JP2020536587A5 - - Google Patents
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- JP2020536587A5 JP2020536587A5 JP2020542046A JP2020542046A JP2020536587A5 JP 2020536587 A5 JP2020536587 A5 JP 2020536587A5 JP 2020542046 A JP2020542046 A JP 2020542046A JP 2020542046 A JP2020542046 A JP 2020542046A JP 2020536587 A5 JP2020536587 A5 JP 2020536587A5
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- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023109290A JP7674420B2 (ja) | 2017-10-13 | 2023-07-03 | Ｌｄｈａの発現を阻害するための方法及び組成物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762572403P | 2017-10-13 | 2017-10-13 | |
| US201762572398P | 2017-10-13 | 2017-10-13 | |
| US62/572,403 | 2017-10-13 | ||
| US62/572,398 | 2017-10-13 | ||
| US201862726950P | 2018-09-04 | 2018-09-04 | |
| US62/726,950 | 2018-09-04 | ||
| PCT/US2018/055735 WO2019075419A1 (en) | 2017-10-13 | 2018-10-12 | METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023109290A Division JP7674420B2 (ja) | 2017-10-13 | 2023-07-03 | Ｌｄｈａの発現を阻害するための方法及び組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020536587A JP2020536587A (ja) | 2020-12-17 |
| JP2020536587A5 true JP2020536587A5 (https=) | 2023-03-01 |
| JPWO2019075419A5 JPWO2019075419A5 (https=) | 2023-03-01 |
| JP7308213B2 JP7308213B2 (ja) | 2023-07-13 |
Family
ID=66101691
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020542046A Active JP7308213B2 (ja) | 2017-10-13 | 2018-10-12 | Ｌｄｈａの発現を阻害するための方法及び組成物 |
| JP2023109290A Active JP7674420B2 (ja) | 2017-10-13 | 2023-07-03 | Ｌｄｈａの発現を阻害するための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023109290A Active JP7674420B2 (ja) | 2017-10-13 | 2023-07-03 | Ｌｄｈａの発現を阻害するための方法及び組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US11286488B2 (https=) |
| EP (2) | EP4265261A3 (https=) |
| JP (2) | JP7308213B2 (https=) |
| KR (2) | KR102609396B1 (https=) |
| CN (3) | CN118530989A (https=) |
| AU (1) | AU2018346971B2 (https=) |
| CA (1) | CA3078933A1 (https=) |
| ES (1) | ES2955045T3 (https=) |
| HR (1) | HRP20231063T1 (https=) |
| HU (1) | HUE063026T2 (https=) |
| IL (1) | IL273875B2 (https=) |
| MX (1) | MX2020003836A (https=) |
| PL (1) | PL3679141T3 (https=) |
| RS (1) | RS64483B1 (https=) |
| WO (1) | WO2019075419A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015330670B2 (en) | 2014-10-10 | 2022-01-06 | Novo Nordisk Health Care Ag | Therapeutic inhibition of lactate dehydrogenase and agents therefor |
| EP3277811B1 (en) | 2015-04-03 | 2020-12-23 | University of Massachusetts | Fully stabilized asymmetric sirna |
| US10633653B2 (en) | 2015-08-14 | 2020-04-28 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| HRP20231063T1 (hr) | 2017-10-13 | 2023-12-22 | Novo Nordisk Health Care Ag | Postupci i pripravci namijenjeni inhibiranju eksprimiranja ldha |
| SI3684377T1 (sl) * | 2017-10-20 | 2023-05-31 | Dicerna Pharmaceuticals, Inc. | Postopki zdravljenja okužbe s hepatitisom B |
| WO2019143621A1 (en) | 2018-01-16 | 2019-07-25 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting aldh2 expression |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| MX2022001710A (es) | 2019-08-09 | 2022-05-10 | Univ Massachusetts | Oligonucleótidos modificados químicamente dirigidos a los snp. |
| JP2022545118A (ja) * | 2019-08-23 | 2022-10-25 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| WO2021067744A1 (en) * | 2019-10-02 | 2021-04-08 | Dicerna Pharmaceuticals, Inc. | Chemical modifications of small interfering rna with minimal fluorine content |
| EP4121534A1 (en) | 2020-03-18 | 2023-01-25 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant |
| US20250205203A1 (en) * | 2020-05-18 | 2025-06-26 | Chinook Therapeutics Canada, Inc. | Substituted pyrazolyl compounds and methods of use thereof |
| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| EP4244356A1 (en) * | 2020-11-13 | 2023-09-20 | Dicerna Pharmaceuticals, Inc. | Chemical modifications for inhibiting expression of aldh2 |
| CA3207897A1 (en) | 2021-03-19 | 2022-09-22 | Ralf Eisenhuth | Improved oligonucleotide synthesis |
| US20250282813A1 (en) | 2021-04-09 | 2025-09-11 | Bachem Holding Ag | Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates |
| WO2022223515A2 (en) * | 2021-04-19 | 2022-10-27 | Novo Nordisk A/S | Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression |
| US20240287512A1 (en) * | 2021-05-11 | 2024-08-29 | Dicerna Pharmaceuticals, Inc. | Lipid conjugation for targeting neurons of the central nervous system |
| JP2024523237A (ja) | 2021-06-18 | 2024-06-28 | ホンジーン バイオテック コーポレイション | 官能化されたｎ－アセチルガラクトサミンヌクレオシド |
| WO2023003805A1 (en) | 2021-07-19 | 2023-01-26 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder |
| JP2024532019A (ja) * | 2021-08-25 | 2024-09-05 | ノボ ノルディスク エー／エス | アルファ－１アンチトリプシン発現を阻害するための組成物及び方法 |
| JP2024532271A (ja) | 2021-08-30 | 2024-09-05 | ホンジーン バイオテック コーポレイション | 官能化ｎ－アセチルガラクトサミンアナログ |
| AR127260A1 (es) * | 2021-10-05 | 2024-01-03 | Dicerna Pharmaceuticals Inc | Composiciones y métodos para inhibir el receptor de melanocortina 2 y la expresión del citocromo p450 11b |
| WO2023102469A2 (en) * | 2021-12-01 | 2023-06-08 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating apoc3 expression |
| WO2023114746A1 (en) | 2021-12-15 | 2023-06-22 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| US20260001902A1 (en) | 2022-09-19 | 2026-01-01 | Bachem Holding Ag | Improved oligonucleotide synthesis |
| JP2025531341A (ja) * | 2022-09-19 | 2025-09-19 | カイロンノヴァ （シャーメン） バイオファーマ カンパニー，リミテッド | 炭水化物－オリゴヌクレオチド複合体、薬物組成物および治療への応用 |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| EP4695265A1 (en) | 2023-10-16 | 2026-02-18 | Bachem Holding AG | Method and composition for oligonucleotide synthesis |
| TW202602463A (zh) | 2024-03-22 | 2026-01-16 | 日商武田藥品工業股份有限公司 | 用於抑制細胞色素ｐ４５０家族７次家族ａ成員１（ｃｙｐ７ａ１）表現之組成物及方法 |
| CN118460650B (zh) * | 2024-07-10 | 2025-02-14 | 凯莱英医药集团（天津）股份有限公司 | 一种Nedosiran的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US10920226B2 (en) | 2002-11-14 | 2021-02-16 | Thermo Fisher Scientific Inc. | siRNA targeting LDHA |
| US20050014692A1 (en) | 2003-01-21 | 2005-01-20 | Newgard Christopher B. | Lactate dehydrogenase as a novel target and reagent for diabetes therapy |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| AU2005222965B8 (en) | 2004-03-15 | 2010-07-01 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| EP1752536A4 (en) | 2004-05-11 | 2008-04-16 | Alphagen Co Ltd | POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME |
| CN102037123A (zh) * | 2008-04-04 | 2011-04-27 | 卡兰多制药股份有限公司 | Epas1抑制剂的组合物和用途 |
| CA2729757A1 (en) | 2008-07-01 | 2010-01-07 | The Johns Hopkins University | Methods for treating neoplasia by inhibiting lactate dehydrogenase and/or nicotinamide phosphoribosyltransferase |
| JP2012504389A (ja) | 2008-09-22 | 2012-02-23 | ダイセルナ ファーマシューティカルズ， インコーポレイテッド | 修飾を有するｄｓＲＮＡによる遺伝子発現の特異的な阻害のための組成物および方法 |
| US20110288147A1 (en) | 2008-09-22 | 2011-11-24 | Bob Dale Brown | Compositions and methods for the specific inhibition of gene expression by DSRNA containing a tetraloop |
| US20100173973A1 (en) | 2008-12-18 | 2010-07-08 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| AU2010223919B2 (en) | 2009-03-13 | 2016-03-31 | Les Laboratoires Servier | Methods and compositions for cell-proliferation-related disorders |
| DK2539451T3 (da) | 2010-02-24 | 2016-04-04 | Arrowhead Res Corp | Sammensætninger til målrettet tilførsel af siRNA |
| PL2576580T3 (pl) | 2010-05-28 | 2017-03-31 | F.Hoffmann-La Roche Ag | Zmniejszenie poziomu mleczanu i zwiększenie wytwarzania polipeptydu przez obniżenie poziomu ekspresji dehydrogenazy mleczanowej i kinazy dehydrogenazy pirogronianowej |
| JP2014518626A (ja) | 2011-05-18 | 2014-08-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 被験者が慢性腎疾患を有する、または発症するリスクがあるかどうかを決定するための方法 |
| EP2780454A2 (en) | 2011-11-18 | 2014-09-24 | Alnylam Pharmaceuticals, Inc. | Modified rnai agents |
| AR090906A1 (es) | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y procedimientos para la administracion de oligonucleotidos |
| AU2015330670B2 (en) | 2014-10-10 | 2022-01-06 | Novo Nordisk Health Care Ag | Therapeutic inhibition of lactate dehydrogenase and agents therefor |
| JP7105065B2 (ja) | 2014-12-15 | 2022-07-22 | ダイセルナ ファーマシューティカルズ， インコーポレイテッド | リガンド修飾二本鎖核酸 |
| JP2018500905A (ja) | 2014-12-18 | 2018-01-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ナノチューブを使用した核酸ポリメラーゼ立体構造変化の検出 |
| HK1252852A1 (zh) * | 2015-05-29 | 2019-06-06 | Arrowhead Pharmaceuticals, Inc. | 阻止HIF2α基因表达的组合物及方法 |
| HRP20231063T1 (hr) | 2017-10-13 | 2023-12-22 | Novo Nordisk Health Care Ag | Postupci i pripravci namijenjeni inhibiranju eksprimiranja ldha |
-
2018
- 2018-10-12 HR HRP20231063TT patent/HRP20231063T1/hr unknown
- 2018-10-12 EP EP23172235.6A patent/EP4265261A3/en active Pending
- 2018-10-12 EP EP18867097.0A patent/EP3679141B1/en active Active
- 2018-10-12 CA CA3078933A patent/CA3078933A1/en active Pending
- 2018-10-12 AU AU2018346971A patent/AU2018346971B2/en active Active
- 2018-10-12 ES ES18867097T patent/ES2955045T3/es active Active
- 2018-10-12 JP JP2020542046A patent/JP7308213B2/ja active Active
- 2018-10-12 CN CN202410538409.2A patent/CN118530989A/zh active Pending
- 2018-10-12 KR KR1020207013207A patent/KR102609396B1/ko active Active
- 2018-10-12 US US16/755,342 patent/US11286488B2/en active Active
- 2018-10-12 KR KR1020237041035A patent/KR20230169413A/ko active Pending
- 2018-10-12 WO PCT/US2018/055735 patent/WO2019075419A1/en not_active Ceased
- 2018-10-12 CN CN201880080394.2A patent/CN111448319B/zh active Active
- 2018-10-12 HU HUE18867097A patent/HUE063026T2/hu unknown
- 2018-10-12 IL IL273875A patent/IL273875B2/en unknown
- 2018-10-12 MX MX2020003836A patent/MX2020003836A/es unknown
- 2018-10-12 PL PL18867097.0T patent/PL3679141T3/pl unknown
- 2018-10-12 RS RS20230689A patent/RS64483B1/sr unknown
- 2018-10-12 CN CN202410538408.8A patent/CN118440940A/zh active Pending
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2020
- 2020-09-16 US US17/022,696 patent/US11661604B2/en active Active
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2022
- 2022-11-29 US US18/071,424 patent/US20240182901A1/en not_active Abandoned
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2023
- 2023-07-03 JP JP2023109290A patent/JP7674420B2/ja active Active
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2025
- 2025-05-23 US US19/217,052 patent/US20250283091A1/en active Pending