JP2022141773A5 - - Google Patents
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- Publication number
- JP2022141773A5 JP2022141773A5 JP2022111844A JP2022111844A JP2022141773A5 JP 2022141773 A5 JP2022141773 A5 JP 2022141773A5 JP 2022111844 A JP2022111844 A JP 2022111844A JP 2022111844 A JP2022111844 A JP 2022111844A JP 2022141773 A5 JP2022141773 A5 JP 2022141773A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carbocyclyl
- pharmaceutically acceptable
- compound
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000004452 carbocyclyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 208000014644 Brain disease Diseases 0.000 claims 2
- 208000032274 Encephalopathy Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 230000001037 epileptic effect Effects 0.000 claims 2
- 201000007547 Dravet syndrome Diseases 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 208000035899 Infantile spasms syndrome Diseases 0.000 claims 1
- 201000006792 Lennox-Gastaut syndrome Diseases 0.000 claims 1
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims 1
- 206010073677 Severe myoclonic epilepsy of infancy Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 208000018360 neuromuscular disease Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024084718A JP7801794B2 (ja) | 2016-11-28 | 2024-05-24 | 化合物及びその使用方法 |
| JP2025279047A JP2026062794A (ja) | 2016-11-28 | 2025-12-23 | 化合物及びその使用方法 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662427044P | 2016-11-28 | 2016-11-28 | |
| US62/427,044 | 2016-11-28 | ||
| US201762458306P | 2017-02-13 | 2017-02-13 | |
| US62/458,306 | 2017-02-13 | ||
| US201762552073P | 2017-08-30 | 2017-08-30 | |
| US62/552,073 | 2017-08-30 | ||
| PCT/US2017/063533 WO2018098499A1 (en) | 2016-11-28 | 2017-11-28 | Compounds and their methods of use |
| JP2019548536A JP7105797B2 (ja) | 2016-11-28 | 2017-11-28 | 化合物及びその使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548536A Division JP7105797B2 (ja) | 2016-11-28 | 2017-11-28 | 化合物及びその使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084718A Division JP7801794B2 (ja) | 2016-11-28 | 2024-05-24 | 化合物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022141773A JP2022141773A (ja) | 2022-09-29 |
| JP2022141773A5 true JP2022141773A5 (https=) | 2023-06-20 |
| JP7495962B2 JP7495962B2 (ja) | 2024-06-05 |
Family
ID=62195384
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548536A Active JP7105797B2 (ja) | 2016-11-28 | 2017-11-28 | 化合物及びその使用方法 |
| JP2022111844A Active JP7495962B2 (ja) | 2016-11-28 | 2022-07-12 | 化合物及びその使用方法 |
| JP2024084718A Active JP7801794B2 (ja) | 2016-11-28 | 2024-05-24 | 化合物及びその使用方法 |
| JP2025279047A Pending JP2026062794A (ja) | 2016-11-28 | 2025-12-23 | 化合物及びその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548536A Active JP7105797B2 (ja) | 2016-11-28 | 2017-11-28 | 化合物及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084718A Active JP7801794B2 (ja) | 2016-11-28 | 2024-05-24 | 化合物及びその使用方法 |
| JP2025279047A Pending JP2026062794A (ja) | 2016-11-28 | 2025-12-23 | 化合物及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11629146B2 (https=) |
| EP (2) | EP3548033B1 (https=) |
| JP (4) | JP7105797B2 (https=) |
| CN (2) | CN116763791A (https=) |
| AU (3) | AU2017364901A1 (https=) |
| BR (1) | BR112019010880A2 (https=) |
| CA (2) | CA3281817A1 (https=) |
| DK (1) | DK3548033T3 (https=) |
| ES (1) | ES2992063T3 (https=) |
| FI (1) | FI3548033T3 (https=) |
| HU (1) | HUE068842T2 (https=) |
| PL (1) | PL3548033T3 (https=) |
| PT (1) | PT3548033T (https=) |
| WO (1) | WO2018098499A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3548033T3 (da) | 2016-11-28 | 2024-07-15 | Praxis Prec Medicines Inc | Forbindelser og deres fremgangsmåde til anvendelse |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| MX2020012838A (es) | 2018-05-30 | 2021-07-16 | Praxis Prec Medicines Inc | Moduladores de los canales ionicos. |
| BR112021003224A2 (pt) | 2018-08-20 | 2021-07-20 | Rogcon, Inc. | oligonucleotídeos antissentido direcionados a scn2a para o tratamento de encefalopatias por scn1a |
| EA202092908A1 (ru) * | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| WO2021039961A1 (ja) * | 2019-08-30 | 2021-03-04 | 大日本住友製薬株式会社 | 縮環ピラゾール誘導体 |
| CN114980899A (zh) * | 2019-11-26 | 2022-08-30 | 普拉西斯精密医药公司 | 离子通道调节剂 |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| PE20221280A1 (es) * | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
| JP2021195367A (ja) * | 2020-06-10 | 2021-12-27 | アムジエン・インコーポレーテツド | シクロプロピルジヒドロキノリンスルホンアミド化合物 |
| PE20242111A1 (es) | 2021-09-13 | 2024-10-28 | Boehringer Ingelheim Vetmedica Gmbh | Derivados de etilsulfonil-piridina sustituidos con ciclopropil-(hetero)arilo |
| KR20250005348A (ko) * | 2022-04-26 | 2025-01-09 | 프락시스 프리시젼 메디신즈, 인크. | 신경 장애의 치료 |
| CN120641418A (zh) * | 2022-10-07 | 2025-09-12 | 腾维治疗公司 | 化合物、组合物和方法 |
| WO2026082004A1 (zh) * | 2024-10-14 | 2026-04-23 | 上海京新生物医药有限公司 | 稠合杂芳基衍生物及其制备方法与应用 |
| CN119613413B (zh) * | 2024-12-26 | 2026-02-06 | 上海皓元医药股份有限公司 | 一种非唑奈坦的制备方法 |
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| DK3548033T3 (da) | 2016-11-28 | 2024-07-15 | Praxis Prec Medicines Inc | Forbindelser og deres fremgangsmåde til anvendelse |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098500A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| MX2020012838A (es) | 2018-05-30 | 2021-07-16 | Praxis Prec Medicines Inc | Moduladores de los canales ionicos. |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| CN114980899A (zh) | 2019-11-26 | 2022-08-30 | 普拉西斯精密医药公司 | 离子通道调节剂 |
| PE20221280A1 (es) | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
-
2017
- 2017-11-28 DK DK17874657.4T patent/DK3548033T3/da active
- 2017-11-28 CN CN202310582446.9A patent/CN116763791A/zh active Pending
- 2017-11-28 CN CN201780084790.8A patent/CN110337295B/zh active Active
- 2017-11-28 FI FIEP17874657.4T patent/FI3548033T3/fi active
- 2017-11-28 US US16/464,468 patent/US11629146B2/en active Active
- 2017-11-28 WO PCT/US2017/063533 patent/WO2018098499A1/en not_active Ceased
- 2017-11-28 CA CA3281817A patent/CA3281817A1/en active Pending
- 2017-11-28 EP EP17874657.4A patent/EP3548033B1/en active Active
- 2017-11-28 EP EP24160394.3A patent/EP4397308A3/en active Pending
- 2017-11-28 PL PL17874657.4T patent/PL3548033T3/pl unknown
- 2017-11-28 AU AU2017364901A patent/AU2017364901A1/en not_active Abandoned
- 2017-11-28 ES ES17874657T patent/ES2992063T3/es active Active
- 2017-11-28 PT PT178746574T patent/PT3548033T/pt unknown
- 2017-11-28 JP JP2019548536A patent/JP7105797B2/ja active Active
- 2017-11-28 CA CA3045121A patent/CA3045121C/en active Active
- 2017-11-28 BR BR112019010880-7A patent/BR112019010880A2/pt not_active Application Discontinuation
- 2017-11-28 HU HUE17874657A patent/HUE068842T2/hu unknown
-
2022
- 2022-07-12 JP JP2022111844A patent/JP7495962B2/ja active Active
-
2023
- 2023-03-10 US US18/119,963 patent/US20230322790A1/en not_active Abandoned
- 2023-12-14 AU AU2023282271A patent/AU2023282271A1/en not_active Abandoned
-
2024
- 2024-05-24 JP JP2024084718A patent/JP7801794B2/ja active Active
- 2024-12-06 US US18/971,281 patent/US20250163068A1/en active Pending
-
2025
- 2025-09-23 AU AU2025237912A patent/AU2025237912A1/en active Pending
- 2025-12-23 JP JP2025279047A patent/JP2026062794A/ja active Pending
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