JP2022512746A - インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用 - Google Patents

インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用 Download PDF

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Publication number
JP2022512746A
JP2022512746A JP2021521245A JP2021521245A JP2022512746A JP 2022512746 A JP2022512746 A JP 2022512746A JP 2021521245 A JP2021521245 A JP 2021521245A JP 2021521245 A JP2021521245 A JP 2021521245A JP 2022512746 A JP2022512746 A JP 2022512746A
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amino acids
substituted
polypeptide
amino acid
group
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Abandoned
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JP2021521245A
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Japanese (ja)
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JP2022512746A5 (enExample
Inventor
カン，ミンチャオ
ル，インチュン
クヌーセン，ニコラス
ラシッド，ムハンマド，ハルナル
ティエン，フェン
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Ambrx Inc
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Ambrx Inc
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Publication of JP2022512746A publication Critical patent/JP2022512746A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021521245A 2018-10-19 2019-10-19 インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用 Abandoned JP2022512746A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862748221P 2018-10-19 2018-10-19
US62/748,221 2018-10-19
US201862752952P 2018-10-30 2018-10-30
US62/752,952 2018-10-30
US201962822727P 2019-03-22 2019-03-22
US62/822,727 2019-03-22
PCT/US2019/057103 WO2020082057A1 (en) 2018-10-19 2019-10-19 Interleukin-10 polypeptide conjugates, dimers thereof, and their uses

Publications (2)

Publication Number Publication Date
JP2022512746A true JP2022512746A (ja) 2022-02-07
JP2022512746A5 JP2022512746A5 (enExample) 2022-10-27

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ID=68470665

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JP2021521245A Abandoned JP2022512746A (ja) 2018-10-19 2019-10-19 インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用

Country Status (6)

Country Link
US (1) US20220009986A1 (enExample)
EP (1) EP3867265A1 (enExample)
JP (1) JP2022512746A (enExample)
CN (1) CN113366015A (enExample)
AU (1) AU2019361206A1 (enExample)
WO (1) WO2020082057A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021005401A2 (pt) 2018-11-08 2021-06-29 Synthorx, Inc. conjugados de interleucina 10 e usos dos mesmos
CA3180304A1 (en) * 2020-05-28 2021-12-02 Kenan Christopher GARCIA Engineered interleukin-10 polypeptides and uses thereof
US12024559B2 (en) 2020-10-23 2024-07-02 Asher Biotherapeutics, Inc. Fusions with CD8 antigen binding molecules for modulating immune cell function
WO2022125712A1 (en) * 2020-12-09 2022-06-16 Asher Biotherapeutics, Inc. Fusions of mutant interleukin-10 polypeptides with antigen binding molecules for modulating immune cell function
CA3214081A1 (en) * 2021-03-18 2022-09-22 Xylonix Pte. Ltd Pharmaceutical polymer conjugates
WO2023060165A2 (en) * 2021-10-06 2023-04-13 Elixiron Immunotherapeutics (hong Kong) Limited Interleukin-10 muteins and fusion proteins thereof
CA3239849A1 (en) * 2021-12-01 2023-06-08 Michael Wong Il10 variants and uses thereof

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