TW202031267A - S-抗原運輸抑制寡核苷酸聚合物及方法 - Google Patents

S-抗原運輸抑制寡核苷酸聚合物及方法 Download PDF

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TW202031267A
TW202031267A TW108140604A TW108140604A TW202031267A TW 202031267 A TW202031267 A TW 202031267A TW 108140604 A TW108140604 A TW 108140604A TW 108140604 A TW108140604 A TW 108140604A TW 202031267 A TW202031267 A TW 202031267A
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modified oligonucleotide
complex
units
ome
phosphorothioate
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TW108140604A
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Chinese (zh)
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里歐尼德 畢戈曼
瑞珍卓拉 潘迪
維韋克 庫瑪爾 拉萬施
大衛 伯納德 史密斯
勞倫斯 Ｍ 布雷特
勁 洪
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美商艾利格斯醫療公司
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/3521—Methyl
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TW108140604A 2018-11-08 2019-11-08 S-抗原運輸抑制寡核苷酸聚合物及方法 TW202031267A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862757632P 2018-11-08 2018-11-08
US62/757,632 2018-11-08
US201962855323P 2019-05-31 2019-05-31
US62/855,323 2019-05-31
US201962907845P 2019-09-30 2019-09-30
US62/907,845 2019-09-30

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TW202031267A true TW202031267A (zh) 2020-09-01

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US (1) US20200147124A1 (https=)
EP (1) EP3853240A4 (https=)
JP (1) JP2022512975A (https=)
KR (1) KR20210090217A (https=)
CN (1) CN113286803A (https=)
AU (1) AU2019376079A1 (https=)
BR (1) BR112021008539A2 (https=)
CA (1) CA3117163A1 (https=)
CL (1) CL2021001202A1 (https=)
CO (1) CO2021005762A2 (https=)
IL (1) IL282640A (https=)
MA (1) MA53674A (https=)
MX (1) MX2021005357A (https=)
PE (1) PE20211783A1 (https=)
PH (1) PH12021551007A1 (https=)
SG (1) SG11202104636XA (https=)
TW (1) TW202031267A (https=)
WO (1) WO2020097342A1 (https=)

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AU2020289537A1 (en) 2019-06-06 2021-11-25 Aligos Therapeutics, Inc. Heterocyclic compounds
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IL291251B1 (en) * 2019-09-10 2026-02-01 Daiichi Sankyo Co Ltd Oligonucleotide-galnac conjugate for targeted delivery to the liver and method for its production
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US20250243491A1 (en) 2021-09-01 2025-07-31 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
EP4399217A2 (en) 2021-09-08 2024-07-17 Aligos Therapeutics, Inc. Modified short interfering nucleic acid (sina) molecules and uses thereof
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