JP2022512935A5 - - Google Patents
Info
- Publication number
- JP2022512935A5 JP2022512935A5 JP2021524303A JP2021524303A JP2022512935A5 JP 2022512935 A5 JP2022512935 A5 JP 2022512935A5 JP 2021524303 A JP2021524303 A JP 2021524303A JP 2021524303 A JP2021524303 A JP 2021524303A JP 2022512935 A5 JP2022512935 A5 JP 2022512935A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- forming
- reacted
- steps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024018294A JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862758814P | 2018-11-12 | 2018-11-12 | |
| US62/758,814 | 2018-11-12 | ||
| PCT/US2019/060677 WO2020102051A1 (en) | 2018-11-12 | 2019-11-11 | Methods of preparing cytotoxic benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024018294A Division JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512935A JP2022512935A (ja) | 2022-02-07 |
| JP2022512935A5 true JP2022512935A5 (enExample) | 2022-11-17 |
| JP7437395B2 JP7437395B2 (ja) | 2024-02-22 |
Family
ID=68835289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524303A Active JP7437395B2 (ja) | 2018-11-12 | 2019-11-11 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
| JP2024018294A Withdrawn JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024018294A Withdrawn JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10851117B2 (enExample) |
| EP (2) | EP3880681B1 (enExample) |
| JP (2) | JP7437395B2 (enExample) |
| KR (1) | KR20210098470A (enExample) |
| CN (2) | CN112996792B (enExample) |
| AU (1) | AU2019379104A1 (enExample) |
| CA (1) | CA3119358A1 (enExample) |
| IL (1) | IL283045A (enExample) |
| MA (1) | MA54228A (enExample) |
| SG (1) | SG11202104360YA (enExample) |
| TW (1) | TW202033530A (enExample) |
| WO (1) | WO2020102051A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL305224B2 (en) * | 2017-04-20 | 2024-09-01 | Immunogen Inc | Methods of preparing indolinobenzodiazepine derivatives |
| MA54228A (fr) | 2018-11-12 | 2021-09-22 | Immunogen Inc | Procédés de préparation de dérivés de benzodiazépine cytotoxiques |
| EP4548932A1 (en) | 2022-06-30 | 2025-05-07 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902707A (en) * | 1985-04-30 | 1990-02-20 | Eli Lilly And Company | Bicyclic pyrazolidinones, compositions and use |
| US5015738A (en) * | 1989-08-07 | 1991-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| CN102050824A (zh) * | 2009-11-04 | 2011-05-11 | 上海阳帆医药科技有限公司 | 哌嗪并三唑衍生物 |
| JP5826863B2 (ja) | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| RU2539658C1 (ru) | 2013-12-10 | 2015-01-20 | Федеральное государственное казенное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации" | Способ получения бензилхлорида |
| SMT202000614T1 (it) * | 2015-06-29 | 2021-01-05 | Immunogen Inc | Coniugati di anticorpi ingegnerizzati con cisteina |
| AU2016285552B2 (en) * | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
| EP3325482B1 (en) * | 2015-07-21 | 2020-06-24 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| US20170189548A1 (en) * | 2015-11-25 | 2017-07-06 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
| EP4148044A1 (en) * | 2017-01-25 | 2023-03-15 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| US11793885B2 (en) * | 2017-12-28 | 2023-10-24 | Immunogen, Inc. | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders |
| MA54228A (fr) | 2018-11-12 | 2021-09-22 | Immunogen Inc | Procédés de préparation de dérivés de benzodiazépine cytotoxiques |
-
2019
- 2019-11-11 MA MA054228A patent/MA54228A/fr unknown
- 2019-11-11 CN CN201980074241.1A patent/CN112996792B/zh not_active Expired - Fee Related
- 2019-11-11 TW TW108140769A patent/TW202033530A/zh unknown
- 2019-11-11 WO PCT/US2019/060677 patent/WO2020102051A1/en not_active Ceased
- 2019-11-11 CN CN202410421643.7A patent/CN118324848A/zh active Pending
- 2019-11-11 SG SG11202104360YA patent/SG11202104360YA/en unknown
- 2019-11-11 KR KR1020217017972A patent/KR20210098470A/ko not_active Withdrawn
- 2019-11-11 EP EP19817455.9A patent/EP3880681B1/en active Active
- 2019-11-11 US US16/679,563 patent/US10851117B2/en active Active
- 2019-11-11 JP JP2021524303A patent/JP7437395B2/ja active Active
- 2019-11-11 CA CA3119358A patent/CA3119358A1/en active Pending
- 2019-11-11 AU AU2019379104A patent/AU2019379104A1/en not_active Abandoned
- 2019-11-11 EP EP24163044.1A patent/EP4361128A3/en not_active Withdrawn
-
2020
- 2020-10-01 US US17/060,611 patent/US11396519B2/en active Active
-
2021
- 2021-05-09 IL IL283045A patent/IL283045A/en unknown
-
2022
- 2022-06-15 US US17/841,046 patent/US11981688B2/en active Active
-
2024
- 2024-02-09 JP JP2024018294A patent/JP2024056819A/ja not_active Withdrawn
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