JP2022166014A5 - - Google Patents
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- JP2022166014A5 JP2022166014A5 JP2022118437A JP2022118437A JP2022166014A5 JP 2022166014 A5 JP2022166014 A5 JP 2022166014A5 JP 2022118437 A JP2022118437 A JP 2022118437A JP 2022118437 A JP2022118437 A JP 2022118437A JP 2022166014 A5 JP2022166014 A5 JP 2022166014A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- biomarker
- caspase
- sample
- therapeutic compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276700P | 2016-01-08 | 2016-01-08 | |
| US62/276,700 | 2016-01-08 | ||
| US201662404638P | 2016-10-05 | 2016-10-05 | |
| US62/404,638 | 2016-10-05 | ||
| JP2018535307A JP6880037B2 (ja) | 2016-01-08 | 2017-01-06 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2021077686A JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021077686A Division JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022166014A JP2022166014A (ja) | 2022-11-01 |
| JP2022166014A5 true JP2022166014A5 (enExample) | 2023-02-02 |
Family
ID=59274055
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535307A Active JP6880037B2 (ja) | 2016-01-08 | 2017-01-06 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2021077686A Active JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2022118437A Pending JP2022166014A (ja) | 2016-01-08 | 2022-07-26 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535307A Active JP6880037B2 (ja) | 2016-01-08 | 2017-01-06 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2021077686A Active JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10648983B2 (enExample) |
| EP (1) | EP3399980B1 (enExample) |
| JP (3) | JP6880037B2 (enExample) |
| KR (1) | KR20180095094A (enExample) |
| AU (1) | AU2017205170B2 (enExample) |
| CA (1) | CA3010801A1 (enExample) |
| ES (1) | ES3042541T3 (enExample) |
| IL (2) | IL296659A (enExample) |
| MX (1) | MX390772B (enExample) |
| WO (1) | WO2017120446A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015085172A2 (en) | 2013-12-06 | 2015-06-11 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| WO2016196580A1 (en) | 2015-06-02 | 2016-12-08 | Celgene Corporation | Methods for determining drug efficacy for treatment of cancer using ratios of cereblon associated proteins |
| WO2017053555A1 (en) | 2015-09-25 | 2017-03-30 | Celgene Corporation | Methods for treating diffuse large b-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs |
| KR20180095094A (ko) | 2016-01-08 | 2018-08-24 | 셀진 코포레이션 | 암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도 |
| US11525165B2 (en) | 2017-12-20 | 2022-12-13 | Inserm | Method of selection of an IRE1-inhibitor therapy for patient suffering from cancer |
| CA3094988A1 (en) * | 2018-03-30 | 2019-10-03 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| KR102718800B1 (ko) * | 2018-05-23 | 2024-10-18 | 셀진 코포레이션 | 다발성 골수종의 치료 및 4-(4-(4-(((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-4-일)옥시)메틸)벤질)피페라진-1-일)-3-플루오로벤조니트릴에 대한 바이오마커의 용도 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2021047627A1 (zh) * | 2019-09-12 | 2021-03-18 | 南京明德新药研发有限公司 | 一种可降解蛋白的并环类化合物及其应用 |
| WO2021086829A1 (en) * | 2019-10-28 | 2021-05-06 | Celgene Corporation | Methods for treating leukemia and use of a leukemic stem cell signature to predict clinical sensitivity to therapies |
| WO2021086830A1 (en) * | 2019-10-28 | 2021-05-06 | Celgene Corporation | Use of biomarkers to predict clinical sensitivity to 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| US11031119B2 (en) * | 2019-11-13 | 2021-06-08 | Cube Click, Inc. | Dental images processed with deep learning for national security |
| MX2022006133A (es) * | 2019-12-06 | 2022-06-17 | Celgene Corp | Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. |
| KR102311390B1 (ko) * | 2020-03-03 | 2021-10-13 | 이화여자대학교 산학협력단 | 교모세포종 예후예측용 조성물 |
| EP4121051A4 (en) * | 2020-03-16 | 2024-04-17 | Celgene Corporation | COMBINATION THERAPY FOR ACUTE MYELOID LEUKEMIA |
| WO2021211742A1 (en) * | 2020-04-14 | 2021-10-21 | The General Hospital Corporation | Use of gcn2 inhibitors in treating mitochondrial myopathies and diseases associated with mitochondrial dysfunction |
| KR20230028798A (ko) | 2020-06-25 | 2023-03-02 | 톨레모 테라퓨틱스 아게 | 암 치료를 위한 CBP/p300 브로모도메인 억제제 및 KRAS 억제제의 조합물 |
| EP4217352A4 (en) | 2020-09-23 | 2024-04-10 | St. Jude Children's Research Hospital, Inc. | Substituted n-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein |
| US20240261274A1 (en) * | 2021-01-13 | 2024-08-08 | Monte Rosa Therapeutics, Inc. | Treatment of myc-driven cancers with gspt1 degraders |
| AU2022207648A1 (en) | 2021-01-13 | 2023-07-27 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
| GB202104635D0 (en) * | 2021-03-31 | 2021-05-12 | Imperial College Innovations Ltd | Methods and compositions for identifying and treating GCN2-dependent cancers |
| IL307402A (en) * | 2021-04-07 | 2023-12-01 | Tolremo Therapeutics Ag | The tercyclic derivatives, pharmaceutical compounds and their use in the treatment or amelioration of cancer |
| WO2022219412A1 (en) * | 2021-04-14 | 2022-10-20 | Monte Rosa Therapeutics Ag | Isoindolinone amide compounds useful to treat diseases associated with gspt1 |
| JP2024544507A (ja) | 2021-11-09 | 2024-12-03 | コリア リサーチ インスティテュート オブ ケミカル テクノロジー | グルタルイミド母核を有するイソインドリノン誘導体及びその用途 |
| KR102823538B1 (ko) | 2021-11-09 | 2025-06-23 | 한국화학연구원 | 글루타이미드 모핵을 갖는 이소인돌리논 유도체 및 이의 용도 |
| CN114660289A (zh) * | 2022-03-03 | 2022-06-24 | 中山大学附属第三医院 | 肝癌标志物及其应用 |
| CA3255290A1 (en) * | 2022-04-14 | 2023-10-19 | Bristol-Myers Squibb Company | NEW GSPT1 COMPOUNDS AND METHODS FOR USING THE NEW COMPOUNDS |
| US20240115557A1 (en) * | 2022-07-29 | 2024-04-11 | The Brigham And Women's Hospital, Inc. | Inhibitors of rna-guided nucleases and uses thereof |
| JP2025530775A (ja) * | 2022-09-02 | 2025-09-17 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｕｌｋ阻害剤及びその使用方法 |
| KR20250075597A (ko) * | 2022-09-16 | 2025-05-28 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 심장 아밀로이드증의 치료를 위한 bag3 방법 및 용도 |
| KR20240066906A (ko) | 2022-11-08 | 2024-05-16 | 주식회사 온코드바이오 | 퀴놀린 아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도 |
| KR20240066904A (ko) | 2022-11-08 | 2024-05-16 | 주식회사 온코드바이오 | 아릴시클로알킬아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도 |
| KR102570883B1 (ko) * | 2023-04-13 | 2023-08-29 | (주) 사이러스테라퓨틱스 | 신규한 gspt1 분해제 및 이의 용도 |
| WO2025164957A1 (ko) * | 2024-01-31 | 2025-08-07 | 남부대학교산학협력단 | 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법 |
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| EP2991651A1 (en) * | 2013-05-03 | 2016-03-09 | Celgene Corporation | Methods for treating cancer using combination therapy |
| WO2015085172A2 (en) | 2013-12-06 | 2015-06-11 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| EP3077547A4 (en) | 2013-12-06 | 2017-11-08 | Celgene Corporation | Methods for treating hematological cancers and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
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| JP2017533727A (ja) | 2014-10-13 | 2017-11-16 | セルジーン コーポレイション | 固形腫瘍の治療方法及び免疫調節療法への臨床的感度の予測因子としてのバイオマーカーの使用 |
| WO2016196580A1 (en) | 2015-06-02 | 2016-12-08 | Celgene Corporation | Methods for determining drug efficacy for treatment of cancer using ratios of cereblon associated proteins |
| WO2017024019A1 (en) | 2015-08-04 | 2017-02-09 | Celgene Corporation | Methods for treating chronic lymphocytic leukemia and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| US20180231561A1 (en) | 2015-08-12 | 2018-08-16 | Celgene Corporation | Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| WO2017053555A1 (en) | 2015-09-25 | 2017-03-30 | Celgene Corporation | Methods for treating diffuse large b-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs |
| WO2017120415A1 (en) * | 2016-01-08 | 2017-07-13 | Celgene Corporation | Solid forms of 2-(4-chlorophenyl)-n-((2-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses |
| KR20180095094A (ko) | 2016-01-08 | 2018-08-24 | 셀진 코포레이션 | 암을 치료하기 위한 방법 및 치료요법에 대한 임상 감수성의 예측변수로서 바이오마커의 용도 |
| CN108601777B (zh) * | 2016-01-08 | 2021-08-03 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的制剂 |
| US10245258B2 (en) * | 2016-06-06 | 2019-04-02 | Celgene Corporation | Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
-
2017
- 2017-01-06 KR KR1020187022882A patent/KR20180095094A/ko not_active Ceased
- 2017-01-06 JP JP2018535307A patent/JP6880037B2/ja active Active
- 2017-01-06 AU AU2017205170A patent/AU2017205170B2/en active Active
- 2017-01-06 MX MX2018008421A patent/MX390772B/es unknown
- 2017-01-06 US US15/400,766 patent/US10648983B2/en active Active
- 2017-01-06 EP EP17736415.5A patent/EP3399980B1/en active Active
- 2017-01-06 ES ES17736415T patent/ES3042541T3/es active Active
- 2017-01-06 CA CA3010801A patent/CA3010801A1/en active Pending
- 2017-01-06 IL IL296659A patent/IL296659A/en unknown
- 2017-01-06 WO PCT/US2017/012496 patent/WO2017120446A1/en not_active Ceased
-
2018
- 2018-07-03 IL IL260400A patent/IL260400B2/en unknown
-
2020
- 2020-04-03 US US16/840,299 patent/US11460471B2/en active Active
-
2021
- 2021-04-30 JP JP2021077686A patent/JP7113942B2/ja active Active
-
2022
- 2022-07-26 JP JP2022118437A patent/JP2022166014A/ja active Pending
- 2022-08-05 US US17/882,278 patent/US12474342B2/en active Active
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