JP2022036976A5 - - Google Patents
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- JP2022036976A5 JP2022036976A5 JP2021188305A JP2021188305A JP2022036976A5 JP 2022036976 A5 JP2022036976 A5 JP 2022036976A5 JP 2021188305 A JP2021188305 A JP 2021188305A JP 2021188305 A JP2021188305 A JP 2021188305A JP 2022036976 A5 JP2022036976 A5 JP 2022036976A5
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- antigen
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- cancer
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- 239000000427 antigen Substances 0.000 claims 32
- 102000036639 antigens Human genes 0.000 claims 32
- 108091007433 antigens Proteins 0.000 claims 32
- LNXLHAWHHNDIDC-QFIPXVFZSA-N (2s)-2-[3-(hexadecanoylamino)propanoylamino]-3-(1h-imidazol-5-yl)propanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 LNXLHAWHHNDIDC-QFIPXVFZSA-N 0.000 claims 9
- 210000002865 immune cell Anatomy 0.000 claims 8
- 230000003834 intracellular effect Effects 0.000 claims 6
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102100039534 Calcium-activated chloride channel regulator 4 Human genes 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims 2
- 102000017691 GABRA6 Human genes 0.000 claims 2
- 101710170439 Glycoprotein 2a Proteins 0.000 claims 2
- 102000017679 HTR3A Human genes 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000761343 Homo sapiens 5-hydroxytryptamine receptor 3A Proteins 0.000 claims 2
- 101000888577 Homo sapiens Calcium-activated chloride channel regulator 4 Proteins 0.000 claims 2
- 101001001400 Homo sapiens Gamma-aminobutyric acid receptor subunit alpha-6 Proteins 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 101001046668 Homo sapiens Integrin alpha-X Proteins 0.000 claims 2
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 2
- 101000688216 Homo sapiens Intestinal-type alkaline phosphatase Proteins 0.000 claims 2
- 101001004865 Homo sapiens Leucine-rich repeat-containing protein 26 Proteins 0.000 claims 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
- 101000615650 Homo sapiens MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Proteins 0.000 claims 2
- 101000986598 Homo sapiens Mas-related G-protein coupled receptor member X3 Proteins 0.000 claims 2
- 101000991618 Homo sapiens Meprin A subunit beta Proteins 0.000 claims 2
- 101001133088 Homo sapiens Mucin-21 Proteins 0.000 claims 2
- 101000753535 Homo sapiens Potassium-transporting ATPase subunit beta Proteins 0.000 claims 2
- 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 claims 2
- 101000612671 Homo sapiens Pulmonary surfactant-associated protein C Proteins 0.000 claims 2
- 101000896517 Homo sapiens Steroid 17-alpha-hydroxylase/17,20 lyase Proteins 0.000 claims 2
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 2
- 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 claims 2
- 101000897407 Homo sapiens T-cell surface glycoprotein CD1e, membrane-associated Proteins 0.000 claims 2
- 101000763314 Homo sapiens Thrombomodulin Proteins 0.000 claims 2
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- 101000818870 Homo sapiens Zona pellucida sperm-binding protein 2 Proteins 0.000 claims 2
- -1 ICOS Proteins 0.000 claims 2
- 102100022297 Integrin alpha-X Human genes 0.000 claims 2
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- 102100024319 Intestinal-type alkaline phosphatase Human genes 0.000 claims 2
- 102000017578 LAG3 Human genes 0.000 claims 2
- 102100025950 Leucine-rich repeat-containing protein 26 Human genes 0.000 claims 2
- 108010017736 Leukocyte Immunoglobulin-like Receptor B1 Proteins 0.000 claims 2
- 102100025584 Leukocyte immunoglobulin-like receptor subfamily B member 1 Human genes 0.000 claims 2
- 102100023117 Long-chain fatty acid transport protein 6 Human genes 0.000 claims 2
- 102100021318 MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Human genes 0.000 claims 2
- 102100028178 Mas-related G-protein coupled receptor member X3 Human genes 0.000 claims 2
- 102100030876 Meprin A subunit beta Human genes 0.000 claims 2
- 102100038354 Metabotropic glutamate receptor 4 Human genes 0.000 claims 2
- 102100034260 Mucin-21 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102100024019 Pancreatic secretory granule membrane major glycoprotein GP2 Human genes 0.000 claims 2
- 102100021944 Potassium-transporting ATPase subunit beta Human genes 0.000 claims 2
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 claims 2
- 102100040971 Pulmonary surfactant-associated protein C Human genes 0.000 claims 2
- 108091006528 SLC27A6 Proteins 0.000 claims 2
- 102000005038 SLC6A4 Human genes 0.000 claims 2
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 claims 2
- 102100021719 Steroid 17-alpha-hydroxylase/17,20 lyase Human genes 0.000 claims 2
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 2
- 102100036014 T-cell surface glycoprotein CD1c Human genes 0.000 claims 2
- 102100021989 T-cell surface glycoprotein CD1e, membrane-associated Human genes 0.000 claims 2
- 102100026966 Thrombomodulin Human genes 0.000 claims 2
- 102100037023 Transmembrane protease serine 11B Human genes 0.000 claims 2
- 102100036759 Transmembrane protein 211 Human genes 0.000 claims 2
- 102100040372 Type-2 angiotensin II receptor Human genes 0.000 claims 2
- 102100021422 Zona pellucida sperm-binding protein 2 Human genes 0.000 claims 2
- 101000779569 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) Alkaline phosphatase PhoD Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims 2
- 108091008042 inhibitory receptors Proteins 0.000 claims 2
- 108010038422 metabotropic glutamate receptor 4 Proteins 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
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- 239000002157 polynucleotide Substances 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 108010062802 CD66 antigens Proteins 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100024530 Carcinoembryonic antigen-related cell adhesion molecule 20 Human genes 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 208000030808 Clear cell renal carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 1
- 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 claims 1
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000981108 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 20 Proteins 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101000945371 Homo sapiens Killer cell immunoglobulin-like receptor 2DL2 Proteins 0.000 claims 1
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims 1
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 1
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 claims 1
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 1
- 101000623904 Homo sapiens Mucin-17 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000764620 Homo sapiens Transmembrane and immunoglobulin domain-containing protein 1 Proteins 0.000 claims 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 1
- 102100033599 Killer cell immunoglobulin-like receptor 2DL2 Human genes 0.000 claims 1
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 1
- 102100025096 Mesothelin Human genes 0.000 claims 1
- 102100023123 Mucin-16 Human genes 0.000 claims 1
- 102100023125 Mucin-17 Human genes 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 1
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 102100026243 Transmembrane and immunoglobulin domain-containing protein 1 Human genes 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
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- 239000012634 fragment Substances 0.000 claims 1
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- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462078927P | 2014-11-12 | 2014-11-12 | |
| US62/078,927 | 2014-11-12 | ||
| US201462081960P | 2014-11-19 | 2014-11-19 | |
| US62/081,960 | 2014-11-19 | ||
| JP2017525517A JP7023708B2 (ja) | 2014-11-12 | 2015-11-09 | 阻害性キメラ抗原受容体 |
| PCT/IB2015/058650 WO2016075612A1 (en) | 2014-11-12 | 2015-11-09 | Inhibitory chimeric antigen receptors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525517A Division JP7023708B2 (ja) | 2014-11-12 | 2015-11-09 | 阻害性キメラ抗原受容体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022036976A JP2022036976A (ja) | 2022-03-08 |
| JP2022036976A5 true JP2022036976A5 (enExample) | 2022-06-28 |
Family
ID=54695797
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525517A Active JP7023708B2 (ja) | 2014-11-12 | 2015-11-09 | 阻害性キメラ抗原受容体 |
| JP2021188305A Pending JP2022036976A (ja) | 2014-11-12 | 2021-11-19 | 阻害性キメラ抗原受容体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525517A Active JP7023708B2 (ja) | 2014-11-12 | 2015-11-09 | 阻害性キメラ抗原受容体 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11072644B2 (enExample) |
| EP (1) | EP3218394A1 (enExample) |
| JP (2) | JP7023708B2 (enExample) |
| AU (1) | AU2015344769B2 (enExample) |
| CA (1) | CA2967222C (enExample) |
| WO (1) | WO2016075612A1 (enExample) |
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| EP2917230B1 (en) * | 2012-11-12 | 2018-07-18 | Ruprecht-Karls-Universität Heidelberg | Development of hbv- and/or hdv-susceptible cells, cell lines and non-human animals |
| EP3143134B1 (en) | 2014-05-15 | 2020-10-28 | National University of Singapore | Modified natural killer cells and uses thereof |
| CN109219445B (zh) | 2016-04-01 | 2022-08-26 | 上海煦顼技术有限公司 | 嵌合抗原受体修饰细胞治疗癌症的应用 |
| US10654934B2 (en) | 2016-04-01 | 2020-05-19 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| AU2017271606B2 (en) * | 2016-05-27 | 2024-08-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | FLT3-specific chimeric antigen receptors and methods using same |
| KR20190052697A (ko) * | 2016-09-28 | 2019-05-16 | 가비쉬-가릴리 바이오 어플리케이션스 리미티드. | 암의 신규한 항원 지표를 표적화하는 ｃａｒ 요법을 위한 보편적 플랫폼 |
| WO2018064921A1 (en) * | 2016-10-06 | 2018-04-12 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| WO2018104473A1 (en) * | 2016-12-07 | 2018-06-14 | Oslo Universitetssykehus Hf | Compositions and methods for cell therapy |
| EP3601537A4 (en) | 2017-03-27 | 2021-01-13 | National University of Singapore | STIMULATING CELL LINES FOR EX VIVO EXPANSION AND ACTIVATION OF NATURAL KILLER CELLS |
| SG11201908492PA (en) | 2017-03-27 | 2019-10-30 | Nat Univ Singapore | Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy |
| MY201327A (en) | 2017-06-02 | 2024-02-16 | Pfizer | Chimeric antigen receptors targeting flt3 |
| PL3688155T3 (pl) | 2017-09-28 | 2023-09-11 | Immpact-Bio Ltd. | Uniwersalna platforma do wytwarzania hamującego chimerycznego receptora antygenowego (icar) |
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| IL318172A (en) * | 2017-12-29 | 2025-03-01 | Memorial Sloan Kettering Cancer Center | Enhanced chimeric antigen receptors and uses thereof |
| CN111801348A (zh) | 2018-02-09 | 2020-10-20 | 新加坡国立大学 | 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| KR20200138741A (ko) | 2018-04-02 | 2020-12-10 | 내셔널 유니버시티 오브 싱가포르 | 면역 세포에서 발현되는 막-결합 항-사이토카인 비-신호전달 결합제를 이용한 인간 사이토카인의 중화 |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| EP3856236B1 (en) * | 2018-09-28 | 2023-05-17 | ImmPACT-Bio Ltd. | Methods for identifying activating antigen receptor (acar)/inhibitory chimeric antigen receptor (icar) pairs for use in cancer therapies |
| EP3632461A1 (en) | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
| EP3860643A1 (en) | 2018-10-05 | 2021-08-11 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
| MX2022001711A (es) * | 2019-08-09 | 2022-05-10 | A2 Biotherapeutics Inc | Receptores en la superficie celular que responden a la perdida de heterocigosidad. |
| CN114585371A (zh) * | 2019-08-20 | 2022-06-03 | 森迪生物科学公司 | 嵌合抑制性受体 |
| CA3151472A1 (en) * | 2019-10-08 | 2021-04-15 | Brad Nelson | Chimeric cytokine receptors |
| US20220389075A1 (en) | 2019-11-12 | 2022-12-08 | A2 Biotherapeutics, Inc. | Engineered t cell receptors and uses thereof |
| BR112022011399A2 (pt) | 2019-12-11 | 2022-08-30 | A2 Biotherapeutics Inc | Receptor de antígeno quimérico baseado em lilrb1 |
| EP4107175A4 (en) * | 2020-02-20 | 2024-03-20 | Senti Biosciences, Inc. | ARCHITECTURES OF INHIBITORY CHIMERIC RECEPTORS |
| EP4107174A4 (en) * | 2020-02-20 | 2024-10-30 | Senti Biosciences, Inc. | ARCHITECTURES OF INHIBITORY CHIMERIC RECEPTORS |
| GB202004832D0 (en) * | 2020-04-01 | 2020-05-13 | Instituto De Medicina Molecular Faculdade De Medicina Univ De Lisboa | Therapeutic agaents, pharmaceutical compositions, and associated biomarkers |
| AU2021329375A1 (en) | 2020-08-20 | 2023-04-20 | A2 Biotherapeutics, Inc. | Compositions and methods for treating ceacam positive cancers |
| MX2023002104A (es) | 2020-08-20 | 2023-07-10 | A2 Biotherapeutics Inc | Composiciones y métodos para tratar cánceres positivos para egfr. |
| KR20250140123A (ko) | 2020-08-20 | 2025-09-24 | 에이투 바이오쎄라퓨틱스, 인크. | 메소텔린 양성 암을 치료하기 위한 조성물 및 방법 |
| WO2022061272A1 (en) * | 2020-09-21 | 2022-03-24 | A2 Biotherapeutics, Inc. | Engineered immune cells |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| US20240336698A1 (en) * | 2021-03-22 | 2024-10-10 | Memorial Sloan Kettering Cancer Center | CD38 Chimeric Co-Stimulating Receptor and Uses Thereof |
| WO2022204326A1 (en) * | 2021-03-24 | 2022-09-29 | The Regents Of The University Of California | Humanized synthetic notch receptors with augmented transactivation domains and uses thereof |
| US20240261332A1 (en) * | 2021-05-26 | 2024-08-08 | Board Of Regents, The University Of Texas System | Inhibitory chimeric antigen receptor prevents on-target off-tumor effects of adoptive cell therapy |
| CN115028682B (zh) * | 2022-06-30 | 2025-06-06 | 合肥工业大学 | 一种来源于干腌火腿的增咸肽及制备方法 |
| TW202442689A (zh) | 2023-03-03 | 2024-11-01 | 美商亞森諾生物科學公司 | 靶向ｐｓｍａ及ｃａ９之系統 |
| CN119506295B (zh) * | 2025-01-21 | 2025-05-30 | 上海皓鸿生物医药科技有限公司 | 一种前列腺特异性膜抗原的制备方法 |
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| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| CN105246504A (zh) * | 2013-03-15 | 2016-01-13 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| DK2981607T3 (da) | 2013-04-03 | 2020-11-16 | Memorial Sloan Kettering Cancer Center | Effektiv generering af tumormålrettede t-celler afledt af pluripotente stamceller |
| WO2016014565A2 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| CA2969384A1 (en) | 2014-12-17 | 2016-06-23 | Cellectis | Inhibitory chimeric antigen receptor (icar or n-car) expressing non-t cell transduction domain |
| KR102624023B1 (ko) * | 2015-02-24 | 2024-01-11 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 결합-촉발된 전사 스위치 및 이들의 이용 방법 |
| WO2017025323A1 (en) * | 2015-08-11 | 2017-02-16 | Cellectis | Cells for immunotherapy engineered for targeting cd38 antigen and for cd38 gene inactivation |
| KR20190052697A (ko) * | 2016-09-28 | 2019-05-16 | 가비쉬-가릴리 바이오 어플리케이션스 리미티드. | 암의 신규한 항원 지표를 표적화하는 ｃａｒ 요법을 위한 보편적 플랫폼 |
| US12049482B2 (en) * | 2017-10-31 | 2024-07-30 | The Brigham And Women's Hospital, Inc. | Molecular switch-mediated control of engineered cells |
| US20230078007A1 (en) * | 2020-02-24 | 2023-03-16 | The Regents Of The University Of California | In-series synthetic receptor and-gate circuits for expression of a therapeutic payload by engineered cells |
-
2015
- 2015-11-09 WO PCT/IB2015/058650 patent/WO2016075612A1/en not_active Ceased
- 2015-11-09 JP JP2017525517A patent/JP7023708B2/ja active Active
- 2015-11-09 CA CA2967222A patent/CA2967222C/en active Active
- 2015-11-09 US US15/525,906 patent/US11072644B2/en active Active
- 2015-11-09 AU AU2015344769A patent/AU2015344769B2/en active Active
- 2015-11-09 EP EP15798238.0A patent/EP3218394A1/en not_active Ceased
-
2021
- 2021-07-26 US US17/385,805 patent/US20220033462A1/en not_active Abandoned
- 2021-11-19 JP JP2021188305A patent/JP2022036976A/ja active Pending
-
2024
- 2024-03-15 US US18/607,387 patent/US20240360196A1/en active Pending
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