JP2021500025A5 - - Google Patents
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- JP2021500025A5 JP2021500025A5 JP2020521880A JP2020521880A JP2021500025A5 JP 2021500025 A5 JP2021500025 A5 JP 2021500025A5 JP 2020521880 A JP2020521880 A JP 2020521880A JP 2020521880 A JP2020521880 A JP 2020521880A JP 2021500025 A5 JP2021500025 A5 JP 2021500025A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- stands
- galnac
- nucleotides
- positions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023151506A JP7645323B2 (ja) | 2017-10-20 | 2023-09-19 | B型肝炎感染の治療方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762575358P | 2017-10-20 | 2017-10-20 | |
| US62/575,358 | 2017-10-20 | ||
| PCT/US2018/056801 WO2019079781A2 (en) | 2017-10-20 | 2018-10-19 | METHODS OF TREATING HEPATITIS B TYPE INFECTIONS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023151506A Division JP7645323B2 (ja) | 2017-10-20 | 2023-09-19 | B型肝炎感染の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021500025A JP2021500025A (ja) | 2021-01-07 |
| JP2021500025A5 true JP2021500025A5 (https=) | 2023-07-21 |
| JP7353276B2 JP7353276B2 (ja) | 2023-09-29 |
Family
ID=66173915
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020521880A Active JP7353276B2 (ja) | 2017-10-20 | 2018-10-19 | B型肝炎感染の治療方法 |
| JP2023151506A Active JP7645323B2 (ja) | 2017-10-20 | 2023-09-19 | B型肝炎感染の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023151506A Active JP7645323B2 (ja) | 2017-10-20 | 2023-09-19 | B型肝炎感染の治療方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US10799524B2 (https=) |
| EP (2) | EP3684377B1 (https=) |
| JP (2) | JP7353276B2 (https=) |
| KR (1) | KR102783206B1 (https=) |
| CN (2) | CN111372593B (https=) |
| AU (1) | AU2018351649B2 (https=) |
| BR (1) | BR112020007476A2 (https=) |
| CA (1) | CA3078960A1 (https=) |
| CL (1) | CL2020001061A1 (https=) |
| CO (1) | CO2020005135A2 (https=) |
| CR (1) | CR20200163A (https=) |
| DK (1) | DK3684377T3 (https=) |
| ES (1) | ES2936863T3 (https=) |
| FI (1) | FI3684377T3 (https=) |
| HR (1) | HRP20230023T1 (https=) |
| HU (1) | HUE061122T2 (https=) |
| IL (4) | IL282881B2 (https=) |
| LT (1) | LT3684377T (https=) |
| MA (1) | MA50264B1 (https=) |
| MX (1) | MX2020004060A (https=) |
| MY (1) | MY201698A (https=) |
| PE (1) | PE20220561A1 (https=) |
| PH (1) | PH12020550591A1 (https=) |
| PL (1) | PL3684377T3 (https=) |
| PT (1) | PT3684377T (https=) |
| RS (1) | RS64001B1 (https=) |
| SG (1) | SG11202003488WA (https=) |
| SI (1) | SI3684377T1 (https=) |
| UA (1) | UA128786C2 (https=) |
| WO (1) | WO2019079781A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA128786C2 (uk) | 2017-10-20 | 2024-10-23 | Дайсерна Фармасьютикалз, Інк | Олігонуклеотид для лікування інфекції гепатиту в |
| CN112534055A (zh) | 2018-07-13 | 2021-03-19 | 豪夫迈·罗氏有限公司 | 用于调节rtel1表达的寡核苷酸 |
| AU2020358016A1 (en) * | 2019-10-02 | 2022-04-21 | Dicerna Pharmaceuticals, Inc. | Chemical modifications of small interfering RNA with minimal fluorine content |
| JP2023506954A (ja) * | 2019-12-19 | 2023-02-20 | エフ. ホフマン-ラ ロシュ エージー. | B型肝炎ウイルス感染を処置するためのsaraf阻害剤の使用 |
| EP4081217A1 (en) * | 2019-12-24 | 2022-11-02 | F. Hoffmann-La Roche AG | Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv |
| MX2022007908A (es) * | 2019-12-24 | 2022-07-21 | Hoffmann La Roche | Combinacion farmaceutica de un oligonucleotido terapeutico que actua sobre hbv y un agonista de tlr7 para el tratamiento de hbv. |
| AU2021318943A1 (en) * | 2020-07-27 | 2023-03-02 | Aligos Therapeutics, Inc. | HBV binding oligonucleotides and methods of use |
| TW202221122A (zh) | 2020-08-05 | 2022-06-01 | 瑞士商赫孚孟拉羅股份公司 | B型肝炎患者之寡核苷酸治療 |
| US20240124879A1 (en) * | 2020-12-18 | 2024-04-18 | Olix Pharmaceuticals, Inc. | Rnai agent for inhibiting hbv expression and use thereof |
| CN114853829A (zh) * | 2021-02-05 | 2022-08-05 | 上海拓界生物医药科技有限公司 | 一种核酸配体、其缀合物、制备方法及用途 |
| CN114940991B (zh) * | 2021-04-13 | 2023-02-03 | 厦门甘宝利生物医药有限公司 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
| WO2022223515A2 (en) | 2021-04-19 | 2022-10-27 | Novo Nordisk A/S | Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression |
| KR20240101580A9 (ko) | 2021-11-11 | 2025-12-10 | 에프. 호프만-라 로슈 아게 | Hbv 치료를 위한 약학 조합물 |
| CA3235672A1 (en) * | 2021-11-29 | 2023-06-01 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of hepatitis b virus (hbv) protein |
| EP4201947A1 (en) | 2021-12-22 | 2023-06-28 | F. Hoffmann-La Roche AG | Process for the backbone deprotection of oligonucleotides containing a terminal alkyl phosphonate group |
| WO2023116764A1 (zh) * | 2021-12-23 | 2023-06-29 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及其用途 |
| US20240309383A1 (en) * | 2023-02-24 | 2024-09-19 | Suzhou Sanegene Bio Inc. | Small interfering rna targeting hbv and uses thereof |
| WO2025199466A1 (en) | 2024-03-22 | 2025-09-25 | Purdue Research Foundation | Liver-specific asialoglycoprotein receptor targeting ligands, conjugates comprising same, and related compositions and methods of use |
| WO2025242321A1 (en) | 2024-05-24 | 2025-11-27 | Glaxosmithkline Intellectual Property (No.3) Limited | Novel use |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040127446A1 (en) | 1992-05-14 | 2004-07-01 | Lawrence Blatt | Oligonucleotide mediated inhibition of hepatitis B virus and hepatitis C virus replication |
| ES2336887T5 (es) | 2000-03-30 | 2019-03-06 | Whitehead Inst Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20030176372A1 (en) | 2001-05-04 | 2003-09-18 | Technologie Integrale Ltd | Anti-virus agent |
| US20050159378A1 (en) | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| WO2003040395A2 (en) | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| CN1257284C (zh) * | 2003-03-05 | 2006-05-24 | 北京博奥生物芯片有限责任公司 | 一种体外阻断乙肝病毒表达的方法 |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| WO2007030167A1 (en) | 2005-09-02 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Modification of double-stranded ribonucleic acid molecules |
| WO2008016391A2 (en) | 2006-01-31 | 2008-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Self-complementary parvoviral vectors, and methods for making and using the same |
| DK2548438T3 (en) * | 2006-11-08 | 2015-10-19 | Veritas Bio LLC | IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL |
| EP2164965B1 (en) | 2007-05-29 | 2013-09-11 | University Of The Witwatersrand, Johannesburg | A primary micro rna expression cassette |
| DK2341943T3 (en) | 2008-09-22 | 2019-02-25 | Dicerna Pharmaceuticals Inc | COMPOSITIONS AND METHODS OF SPECIFIC INHIBITION OF DSRNA REPRINT WITH MODIFICATIONS |
| US8691971B2 (en) | 2008-09-23 | 2014-04-08 | Scott G. Petersen | Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| KR101728655B1 (ko) | 2008-12-18 | 2017-04-19 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| WO2011005860A2 (en) | 2009-07-07 | 2011-01-13 | Alnylam Pharmaceuticals, Inc. | 5' phosphate mimics |
| BR112012008865A2 (pt) * | 2009-10-16 | 2019-09-24 | Glaxo Group Ltd | inibidores de hbv anti-sentido. |
| WO2011133871A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
| US9029341B2 (en) * | 2010-08-17 | 2015-05-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| RS61447B1 (sr) * | 2011-04-21 | 2021-03-31 | Glaxo Group Ltd | Modulacija ekspresije virusa hepatitisa b (hbv) |
| EA024762B9 (ru) * | 2011-06-30 | 2017-04-28 | Эрроухэд Рисерч Корпорейшн | Композиции и способы ингибирования экспрессии генов вируса гепатита в |
| AU2012328680A1 (en) | 2011-10-25 | 2014-05-01 | Ionis Pharmaceuticals, Inc. | Antisense modulation of GCCR expression |
| EP2928877B1 (en) | 2012-12-06 | 2020-01-22 | Merck Sharp & Dohme Corp. | Disulfide masked prodrug compositions and methods |
| CA2893824A1 (en) * | 2012-12-14 | 2014-06-19 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of ckap5 by double-stranded rna |
| CN103333890B (zh) | 2012-12-21 | 2015-04-15 | 厦门成坤生物技术有限公司 | 治疗乙型病毒性肝炎的rna干扰制剂 |
| AU2015226206B2 (en) | 2014-03-07 | 2017-03-16 | F. Hoffmann-La Roche Ag | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection |
| GB201408623D0 (en) * | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
| CA2950960A1 (en) | 2014-06-06 | 2015-12-10 | Solstice Biologics, Ltd. | Polynucleotide constructs having bioreversible and non-bioreversible groups |
| CN104059916A (zh) | 2014-06-17 | 2014-09-24 | 湖北医药学院附属太和医院 | 乙肝病毒特异性的microRNA样siRNA序列及其用途 |
| WO2016030863A1 (en) * | 2014-08-29 | 2016-03-03 | Glaxosmithkline Intellectual Property Development Limited | Compounds and methods for treating viral infections |
| KR102545316B1 (ko) * | 2014-11-10 | 2023-06-22 | 알닐람 파마슈티칼스 인코포레이티드 | B형 간염 바이러스(hbv) irna 조성물 및 그의 이용 방법 |
| DK3569711T3 (da) | 2014-12-15 | 2021-02-22 | Dicerna Pharmaceuticals Inc | Ligandmodificerede dobbeltstrengede nukleinsyrer |
| US10689647B2 (en) * | 2015-05-08 | 2020-06-23 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of antithrombin 3 (AT3) by double-stranded RNA |
| AU2016306275A1 (en) | 2015-08-07 | 2018-02-08 | Arrowhead Pharmaceuticals, Inc. | RNAi therapy for Hepatitis B virus infection |
| RU2747822C2 (ru) | 2016-03-14 | 2021-05-14 | Ф. Хоффманн-Ля Рош Аг | Олигонуклеотиды для понижения экспрессии pd-l1 |
| WO2017211791A1 (en) | 2016-06-07 | 2017-12-14 | F. Hoffmann-La Roche Ag | Combination therapy of an hbsag inhibitor and a tlr7 agonist |
| JOP20190015A1 (ar) | 2016-08-04 | 2019-02-04 | Arrowhead Pharmaceuticals Inc | عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب |
| WO2019075419A1 (en) * | 2017-10-13 | 2019-04-18 | Dicerna Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION |
| UA128786C2 (uk) | 2017-10-20 | 2024-10-23 | Дайсерна Фармасьютикалз, Інк | Олігонуклеотид для лікування інфекції гепатиту в |
| TW202221122A (zh) | 2020-08-05 | 2022-06-01 | 瑞士商赫孚孟拉羅股份公司 | B型肝炎患者之寡核苷酸治療 |
-
2018
- 2018-10-19 UA UAA202002978A patent/UA128786C2/uk unknown
- 2018-10-19 ES ES18868404T patent/ES2936863T3/es active Active
- 2018-10-19 FI FIEP18868404.7T patent/FI3684377T3/fi active
- 2018-10-19 HR HRP20230023TT patent/HRP20230023T1/hr unknown
- 2018-10-19 AU AU2018351649A patent/AU2018351649B2/en active Active
- 2018-10-19 CR CR20200163A patent/CR20200163A/es unknown
- 2018-10-19 MX MX2020004060A patent/MX2020004060A/es unknown
- 2018-10-19 EP EP18868404.7A patent/EP3684377B1/en active Active
- 2018-10-19 PT PT188684047T patent/PT3684377T/pt unknown
- 2018-10-19 IL IL282881A patent/IL282881B2/en unknown
- 2018-10-19 LT LTEPPCT/US2018/056801T patent/LT3684377T/lt unknown
- 2018-10-19 SI SI201830840T patent/SI3684377T1/sl unknown
- 2018-10-19 SG SG11202003488WA patent/SG11202003488WA/en unknown
- 2018-10-19 CA CA3078960A patent/CA3078960A1/en active Pending
- 2018-10-19 WO PCT/US2018/056801 patent/WO2019079781A2/en not_active Ceased
- 2018-10-19 EP EP22201680.0A patent/EP4197544A1/en active Pending
- 2018-10-19 IL IL319113A patent/IL319113A/en unknown
- 2018-10-19 HU HUE18868404A patent/HUE061122T2/hu unknown
- 2018-10-19 RS RS20230047A patent/RS64001B1/sr unknown
- 2018-10-19 CN CN201880068102.3A patent/CN111372593B/zh active Active
- 2018-10-19 IL IL274040A patent/IL274040B2/en unknown
- 2018-10-19 MY MYPI2020001980A patent/MY201698A/en unknown
- 2018-10-19 PL PL18868404.7T patent/PL3684377T3/pl unknown
- 2018-10-19 BR BR112020007476-4A patent/BR112020007476A2/pt unknown
- 2018-10-19 IL IL312809A patent/IL312809B2/en unknown
- 2018-10-19 JP JP2020521880A patent/JP7353276B2/ja active Active
- 2018-10-19 KR KR1020207013967A patent/KR102783206B1/ko active Active
- 2018-10-19 CN CN202410274712.6A patent/CN118185936A/zh active Pending
- 2018-10-19 DK DK18868404.7T patent/DK3684377T3/da active
- 2018-10-19 PE PE2020000748A patent/PE20220561A1/es unknown
- 2018-10-19 MA MA50264A patent/MA50264B1/fr unknown
-
2020
- 2020-02-14 US US16/790,986 patent/US10799524B2/en active Active
- 2020-04-17 PH PH12020550591A patent/PH12020550591A1/en unknown
- 2020-04-20 CL CL2020001061A patent/CL2020001061A1/es unknown
- 2020-04-24 CO CONC2020/0005135A patent/CO2020005135A2/es unknown
- 2020-07-07 US US16/922,007 patent/US11052104B2/en active Active
- 2020-07-07 US US16/922,033 patent/US11052105B2/en active Active
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2021
- 2021-05-12 US US17/318,864 patent/US11273173B2/en active Active
-
2022
- 2022-02-02 US US17/649,781 patent/US12564601B2/en active Active
-
2023
- 2023-09-19 JP JP2023151506A patent/JP7645323B2/ja active Active
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