JP2017538104A5 - - Google Patents
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- JP2017538104A5 JP2017538104A5 JP2017518455A JP2017518455A JP2017538104A5 JP 2017538104 A5 JP2017538104 A5 JP 2017538104A5 JP 2017518455 A JP2017518455 A JP 2017518455A JP 2017518455 A JP2017518455 A JP 2017518455A JP 2017538104 A5 JP2017538104 A5 JP 2017538104A5
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- 238000000034 method Methods 0.000 claims description 63
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000090 biomarker Substances 0.000 description 61
- 150000001875 compounds Chemical class 0.000 description 37
- 230000001225 therapeutic effect Effects 0.000 description 30
- 239000000523 sample Substances 0.000 description 29
- 206010028980 Neoplasm Diseases 0.000 description 25
- 201000011510 cancer Diseases 0.000 description 25
- 229910052736 halogen Inorganic materials 0.000 description 22
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 239000013074 reference sample Substances 0.000 description 10
- 125000005843 halogen group Chemical group 0.000 description 9
- 239000013078 crystal Substances 0.000 description 8
- 229940002612 prodrug Drugs 0.000 description 8
- 239000000651 prodrug Substances 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 239000012453 solvate Substances 0.000 description 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 7
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 7
- 125000005530 alkylenedioxy group Chemical group 0.000 description 7
- 125000004093 cyano group Chemical group *C#N 0.000 description 7
- 125000001072 heteroaryl group Chemical group 0.000 description 7
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 description 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 6
- 208000032839 leukemia Diseases 0.000 description 5
- 239000013068 control sample Substances 0.000 description 4
- 108010086507 peptide-chain-release factor 3 Proteins 0.000 description 4
- 102100036816 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Human genes 0.000 description 3
- 101710151739 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Proteins 0.000 description 3
- 102100036813 Eukaryotic peptide chain release factor GTP-binding subunit ERF3B Human genes 0.000 description 3
- 102100027377 HBS1-like protein Human genes 0.000 description 3
- 101001009070 Homo sapiens HBS1-like protein Proteins 0.000 description 3
- 230000019491 signal transduction Effects 0.000 description 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
- 102000015367 CRBN Human genes 0.000 description 2
- 102100023580 Cyclic AMP-dependent transcription factor ATF-4 Human genes 0.000 description 2
- 102100029145 DNA damage-inducible transcript 3 protein Human genes 0.000 description 2
- 101000905743 Homo sapiens Cyclic AMP-dependent transcription factor ATF-4 Proteins 0.000 description 2
- 101000941994 Homo sapiens Protein cereblon Proteins 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 108010057666 Transcription Factor CHOP Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- DOEVCIHTTTYVCC-UHFFFAOYSA-N 1-(3-chloro-4-methylphenyl)-3-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3h-isoindol-5-yl]methyl]urea Chemical compound C1=C(Cl)C(C)=CC=C1NC(=O)NCC1=CC=C(C(=O)N(C2)C3C(NC(=O)CC3)=O)C2=C1 DOEVCIHTTTYVCC-UHFFFAOYSA-N 0.000 description 1
- -1 ATF3 Proteins 0.000 description 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
- 102100023583 Cyclic AMP-dependent transcription factor ATF-6 alpha Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 101000905751 Homo sapiens Cyclic AMP-dependent transcription factor ATF-6 alpha Proteins 0.000 description 1
- 101000666295 Homo sapiens X-box-binding protein 1 Proteins 0.000 description 1
- 108010002386 Interleukin-3 Proteins 0.000 description 1
- 102100039064 Interleukin-3 Human genes 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 102100038151 X-box-binding protein 1 Human genes 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229940111134 coxibs Drugs 0.000 description 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 230000003938 response to stress Effects 0.000 description 1
- 238000009120 supportive therapy Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462061050P | 2014-10-07 | 2014-10-07 | |
| US62/061,050 | 2014-10-07 | ||
| US201462087111P | 2014-12-03 | 2014-12-03 | |
| US62/087,111 | 2014-12-03 | ||
| PCT/US2014/068795 WO2015085172A2 (en) | 2013-12-06 | 2014-12-05 | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| USPCT/US2014/068795 | 2014-12-05 | ||
| PCT/US2015/054227 WO2016057503A1 (en) | 2014-10-07 | 2015-10-06 | Use of biomarkers for predicting clinical sensitivity to cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538104A JP2017538104A (ja) | 2017-12-21 |
| JP2017538104A5 true JP2017538104A5 (enExample) | 2018-11-29 |
Family
ID=55653639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518455A Pending JP2017538104A (ja) | 2014-10-07 | 2015-10-06 | 癌治療に対する臨床的感応性を予測するためのバイオマーカーの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20180267043A1 (enExample) |
| EP (1) | EP3204008A4 (enExample) |
| JP (1) | JP2017538104A (enExample) |
| WO (1) | WO2016057503A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3737946B1 (en) * | 2018-01-12 | 2024-11-20 | Celgene Corporation | Methods for screening cereblon modifying compounds |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN114761400B (zh) * | 2019-09-12 | 2024-08-13 | 南京明德新药研发有限公司 | 一种可降解蛋白的并环类化合物及其应用 |
| WO2021179084A1 (en) * | 2020-03-11 | 2021-09-16 | University Health Network | Methods and systems for determining a stem cell type in a glioblastoma |
| JP2024504932A (ja) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス， インコーポレイテッド | イソインドリノン化合物 |
| CN112980882A (zh) * | 2021-03-15 | 2021-06-18 | 上海科技大学 | Crbn基因在构建GSPT1敏感模型中的用途 |
| CN113046391A (zh) * | 2021-03-22 | 2021-06-29 | 上海科技大学 | 一种crbn基因人源化动物肿瘤细胞模型的构建方法和用途 |
| WO2022240891A1 (en) * | 2021-05-10 | 2022-11-17 | The Cleveland Clinic Foundation | Salivary metabolites are non-invasive biomarkers of hcc |
| EP4448799A2 (en) * | 2021-12-17 | 2024-10-23 | Allen Institute | Molecular signatures for cell typing and monitoring immune health |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7504225B2 (en) * | 2005-05-12 | 2009-03-17 | Applied Genomics, Inc. | Reagents and methods for use in cancer diagnosis, classification and therapy |
| US8445198B2 (en) * | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| US8877780B2 (en) * | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
| BRPI0716092A2 (pt) * | 2006-08-30 | 2013-09-17 | Celgene Corp | composto ou um sal, solvato, ou estereoisâmero do mesmo, composiÇço farmacÊutica, mÉtodo para tratar, controlar ou prevenir uma doenÇa ou distérbio, e, forma de dosagem de unidade simples. |
| WO2010017515A2 (en) * | 2008-08-08 | 2010-02-11 | Integrated Diagnostics Inc. | Breast cancer specific markers and methods of use |
| EP3354646A1 (en) * | 2008-10-29 | 2018-08-01 | Celgene Corporation | Isoindoline compounds for use in the treatment of cancer |
| ES2881220T3 (es) * | 2012-08-09 | 2021-11-29 | Celgene Corp | Métodos de tratamiento del cáncer usando 3-(4-((4-(morfolinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona |
| BR112015026006B1 (pt) * | 2013-04-17 | 2022-10-18 | Signal Pharmaceuticals, Llc | Uso de um composto em combinação com um fármaco imunomodulador imid® para tratamento ou prevenção de um câncer, composição farmacêutica e kit compreendendo os referidos compostos |
| US20180231561A1 (en) * | 2015-08-12 | 2018-08-16 | Celgene Corporation | Methods for treating solid tumors and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
-
2015
- 2015-10-06 WO PCT/US2015/054227 patent/WO2016057503A1/en not_active Ceased
- 2015-10-06 JP JP2017518455A patent/JP2017538104A/ja active Pending
- 2015-10-06 EP EP15848775.1A patent/EP3204008A4/en not_active Withdrawn
- 2015-10-06 US US15/517,445 patent/US20180267043A1/en not_active Abandoned
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