JP2022551269A5 - - Google Patents
Info
- Publication number
- JP2022551269A5 JP2022551269A5 JP2022520472A JP2022520472A JP2022551269A5 JP 2022551269 A5 JP2022551269 A5 JP 2022551269A5 JP 2022520472 A JP2022520472 A JP 2022520472A JP 2022520472 A JP2022520472 A JP 2022520472A JP 2022551269 A5 JP2022551269 A5 JP 2022551269A5
- Authority
- JP
- Japan
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962909278P | 2019-10-02 | 2019-10-02 | |
| US62/909,278 | 2019-10-02 | ||
| PCT/US2020/053999 WO2021067744A1 (en) | 2019-10-02 | 2020-10-02 | Chemical modifications of small interfering rna with minimal fluorine content |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022551269A JP2022551269A (ja) | 2022-12-08 |
| JP2022551269A5 true JP2022551269A5 (https=) | 2023-10-25 |
| JPWO2021067744A5 JPWO2021067744A5 (https=) | 2023-10-25 |
Family
ID=73038388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520472A Withdrawn JP2022551269A (ja) | 2019-10-02 | 2020-10-02 | 最小フッ素含有量を用いた低分子干渉ｒｎａの化学修飾 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220389430A1 (https=) |
| EP (1) | EP4038191A1 (https=) |
| JP (1) | JP2022551269A (https=) |
| KR (1) | KR20220069103A (https=) |
| CN (1) | CN114761557B (https=) |
| AU (1) | AU2020358016A1 (https=) |
| CA (1) | CA3153026A1 (https=) |
| CL (1) | CL2022000825A1 (https=) |
| IL (1) | IL291841A (https=) |
| MX (1) | MX2022004032A (https=) |
| TW (1) | TW202126809A (https=) |
| WO (1) | WO2021067744A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4323518A2 (en) | 2021-04-12 | 2024-02-21 | Boehringer Ingelheim International GmbH | Compositions and methods for inhibiting ketohexokinase (khk) |
| US12084662B2 (en) * | 2021-04-14 | 2024-09-10 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating PNPLA3 expression |
| CN117580953B (zh) * | 2021-07-16 | 2025-07-18 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| EP4405368A1 (en) * | 2021-09-22 | 2024-07-31 | Sanegene Bio USA Inc. | 2'-alkyl or 3'- alkyl modified ribose derivatives for use in the in-vivo delivery of oligonucleotides |
| US20250223588A1 (en) * | 2021-10-19 | 2025-07-10 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides with 2'-deoxy-2'-f-2'-c-methyl nucleotides |
| WO2023102469A2 (en) | 2021-12-01 | 2023-06-08 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating apoc3 expression |
| WO2023208023A1 (zh) * | 2022-04-26 | 2023-11-02 | 上海拓界生物医药科技有限公司 | 氘代化学修饰和包含其的寡核苷酸 |
| TW202526017A (zh) * | 2023-09-14 | 2025-07-01 | 美商Ionis製藥公司 | 用於減少ａｐｏｃｉｉｉ表現的化合物及方法 |
| WO2025191337A2 (en) * | 2024-03-11 | 2025-09-18 | Synerk Biotech Limited | Oligonucleotide terminal phosphate derivatives and method of use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| JP2005508196A (ja) | 2001-11-07 | 2005-03-31 | アプレラ コーポレイション | 核酸分析の汎用ヌクレオチド |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| WO2007030167A1 (en) | 2005-09-02 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Modification of double-stranded ribonucleic acid molecules |
| JP2012504389A (ja) | 2008-09-22 | 2012-02-23 | ダイセルナ ファーマシューティカルズ， インコーポレイテッド | 修飾を有するｄｓＲＮＡによる遺伝子発現の特異的な阻害のための組成物および方法 |
| US8691971B2 (en) | 2008-09-23 | 2014-04-08 | Scott G. Petersen | Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference |
| AU2009336191B2 (en) | 2008-12-18 | 2017-08-24 | Novo Nordisk A/S | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| US8927513B2 (en) | 2009-07-07 | 2015-01-06 | Alnylam Pharmaceuticals, Inc. | 5′ phosphate mimics |
| WO2011133871A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
| EP2928877B1 (en) | 2012-12-06 | 2020-01-22 | Merck Sharp & Dohme Corp. | Disulfide masked prodrug compositions and methods |
| JP2017522046A (ja) | 2014-06-06 | 2017-08-10 | ソルスティス バイオロジクス，リミティッド | 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 |
| JP7105065B2 (ja) | 2014-12-15 | 2022-07-22 | ダイセルナ ファーマシューティカルズ， インコーポレイテッド | リガンド修飾二本鎖核酸 |
| HRP20231063T1 (hr) * | 2017-10-13 | 2023-12-22 | Novo Nordisk Health Care Ag | Postupci i pripravci namijenjeni inhibiranju eksprimiranja ldha |
| SI3684377T1 (sl) * | 2017-10-20 | 2023-05-31 | Dicerna Pharmaceuticals, Inc. | Postopki zdravljenja okužbe s hepatitisom B |
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2020
- 2020-10-02 WO PCT/US2020/053999 patent/WO2021067744A1/en not_active Ceased
- 2020-10-02 JP JP2022520472A patent/JP2022551269A/ja not_active Withdrawn
- 2020-10-02 AU AU2020358016A patent/AU2020358016A1/en not_active Abandoned
- 2020-10-02 MX MX2022004032A patent/MX2022004032A/es unknown
- 2020-10-02 KR KR1020227014229A patent/KR20220069103A/ko not_active Withdrawn
- 2020-10-02 US US17/766,153 patent/US20220389430A1/en not_active Abandoned
- 2020-10-02 IL IL291841A patent/IL291841A/en unknown
- 2020-10-02 CA CA3153026A patent/CA3153026A1/en active Pending
- 2020-10-02 EP EP20799874.1A patent/EP4038191A1/en not_active Withdrawn
- 2020-10-02 CN CN202080082980.8A patent/CN114761557B/zh active Active
- 2020-10-05 TW TW109134478A patent/TW202126809A/zh unknown
-
2022
- 2022-04-01 CL CL2022000825A patent/CL2022000825A1/es unknown