JP2022166014A5 - - Google Patents
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- JP2022166014A5 JP2022166014A5 JP2022118437A JP2022118437A JP2022166014A5 JP 2022166014 A5 JP2022166014 A5 JP 2022166014A5 JP 2022118437 A JP2022118437 A JP 2022118437A JP 2022118437 A JP2022118437 A JP 2022118437A JP 2022166014 A5 JP2022166014 A5 JP 2022166014A5
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- optionally substituted
- biomarker
- caspase
- sample
- therapeutic compound
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- 239000000090 biomarker Substances 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 36
- 238000000034 method Methods 0.000 claims 30
- 230000001225 therapeutic effect Effects 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 24
- 125000005843 halogen group Chemical group 0.000 claims 19
- 125000001188 haloalkyl group Chemical group 0.000 claims 18
- 239000000523 sample Substances 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000003107 substituted aryl group Chemical group 0.000 claims 12
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 239000013078 crystal Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- -1 BIP Proteins 0.000 claims 8
- 239000013074 reference sample Substances 0.000 claims 7
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 6
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 6
- 108090000397 Caspase 3 Proteins 0.000 claims 6
- 108090000567 Caspase 7 Proteins 0.000 claims 6
- 102100029855 Caspase-3 Human genes 0.000 claims 6
- 102100038902 Caspase-7 Human genes 0.000 claims 6
- 102000004091 Caspase-8 Human genes 0.000 claims 6
- 108090000538 Caspase-8 Proteins 0.000 claims 6
- 102000004039 Caspase-9 Human genes 0.000 claims 6
- 108090000566 Caspase-9 Proteins 0.000 claims 6
- 102100023583 Cyclic AMP-dependent transcription factor ATF-6 alpha Human genes 0.000 claims 6
- 102100035419 DnaJ homolog subfamily B member 9 Human genes 0.000 claims 6
- 101100072149 Drosophila melanogaster eIF2alpha gene Proteins 0.000 claims 6
- 102100021807 ER degradation-enhancing alpha-mannosidase-like protein 1 Human genes 0.000 claims 6
- 102100030013 Endoribonuclease Human genes 0.000 claims 6
- 102100030667 Eukaryotic peptide chain release factor subunit 1 Human genes 0.000 claims 6
- 101710175705 Eukaryotic peptide chain release factor subunit 1 Proteins 0.000 claims 6
- 102100031150 Growth arrest and DNA damage-inducible protein GADD45 alpha Human genes 0.000 claims 6
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 6
- 101000905751 Homo sapiens Cyclic AMP-dependent transcription factor ATF-6 alpha Proteins 0.000 claims 6
- 101000804119 Homo sapiens DnaJ homolog subfamily B member 9 Proteins 0.000 claims 6
- 101000895701 Homo sapiens ER degradation-enhancing alpha-mannosidase-like protein 1 Proteins 0.000 claims 6
- 101001010783 Homo sapiens Endoribonuclease Proteins 0.000 claims 6
- 101001066158 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 alpha Proteins 0.000 claims 6
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims 6
- 101000611643 Homo sapiens Protein phosphatase 1 regulatory subunit 15A Proteins 0.000 claims 6
- 101000822339 Homo sapiens Protein transport protein Sec24D Proteins 0.000 claims 6
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims 6
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 6
- 101000666295 Homo sapiens X-box-binding protein 1 Proteins 0.000 claims 6
- 101000926525 Homo sapiens eIF-2-alpha kinase GCN2 Proteins 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims 6
- 102100040714 Protein phosphatase 1 regulatory subunit 15A Human genes 0.000 claims 6
- 102100022542 Protein transport protein Sec24D Human genes 0.000 claims 6
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims 6
- 102100038151 X-box-binding protein 1 Human genes 0.000 claims 6
- 125000004450 alkenylene group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
- 102100034175 eIF-2-alpha kinase GCN2 Human genes 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 208000032839 leukemia Diseases 0.000 claims 5
- 239000013068 control sample Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 230000004043 responsiveness Effects 0.000 claims 2
- PWBHUSLMHZLGRN-UHFFFAOYSA-N 2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide Chemical compound ClC1=CC=C(C=C1)C(C(=O)NCC=1C=C2CN(C(C2=CC=1)=O)C1C(NC(CC1)=O)=O)(F)F PWBHUSLMHZLGRN-UHFFFAOYSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 102100039064 Interleukin-3 Human genes 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- DOCFCULFTLNCRC-UHFFFAOYSA-N N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoro-2-(4-fluorophenyl)acetamide Chemical compound O=C1NC(CCC1N1C(C2=CC=C(C=C2C1)CNC(C(C1=CC=C(C=C1)F)(F)F)=O)=O)=O DOCFCULFTLNCRC-UHFFFAOYSA-N 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 claims 1
- 238000011443 conventional therapy Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 230000003319 supportive effect Effects 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276700P | 2016-01-08 | 2016-01-08 | |
| US62/276,700 | 2016-01-08 | ||
| US201662404638P | 2016-10-05 | 2016-10-05 | |
| US62/404,638 | 2016-10-05 | ||
| JP2018535307A JP6880037B2 (ja) | 2016-01-08 | 2017-01-06 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2021077686A JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021077686A Division JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022166014A JP2022166014A (ja) | 2022-11-01 |
| JP2022166014A5 true JP2022166014A5 (enExample) | 2023-02-02 |
Family
ID=59274055
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535307A Active JP6880037B2 (ja) | 2016-01-08 | 2017-01-06 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2021077686A Active JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2022118437A Pending JP2022166014A (ja) | 2016-01-08 | 2022-07-26 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535307A Active JP6880037B2 (ja) | 2016-01-08 | 2017-01-06 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
| JP2021077686A Active JP7113942B2 (ja) | 2016-01-08 | 2021-04-30 | がんの治療方法と、治療法に対する臨床的感度の予測因子としてのバイオマーカーの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10648983B2 (enExample) |
| EP (1) | EP3399980B1 (enExample) |
| JP (3) | JP6880037B2 (enExample) |
| KR (1) | KR20180095094A (enExample) |
| AU (1) | AU2017205170B2 (enExample) |
| CA (1) | CA3010801A1 (enExample) |
| ES (1) | ES3042541T3 (enExample) |
| IL (2) | IL296659A (enExample) |
| MX (1) | MX390772B (enExample) |
| WO (1) | WO2017120446A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IL278381B2 (en) | 2013-12-06 | 2024-08-01 | Celgene Corp | Methods for determining the effectiveness of a drug for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancer |
| WO2016196580A1 (en) | 2015-06-02 | 2016-12-08 | Celgene Corporation | Methods for determining drug efficacy for treatment of cancer using ratios of cereblon associated proteins |
| WO2017053555A1 (en) | 2015-09-25 | 2017-03-30 | Celgene Corporation | Methods for treating diffuse large b-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs |
| US10648983B2 (en) | 2016-01-08 | 2020-05-12 | Celgene Corporation | Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies |
| EP3728639B1 (en) | 2017-12-20 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of selection of an ire1-inhibitor therapy for patient suffering from cancer |
| AU2019243186A1 (en) * | 2018-03-30 | 2020-10-15 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| CA3101174A1 (en) * | 2018-05-23 | 2019-11-28 | Celgene Corporation | Treating multiple myeloma and the use of biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-4-yl)oxy)methyl)benzyl) piperazin-1-yl)-3-fluorobenzonitrile |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2021047627A1 (zh) * | 2019-09-12 | 2021-03-18 | 南京明德新药研发有限公司 | 一种可降解蛋白的并环类化合物及其应用 |
| CA3156232A1 (en) * | 2019-10-28 | 2021-05-06 | Gang Lu | Use of biomarkers to predict clinical sensitivity to 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| US20220378773A1 (en) * | 2019-10-28 | 2022-12-01 | Celgene Corporation | Methods for treating leukemia and use of a leukemic stem cell signature to predict clinical sensitivity to therapies |
| US11031119B2 (en) * | 2019-11-13 | 2021-06-08 | Cube Click, Inc. | Dental images processed with deep learning for national security |
| CN114761004A (zh) * | 2019-12-06 | 2022-07-15 | 细胞基因公司 | 用于制备2-(4-氯苯基)-n-((2-(2，6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2，2-二氟乙酰胺的方法 |
| KR102311390B1 (ko) * | 2020-03-03 | 2021-10-13 | 이화여자대학교 산학협력단 | 교모세포종 예후예측용 조성물 |
| BR112022018515A2 (pt) * | 2020-03-16 | 2022-11-16 | Celgene Corp | Terapia de combinação para leucemia mieloide aguda |
| WO2021211742A1 (en) * | 2020-04-14 | 2021-10-21 | The General Hospital Corporation | Use of gcn2 inhibitors in treating mitochondrial myopathies and diseases associated with mitochondrial dysfunction |
| IL299344A (en) | 2020-06-25 | 2023-02-01 | Tolremo Therapeutics Ag | Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer |
| PE20230847A1 (es) | 2020-09-23 | 2023-05-23 | St Jude Childrens Res Hospital Inc | Analogos de n-(2-(2,6-dioxopiperidin-3-il)-1,3-dioxoisoindolin-5-il)arilsufonamida sustituidos como modulares de la proteina cereblon |
| JP2024504932A (ja) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス， インコーポレイテッド | イソインドリノン化合物 |
| US20240261274A1 (en) * | 2021-01-13 | 2024-08-08 | Monte Rosa Therapeutics, Inc. | Treatment of myc-driven cancers with gspt1 degraders |
| GB202104635D0 (en) * | 2021-03-31 | 2021-05-12 | Imperial College Innovations Ltd | Methods and compositions for identifying and treating GCN2-dependent cancers |
| AR125312A1 (es) * | 2021-04-07 | 2023-07-05 | Tolremo Therapeutics Ag | Derivados heterocíclicos, composiciones farmacéuticas y su uso en el tratamiento o la mejora del cáncer |
| WO2022219412A1 (en) * | 2021-04-14 | 2022-10-20 | Monte Rosa Therapeutics Ag | Isoindolinone amide compounds useful to treat diseases associated with gspt1 |
| WO2023085785A1 (ko) | 2021-11-09 | 2023-05-19 | 한국화학연구원 | 글루타이미드 모핵을 갖는 이소인돌리논 유도체 및 이의 용도 |
| KR102823538B1 (ko) | 2021-11-09 | 2025-06-23 | 한국화학연구원 | 글루타이미드 모핵을 갖는 이소인돌리논 유도체 및 이의 용도 |
| CN114660289A (zh) * | 2022-03-03 | 2022-06-24 | 中山大学附属第三医院 | 肝癌标志物及其应用 |
| US12187699B2 (en) * | 2022-04-14 | 2025-01-07 | Bristol-Myers Squibb Company | GSPT1 compounds and methods of use of the novel compounds |
| US20240115557A1 (en) * | 2022-07-29 | 2024-04-11 | The Brigham And Women's Hospital, Inc. | Inhibitors of rna-guided nucleases and uses thereof |
| JP2025530775A (ja) * | 2022-09-02 | 2025-09-17 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｕｌｋ阻害剤及びその使用方法 |
| IL319564A (en) * | 2022-09-16 | 2025-05-01 | Univ Temple | BAG 3 methods and uses for treating cardiac amyloidosis |
| KR20240066906A (ko) | 2022-11-08 | 2024-05-16 | 주식회사 온코드바이오 | 퀴놀린 아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도 |
| KR20240066904A (ko) | 2022-11-08 | 2024-05-16 | 주식회사 온코드바이오 | 아릴시클로알킬아마이드 구조를 갖는 이소인돌리논 유도체 및 이의 용도 |
| KR102570883B1 (ko) * | 2023-04-13 | 2023-08-29 | (주) 사이러스테라퓨틱스 | 신규한 gspt1 분해제 및 이의 용도 |
| WO2025164957A1 (ko) * | 2024-01-31 | 2025-08-07 | 남부대학교산학협력단 | 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법 |
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