|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4666848A
(en)
|
1984-08-31 |
1987-05-19 |
Cetus Corporation |
Polypeptide expression using a portable temperature sensitive control cassette with a positive retroregulatory element
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5079352A
(en)
|
1986-08-22 |
1992-01-07 |
Cetus Corporation |
Purified thermostable enzyme
|
|
US4889818A
(en)
|
1986-08-22 |
1989-12-26 |
Cetus Corporation |
Purified thermostable enzyme
|
|
US5693502A
(en)
|
1990-06-11 |
1997-12-02 |
Nexstar Pharmaceuticals, Inc. |
Nucleic acid ligand inhibitors to DNA polymerases
|
|
US5210015A
(en)
|
1990-08-06 |
1993-05-11 |
Hoffman-La Roche Inc. |
Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
|
|
JP2709311B2
(ja)
|
1990-09-28 |
1998-02-04 |
エフ．ホフマン−ラ ロシュ アクチェンゲゼルシャフト |
熱安定性ｄｎａポリメラーゼの５→３′のエキソヌクレアーゼ突然変異
|
|
US5994056A
(en)
|
1991-05-02 |
1999-11-30 |
Roche Molecular Systems, Inc. |
Homogeneous methods for nucleic acid amplification and detection
|
|
US5773258A
(en)
|
1995-08-25 |
1998-06-30 |
Roche Molecular Systems, Inc. |
Nucleic acid amplification using a reversibly inactivated thermostable enzyme
|
|
WO1997009451A1
(en)
|
1995-09-08 |
1997-03-13 |
Life Technologies, Inc. |
Cloned dna polymerases from thermotoga and mutants thereof
|
|
EP0834569A1
(en)
|
1996-10-03 |
1998-04-08 |
Roche Diagnostics GmbH |
Thermostable DNA polymerase from carboxydothermus hydrogenoformans
|
|
US6228628B1
(en)
|
1997-07-09 |
2001-05-08 |
Roche Molecular Systems |
Mutant chimeric DNA polymerase
|
|
US6346379B1
(en)
|
1997-09-11 |
2002-02-12 |
F. Hoffman-La Roche Ag |
Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
|
|
EP0921196A1
(en)
|
1997-12-02 |
1999-06-09 |
Roche Diagnostics GmbH |
Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
|
|
ATE286981T1
(de)
|
1999-09-28 |
2005-01-15 |
Roche Diagnostics Gmbh |
Thermostabiles enzym welches die genauigkeit thermostabiler dna polymerasen erhöht - zur verbesserung der nucleinsäuresynthese und in vitro amplifikation
|
|
US6329178B1
(en)
|
2000-01-14 |
2001-12-11 |
University Of Washington |
DNA polymerase mutant having one or more mutations in the active site
|
|
JP2001269188A
(ja)
|
2000-03-11 |
2001-10-02 |
Roche Diagnostics Gmbh |
Ｐｃｒにおける性能が向上したｂ型ｄｎａポリメラーゼ変異体
|
|
US7179590B2
(en)
|
2000-04-18 |
2007-02-20 |
Roche Molecular Systems, Inc |
High temperature reverse transcription using mutant DNA polymerases
|
|
CA2409775C
(en)
|
2001-12-03 |
2010-07-13 |
F. Hoffmann-La Roche Ag |
Reversibly modified thermostable enzymes for dna synthesis and amplification in vitro
|
|
US7148049B2
(en)
|
2002-04-02 |
2006-12-12 |
Roche Molecular Systems, Inc. |
Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity
|
|
US7572581B2
(en)
|
2003-06-30 |
2009-08-11 |
Roche Molecular Systems, Inc. |
2′-terminator nucleotide-related methods and systems
|
|
US7947817B2
(en)
|
2003-06-30 |
2011-05-24 |
Roche Molecular Systems, Inc. |
Synthesis and compositions of 2'-terminator nucleotides
|
|
US20060172324A1
(en)
|
2005-01-28 |
2006-08-03 |
Roche Molecular Systems, Inc. |
Methods of genotyping using differences in melting temperature
|
|
WO2007076461A1
(en)
*
|
2005-12-22 |
2007-07-05 |
Ge Healthcare Bio-Sciences Corp. |
Thermostable dna polymerase from thermus scotoductus
|
|
US8962293B2
(en)
|
2006-10-18 |
2015-02-24 |
Roche Molecular Systems, Inc. |
DNA polymerases and related methods
|
|
US8026091B2
(en)
|
2007-07-13 |
2011-09-27 |
Roche Molecular Systems, Inc. |
DNA polymerases and related methods
|
|
ES2536252T3
(es)
|
2010-06-18 |
2015-05-21 |
F. Hoffmann-La Roche Ag |
ADN polimerasas con diferenciación de desapareamientos 3' aumentada
|
|
JP5847200B2
(ja)
*
|
2011-02-15 |
2016-01-20 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
|
|
ES2561885T3
(es)
|
2011-04-11 |
2016-03-01 |
F. Hoffmann-La Roche Ag |
ADN polimerasas de actividad mejorada
|
|
ES2668448T3
(es)
|
2011-12-08 |
2018-05-18 |
F. Hoffmann-La Roche Ag |
ADN polimerasas con actividad mejorada
|
|
EP2777843B1
(de)
|
2013-03-15 |
2015-09-30 |
ZF Friedrichshafen AG |
Verfahren und Vorrichtung für das Verfahren zur Herstellung eines Gusswerkstücks
|
|
EP2981609B1
(en)
*
|
2013-04-05 |
2020-04-29 |
Bioron GmbH |
Novel dna-polymerases
|