KR20210090217A - S-항원 수송 저해 올리고뉴클레오타이드 중합체 및 방법 - Google Patents

S-항원 수송 저해 올리고뉴클레오타이드 중합체 및 방법 Download PDF

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KR20210090217A
KR20210090217A KR1020217017323A KR20217017323A KR20210090217A KR 20210090217 A KR20210090217 A KR 20210090217A KR 1020217017323 A KR1020217017323 A KR 1020217017323A KR 20217017323 A KR20217017323 A KR 20217017323A KR 20210090217 A KR20210090217 A KR 20210090217A
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units
complex
modified oligonucleotide
modified
oligonucleotide
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Korean (ko)
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레오니드 베이겔먼
라젠드라 팬디
비베크 쿠마르 라지완쉬
데이비드 버나드 스미스
로렌스 엠. 블랫
진 홍
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알리고스 테라퓨틱스 인코포레이티드
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Publication of KR20210090217A publication Critical patent/KR20210090217A/ko
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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KR1020217017323A 2018-11-08 2019-11-07 S-항원 수송 저해 올리고뉴클레오타이드 중합체 및 방법 Withdrawn KR20210090217A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862757632P 2018-11-08 2018-11-08
US62/757,632 2018-11-08
US201962855323P 2019-05-31 2019-05-31
US62/855,323 2019-05-31
US201962907845P 2019-09-30 2019-09-30
US62/907,845 2019-09-30
PCT/US2019/060283 WO2020097342A1 (en) 2018-11-08 2019-11-07 S-antigen transport inhibiting oligonucleotide polymers and methods

Publications (1)

Publication Number Publication Date
KR20210090217A true KR20210090217A (ko) 2021-07-19

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KR1020217017323A Withdrawn KR20210090217A (ko) 2018-11-08 2019-11-07 S-항원 수송 저해 올리고뉴클레오타이드 중합체 및 방법

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Country Link
US (1) US20200147124A1 (https=)
EP (1) EP3853240A4 (https=)
JP (1) JP2022512975A (https=)
KR (1) KR20210090217A (https=)
CN (1) CN113286803A (https=)
AU (1) AU2019376079A1 (https=)
BR (1) BR112021008539A2 (https=)
CA (1) CA3117163A1 (https=)
CL (1) CL2021001202A1 (https=)
CO (1) CO2021005762A2 (https=)
IL (1) IL282640A (https=)
MA (1) MA53674A (https=)
MX (1) MX2021005357A (https=)
PE (1) PE20211783A1 (https=)
PH (1) PH12021551007A1 (https=)
SG (1) SG11202104636XA (https=)
TW (1) TW202031267A (https=)
WO (1) WO2020097342A1 (https=)

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AU2020260105A1 (en) 2019-04-17 2021-11-04 Aligos Therapeutics, Inc. Bicyclic and tricyclic compounds
SG11202112741XA (en) 2019-05-31 2021-12-30 Aligos Therapeutics Inc Modified gapmer oligonucleotides and methods of use
AU2020289537A1 (en) 2019-06-06 2021-11-25 Aligos Therapeutics, Inc. Heterocyclic compounds
US20220281911A1 (en) * 2019-08-19 2022-09-08 Mina Therapeutics Limited Oligonucleotide conjugate compositions and methods of use
IL291251B1 (en) * 2019-09-10 2026-02-01 Daiichi Sankyo Co Ltd Oligonucleotide-galnac conjugate for targeted delivery to the liver and method for its production
US20210189392A1 (en) * 2019-12-12 2021-06-24 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
PE20221578A1 (es) 2020-03-06 2022-10-06 Aligos Therapeutics Inc Moleculas de acido nucleico interferente corto (sina, por sus siglas en ingles) modificadas y usos de estas
JP2023534557A (ja) * 2020-07-23 2023-08-09 エフ． ホフマン－ラ ロシュ アーゲー Ｒｎａ結合タンパク質部位を標的とするオリゴヌクレオチド
AU2021318943A1 (en) * 2020-07-27 2023-03-02 Aligos Therapeutics, Inc. HBV binding oligonucleotides and methods of use
EP4229062A4 (en) 2020-10-15 2024-10-30 Aligos Therapeutics, Inc. Bicyclic compounds
JP2023548031A (ja) 2020-10-21 2023-11-15 アリゴス セラピューティクス インコーポレイテッド 二環式化合物
WO2022109129A1 (en) * 2020-11-20 2022-05-27 Aligos Therapeutics, Inc. Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting
EP4251625A4 (en) 2020-11-24 2024-10-09 Aligos Therapeutics, Inc. Tricyclic compounds
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
WO2022152869A1 (en) 2021-01-15 2022-07-21 Janssen Sciences Ireland Unlimited Company Use of oligonucleotides for individuals with hepatic impairment
CA3204340A1 (en) * 2021-01-30 2022-08-04 Ahmad Ali MORTAZAVI Conjugated oligonucleotide compounds, methods of making and uses thereof
JP2024504504A (ja) * 2021-01-30 2024-01-31 イー セラピューティクス パブリック リミテッド カンパニー コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用
WO2022162157A1 (en) * 2021-01-30 2022-08-04 E-Therapeutics Plc Conjugated oligonucleotide compounds, methods of making and uses thereof
CN115850358B (zh) * 2021-03-08 2026-04-24 南京吉迈生物技术有限公司 GalNAc簇亚磷酰胺和靶向治疗性核苷
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