JPWO2019173291A5 - - Google Patents
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- JPWO2019173291A5 JPWO2019173291A5 JP2020546997A JP2020546997A JPWO2019173291A5 JP WO2019173291 A5 JPWO2019173291 A5 JP WO2019173291A5 JP 2020546997 A JP2020546997 A JP 2020546997A JP 2020546997 A JP2020546997 A JP 2020546997A JP WO2019173291 A5 JPWO2019173291 A5 JP WO2019173291A5
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- JP
- Japan
- Prior art keywords
- seq
- variable region
- chain variable
- polypeptide sequence
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 195
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 195
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 195
- 239000000427 antigen Substances 0.000 claims description 37
- 102000036639 antigens Human genes 0.000 claims description 37
- 108091007433 antigens Proteins 0.000 claims description 37
- 239000012634 fragment Substances 0.000 claims description 37
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 23
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 210000004027 cell Anatomy 0.000 claims description 9
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 238000006471 dimerization reaction Methods 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 102000045309 human NT5E Human genes 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 230000005945 translocation Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108010028584 nucleotidase Proteins 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023132024A JP7636483B2 (ja) | 2018-03-09 | 2023-08-14 | 抗cd73抗体及びその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862640955P | 2018-03-09 | 2018-03-09 | |
| US62/640,955 | 2018-03-09 | ||
| US201862721044P | 2018-08-22 | 2018-08-22 | |
| US62/721,044 | 2018-08-22 | ||
| US201862786598P | 2018-12-31 | 2018-12-31 | |
| US62/786,598 | 2018-12-31 | ||
| PCT/US2019/020688 WO2019173291A1 (en) | 2018-03-09 | 2019-03-05 | Anti-cd73 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023132024A Division JP7636483B2 (ja) | 2018-03-09 | 2023-08-14 | 抗cd73抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021516057A JP2021516057A (ja) | 2021-07-01 |
| JPWO2019173291A5 true JPWO2019173291A5 (OSRAM) | 2022-03-10 |
| JP7334177B2 JP7334177B2 (ja) | 2023-08-28 |
Family
ID=67846304
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546997A Active JP7334177B2 (ja) | 2018-03-09 | 2019-03-05 | 抗cd73抗体及びその使用 |
| JP2023132024A Active JP7636483B2 (ja) | 2018-03-09 | 2023-08-14 | 抗cd73抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023132024A Active JP7636483B2 (ja) | 2018-03-09 | 2023-08-14 | 抗cd73抗体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11299550B2 (OSRAM) |
| EP (1) | EP3762030A4 (OSRAM) |
| JP (2) | JP7334177B2 (OSRAM) |
| KR (2) | KR102804816B1 (OSRAM) |
| CN (2) | CN111867628B (OSRAM) |
| AU (1) | AU2019231172B2 (OSRAM) |
| BR (1) | BR112020016049A2 (OSRAM) |
| CA (1) | CA3090008A1 (OSRAM) |
| IL (1) | IL276950B1 (OSRAM) |
| MX (1) | MX2020009366A (OSRAM) |
| SG (1) | SG11202007199XA (OSRAM) |
| WO (1) | WO2019173291A1 (OSRAM) |
| ZA (1) | ZA202004827B (OSRAM) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11786551B2 (en) | 2017-09-26 | 2023-10-17 | The Trustees Of The University Of Pennsylvania | Methods for treating heart disease via redirected T cell immunotherapies |
| MA52422A (fr) | 2018-02-27 | 2021-01-06 | Incyte Corp | Imidazopyrimidines et triazolopyrimidines en tant qu'inhibiteurs a2a/a2b |
| MX2020012376A (es) | 2018-05-18 | 2021-03-09 | Incyte Corp | Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b. |
| MA53097A (fr) | 2018-07-05 | 2021-05-12 | Incyte Corp | Dérivés de pyrazine fusionnés en tant qu'inhibiteurs d'a2a/a2b |
| US12422440B2 (en) | 2018-10-05 | 2025-09-23 | Seattle Children's Hospital | Newborn screening for primary immunodeficiencies, cystinosis, and Wilson disease |
| CN111434688A (zh) * | 2019-01-11 | 2020-07-21 | 上海开拓者生物医药有限公司 | Cd73抗体及其制备方法和应用 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| AU2020353000A1 (en) | 2019-09-23 | 2022-04-07 | The Trustees Of The University Of Pennsylvania | Disrupting tumor tissues by targeting fibroblast activation protein (FAP) |
| KR20220066090A (ko) | 2019-09-23 | 2022-05-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 마우스 및 인간 섬유아세포 활성화 단백질(fap)과 교차 반응하는 개과 섬유아세포 활성화 단백질에 대한 모노클로날 항체 |
| PH12022551150A1 (en) * | 2019-11-15 | 2023-10-09 | Genzyme Corp | Biparatopic cd73 antibodies |
| EP4061420A1 (en) * | 2019-11-20 | 2022-09-28 | Abvision, Inc. | Monoclonal antibodies that target human cd47 protein |
| WO2021126538A1 (en) * | 2019-12-17 | 2021-06-24 | Phanes Therapeutics, Inc. | Bispecific antibodies with alternatively matched interchain cycteines and uses thereof |
| MX2022007573A (es) | 2020-01-03 | 2022-09-23 | Incyte Corp | Terapia de combinación de inhibidor de grupo de diferenciación 73 (cd73) e inhibidor del receptor de adenosina a2a/a2b. |
| TWI873265B (zh) * | 2020-01-03 | 2025-02-21 | 美商英塞特公司 | 抗cd73抗體及其用途 |
| US11940448B2 (en) | 2020-03-31 | 2024-03-26 | Seattle Children's Hospital | Proteomic screening for lysosomal storage diseases |
| US20230159655A1 (en) * | 2020-04-22 | 2023-05-25 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
| MX2022013311A (es) * | 2020-04-22 | 2022-11-14 | Akeso Biopharma Inc | Anticuerpo biespecifico anti-cd73-anti-pd-1 y uso del mismo. |
| US20230279108A1 (en) * | 2020-04-30 | 2023-09-07 | Arch Oncology, Inc. | Therapeutic sirp-alpha antibodies |
| CN114075289B (zh) * | 2020-08-17 | 2024-07-02 | 中山康方生物医药有限公司 | 抗cd73的抗体及其用途 |
| AU2021363350A1 (en) * | 2020-10-23 | 2023-06-22 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
| CN114456268B (zh) * | 2020-11-09 | 2023-08-18 | 江苏中新医药有限公司 | 抗胞外-5’-核苷酸酶的抗体序列 |
| CN116529265A (zh) * | 2020-12-11 | 2023-08-01 | 上海华奥泰生物药业股份有限公司 | Cd73的抗原结合蛋白及其应用 |
| MX2023007850A (es) | 2020-12-29 | 2023-09-11 | Incyte Corp | Terapia combinada que comprende inhibidores de adora2a/adora2b (a2a/a2b), inhibidores de muerte programada/ligando 1 de muerte programada (pd-1/pd-l1) y anticuerpos de cumulo de diferenciacion 73 (anti-cd73). |
| CN113061177B (zh) * | 2020-12-31 | 2022-07-01 | 浙江大学 | 一种cd73酶活性相关的抗原表位及针对该表位的特异性抗体的制备方法 |
| EP4299589A4 (en) * | 2021-02-24 | 2025-06-11 | Novoprotein Scientififc Inc. | HUMAN ANTI-CD73 ANTIBODY AND ITS USE |
| GB202105110D0 (en) * | 2021-04-09 | 2021-05-26 | Cancer Research Tech Ltd | Anti-CD73 antibodies |
| KR20240112375A (ko) * | 2021-08-19 | 2024-07-18 | 아디셋 테라퓨틱스, 인크. | 막 결합된 글리피칸-3의 검출 방법 |
| CN116265486A (zh) * | 2021-12-17 | 2023-06-20 | 三生国健药业(上海)股份有限公司 | 结合人cd73的抗体、其制备方法和用途 |
| US12187806B2 (en) * | 2022-03-04 | 2025-01-07 | Development Center For Biotechnology | Anti-CD73 antibodies and use thereof |
| AU2023252914A1 (en) | 2022-04-13 | 2024-10-17 | Arcus Biosciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| EP4572772A1 (en) | 2022-08-17 | 2025-06-25 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| CN116063467B (zh) * | 2022-08-24 | 2025-10-14 | 浙江大学医学院附属第一医院 | 抗h10亚型禽流感病毒血凝素蛋白单克隆抗体1f3及其在检测中的应用 |
| WO2024243189A2 (en) * | 2023-05-22 | 2024-11-28 | Board Of Regents, The University Of Texas System | Antigen binding proteins targeting pd-1 |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| CN117567632B (zh) * | 2023-11-27 | 2025-10-24 | 福州迈新生物技术开发有限公司 | 抗cd73蛋白单克隆抗体及其制备方法和应用 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025233264A1 (en) | 2024-05-07 | 2025-11-13 | Innate Pharma | Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2975057A1 (en) | 2006-07-10 | 2016-01-20 | Fujita Health University | Novel anti-cd73 antibody |
| FR3011240A1 (fr) | 2013-10-01 | 2015-04-03 | Centre Nat Rech Scient | Inhibiteurs de 5'-nucleotidases et leurs utilisations therapeutiques |
| EP3134411B1 (en) | 2014-04-25 | 2021-06-30 | Boehringer Ingelheim International GmbH | Purine derivatives as cd73 inhibitors for the treatment of cancer |
| PT3204417T (pt) | 2014-10-10 | 2020-10-08 | Innate Pharma | Bloqueio de cd73 |
| US9938356B2 (en) | 2014-11-10 | 2018-04-10 | Medimmune Limited | Binding molecules specific for CD73 and uses thereof |
| HK1246304A1 (zh) * | 2014-11-11 | 2018-09-07 | Medimmune Limited | 包含抗cd73抗体和a2a受体抑制剂的治疗组合及其用途 |
| DK3221363T3 (da) | 2014-11-21 | 2020-08-10 | Bristol Myers Squibb Co | Antistoffer mod cd73 og anvendelser deraf |
| HRP20201756T8 (hr) | 2014-11-21 | 2021-08-20 | Bristol-Myers Squibb Company | Antitijela koja sadrže modificirane regije teškog lanca |
| EP3259288A1 (en) | 2015-02-20 | 2017-12-27 | Innate Pharma | Cd73 blockade |
| WO2017064043A1 (en) | 2015-10-12 | 2017-04-20 | Innate Pharma | Cd73 blocking agents |
| MX2018006973A (es) * | 2015-12-09 | 2019-05-16 | Corvus Pharmaceuticals Inc | Anticuerpos anti-cd73 humanizados. |
| WO2017118613A1 (en) | 2016-01-08 | 2017-07-13 | Syddansk Universitet | Bispecific antibodies targeting human cd73 |
| KR20180118725A (ko) | 2016-03-04 | 2018-10-31 | 브리스톨-마이어스 스큅 컴퍼니 | 항-cd73 항체와의 조합 요법 |
| US10793636B2 (en) | 2016-07-11 | 2020-10-06 | Corvus Pharmaceuticals, Inc. | Anti-CD73 antibodies |
-
2019
- 2019-03-05 KR KR1020207027633A patent/KR102804816B1/ko active Active
- 2019-03-05 CA CA3090008A patent/CA3090008A1/en active Pending
- 2019-03-05 EP EP19764477.6A patent/EP3762030A4/en active Pending
- 2019-03-05 SG SG11202007199XA patent/SG11202007199XA/en unknown
- 2019-03-05 AU AU2019231172A patent/AU2019231172B2/en active Active
- 2019-03-05 JP JP2020546997A patent/JP7334177B2/ja active Active
- 2019-03-05 MX MX2020009366A patent/MX2020009366A/es unknown
- 2019-03-05 KR KR1020257013451A patent/KR20250065424A/ko active Pending
- 2019-03-05 US US15/733,540 patent/US11299550B2/en active Active
- 2019-03-05 BR BR112020016049-0A patent/BR112020016049A2/pt unknown
- 2019-03-05 WO PCT/US2019/020688 patent/WO2019173291A1/en not_active Ceased
- 2019-03-05 CN CN201980018305.6A patent/CN111867628B/zh active Active
- 2019-03-05 CN CN202411072731.7A patent/CN118955714A/zh active Pending
-
2020
- 2020-08-04 ZA ZA2020/04827A patent/ZA202004827B/en unknown
- 2020-08-26 IL IL276950A patent/IL276950B1/en unknown
-
2023
- 2023-08-14 JP JP2023132024A patent/JP7636483B2/ja active Active
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