3
(da)
|
2010-04-20 |
2024-10-14 |
Genmab As |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
|
CN102946906B
(zh)
|
2010-04-23 |
2015-07-15 |
弗·哈夫曼-拉罗切有限公司 |
生产异源多聚体蛋白质
|
|
US9527926B2
(en)
|
2010-05-14 |
2016-12-27 |
Rinat Neuroscience Corp. |
Heterodimeric proteins and methods for producing and purifying them
|
|
CA2808154A1
(en)
|
2010-08-13 |
2012-02-16 |
Medimmmune Limited |
Monomeric polypeptides comprising variant fc regions and methods of use
|
|
PL2635607T3
(pl)
|
2010-11-05 |
2020-05-18 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
|
|
WO2012104344A1
(en)
|
2011-02-01 |
2012-08-09 |
Genmab A/S |
Human antibodies and antibody-drug conjugates against cd74
|
|
AU2012222833B2
(en)
|
2011-03-03 |
2017-03-16 |
Zymeworks Inc. |
Multivalent heteromultimer scaffold design and constructs
|
|
US10239952B2
(en)
|
2011-04-01 |
2019-03-26 |
Memorial Sloan Kettering Cancer Center |
Anti-WT1/HLA bi-specific antibody
|
|
JP6177231B2
(ja)
|
2011-04-20 |
2017-08-09 |
ゲンマブ エー/エス |
Her2に対する二重特異性抗体
|
|
US20140170148A1
(en)
|
2011-04-20 |
2014-06-19 |
Genmab A/S |
Bispecific antibodies against her2
|
|
CA2832389A1
(en)
|
2011-04-20 |
2012-10-26 |
Genmab A/S |
Bispecific antibodies against her2 and cd3
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
EP2768857B1
(en)
|
2011-10-19 |
2020-01-01 |
NovImmune SA |
Methods of purifying antibodies
|
|
US10344050B2
(en)
*
|
2011-10-27 |
2019-07-09 |
Genmab A/S |
Production of heterodimeric proteins
|
|
CA2854233C
(en)
|
2011-11-04 |
2020-05-12 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
|
LT2794905T
(lt)
|
2011-12-20 |
2020-07-10 |
Medimmune, Llc |
Modifikuoti polipeptidai, skirti bispecifinių antikūnų karkasams
|
|
PT2825559T
(pt)
|
2012-03-13 |
2019-06-07 |
Novimmune Sa |
Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo
|
|
SI2838917T1
(sl)
|
2012-04-20 |
2019-11-29 |
Merus Nv |
Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul
|
|
US9062120B2
(en)
|
2012-05-02 |
2015-06-23 |
Janssen Biotech, Inc. |
Binding proteins having tethered light chains
|
|
BR112015000167B1
(pt)
|
2012-07-06 |
2021-11-23 |
Genmab B.V. |
Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante
|
|
ES2758979T3
(es)
|
2012-07-06 |
2020-05-07 |
Genmab Bv |
Proteína dimérica con mutaciones triples
|
|
US20170275367A1
(en)
*
|
2012-11-21 |
2017-09-28 |
Janssen Biotech, Inc. |
Bispecific EGFR/C-Met Antibodies
|
|
CN113201073A
(zh)
|
2012-11-21 |
2021-08-03 |
詹森生物科技公司 |
双特异性EGFR/c-Met抗体
|
|
KR20200024345A
(ko)
|
2013-01-10 |
2020-03-06 |
젠맵 비. 브이 |
인간 IgG1 Fc 영역 변이체 및 그의 용도
|
|
LT2953969T
(lt)
*
|
2013-02-08 |
2019-12-10 |
Novartis Ag |
Anti-il-17a antikūnai ir jų panaudojimas autoimuninių ir uždegiminių ligų gydymui
|
|
KR102216003B1
(ko)
|
2013-03-15 |
2021-02-16 |
얀센 바이오테크 인코포레이티드 |
재조합 단백질에서 c-말단 라이신, 갈락토스 및 시알산 함량을 제어하기 위한 제조 방법
|
|
JP6586016B2
(ja)
|
2013-03-15 |
2019-10-02 |
ノヴォ ノルディスク アー/エス |
組織因子系凝固インヒビター上の2つのエピトープに特異的に結合することが可能な抗体
|
|
US9595164B2
(en)
|
2013-05-16 |
2017-03-14 |
Bally Gaming, Inc. |
Social gaming website and related in-advertisement gaming
|
|
JO3568B1
(ar)
|
2014-09-05 |
2020-07-05 |
Janssen Pharmaceutica Nv |
عوامل ربط cd123 واستخداماتها
|
|
CN104301917A
(zh)
|
2014-09-15 |
2015-01-21 |
浙江生辉照明有限公司 |
基于照明装置的网络异常自愈方法及系统
|
|
DK3233907T3
(da)
|
2014-12-19 |
2021-06-07 |
Genmab As |
Bispecifikke heterodimeriske proteiner hos gnavere
|
|
JP6247241B2
(ja)
|
2015-02-27 |
2017-12-13 |
ノバルティス アーゲー |
抗体処方
|
|
ES2973885T3
(es)
|
2015-07-09 |
2024-06-24 |
Genmab As |
Anticuerpos biespecíficos y multiespecíficos y método para aislarlos
|
|
CN109071658A
(zh)
|
2016-02-05 |
2018-12-21 |
根马布股份公司 |
具有改进的内化特性的多特异性抗原-结合分子
|
|
KR102329490B1
(ko)
*
|
2016-09-14 |
2021-11-23 |
베이징 한미 파마슈티컬 컴퍼니 리미티드 |
Il-17a에 특이적으로 결합하는 항체 및 그의 기능성 단편
|
|
ES2897217T3
(es)
|
2016-09-30 |
2022-02-28 |
Hoffmann La Roche |
Anticuerpos biespecíficos frente a p95HER2
|
|
KR20250140128A
(ko)
|
2017-02-10 |
2025-09-24 |
젠맵 비. 브이 |
폴리펩티드 변이체 및 그의 용도
|
|
EP3743440A1
(en)
|
2018-01-24 |
2020-12-02 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
|
CN112513074A
(zh)
|
2018-06-22 |
2021-03-16 |
健玛保 |
生产两种或更多种不同抗体的受控混合物的方法
|