JP2022512975A5 - - Google Patents
Info
- Publication number
- JP2022512975A5 JP2022512975A5 JP2021525122A JP2021525122A JP2022512975A5 JP 2022512975 A5 JP2022512975 A5 JP 2022512975A5 JP 2021525122 A JP2021525122 A JP 2021525122A JP 2021525122 A JP2021525122 A JP 2021525122A JP 2022512975 A5 JP2022512975 A5 JP 2022512975A5
- Authority
- JP
- Japan
- Prior art keywords
- units
- modified oligonucleotide
- complex
- sequence
- hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862757632P | 2018-11-08 | 2018-11-08 | |
| US62/757,632 | 2018-11-08 | ||
| US201962855323P | 2019-05-31 | 2019-05-31 | |
| US62/855,323 | 2019-05-31 | ||
| US201962907845P | 2019-09-30 | 2019-09-30 | |
| US62/907,845 | 2019-09-30 | ||
| PCT/US2019/060283 WO2020097342A1 (en) | 2018-11-08 | 2019-11-07 | S-antigen transport inhibiting oligonucleotide polymers and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022512975A JP2022512975A (ja) | 2022-02-07 |
| JP2022512975A5 true JP2022512975A5 (https=) | 2022-11-11 |
Family
ID=70551410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021525122A Pending JP2022512975A (ja) | 2018-11-08 | 2019-11-07 | Ｓ－抗原輸送阻害オリゴヌクレオチドポリマーおよび方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20200147124A1 (https=) |
| EP (1) | EP3853240A4 (https=) |
| JP (1) | JP2022512975A (https=) |
| KR (1) | KR20210090217A (https=) |
| CN (1) | CN113286803A (https=) |
| AU (1) | AU2019376079A1 (https=) |
| BR (1) | BR112021008539A2 (https=) |
| CA (1) | CA3117163A1 (https=) |
| CL (1) | CL2021001202A1 (https=) |
| CO (1) | CO2021005762A2 (https=) |
| IL (1) | IL282640A (https=) |
| MA (1) | MA53674A (https=) |
| MX (1) | MX2021005357A (https=) |
| PE (1) | PE20211783A1 (https=) |
| PH (1) | PH12021551007A1 (https=) |
| SG (1) | SG11202104636XA (https=) |
| TW (1) | TW202031267A (https=) |
| WO (1) | WO2020097342A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11166976B2 (en) | 2018-11-08 | 2021-11-09 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| US20200385713A1 (en) * | 2019-01-22 | 2020-12-10 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| AU2020260105A1 (en) | 2019-04-17 | 2021-11-04 | Aligos Therapeutics, Inc. | Bicyclic and tricyclic compounds |
| SG11202112741XA (en) | 2019-05-31 | 2021-12-30 | Aligos Therapeutics Inc | Modified gapmer oligonucleotides and methods of use |
| AU2020289537A1 (en) | 2019-06-06 | 2021-11-25 | Aligos Therapeutics, Inc. | Heterocyclic compounds |
| US20220281911A1 (en) * | 2019-08-19 | 2022-09-08 | Mina Therapeutics Limited | Oligonucleotide conjugate compositions and methods of use |
| IL291251B1 (en) * | 2019-09-10 | 2026-02-01 | Daiichi Sankyo Co Ltd | Oligonucleotide-galnac conjugate for targeted delivery to the liver and method for its production |
| US20210189392A1 (en) * | 2019-12-12 | 2021-06-24 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| PE20221578A1 (es) | 2020-03-06 | 2022-10-06 | Aligos Therapeutics Inc | Moleculas de acido nucleico interferente corto (sina, por sus siglas en ingles) modificadas y usos de estas |
| JP2023534557A (ja) * | 2020-07-23 | 2023-08-09 | エフ． ホフマン－ラ ロシュ アーゲー | Ｒｎａ結合タンパク質部位を標的とするオリゴヌクレオチド |
| AU2021318943A1 (en) * | 2020-07-27 | 2023-03-02 | Aligos Therapeutics, Inc. | HBV binding oligonucleotides and methods of use |
| EP4229062A4 (en) | 2020-10-15 | 2024-10-30 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| JP2023548031A (ja) | 2020-10-21 | 2023-11-15 | アリゴス セラピューティクス インコーポレイテッド | 二環式化合物 |
| WO2022109129A1 (en) * | 2020-11-20 | 2022-05-27 | Aligos Therapeutics, Inc. | Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting |
| EP4251625A4 (en) | 2020-11-24 | 2024-10-09 | Aligos Therapeutics, Inc. | Tricyclic compounds |
| TW202245809A (zh) | 2020-12-18 | 2022-12-01 | 美商詹森藥物公司 | 用於治療b型肝炎病毒感染之組合療法 |
| WO2022152869A1 (en) | 2021-01-15 | 2022-07-21 | Janssen Sciences Ireland Unlimited Company | Use of oligonucleotides for individuals with hepatic impairment |
| CA3204340A1 (en) * | 2021-01-30 | 2022-08-04 | Ahmad Ali MORTAZAVI | Conjugated oligonucleotide compounds, methods of making and uses thereof |
| JP2024504504A (ja) * | 2021-01-30 | 2024-01-31 | イー セラピューティクス パブリック リミテッド カンパニー | コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用 |
| WO2022162157A1 (en) * | 2021-01-30 | 2022-08-04 | E-Therapeutics Plc | Conjugated oligonucleotide compounds, methods of making and uses thereof |
| CN115850358B (zh) * | 2021-03-08 | 2026-04-24 | 南京吉迈生物技术有限公司 | GalNAc簇亚磷酰胺和靶向治疗性核苷 |
| EP4349986A4 (en) * | 2021-05-25 | 2025-11-19 | Univ Nat Corp Tokyo Medical & Dental | HETERONUCLEIC ACID WITH A CONTENT OF ?????? OR ???? |
| US11957683B2 (en) | 2021-06-18 | 2024-04-16 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| JP2024527380A (ja) | 2021-07-09 | 2024-07-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー３）、リミテッド | 腎機能障害を有する個体へのオリゴヌクレオチドの使用 |
| US20250243491A1 (en) | 2021-09-01 | 2025-07-31 | Aligos Therapeutics, Inc. | Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof |
| EP4399217A2 (en) | 2021-09-08 | 2024-07-17 | Aligos Therapeutics, Inc. | Modified short interfering nucleic acid (sina) molecules and uses thereof |
| CN118234862A (zh) | 2021-09-08 | 2024-06-21 | 阿利戈斯治疗公司 | 经修饰的短干扰核酸分子(siNA)及其用途 |
| CN114230624A (zh) * | 2021-12-22 | 2022-03-25 | 上海兆维科技发展有限公司 | 一种核苷二聚体亚膦酰胺的合成方法 |
| KR20240158340A (ko) | 2022-03-17 | 2024-11-04 | 알리고스 테라퓨틱스 인코포레이티드 | 변형 갭머 올리고머 및 이의 사용 방법 |
| EP4511374A4 (en) | 2022-04-20 | 2026-04-08 | Aligos Therapeutics Inc | BICYCLE COMPOUNDS |
| WO2023222858A1 (en) * | 2022-05-18 | 2023-11-23 | F. Hoffmann-La Roche Ag | Improved oligonucleotides targeting rna binding protein sites |
| WO2024182446A2 (en) | 2023-02-28 | 2024-09-06 | Aligos Therapeutics, Inc. | Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof |
| US20240352464A1 (en) | 2023-03-07 | 2024-10-24 | Aligos Therapeutics, Inc. | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof |
| CN121175419A (zh) * | 2023-04-14 | 2025-12-19 | 苏州炫景生物科技有限公司 | 抑制c3基因表达的化合物、药物组合物及其用途 |
| WO2025143262A1 (ja) * | 2023-12-28 | 2025-07-03 | 日産化学株式会社 | カルバモイルエチル修飾を含有する二本鎖ｒｎａ |
| CN117534717A (zh) * | 2024-01-09 | 2024-02-09 | 凯莱英生命科学技术(天津)有限公司 | 5′-(e)-乙烯基磷酸酯的合成方法 |
| US20250368996A1 (en) | 2024-05-14 | 2025-12-04 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
| US20250382618A1 (en) * | 2024-06-14 | 2025-12-18 | Aligos Therapeutics, Inc. | Methods and compositions for inhibiting virus |
| CN119569802B (zh) * | 2025-02-06 | 2025-06-13 | 北京安龙生物医药有限公司 | 修饰寡核苷酸的化合物、其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084232A (zh) * | 2004-10-19 | 2007-12-05 | 里普利科股份有限公司 | 抗病毒寡核苷酸 |
| JPWO2006043521A1 (ja) * | 2004-10-19 | 2008-05-22 | 日本新薬株式会社 | ホスホロチオエート結合を有する光学活性なオリゴ核酸化合物 |
| WO2007090071A2 (en) * | 2006-01-27 | 2007-08-09 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
| BR112013003875B1 (pt) * | 2010-08-20 | 2021-10-05 | Replicor Inc | Composições farmacêuticas compreendendo complexo de quelato de oligonucleotídeo, formulação de oligonucleotídeo, e usos |
| SMT202100319T1 (it) * | 2012-05-18 | 2021-09-14 | Replicor Inc | Composizioni e metodi del complesso oligonucleotide chelato polipeptidico |
| CN106659730A (zh) * | 2014-07-10 | 2017-05-10 | 里普利科股份有限公司 | 治疗b型肝炎和d型肝炎病毒感染的方法 |
| KR102533038B1 (ko) * | 2016-09-14 | 2023-05-17 | 얀센 바이오파마, 인크. | 변형된 올리고뉴클레오티드 및 사용 방법 |
-
2019
- 2019-11-07 PE PE2021000674A patent/PE20211783A1/es unknown
- 2019-11-07 CA CA3117163A patent/CA3117163A1/en active Pending
- 2019-11-07 AU AU2019376079A patent/AU2019376079A1/en not_active Abandoned
- 2019-11-07 WO PCT/US2019/060283 patent/WO2020097342A1/en not_active Ceased
- 2019-11-07 KR KR1020217017323A patent/KR20210090217A/ko not_active Withdrawn
- 2019-11-07 CN CN201980088039.4A patent/CN113286803A/zh active Pending
- 2019-11-07 EP EP19880948.5A patent/EP3853240A4/en not_active Withdrawn
- 2019-11-07 JP JP2021525122A patent/JP2022512975A/ja active Pending
- 2019-11-07 SG SG11202104636XA patent/SG11202104636XA/en unknown
- 2019-11-07 MX MX2021005357A patent/MX2021005357A/es unknown
- 2019-11-07 MA MA053674A patent/MA53674A/fr unknown
- 2019-11-07 BR BR112021008539-4A patent/BR112021008539A2/pt not_active IP Right Cessation
- 2019-11-07 US US16/676,929 patent/US20200147124A1/en not_active Abandoned
- 2019-11-08 TW TW108140604A patent/TW202031267A/zh unknown
-
2021
- 2021-04-26 IL IL282640A patent/IL282640A/en unknown
- 2021-04-30 CO CONC2021/0005762A patent/CO2021005762A2/es unknown
- 2021-05-03 PH PH12021551007A patent/PH12021551007A1/en unknown
- 2021-05-06 CL CL2021001202A patent/CL2021001202A1/es unknown
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