JP2022137047A5 - - Google Patents
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- JP2022137047A5 JP2022137047A5 JP2022096439A JP2022096439A JP2022137047A5 JP 2022137047 A5 JP2022137047 A5 JP 2022137047A5 JP 2022096439 A JP2022096439 A JP 2022096439A JP 2022096439 A JP2022096439 A JP 2022096439A JP 2022137047 A5 JP2022137047 A5 JP 2022137047A5
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- Prior art keywords
- cancer
- pharmaceutically acceptable
- alkyl
- acceptable salt
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003839 salts Chemical class 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 32
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000001188 haloalkyl group Chemical group 0.000 claims 14
- 201000010536 head and neck cancer Diseases 0.000 claims 12
- 208000014829 head and neck neoplasm Diseases 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 125000004438 haloalkoxy group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 206010039491 Sarcoma Diseases 0.000 claims 5
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 5
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 4
- 206010025323 Lymphomas Diseases 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- -1 cyano, carboxy Chemical group 0.000 claims 4
- 229910052805 deuterium Inorganic materials 0.000 claims 4
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 4
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- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 3
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 3
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 3
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 239000001301 oxygen Chemical group 0.000 claims 3
- 229910052760 oxygen Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
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- 201000009030 Carcinoma Diseases 0.000 claims 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 2
- 206010061252 Intraocular melanoma Diseases 0.000 claims 2
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 claims 2
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- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 2
- 201000005969 Uveal melanoma Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 125000003725 azepanyl group Chemical group 0.000 claims 2
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- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 201000011216 nasopharynx carcinoma Diseases 0.000 claims 2
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- 210000002784 stomach Anatomy 0.000 claims 2
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- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
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- 206010007279 Carcinoid tumour of the gastrointestinal tract Diseases 0.000 claims 1
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 201000009047 Chordoma Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010056979 Colitis microscopic Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
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- 208000009798 Craniopharyngioma Diseases 0.000 claims 1
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- 208000006926 Discoid Lupus Erythematosus Diseases 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000017259 Extragonadal germ cell tumor Diseases 0.000 claims 1
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
- 206010053717 Fibrous histiocytoma Diseases 0.000 claims 1
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- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010018691 Granuloma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
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- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
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- 208000037396 Intraductal Noninfiltrating Carcinoma Diseases 0.000 claims 1
- 208000009164 Islet Cell Adenoma Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 201000005099 Langerhans cell histiocytosis Diseases 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 1
- 208000004059 Male Breast Neoplasms Diseases 0.000 claims 1
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 1
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 1
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010063569 Metastatic squamous cell carcinoma Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 206010028729 Nasal cavity cancer Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 1
- 208000033383 Neuroendocrine tumor of pancreas Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438121P | 2016-12-22 | 2016-12-22 | |
| US62/438,121 | 2016-12-22 | ||
| PCT/US2017/067855 WO2018119208A1 (en) | 2016-12-22 | 2017-12-21 | Histone methyltransferase inhibitors |
| JP2019531160A JP7091336B2 (ja) | 2016-12-22 | 2017-12-21 | ヒストンメチルトランスフェラーゼ阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531160A Division JP7091336B2 (ja) | 2016-12-22 | 2017-12-21 | ヒストンメチルトランスフェラーゼ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022137047A JP2022137047A (ja) | 2022-09-21 |
| JP2022137047A5 true JP2022137047A5 (https=) | 2023-03-20 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531160A Expired - Fee Related JP7091336B2 (ja) | 2016-12-22 | 2017-12-21 | ヒストンメチルトランスフェラーゼ阻害剤 |
| JP2022096439A Pending JP2022137047A (ja) | 2016-12-22 | 2022-06-15 | ヒストンメチルトランスフェラーゼ阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531160A Expired - Fee Related JP7091336B2 (ja) | 2016-12-22 | 2017-12-21 | ヒストンメチルトランスフェラーゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10829452B2 (https=) |
| EP (2) | EP3558971B1 (https=) |
| JP (2) | JP7091336B2 (https=) |
| AR (1) | AR110443A1 (https=) |
| ES (2) | ES2910108T3 (https=) |
| TW (1) | TW201829386A (https=) |
| WO (1) | WO2018119208A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018119208A1 (en) * | 2016-12-22 | 2018-06-28 | Global Blood Therapeutics, Inc. | Histone methyltransferase inhibitors |
| CN110621316B (zh) | 2017-04-21 | 2024-01-26 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| IL273824B2 (en) * | 2017-10-18 | 2024-07-01 | Epizyme Inc | Methods for using EHMT2 inhibitors in the treatment or prevention of blood disorders |
| EP3697420A4 (en) * | 2017-10-18 | 2021-11-24 | Epizyme, Inc. | METHOD OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPY |
| CN112105796B (zh) | 2018-03-09 | 2024-10-25 | 斯伦贝谢技术有限公司 | 集成井施工系统操作 |
| CN111196817B (zh) * | 2018-11-19 | 2021-06-11 | 四川大学华西医院 | 作为brpf1抑制剂的三环化合物 |
| US20220056043A1 (en) * | 2019-02-19 | 2022-02-24 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Nitrogen-containing fused cyclic compound, preparation method therefor and use thereof |
| CN111620818B (zh) * | 2019-02-28 | 2023-09-29 | 暨南大学 | 8,9-二甲氧基啡啶类化合物及其应用 |
| CN116710431A (zh) * | 2020-11-19 | 2023-09-05 | 泰洛治疗公司 | 小分子化合物和组合物 |
| CR20230286A (es) * | 2020-11-24 | 2023-08-24 | Amgen Inc | Inhibidores de prmt5 novedosos |
| CA3206062A1 (en) | 2021-01-27 | 2022-08-04 | Said Oumouch | Urolithin derivatives and methods of use thereof |
| CN113004294B (zh) * | 2021-03-08 | 2023-01-17 | 温州大学新材料与产业技术研究院 | 一种四氢呋喃并1,4-二氢喹啉类化合物及其制备方法和应用 |
| CN114573569B (zh) * | 2022-03-30 | 2023-07-04 | 邦恩泰(山东)生物医药科技集团股份有限公司 | 一种异喹啉类化合物的制备方法 |
| CN117903150A (zh) * | 2024-01-11 | 2024-04-19 | 中国科学技术大学 | 一种烯基取代的多环氮杂环的合成方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
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| HUP0300894A3 (en) | 2000-03-15 | 2008-05-28 | Sanofi Aventis Deutschland | Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use |
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2017
- 2017-12-21 WO PCT/US2017/067855 patent/WO2018119208A1/en not_active Ceased
- 2017-12-21 ES ES17829543T patent/ES2910108T3/es active Active
- 2017-12-21 JP JP2019531160A patent/JP7091336B2/ja not_active Expired - Fee Related
- 2017-12-21 ES ES22153996T patent/ES2981507T3/es active Active
- 2017-12-21 EP EP17829543.2A patent/EP3558971B1/en active Active
- 2017-12-21 EP EP22153996.8A patent/EP4063358B1/en active Active
- 2017-12-21 TW TW106145167A patent/TW201829386A/zh unknown
- 2017-12-21 US US15/850,389 patent/US10829452B2/en active Active
- 2017-12-22 AR ARP170103662A patent/AR110443A1/es unknown
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2020
- 2020-11-04 US US17/089,239 patent/US11713299B2/en active Active
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2022
- 2022-06-15 JP JP2022096439A patent/JP2022137047A/ja active Pending
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