SG11202104360YA - Methods of preparing cytotoxic benzodiazepine derivatives - Google Patents
Methods of preparing cytotoxic benzodiazepine derivativesInfo
- Publication number
- SG11202104360YA SG11202104360YA SG11202104360YA SG11202104360YA SG11202104360YA SG 11202104360Y A SG11202104360Y A SG 11202104360YA SG 11202104360Y A SG11202104360Y A SG 11202104360YA SG 11202104360Y A SG11202104360Y A SG 11202104360YA SG 11202104360Y A SG11202104360Y A SG 11202104360YA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- benzodiazepine derivatives
- cytotoxic benzodiazepine
- preparing cytotoxic
- preparing
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
- C07C321/20—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862758814P | 2018-11-12 | 2018-11-12 | |
| PCT/US2019/060677 WO2020102051A1 (en) | 2018-11-12 | 2019-11-11 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202104360YA true SG11202104360YA (en) | 2021-05-28 |
Family
ID=68835289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202104360YA SG11202104360YA (en) | 2018-11-12 | 2019-11-11 | Methods of preparing cytotoxic benzodiazepine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10851117B2 (enExample) |
| EP (2) | EP3880681B1 (enExample) |
| JP (2) | JP7437395B2 (enExample) |
| KR (1) | KR20210098470A (enExample) |
| CN (2) | CN112996792B (enExample) |
| AU (1) | AU2019379104A1 (enExample) |
| CA (1) | CA3119358A1 (enExample) |
| IL (1) | IL283045A (enExample) |
| MA (1) | MA54228A (enExample) |
| SG (1) | SG11202104360YA (enExample) |
| TW (1) | TW202033530A (enExample) |
| WO (1) | WO2020102051A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL305224B2 (en) * | 2017-04-20 | 2024-09-01 | Immunogen Inc | Methods of preparing indolinobenzodiazepine derivatives |
| MA54228A (fr) | 2018-11-12 | 2021-09-22 | Immunogen Inc | Procédés de préparation de dérivés de benzodiazépine cytotoxiques |
| EP4548932A1 (en) | 2022-06-30 | 2025-05-07 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902707A (en) * | 1985-04-30 | 1990-02-20 | Eli Lilly And Company | Bicyclic pyrazolidinones, compositions and use |
| US5015738A (en) * | 1989-08-07 | 1991-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| CN102050824A (zh) * | 2009-11-04 | 2011-05-11 | 上海阳帆医药科技有限公司 | 哌嗪并三唑衍生物 |
| JP5826863B2 (ja) | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| RU2539658C1 (ru) | 2013-12-10 | 2015-01-20 | Федеральное государственное казенное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации" | Способ получения бензилхлорида |
| SMT202000614T1 (it) * | 2015-06-29 | 2021-01-05 | Immunogen Inc | Coniugati di anticorpi ingegnerizzati con cisteina |
| AU2016285552B2 (en) * | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
| EP3325482B1 (en) * | 2015-07-21 | 2020-06-24 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| US20170189548A1 (en) * | 2015-11-25 | 2017-07-06 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
| EP4148044A1 (en) * | 2017-01-25 | 2023-03-15 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| US11793885B2 (en) * | 2017-12-28 | 2023-10-24 | Immunogen, Inc. | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders |
| MA54228A (fr) | 2018-11-12 | 2021-09-22 | Immunogen Inc | Procédés de préparation de dérivés de benzodiazépine cytotoxiques |
-
2019
- 2019-11-11 MA MA054228A patent/MA54228A/fr unknown
- 2019-11-11 CN CN201980074241.1A patent/CN112996792B/zh not_active Expired - Fee Related
- 2019-11-11 TW TW108140769A patent/TW202033530A/zh unknown
- 2019-11-11 WO PCT/US2019/060677 patent/WO2020102051A1/en not_active Ceased
- 2019-11-11 CN CN202410421643.7A patent/CN118324848A/zh active Pending
- 2019-11-11 SG SG11202104360YA patent/SG11202104360YA/en unknown
- 2019-11-11 KR KR1020217017972A patent/KR20210098470A/ko not_active Withdrawn
- 2019-11-11 EP EP19817455.9A patent/EP3880681B1/en active Active
- 2019-11-11 US US16/679,563 patent/US10851117B2/en active Active
- 2019-11-11 JP JP2021524303A patent/JP7437395B2/ja active Active
- 2019-11-11 CA CA3119358A patent/CA3119358A1/en active Pending
- 2019-11-11 AU AU2019379104A patent/AU2019379104A1/en not_active Abandoned
- 2019-11-11 EP EP24163044.1A patent/EP4361128A3/en not_active Withdrawn
-
2020
- 2020-10-01 US US17/060,611 patent/US11396519B2/en active Active
-
2021
- 2021-05-09 IL IL283045A patent/IL283045A/en unknown
-
2022
- 2022-06-15 US US17/841,046 patent/US11981688B2/en active Active
-
2024
- 2024-02-09 JP JP2024018294A patent/JP2024056819A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022512935A (ja) | 2022-02-07 |
| KR20210098470A (ko) | 2021-08-10 |
| US20230045079A1 (en) | 2023-02-09 |
| JP7437395B2 (ja) | 2024-02-22 |
| CN112996792B (zh) | 2024-04-26 |
| EP3880681B1 (en) | 2024-03-13 |
| AU2019379104A1 (en) | 2021-06-03 |
| US11396519B2 (en) | 2022-07-26 |
| JP2024056819A (ja) | 2024-04-23 |
| IL283045A (en) | 2021-06-30 |
| TW202033530A (zh) | 2020-09-16 |
| US20210122768A1 (en) | 2021-04-29 |
| US20200172555A1 (en) | 2020-06-04 |
| EP4361128A3 (en) | 2024-07-17 |
| CN112996792A (zh) | 2021-06-18 |
| US11981688B2 (en) | 2024-05-14 |
| US10851117B2 (en) | 2020-12-01 |
| CN118324848A (zh) | 2024-07-12 |
| WO2020102051A1 (en) | 2020-05-22 |
| EP4361128A2 (en) | 2024-05-01 |
| EP3880681A1 (en) | 2021-09-22 |
| CA3119358A1 (en) | 2020-05-22 |
| MA54228A (fr) | 2021-09-22 |
| WO2020102051A8 (en) | 2020-06-18 |
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