JP2022106952A5 - - Google Patents
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- JP2022106952A5 JP2022106952A5 JP2022077865A JP2022077865A JP2022106952A5 JP 2022106952 A5 JP2022106952 A5 JP 2022106952A5 JP 2022077865 A JP2022077865 A JP 2022077865A JP 2022077865 A JP2022077865 A JP 2022077865A JP 2022106952 A5 JP2022106952 A5 JP 2022106952A5
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- nucleotide sequence
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- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023146751A JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2025080407A JP2025134088A (ja) | 2016-06-14 | 2025-05-13 | 抗ｃ５抗体及びそれらの使用 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662349705P | 2016-06-14 | 2016-06-14 | |
| US62/349,705 | 2016-06-14 | ||
| US201662405561P | 2016-10-07 | 2016-10-07 | |
| US62/405,561 | 2016-10-07 | ||
| US201662422107P | 2016-11-15 | 2016-11-15 | |
| US62/422,107 | 2016-11-15 | ||
| JP2018565286A JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
| PCT/US2017/037226 WO2017218515A1 (en) | 2016-06-14 | 2017-06-13 | Anti-c5 antibodies and uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565286A Division JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023146751A Division JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022106952A JP2022106952A (ja) | 2022-07-20 |
| JP2022106952A5 true JP2022106952A5 (OSRAM) | 2022-12-09 |
| JP7368543B2 JP7368543B2 (ja) | 2023-10-24 |
Family
ID=59091673
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565286A Active JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
| JP2022077865A Active JP7368543B2 (ja) | 2016-06-14 | 2022-05-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2023146751A Active JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2025080407A Pending JP2025134088A (ja) | 2016-06-14 | 2025-05-13 | 抗ｃ５抗体及びそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565286A Active JP7102353B2 (ja) | 2016-06-14 | 2017-06-13 | 抗ｃ５抗体及びそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023146751A Active JP7682964B2 (ja) | 2016-06-14 | 2023-09-11 | 抗ｃ５抗体及びそれらの使用 |
| JP2025080407A Pending JP2025134088A (ja) | 2016-06-14 | 2025-05-13 | 抗ｃ５抗体及びそれらの使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US10633434B2 (OSRAM) |
| EP (2) | EP3468990B1 (OSRAM) |
| JP (4) | JP7102353B2 (OSRAM) |
| KR (3) | KR102534895B1 (OSRAM) |
| CN (3) | CN116751293A (OSRAM) |
| AU (2) | AU2017283470B2 (OSRAM) |
| CA (1) | CA3027487A1 (OSRAM) |
| CL (1) | CL2018003563A1 (OSRAM) |
| CO (1) | CO2018014413A2 (OSRAM) |
| DK (1) | DK3468990T3 (OSRAM) |
| ES (1) | ES2984352T3 (OSRAM) |
| FI (1) | FI3468990T3 (OSRAM) |
| HR (1) | HRP20240815T1 (OSRAM) |
| HU (1) | HUE067224T2 (OSRAM) |
| IL (2) | IL263481B2 (OSRAM) |
| LT (1) | LT3468990T (OSRAM) |
| MA (1) | MA45235B1 (OSRAM) |
| MD (1) | MD3468990T2 (OSRAM) |
| MX (3) | MX2018015149A (OSRAM) |
| MY (3) | MY196006A (OSRAM) |
| PH (2) | PH12023500007A1 (OSRAM) |
| PL (1) | PL3468990T3 (OSRAM) |
| PT (1) | PT3468990T (OSRAM) |
| RS (1) | RS65633B1 (OSRAM) |
| SG (2) | SG11201810933QA (OSRAM) |
| SI (1) | SI3468990T1 (OSRAM) |
| SM (1) | SMT202400269T1 (OSRAM) |
| UA (1) | UA124734C2 (OSRAM) |
| WO (1) | WO2017218515A1 (OSRAM) |
Families Citing this family (67)
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| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| MX2011001371A (es) * | 2008-08-05 | 2011-06-16 | Novartis Ag | Composiciones y metodos para anticuerpos que se dirigen a la proteina de complementos c5. |
| BR112013013354A2 (pt) | 2010-11-30 | 2020-10-06 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno capaz de se ligar a uma pluralidade de moléculas de antígeno repetidamente |
| NZ711451A (en) | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| MY181199A (en) | 2014-12-19 | 2020-12-21 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| TWI617580B (zh) | 2014-12-19 | 2018-03-11 | 中外製藥股份有限公司 | 抗ｃ５抗體及使用方法 |
| WO2017205101A1 (en) | 2016-05-27 | 2017-11-30 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis |
| MY196006A (en) | 2016-06-14 | 2023-03-06 | Regeneron Pharma | Anti-C5 Antibodies and Uses Thereof |
| JP6527643B2 (ja) | 2016-08-05 | 2019-06-05 | 中外製薬株式会社 | Ｉｌ−８関連疾患の治療用又は予防用組成物 |
| MX2019010574A (es) * | 2017-03-06 | 2020-01-15 | Univ Pennsylvania | Anticuerpos anti-c5 y su uso. |
| FI3658184T3 (fi) | 2017-07-27 | 2023-11-30 | Alexion Pharma Inc | Korkean pitoisuuden omaavia anti-c5-vasta-aineformulaatioita |
| WO2019075097A1 (en) | 2017-10-11 | 2019-04-18 | Board Of Regents, The University Of Texas System | PD-L1 HUMAN ANTIBODIES AND METHODS OF USE |
| JP7518764B2 (ja) | 2017-10-26 | 2024-07-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 発作性夜間ヘモグロビン尿症（ＰＮＨ）および非典型溶血性尿毒症症候群（ａＨＵＳ）の処置のための抗Ｃ５抗体の投薬量および投与 |
| KR20200098528A (ko) | 2017-12-13 | 2020-08-20 | 리제너론 파아마슈티컬스, 인크. | 항-c5 항체 조합물 및 이의 용도 |
| US20190247560A1 (en) * | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| JP7390301B2 (ja) | 2018-03-23 | 2023-12-01 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ヒトｐｄ－ｌ２抗体およびその使用方法 |
| EP3768726B1 (en) | 2018-03-23 | 2024-10-30 | Board of Regents, The University of Texas System | Dual specificity antibodies to pd-l1 and pd-l2 and methods of use therefor |
| WO2019182867A1 (en) | 2018-03-23 | 2019-09-26 | Board Of Regents, The University Of Texas System | Dual specificity antibodies to human pd-l1 and pd-l2 and methods of use therefor |
| EP3784990A4 (en) | 2018-04-26 | 2022-06-22 | The Trustees of the University of Pennsylvania | COMPOSITIONS AND METHODS FOR DETECTING TUMOR-RELATED ANTIBODIES AND ANTIGENS |
| WO2019231983A1 (en) * | 2018-05-31 | 2019-12-05 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients |
| JP7577542B2 (ja) | 2018-06-04 | 2024-11-05 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 小児患者における非典型溶血性尿毒症症候群（ａＨＵＳ）の治療のための抗Ｃ５抗体の用量および投与 |
| JP7538723B2 (ja) | 2018-06-28 | 2024-08-22 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 抗ｃ５抗体の産生方法 |
| EP3846850A4 (en) * | 2018-09-06 | 2022-06-15 | The Trustees of the University of Pennsylvania | HUMANIZED ANTI-C5 ANTIBODIES AND USES THEREOF |
| JP2022500427A (ja) * | 2018-09-17 | 2022-01-04 | 国立大学法人京都大学 | 肝傷害又は肝不全の処置のための抗ｃ５剤の投与 |
| JP2022501378A (ja) | 2018-09-21 | 2022-01-06 | アレクシオン ファーマシューティカルズ インコーポレイテッドAlexion Pharmaceuticals, Inc. | 視神経脊髄炎の処置のためのエクリズマブ |
| AU2019370295A1 (en) | 2018-10-30 | 2021-06-03 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-C5 antibodies for treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) |
| WO2020092546A1 (en) | 2018-10-30 | 2020-05-07 | Alexion Pharmaceuticals, Inc. | Co-administration of a hyaluronidase and anti-c5 antibody for treatment of complement-associated conditions |
| CA3127797A1 (en) | 2019-01-25 | 2020-07-30 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus) |
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| US20220227851A1 (en) * | 2019-05-24 | 2022-07-21 | Alexion Pharmaceuticals, Inc. | Methods of treating vitiligo using an anti-c5 antibody |
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| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
| CN116096381A (zh) | 2020-04-30 | 2023-05-09 | 阿尔尼拉姆医药品有限公司 | 补体因子B（CFB）iRNA组合物及其使用方法 |
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| TW202423479A (zh) | 2022-09-28 | 2024-06-16 | 美商阿雷希昂製藥公司 | 用於預防或最小化患有慢性腎病的患者中的心臟手術相關急性腎損傷（csa-aki）和/或隨後的主要不良腎事件（make）的抗c5抗體之劑量及投與 |
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