JP2013519379A5 - - Google Patents
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- Publication number
- JP2013519379A5 JP2013519379A5 JP2012553038A JP2012553038A JP2013519379A5 JP 2013519379 A5 JP2013519379 A5 JP 2013519379A5 JP 2012553038 A JP2012553038 A JP 2012553038A JP 2012553038 A JP2012553038 A JP 2012553038A JP 2013519379 A5 JP2013519379 A5 JP 2013519379A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cell
- seq
- immunoglobulin
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 162
- 210000004027 cell Anatomy 0.000 claims description 159
- 229920001184 polypeptide Polymers 0.000 claims description 153
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 153
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 153
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 54
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 54
- 102000040430 polynucleotide Human genes 0.000 claims description 49
- 108091033319 polynucleotide Proteins 0.000 claims description 49
- 239000002157 polynucleotide Substances 0.000 claims description 49
- 238000001514 detection method Methods 0.000 claims description 44
- 108060003951 Immunoglobulin Proteins 0.000 claims description 28
- 210000000628 antibody-producing cell Anatomy 0.000 claims description 28
- 102000018358 immunoglobulin Human genes 0.000 claims description 28
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 26
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 26
- 241001465754 Metazoa Species 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 210000004408 hybridoma Anatomy 0.000 claims description 14
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims description 8
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims description 8
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 4
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 4
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 4
- 101100347633 Drosophila melanogaster Mhc gene Proteins 0.000 claims description 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 4
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims description 4
- 101000599858 Homo sapiens Intercellular adhesion molecule 2 Proteins 0.000 claims description 4
- 101000599868 Homo sapiens Intercellular adhesion molecule 4 Proteins 0.000 claims description 4
- 101000960337 Homo sapiens Intercellular adhesion molecule 5 Proteins 0.000 claims description 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 4
- 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 claims description 4
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims description 4
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims description 4
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims description 4
- 102100037874 Intercellular adhesion molecule 4 Human genes 0.000 claims description 4
- 102100039919 Intercellular adhesion molecule 5 Human genes 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 238000000684 flow cytometry Methods 0.000 claims description 4
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 4
- 210000004180 plasmocyte Anatomy 0.000 claims description 4
- -1 zeta chain Proteins 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 description 5
- 238000006471 dimerization reaction Methods 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 239000013598 vector Substances 0.000 description 5
- 210000005260 human cell Anatomy 0.000 description 4
- 238000002955 isolation Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 2
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30425110P | 2010-02-12 | 2010-02-12 | |
| US61/304,251 | 2010-02-12 | ||
| US201161437889P | 2011-01-31 | 2011-01-31 | |
| US61/437,889 | 2011-01-31 | ||
| PCT/US2011/024554 WO2011100566A2 (en) | 2010-02-12 | 2011-02-11 | Methods for identifying and isolating cells expressing a polypeptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016139165A Division JP2017014220A (ja) | 2010-02-12 | 2016-07-14 | ポリペプチド発現細胞の同定及び単離の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519379A JP2013519379A (ja) | 2013-05-30 |
| JP2013519379A5 true JP2013519379A5 (enExample) | 2014-04-03 |
| JP6034696B2 JP6034696B2 (ja) | 2016-11-30 |
Family
ID=44368462
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553038A Expired - Fee Related JP6034696B2 (ja) | 2010-02-12 | 2011-02-11 | ポリペプチド発現細胞の同定及び単離の方法 |
| JP2016139165A Withdrawn JP2017014220A (ja) | 2010-02-12 | 2016-07-14 | ポリペプチド発現細胞の同定及び単離の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016139165A Withdrawn JP2017014220A (ja) | 2010-02-12 | 2016-07-14 | ポリペプチド発現細胞の同定及び単離の方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US8551715B2 (enExample) |
| EP (1) | EP2534257B1 (enExample) |
| JP (2) | JP6034696B2 (enExample) |
| KR (1) | KR20120117931A (enExample) |
| CN (1) | CN102844442B (enExample) |
| AU (1) | AU2011215685B2 (enExample) |
| CA (1) | CA2789446A1 (enExample) |
| IL (1) | IL221349A0 (enExample) |
| MX (1) | MX2012009175A (enExample) |
| NZ (1) | NZ601743A (enExample) |
| SG (2) | SG10201503736XA (enExample) |
| WO (1) | WO2011100566A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2032166T3 (pl) | 2006-06-13 | 2013-09-30 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworów |
| US7750124B2 (en) | 2006-09-29 | 2010-07-06 | Oncomed Pharmaceuticals, Inc. | Anti-human DLL4 antibodies and compositions |
| JP5618544B2 (ja) | 2007-01-24 | 2014-11-05 | オンコメッドファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| US8859229B2 (en) * | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
| CN102316897B (zh) | 2008-07-08 | 2014-11-05 | 昂考梅德药品有限公司 | Notch结合剂和拮抗剂及其应用方法 |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| US8551715B2 (en) | 2010-02-12 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| US9365846B2 (en) | 2010-12-01 | 2016-06-14 | Merck Sharp & Dohme Corp. | Surface, anchored Fc-bait antibody display system |
| US10106598B2 (en) | 2010-12-01 | 2018-10-23 | Merck Sharp & Dohme Corp. | Surface, anchored Fc-bait antibody display system |
| CN106167526A (zh) | 2011-07-15 | 2016-11-30 | 昂考梅德药品有限公司 | Rspo结合剂和其应用 |
| HRP20190044T1 (hr) * | 2011-09-23 | 2019-02-22 | Oncomed Pharmaceuticals, Inc. | Agensi koji vežu vegf/dll4 i njihove uporabe |
| WO2013184912A2 (en) | 2012-06-06 | 2013-12-12 | Oncomed Pharmaceuticals, Inc. | Binding agents that modulate the hippo pathway and uses thereof |
| CA2878868A1 (en) | 2012-07-13 | 2014-01-16 | Austin L. Gurney | Rspo3 binding agents and uses thereof |
| PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
| WO2014062659A2 (en) * | 2012-10-15 | 2014-04-24 | Oncomed Pharmaceuticals, Inc. | Methods of treating ocular diseases |
| US8921055B2 (en) * | 2012-10-30 | 2014-12-30 | Berkeley Lights, Inc. | Detecting cells secreting a protein of interest |
| AU2013337811A1 (en) | 2012-10-31 | 2015-05-14 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| AU2014249148B2 (en) * | 2013-03-11 | 2020-04-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
| GB201407852D0 (en) | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
| MX382902B (es) | 2014-10-31 | 2025-03-13 | Oncomed Pharm Inc | Inhibidor de la vía noth en combinación con un agente inmunoterapéutico para usarse en el tratamiento de cáncer. |
| AU2015343048A1 (en) * | 2014-11-06 | 2017-05-18 | Children's Research Institute, Children's National Medical Center | Immunotherapeutics for cancer and autoimmune diseases |
| KR102558502B1 (ko) | 2014-12-05 | 2023-07-20 | 시티 오브 호프 | Ｃｓ1 표적화된 키메라 항원 수용체-변형된 ｔ 세포 |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| WO2017053705A1 (en) | 2015-09-23 | 2017-03-30 | Oncomed Pharmaceuticals, Inc. | Methods and compositions for treatment of cancer |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| CA3029003A1 (en) | 2016-06-27 | 2018-01-04 | The Regents Of The University Of California | Cancer treatment combinations |
| US11230596B2 (en) | 2016-11-30 | 2022-01-25 | Mereo Biopharma 5, Inc. | Methods for treatment of cancer comprising TIGIT-binding agents |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| CA3056249A1 (en) | 2017-03-24 | 2018-09-27 | Lankenau Institute For Medical Research | Methods and compositions for inducible extracellular membrane capture of monoclonal immunoglobulins secreted by hybridomas |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院（Dba西雅图儿童研究所） | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| WO2020037181A2 (en) * | 2018-08-16 | 2020-02-20 | Memorial Sloan-Kettering Cancer Center | Cell sorting systems and methods of use |
| TW202033218A (zh) * | 2018-12-07 | 2020-09-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 多特異性蛋白分子 |
| CN109738506B (zh) * | 2019-01-10 | 2021-02-26 | 青岛大学附属医院 | 一种成熟脂肪细胞中自噬相关蛋白乙酰化位点研究方法 |
| US20220177912A1 (en) * | 2019-04-12 | 2022-06-09 | The Methodist Hospital | Therapeutic particles that enable antigen presenting cells to attack cancer cells |
| CN118525099A (zh) | 2021-08-25 | 2024-08-20 | 艾恩塔斯有限公司 | 真核细胞中表达的蛋白质变体文库的制备 |
| JP2025521114A (ja) * | 2022-05-16 | 2025-07-08 | シティ・オブ・ホープ | 抗ｃｄ８４抗体及びその使用 |
| WO2024163796A2 (en) * | 2023-02-01 | 2024-08-08 | Allen Institute | Intein-mediated reconstitution of voltage-gated sodium channel function |
| WO2024251820A1 (en) | 2023-06-06 | 2024-12-12 | Iontas Limited | Preparation of libraries of bispecific binders expressed in eukaryotic cells |
| WO2025151797A1 (en) * | 2024-01-12 | 2025-07-17 | Sonoma Biotherapeutics, Inc. | Chimeric antigen receptors with atypical transmembrane and/or hinge domains |
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-
2011
- 2011-02-11 US US13/025,733 patent/US8551715B2/en not_active Expired - Fee Related
- 2011-02-11 CA CA2789446A patent/CA2789446A1/en not_active Abandoned
- 2011-02-11 JP JP2012553038A patent/JP6034696B2/ja not_active Expired - Fee Related
- 2011-02-11 EP EP11742877.1A patent/EP2534257B1/en active Active
- 2011-02-11 KR KR1020127023732A patent/KR20120117931A/ko not_active Ceased
- 2011-02-11 NZ NZ601743A patent/NZ601743A/en not_active IP Right Cessation
- 2011-02-11 SG SG10201503736XA patent/SG10201503736XA/en unknown
- 2011-02-11 WO PCT/US2011/024554 patent/WO2011100566A2/en not_active Ceased
- 2011-02-11 CN CN201180009377.8A patent/CN102844442B/zh not_active Expired - Fee Related
- 2011-02-11 SG SG2012058194A patent/SG183196A1/en unknown
- 2011-02-11 MX MX2012009175A patent/MX2012009175A/es active IP Right Grant
- 2011-02-11 AU AU2011215685A patent/AU2011215685B2/en not_active Ceased
-
2012
- 2012-08-08 IL IL221349A patent/IL221349A0/en unknown
-
2013
- 2013-09-06 US US14/020,030 patent/US8945878B2/en not_active Expired - Fee Related
- 2013-09-06 US US14/020,012 patent/US9023621B2/en active Active
-
2015
- 2015-04-03 US US14/678,592 patent/US9422546B2/en not_active Expired - Fee Related
-
2016
- 2016-07-14 US US15/210,250 patent/US9873726B2/en not_active Expired - Fee Related
- 2016-07-14 JP JP2016139165A patent/JP2017014220A/ja not_active Withdrawn
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