|
ZA935112B
(en)
*
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
US5260300A
(en)
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
|
WO1994025072A1
(en)
|
1993-04-23 |
1994-11-10 |
American Home Products Corporation |
Rapamycin conjugates and antibodies
|
|
CA2175215C
(en)
|
1993-11-19 |
2008-06-03 |
Yat Sun Or |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
|
SK78196A3
(en)
|
1993-12-17 |
1997-02-05 |
Sandoz Ag |
Rapamycin demethoxy-derivatives, preparation method thereof and pharmaceutical agent containing them
|
|
US5362735A
(en)
|
1994-02-23 |
1994-11-08 |
Smithkline Beecham Corporation |
Rapamycin derivatives
|
|
US5639600A
(en)
|
1994-08-05 |
1997-06-17 |
The Regents Of The University Of California |
Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement
|
|
JP3934705B2
(ja)
*
|
1995-05-26 |
2007-06-20 |
ノバルティス ファーマ株式会社 |
サイクロデキストリン組成物
|
|
WO1996041865A1
(en)
|
1995-06-07 |
1996-12-27 |
Ariad Gene Therapeutics, Inc. |
Rapamcycin-based regulation of biological events
|
|
US5985890A
(en)
|
1995-06-09 |
1999-11-16 |
Novartis Ag |
Rapamycin derivatives
|
|
AU735648B2
(en)
*
|
1996-07-12 |
2001-07-12 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
|
CA2257803C
(en)
|
1996-07-12 |
2008-12-02 |
Ariad Pharmaceuticals, Inc. |
Non immunosuppressive antifungal rapalogs
|
|
EP0927182A2
(en)
|
1996-09-09 |
1999-07-07 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
|
US5922730A
(en)
|
1996-09-09 |
1999-07-13 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
|
US6342507B1
(en)
|
1997-09-05 |
2002-01-29 |
Isotechnika, Inc. |
Deuterated rapamycin compounds, method and uses thereof
|
|
US7087648B1
(en)
|
1997-10-27 |
2006-08-08 |
The Regents Of The University Of California |
Methods for modulating macrophage proliferation using polyamine analogs
|
|
JP2002508971A
(ja)
*
|
1998-01-15 |
2002-03-26 |
アリアド・ジーン・セラピューティクス・インコーポレーテッド |
多量体キメラ蛋白質を使用する生物学的イベントの調節
|
|
US7067526B1
(en)
|
1999-08-24 |
2006-06-27 |
Ariad Gene Therapeutics, Inc. |
28-epirapalogs
|
|
ATE264863T1
(de)
*
|
1999-08-24 |
2004-05-15 |
Ariad Gene Therapeutics Inc |
28-epirapaloge
|
|
TWI256395B
(en)
|
1999-09-29 |
2006-06-11 |
Wyeth Corp |
Regioselective synthesis of rapamycin derivatives
|
|
DE60037345T2
(de)
|
1999-12-10 |
2008-11-13 |
Pfizer Products Inc., Groton |
Pyrrolo(2,3-d)pyrimidin-Verbindungen
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
DE60217322T2
(de)
|
2001-04-27 |
2007-10-04 |
Zenyaku Kogyo K.K. |
Heterocyclische verbindung und antitumormittel, das diese als wirkstoff enthält
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
US20040001878A1
(en)
*
|
2002-06-26 |
2004-01-01 |
Deroyal Industries, Inc. |
Infused wound care dressings
|
|
PT1536827E
(pt)
|
2002-08-14 |
2009-03-20 |
Silence Therapeutics Ag |
Utilização de proteína cinase n beta
|
|
AU2004228668B2
(en)
|
2003-04-03 |
2011-10-27 |
Park Funding, Llc |
PI-3 kinase inhibitor prodrugs
|
|
ES2382377T3
(es)
|
2003-05-30 |
2012-06-07 |
Gemin X Pharmaceuticals Canada Inc. |
Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer
|
|
EP1692153A4
(en)
|
2003-07-03 |
2007-03-21 |
Univ Pennsylvania |
INHIBITION OF EXPRESSION OF SYK-KINASE
|
|
US20060173033A1
(en)
*
|
2003-07-08 |
2006-08-03 |
Michaela Kneissel |
Use of rapamycin and rapamycin derivatives for the treatment of bone loss
|
|
US7220755B2
(en)
|
2003-11-12 |
2007-05-22 |
Biosensors International Group, Ltd. |
42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
|
|
WO2005113556A1
(en)
|
2004-05-13 |
2005-12-01 |
Icos Corporation |
Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
|
|
US20060189551A1
(en)
*
|
2004-10-04 |
2006-08-24 |
Duke University |
Combination therapies for fungal pathogens
|
|
AU2006206458B2
(en)
|
2005-01-19 |
2012-10-25 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
GB0504994D0
(en)
|
2005-03-11 |
2005-04-20 |
Biotica Tech Ltd |
Novel compounds
|
|
US20060257337A1
(en)
|
2005-04-28 |
2006-11-16 |
David Sherris |
Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
|
|
PL1888550T3
(pl)
|
2005-05-12 |
2014-12-31 |
Abbvie Bahamas Ltd |
Promotory apoptozy
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
US7402325B2
(en)
|
2005-07-28 |
2008-07-22 |
Phoenix Biotechnology, Inc. |
Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
|
|
US7989622B2
(en)
|
2005-10-07 |
2011-08-02 |
Exelixis, Inc. |
Phosphatidylinositol 3-kinase inhibitors and methods of their use
|
|
EA016945B1
(ru)
|
2005-10-07 |
2012-08-30 |
Экселиксис, Инк. |
ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
|
|
JP5191391B2
(ja)
|
2005-11-01 |
2013-05-08 |
ターゲジェン インコーポレーティッド |
キナーゼのビ−アリールメタ−ピリミジン阻害剤
|
|
ES2365869T3
(es)
|
2005-11-17 |
2011-10-11 |
OSI Pharmaceuticals, LLC |
COMPUESTOS BICÍCLICOS FUSIONADOS INHIBIDORES DE LA mTOR.
|
|
SG10202003901UA
(en)
|
2005-12-13 |
2020-05-28 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
US20070203168A1
(en)
|
2006-02-28 |
2007-08-30 |
Zhao Jonathon Z |
Isomers of rapamycin and 42-Epi-rapamycin, methods of making and using the same
|
|
CL2007000995A1
(es)
|
2006-04-11 |
2008-06-27 |
Smithkline Beecham Corp |
Compuestos derivados de tiazolidinadiona; composicion farmaceutica; y uso para tratar uno o mas estados de enfermedad seleccionada entre trastornos autoinmunes, enfermedad inflamatoria, cardiovascular y neurodegenerativa entre otras.
|
|
WO2007129161A2
(en)
|
2006-04-26 |
2007-11-15 |
F. Hoffmann-La Roche Ag |
Thieno [3, 2-d] pyrimidine derivative useful as pi3k inhibitor
|
|
WO2008014434A2
(en)
|
2006-07-28 |
2008-01-31 |
Caracal, Inc. |
Crystal growth method and reactor design
|
|
PT2074122E
(pt)
|
2006-09-15 |
2011-08-24 |
Pfizer Prod Inc |
Compostos de pirido(2,3-d)-pirimidinona e sua utilização como inibidores de pi3
|
|
DK2526933T3
(en)
|
2006-09-22 |
2015-05-18 |
Pharmacyclics Inc |
Inhibitors of Bruton's tyrosine kinase
|
|
MX2009005950A
(es)
|
2006-12-07 |
2009-10-12 |
Genentech Inc |
Compuestos inhibidores de fosfoinositido 3-quinasas y metodos de uso.
|
|
WO2008110491A2
(en)
|
2007-03-09 |
2008-09-18 |
University Of Basel |
Chemotherapy of neoplastic diseases using combinations of rapamycin and compounds modulating mtor pathway alone or in combination with heat
|
|
KR101566840B1
(ko)
|
2007-03-12 |
2015-11-06 |
와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 |
페닐 아미노 피리미딘 화합물 및 이의 용도
|
|
WO2008118802A1
(en)
|
2007-03-23 |
2008-10-02 |
Regents Of The University Of Minnesota |
Therapeutic compounds
|
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
HUE029767T2
(en)
|
2008-03-11 |
2017-04-28 |
Incyte Holdings Corp |
JAK inhibitor azetidine and cyclobutane derivatives
|
|
US20090253733A1
(en)
|
2008-04-02 |
2009-10-08 |
Biointeractions, Ltd. |
Rapamycin carbonate esters
|
|
LT2294072T
(lt)
|
2008-05-23 |
2017-06-12 |
Wyeth Llc |
Triazino junginiai, kaip p13 kinazės ir mtor inhibitoriai
|
|
MX2010014230A
(es)
|
2008-06-20 |
2011-03-29 |
Astrazeneca Ab |
Composiciones que contienen pirido [2,3-d] pirimidinas sustituidas con metilmorfolina y proceso relacionado.
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US8110578B2
(en)
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
ES2345241B1
(es)
|
2009-03-16 |
2011-09-08 |
Lipopharma Therapeutics |
Uso de 2-hidroxiderivados de acidos grasos poliinsaturados como medicamentos.
|
|
TW201038567A
(en)
|
2009-03-27 |
2010-11-01 |
Pathway Therapeutics Ltd |
Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
|
|
WO2010114484A1
(en)
|
2009-04-03 |
2010-10-07 |
S*Bio Pte Ltd |
Pyrimidine substituted purine compounds as kinase (s) inhibitors
|
|
WO2010118208A1
(en)
|
2009-04-09 |
2010-10-14 |
Exelixis, Inc. |
Benzoxazepin-4- (5h) -yl derivatives and their use to treat cancer
|
|
EP2558092B1
(en)
|
2010-04-13 |
2018-06-27 |
Novartis AG |
Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase 6 (cdk4/6) inhibitor and an mtor inhibitor for treating cancer
|
|
MX2013000617A
(es)
|
2010-07-16 |
2013-06-13 |
Piramal Entpr Ltd |
Derivados sustituidos de imidazoquinolina como inhibidores de quinasa.
|
|
JO3003B1
(ar)
|
2011-01-14 |
2016-09-05 |
Lilly Co Eli |
مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
|
|
US8808256B2
(en)
|
2012-01-16 |
2014-08-19 |
Johnson & Johnson Vision Care, Inc. |
Eye drug delivery system
|
|
US9072678B2
(en)
|
2013-03-14 |
2015-07-07 |
Pathak Holdings Llc |
Methods for local drug delivery by microinjection
|
|
US9663508B2
(en)
|
2013-10-01 |
2017-05-30 |
Amgen Inc. |
Biaryl acyl-sulfonamide compounds as sodium channel inhibitors
|
|
AU2015210833B2
(en)
|
2014-02-03 |
2019-01-03 |
Vitae Pharmaceuticals, Llc |
Dihydropyrrolopyridine inhibitors of ROR-gamma
|
|
CN113620978A
(zh)
|
2014-09-11 |
2021-11-09 |
加利福尼亚大学董事会 |
mTORC1抑制剂
|
|
US20160279108A1
(en)
|
2015-02-24 |
2016-09-29 |
University Of Kansas |
Targeted mtor inhibitors
|
|
US10683308B2
(en)
*
|
2015-09-11 |
2020-06-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
WO2018204416A1
(en)
|
2017-05-02 |
2018-11-08 |
Revolution Medicines, Inc. |
Rapamycin analogs as mtor inhibitors
|
|
AR112834A1
(es)
|
2017-09-26 |
2019-12-18 |
Novartis Ag |
Derivados de rapamicina
|
|
WO2019241789A1
(en)
*
|
2018-06-15 |
2019-12-19 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
WO2020076738A2
(en)
*
|
2018-10-12 |
2020-04-16 |
Bellicum Pharmaceuticals, Inc |
Protein-binding compounds
|
|
HRP20250197T1
(hr)
|
2018-12-18 |
2025-04-11 |
Novartis Ag |
Derivati rapamicina
|
|
IL285067B2
(en)
|
2019-01-22 |
2025-02-01 |
Aeovian Pharmaceuticals Inc |
MTORC Modulators and Their Uses
|
|
US20220202787A1
(en)
|
2019-03-26 |
2022-06-30 |
Novartis Ag |
Isothiazolidine 1,1-dioxide and 1,4-butan sultone containing rapamycin derivatives and uses thereof
|
|
AU2020397938A1
(en)
*
|
2019-12-05 |
2022-06-23 |
Janssen Pharmaceutica Nv |
Rapamycin analogs and uses thereof
|
|
CN115776907B
(zh)
|
2020-03-27 |
2025-02-25 |
艾奥维安制药公司 |
Mtorc1调节剂及其用途
|
|
CN121426814A
(zh)
|
2020-07-21 |
2026-01-30 |
艾奥维安制药公司 |
Mtorc1调节剂及其用途
|