JP2022512975A - Ｓ－抗原輸送阻害オリゴヌクレオチドポリマーおよび方法 - Google Patents

Ｓ－抗原輸送阻害オリゴヌクレオチドポリマーおよび方法 Download PDF

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JP2022512975A
JP2022512975A JP2021525122A JP2021525122A JP2022512975A JP 2022512975 A JP2022512975 A JP 2022512975A JP 2021525122 A JP2021525122 A JP 2021525122A JP 2021525122 A JP2021525122 A JP 2021525122A JP 2022512975 A JP2022512975 A JP 2022512975A
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complex
modified oligonucleotide
units
oligonucleotide
modified
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JP2022512975A5 (https=
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レオニド ベイゲルマン
ラジェンドラ パンデイ
ヴィヴェク クマール ラジュワンシ
デヴィッド バーナード スミス
ローレンス エム ブラット
ジン ホン
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アリゴス セラピューティクス インコーポレイテッド
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    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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JP2021525122A 2018-11-08 2019-11-07 Ｓ－抗原輸送阻害オリゴヌクレオチドポリマーおよび方法 Pending JP2022512975A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862757632P 2018-11-08 2018-11-08
US62/757,632 2018-11-08
US201962855323P 2019-05-31 2019-05-31
US62/855,323 2019-05-31
US201962907845P 2019-09-30 2019-09-30
US62/907,845 2019-09-30
PCT/US2019/060283 WO2020097342A1 (en) 2018-11-08 2019-11-07 S-antigen transport inhibiting oligonucleotide polymers and methods

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JP2022512975A true JP2022512975A (ja) 2022-02-07
JP2022512975A5 JP2022512975A5 (https=) 2022-11-11

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US (1) US20200147124A1 (https=)
EP (1) EP3853240A4 (https=)
JP (1) JP2022512975A (https=)
KR (1) KR20210090217A (https=)
CN (1) CN113286803A (https=)
AU (1) AU2019376079A1 (https=)
BR (1) BR112021008539A2 (https=)
CA (1) CA3117163A1 (https=)
CL (1) CL2021001202A1 (https=)
CO (1) CO2021005762A2 (https=)
IL (1) IL282640A (https=)
MA (1) MA53674A (https=)
MX (1) MX2021005357A (https=)
PE (1) PE20211783A1 (https=)
PH (1) PH12021551007A1 (https=)
SG (1) SG11202104636XA (https=)
TW (1) TW202031267A (https=)
WO (1) WO2020097342A1 (https=)

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SG11202112741XA (en) 2019-05-31 2021-12-30 Aligos Therapeutics Inc Modified gapmer oligonucleotides and methods of use
AU2020289537A1 (en) 2019-06-06 2021-11-25 Aligos Therapeutics, Inc. Heterocyclic compounds
US20220281911A1 (en) * 2019-08-19 2022-09-08 Mina Therapeutics Limited Oligonucleotide conjugate compositions and methods of use
IL291251B1 (en) * 2019-09-10 2026-02-01 Daiichi Sankyo Co Ltd Oligonucleotide-galnac conjugate for targeted delivery to the liver and method for its production
US20210189392A1 (en) * 2019-12-12 2021-06-24 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
PE20221578A1 (es) 2020-03-06 2022-10-06 Aligos Therapeutics Inc Moleculas de acido nucleico interferente corto (sina, por sus siglas en ingles) modificadas y usos de estas
JP2023534557A (ja) * 2020-07-23 2023-08-09 エフ． ホフマン－ラ ロシュ アーゲー Ｒｎａ結合タンパク質部位を標的とするオリゴヌクレオチド
AU2021318943A1 (en) * 2020-07-27 2023-03-02 Aligos Therapeutics, Inc. HBV binding oligonucleotides and methods of use
EP4229062A4 (en) 2020-10-15 2024-10-30 Aligos Therapeutics, Inc. Bicyclic compounds
JP2023548031A (ja) 2020-10-21 2023-11-15 アリゴス セラピューティクス インコーポレイテッド 二環式化合物
WO2022109129A1 (en) * 2020-11-20 2022-05-27 Aligos Therapeutics, Inc. Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting
EP4251625A4 (en) 2020-11-24 2024-10-09 Aligos Therapeutics, Inc. Tricyclic compounds
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
WO2022152869A1 (en) 2021-01-15 2022-07-21 Janssen Sciences Ireland Unlimited Company Use of oligonucleotides for individuals with hepatic impairment
CA3204340A1 (en) * 2021-01-30 2022-08-04 Ahmad Ali MORTAZAVI Conjugated oligonucleotide compounds, methods of making and uses thereof
JP2024504504A (ja) * 2021-01-30 2024-01-31 イー セラピューティクス パブリック リミテッド カンパニー コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用
WO2022162157A1 (en) * 2021-01-30 2022-08-04 E-Therapeutics Plc Conjugated oligonucleotide compounds, methods of making and uses thereof
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