JP2022022550A - アピキサバンの新規製造方法 - Google Patents

アピキサバンの新規製造方法 Download PDF

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Publication number
JP2022022550A
JP2022022550A JP2020110365A JP2020110365A JP2022022550A JP 2022022550 A JP2022022550 A JP 2022022550A JP 2020110365 A JP2020110365 A JP 2020110365A JP 2020110365 A JP2020110365 A JP 2020110365A JP 2022022550 A JP2022022550 A JP 2022022550A
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JP
Japan
Prior art keywords
apixaban
reaction
compound
formamide
production method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020110365A
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English (en)
Japanese (ja)
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JP2022022550A5 (enExample
Inventor
瑶平 堀
Yohei Hori
悠 忠田
Yu Chuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daito KK
Original Assignee
Daito KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daito KK filed Critical Daito KK
Priority to JP2020110365A priority Critical patent/JP2022022550A/ja
Priority to PCT/JP2021/020478 priority patent/WO2021261172A1/ja
Priority to CN202180059664.3A priority patent/CN116137814A/zh
Publication of JP2022022550A publication Critical patent/JP2022022550A/ja
Publication of JP2022022550A5 publication Critical patent/JP2022022550A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020110365A 2020-06-26 2020-06-26 アピキサバンの新規製造方法 Pending JP2022022550A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2020110365A JP2022022550A (ja) 2020-06-26 2020-06-26 アピキサバンの新規製造方法
PCT/JP2021/020478 WO2021261172A1 (ja) 2020-06-26 2021-05-28 アピキサバンの新規製造方法
CN202180059664.3A CN116137814A (zh) 2020-06-26 2021-05-28 阿哌沙班的新型制造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2020110365A JP2022022550A (ja) 2020-06-26 2020-06-26 アピキサバンの新規製造方法

Publications (2)

Publication Number Publication Date
JP2022022550A true JP2022022550A (ja) 2022-02-07
JP2022022550A5 JP2022022550A5 (enExample) 2022-11-29

Family

ID=79282492

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020110365A Pending JP2022022550A (ja) 2020-06-26 2020-06-26 アピキサバンの新規製造方法

Country Status (3)

Country Link
JP (1) JP2022022550A (enExample)
CN (1) CN116137814A (enExample)
WO (1) WO2021261172A1 (enExample)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007001385A2 (en) * 2004-09-28 2007-01-04 Bristol-Myers Squibb Company Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
CN104045637A (zh) * 2014-04-18 2014-09-17 河北科技大学 一种阿哌沙班的制备方法
JP2017521437A (ja) * 2014-07-11 2017-08-03 ラボラトリオス、レスビ、ソシエダッド、リミターダＬａｂｏｒａｔｏｒｉｏｓ Ｌｅｓｖｉ，Ｓ．Ｌ． アピキサバンの製造方法
CN110862389A (zh) * 2018-08-28 2020-03-06 江苏康缘药业股份有限公司 一种阿哌沙班晶型的制备方法
WO2020120485A1 (en) * 2018-12-11 2020-06-18 Krka, D.D., Novo Mesto Process for preparing apixaban

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200303201A (en) * 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
CN104892601B (zh) * 2015-06-09 2017-09-19 江苏中邦制药有限公司 一种抗血栓药物阿哌沙班的制备方法
CN110615788B (zh) * 2019-10-17 2021-07-06 江西国药有限责任公司 一种高纯度阿哌沙班的制备工艺

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007001385A2 (en) * 2004-09-28 2007-01-04 Bristol-Myers Squibb Company Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
CN104045637A (zh) * 2014-04-18 2014-09-17 河北科技大学 一种阿哌沙班的制备方法
JP2017521437A (ja) * 2014-07-11 2017-08-03 ラボラトリオス、レスビ、ソシエダッド、リミターダＬａｂｏｒａｔｏｒｉｏｓ Ｌｅｓｖｉ，Ｓ．Ｌ． アピキサバンの製造方法
CN110862389A (zh) * 2018-08-28 2020-03-06 江苏康缘药业股份有限公司 一种阿哌沙班晶型的制备方法
WO2020120485A1 (en) * 2018-12-11 2020-06-18 Krka, D.D., Novo Mesto Process for preparing apixaban

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WANG, Y. ET AL.: "Design, synthesis, and structure-activity relationship of novel and effective apixaban derivatives a", BIOORG. MED. CHEM., vol. 24, JPN6021024814, 2016, pages 5646 - 5661, ISSN: 0005169685 *

Also Published As

Publication number Publication date
WO2021261172A1 (ja) 2021-12-30
CN116137814A (zh) 2023-05-19

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