JP2021535227A5 - - Google Patents
Info
- Publication number
- JP2021535227A5 JP2021535227A5 JP2021536681A JP2021536681A JP2021535227A5 JP 2021535227 A5 JP2021535227 A5 JP 2021535227A5 JP 2021536681 A JP2021536681 A JP 2021536681A JP 2021536681 A JP2021536681 A JP 2021536681A JP 2021535227 A5 JP2021535227 A5 JP 2021535227A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- sort
- pharmaceutical composition
- composition according
- cationic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023189771A JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726741P | 2018-09-04 | 2018-09-04 | |
| US62/726,741 | 2018-09-04 | ||
| PCT/US2019/049565 WO2020051223A1 (en) | 2018-09-04 | 2019-09-04 | Compositions and methods for organ specific delivery of nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189771A Division JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535227A JP2021535227A (ja) | 2021-12-16 |
| JP2021535227A5 true JP2021535227A5 (enExample) | 2022-09-13 |
| JP7425066B2 JP7425066B2 (ja) | 2024-01-30 |
Family
ID=69722750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536681A Active JP7425066B2 (ja) | 2018-09-04 | 2019-09-04 | 核酸を臓器特異的送達するための組成物および方法 |
| JP2023189771A Active JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189771A Active JP7815196B2 (ja) | 2018-09-04 | 2023-11-07 | 核酸を臓器特異的送達するための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (9) | US11229609B2 (enExample) |
| EP (1) | EP3846822A4 (enExample) |
| JP (2) | JP7425066B2 (enExample) |
| CN (2) | CN112996519B (enExample) |
| AU (2) | AU2019336679B2 (enExample) |
| CA (1) | CA3111484A1 (enExample) |
| GB (3) | GB2592505B (enExample) |
| WO (1) | WO2020051223A1 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| CN117018228A (zh) | 2016-05-27 | 2023-11-10 | 创思瑞普泰克斯公司 | 用合成信使rna治疗原发性纤毛运动障碍 |
| JP2020500150A (ja) | 2016-09-23 | 2020-01-09 | デューク ユニバーシティ | 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド |
| WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
| LT3675826T (lt) * | 2017-08-31 | 2023-09-11 | Life Technologies Corporation | Katijoninės lipidų kompozicijos audiniams-specifiniam įterpimui |
| WO2019147954A1 (en) | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| EP3788343B1 (en) | 2018-04-30 | 2024-03-27 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| WO2020051223A1 (en) | 2018-09-04 | 2020-03-12 | The Board Of Regents Of The University Of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| EP3846857A4 (en) | 2018-09-04 | 2022-10-12 | The Board Of Regents Of The University Of Texas System | COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS |
| US12594347B2 (en) | 2018-09-07 | 2026-04-07 | Duke University | Nanoparticulate drug delivery systems |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| KR20220044816A (ko) * | 2019-08-12 | 2022-04-11 | 인티그레이티드 나노테라퓨틱스 아이엔씨. | 하전 물질 전달을 위한 지질, 이의 제형 및 그 제조 방법 |
| US20240293317A1 (en) * | 2020-04-20 | 2024-09-05 | Board Of Regents, The University Of Texas System | Lipid nanoparticle (lnp) delivery systems and uses thereof |
| EP4153560A4 (en) * | 2020-05-19 | 2024-04-24 | Ramot at Tel-Aviv University Ltd. | LIPID PARTICLES FOR NUCLEIC ACID DELIVERY AND CLINICAL APPLICATIONS THEREOF |
| EP4228658A4 (en) * | 2020-10-14 | 2025-02-19 | George Mason Research Foundation, Inc. | IONIZABLE LIPIDS AND METHODS FOR THE PRODUCTION AND USE THEREOF |
| JP2024500879A (ja) * | 2020-12-22 | 2024-01-10 | コーネル ユニヴァーシティー | 双性イオン性脂質ナノ粒子組成物およびその使用方法 |
| WO2022204215A1 (en) * | 2021-03-22 | 2022-09-29 | Recode Therapeutics, Inc. | Polynucleotide compositions, related formulations, and methods of use thereof |
| WO2022204043A1 (en) * | 2021-03-22 | 2022-09-29 | The Board Of Regents Of The University Of Texas System | Compositions and methods for targeted delivery to cells |
| JP2024511463A (ja) * | 2021-03-22 | 2024-03-13 | リコード セラピューティクス,インク. | 細胞への標的送達のための組成物および方法 |
| IL305998A (en) * | 2021-03-23 | 2023-11-01 | Recode Therapeutics Inc | Formulations and methods for targeted systemic delivery to cells |
| CA3213107A1 (en) * | 2021-03-23 | 2022-09-29 | Mirko HENNIG | Polynucleotide compositions, related formulations, and methods of use thereof |
| US20240207442A1 (en) * | 2021-04-22 | 2024-06-27 | The Board Of Regents Of The University Of Texas System | All-in-one dendrimer-based lipid nanoparticles enable precise hdr-mediated gene editing in vivo |
| KR20240027630A (ko) * | 2021-06-01 | 2024-03-04 | 나노베이션 테라퓨틱스 인크. | 지질 나노입자를 사용한 dna 벡터 전달 |
| CN118201605A (zh) * | 2021-10-25 | 2024-06-14 | 杜克大学 | 基于poegma的脂质纳米粒子 |
| IL313876A (en) * | 2021-12-27 | 2024-08-01 | Univ Texas | Compositions and methods for targeted delivery to cells |
| WO2023158738A2 (en) * | 2022-02-16 | 2023-08-24 | Trustees Of Tufts College | Lipid nanoparticles for delivery to the eye or ear |
| WO2023165583A1 (zh) * | 2022-03-04 | 2023-09-07 | 益杰立科(上海)生物科技有限公司 | 靶向眼部细胞的递送系统和方法 |
| WO2023178425A1 (en) | 2022-03-23 | 2023-09-28 | Nanovation Therapeutics Inc. | High sterol-containing lipid nanoparticles |
| CA3246723A1 (en) * | 2022-03-30 | 2023-10-05 | The Johns Hopkins University | Lipid nanoparticle compositions for the delivery of plasma DNA to the liver and their preparation methods |
| WO2023184038A1 (en) * | 2022-04-01 | 2023-10-05 | Nanovation Therapeutics Inc. | Mrna delivery method and composition thereof |
| WO2023218420A1 (en) | 2022-05-13 | 2023-11-16 | Janssen Pharmaceuticals, Inc. | Mrna compositions for inducing latent hiv-1 reversal |
| CN114887071B (zh) * | 2022-06-06 | 2023-09-22 | 郑州大学第一附属医院 | 一种靶向脾脏的纳米递送载体 |
| CN114887070B (zh) * | 2022-06-06 | 2023-09-22 | 郑州大学第一附属医院 | 一种脾脏靶向的纳米药物 |
| CN114891808B (zh) * | 2022-06-21 | 2023-10-27 | 珠海丽凡达生物技术有限公司 | 编码ALDH2多肽的mRNA分子、应用及mRNA药物 |
| EP4547230A1 (en) * | 2022-06-29 | 2025-05-07 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids |
| US20250312287A1 (en) | 2022-07-08 | 2025-10-09 | Polyplus Transfection | Lipid nanoparticles comprising an imidazolium-based cationic lipid |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| US20250360083A1 (en) * | 2022-09-21 | 2025-11-27 | Board Of Regents Of The University Of Nebraska | Lipid nanoparticle formulations and methods of use thereof |
| CN116236565B (zh) * | 2022-11-21 | 2025-06-27 | 成都诺恩生物科技有限公司 | 适合于肌注给药的核酸-脂质纳米颗粒、制剂及其应用 |
| JP2025538636A (ja) * | 2022-11-24 | 2025-11-28 | ザミディアム セラピューティクス カンパニー リミテッド | 核酸送達のための新規脂質及び脂質ナノ粒子組成物 |
| EP4630057A1 (en) | 2022-12-08 | 2025-10-15 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| CN116270534B (zh) * | 2022-12-13 | 2024-11-26 | 山东大学 | 一种组织选择性递送核酸药物的类脂质纳米颗粒及其制备方法和应用 |
| EP4385523A1 (en) * | 2022-12-14 | 2024-06-19 | Beijing Jitai Pharmaceutical Technology Co., Ltd. | Lipid-based topical injection formulations |
| CN116211831A (zh) * | 2022-12-14 | 2023-06-06 | 北京剂泰医药科技有限公司 | 脂质基质局部注射制剂 |
| CN121263401A (zh) | 2022-12-22 | 2026-01-02 | 内诺维什疗法股份有限公司 | 用于递送核酸和其他治疗剂的含硫的可电离脂质 |
| CN116199646B (zh) * | 2023-03-07 | 2024-01-26 | 山东大学 | 一种基于Tris的可电离脂质及其制备方法与应用 |
| CN116271105B (zh) * | 2023-05-18 | 2023-08-25 | 上海贝斯昂科生物科技有限公司 | 一种适于rpe细胞转染的脂质纳米颗粒及其应用 |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025029927A1 (en) * | 2023-07-31 | 2025-02-06 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle |
| CN121752254A (zh) | 2023-08-11 | 2026-03-27 | 浙江海昶生物医药股份有限公司 | 一种具有靶向性的脂质组合物及其制备方法 |
| WO2025073054A1 (en) | 2023-10-05 | 2025-04-10 | Nanovation Therapeutics Inc. | Method of delivery of dna or rna cargo using unshielded lipid nanoparticles |
| WO2025073056A1 (en) * | 2023-10-05 | 2025-04-10 | Nanovation Therapeutics Inc. | Haematopoietic stem and/or progenitor cell delivery method and compositions for use thereof |
| WO2025081189A1 (en) * | 2023-10-12 | 2025-04-17 | Georgia Tech Research Corporation | Methods and compositions for lipid nanoparticle (lnp) mediated delivery of mrna encoded synthetic antigens for universal tumor targeting by car t cells |
| WO2025088597A1 (en) * | 2023-10-26 | 2025-05-01 | New Phase Ltd. | Nanoparticle combination therapy for tumors |
| WO2025108545A1 (en) * | 2023-11-22 | 2025-05-30 | Danmarks Tekniske Universitet | Delivery of nucleotides from injectable biomaterial |
| US12553042B2 (en) * | 2023-12-01 | 2026-02-17 | Recode Therapeutics, Inc. | Method for quantifying an amount of capped messenger RNA |
| US12364773B2 (en) * | 2023-12-01 | 2025-07-22 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| WO2025133684A1 (en) * | 2023-12-21 | 2025-06-26 | Vilnius University | Liposomal nanoparticles for crispr/cas9 delivery |
| CN120398741A (zh) * | 2024-01-29 | 2025-08-01 | 江苏中天药业有限公司 | 一种用于递送核酸物质的脂肪酸衍生物及其合成方法 |
| CN118001254B (zh) | 2024-04-09 | 2024-07-26 | 北京悦康科创医药科技股份有限公司 | 靶向抗原呈递细胞的脂质组合物及其应用 |
| WO2025213271A1 (en) * | 2024-04-11 | 2025-10-16 | Nanovation Therapeutics Inc. | Method of delivering nucleic acid to macrophages and/or monocytes and compositions for use thereof |
| WO2025226642A1 (en) * | 2024-04-25 | 2025-10-30 | Eli Lilly And Company | Lipid nano delivery particles for targeted transport of nucleic acids and methods of making and using the same |
| WO2025228975A1 (en) * | 2024-04-29 | 2025-11-06 | BioNTech SE | Particles, compositions and methods |
| WO2025228979A1 (en) | 2024-04-30 | 2025-11-06 | Neovac Ltd. | Lipids nanoparticle formulations suitable for lung targeting |
| WO2026025110A1 (en) * | 2024-07-26 | 2026-01-29 | Trevi Therapeutics, Inc. | Treatment of refractory chronic cough |
| CN118750468B (zh) * | 2024-09-05 | 2025-02-18 | 北京悦康科创医药科技股份有限公司 | 一种核酸-脂质纳米颗粒冻干组合物及其制备方法和应用 |
| KR20260043575A (ko) * | 2024-09-24 | 2026-03-31 | 주식회사 녹십자 | 선택적 장기 표적 지질을 포함하는 조성물 |
| CN121610533B (zh) * | 2026-02-03 | 2026-04-17 | 中国海洋大学三亚海洋研究院 | 用于鱼类在体皮肤基因编辑的脂质纳米颗粒及其应用 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US7053150B2 (en) | 2000-12-18 | 2006-05-30 | Nektar Therapeutics Al, Corporation | Segmented polymers and their conjugates |
| US7314956B2 (en) | 2001-08-08 | 2008-01-01 | Vaxim, Inc. | Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell |
| US8871709B2 (en) * | 2003-02-05 | 2014-10-28 | Queensland University of Technolgy | Synthetic chimeric proteins comprising epidermal growth factor and vitronectin |
| US7985424B2 (en) | 2004-04-20 | 2011-07-26 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
| MXPA06012722A (es) | 2004-05-05 | 2007-02-14 | Atugen Ag | Lipidos, complejos de lipido y su uso. |
| CA2569664C (en) | 2004-06-07 | 2013-07-16 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| WO2006138380A2 (en) | 2005-06-15 | 2006-12-28 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| US20090221684A1 (en) | 2005-12-22 | 2009-09-03 | Trustees Of Boston University | Molecules for Gene Delivery and Gene Therapy, and Methods of Use Thereof |
| EP2046266A4 (en) | 2006-07-21 | 2009-11-04 | Massachusetts Inst Technology | ENDMODICIFIED POLY (BETA AMINO ESTER) AND ITS USE |
| CA2710983A1 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
| WO2009111088A2 (en) | 2008-01-02 | 2009-09-11 | The Johns Hopkins University | Antitumor immunization by liposomal delivery of vaccine to the spleen |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| EP3269395A1 (en) | 2008-11-07 | 2018-01-17 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US8163861B2 (en) | 2009-01-15 | 2012-04-24 | Living Proof, Inc. | Beta-amino ester compounds and uses thereof |
| CA3045126A1 (en) | 2009-05-05 | 2010-11-11 | Arbutus Biopharma Corporation | Methods of delivering oligonucleotides to immune cells |
| BRPI1010175A2 (pt) | 2009-06-02 | 2016-03-29 | Keller Brian Charles | "composição química que inclui um conjugado de lipídio-peg e lipossoma" |
| CN101591428B (zh) | 2009-06-29 | 2011-05-25 | 浙江大学 | 一种聚酯树枝状大分子的制备方法 |
| EP3318248B1 (en) | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| ES2557382T3 (es) | 2010-07-06 | 2016-01-25 | Glaxosmithkline Biologicals Sa | Liposomas con lípidos que tienen un valor de pKa ventajoso para el suministro de ARN |
| EP2618817B1 (en) * | 2010-07-31 | 2018-06-13 | The Scripps Research Institute | Liposome targeting compounds and related uses |
| WO2012090223A1 (en) | 2010-12-29 | 2012-07-05 | Indian Institute Of Science | Poly(ether imine) dendrimers and uses thereof |
| RU2013154295A (ru) | 2011-06-08 | 2015-07-20 | Шир Хьюман Дженетик Терапис, Инк. | КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК |
| EP2718261B1 (en) | 2011-06-08 | 2016-02-24 | Nitto Denko Corporation | Compounds for targeting drug delivery and enhancing sirna activity |
| CN107266391B (zh) | 2011-10-18 | 2020-04-17 | 迪克纳制药公司 | 胺阳离子脂质及其用途 |
| BR112014024131A2 (pt) | 2012-03-29 | 2017-07-25 | Shire Human Genetic Therapies | lipídios catiônicos ionizáveis |
| CN104411338A (zh) * | 2012-04-02 | 2015-03-11 | 现代治疗公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| US20160289674A1 (en) * | 2012-04-02 | 2016-10-06 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of membrane proteins |
| EP2852380A4 (en) | 2012-05-23 | 2016-01-20 | Univ Ohio State | LIPID-COATED ALBUMIN NANOPARTICLE COMPOSITIONS AND METHOD FOR THE PREPARATION AND METHOD OF USE THEREOF |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| JP6241193B2 (ja) | 2012-10-23 | 2017-12-06 | コニカミノルタ株式会社 | 透明電極、電子デバイス及び有機エレクトロルミネッセンス素子 |
| JP6118914B2 (ja) * | 2012-12-28 | 2017-04-19 | ターベダ セラピューティクス インコーポレイテッドTarveda Therapeutics,Inc. | 放出制御型の固体ポリマーナノ粒子 |
| US20140186332A1 (en) * | 2012-12-28 | 2014-07-03 | NX Pharmagen | Biomarkers of preterm birth |
| US9820942B2 (en) | 2013-03-06 | 2017-11-21 | Biomics Biotechnologies Co., Ltd. | Lipidosome preparation, preparation method and application thereof |
| RS57739B1 (sr) * | 2013-03-14 | 2018-12-31 | Translate Bio Inc | Kompozicije cftr irnk i postupci i upotrebe u vezi sa njima |
| EP3388834B1 (en) | 2013-03-15 | 2020-04-15 | Translate Bio, Inc. | Synergistic enhancement of the delivery of nucleic acids via blended formulations |
| CN106413811A (zh) | 2013-10-22 | 2017-02-15 | 夏尔人类遗传性治疗公司 | 精氨基琥珀酸合成酶缺乏症的mrna疗法 |
| JP7103750B2 (ja) | 2013-12-12 | 2022-07-20 | ザ・ブロード・インスティテュート・インコーポレイテッド | ゲノム編集のためのCRISPR-Cas系及び組成物の送達、使用及び治療適用 |
| US20170143848A1 (en) | 2014-03-24 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Mrna therapy for the treatment of ocular diseases |
| US9833416B2 (en) | 2014-04-04 | 2017-12-05 | Ohio State Innovation Foundation | Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| EP3155116A4 (en) * | 2014-06-10 | 2017-12-27 | Massachusetts Institute Of Technology | Method for gene editing |
| CN103999853B (zh) | 2014-06-11 | 2015-07-22 | 中国农业大学 | 荧光树枝状纳米大分子在制备药物载体中的应用 |
| CN106794141B (zh) * | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| CA2964234A1 (en) | 2014-10-10 | 2016-04-14 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules in vitro and in vivo |
| JP6767976B2 (ja) | 2014-12-05 | 2020-10-14 | トランスレイト バイオ, インコーポレイテッド | 関節疾患の治療のためのメッセンジャーrna治療法 |
| WO2016094342A1 (en) | 2014-12-08 | 2016-06-16 | The Board Of Regents Of The University Of Texas System | Lipocationic polymers and uses thereof |
| JP2018509387A (ja) | 2015-01-21 | 2018-04-05 | フェーズアールエックス インコーポレイテッド | 細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム |
| EP3247398A4 (en) * | 2015-01-23 | 2018-09-26 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| US20180200186A1 (en) * | 2015-07-09 | 2018-07-19 | Insmed Incorporated | Compositions and methods for treating lung diseases and lung injury |
| WO2017048789A1 (en) * | 2015-09-14 | 2017-03-23 | The Board Of Regents Of The University Of Texas System | Lipocationic dendrimers and uses thereof |
| EP3353309A4 (en) | 2015-09-25 | 2019-04-10 | Tarveda Therapeutics, Inc. | COMPOSITIONS AND METHOD FOR GENERIC EDITING |
| WO2017066793A1 (en) * | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs and methods of mrna capping |
| JP7384512B2 (ja) * | 2015-10-22 | 2023-11-21 | モデルナティエックス インコーポレイテッド | 広域インフルエンザウイルスワクチン |
| LT3436077T (lt) * | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| WO2017180917A2 (en) * | 2016-04-13 | 2017-10-19 | Modernatx, Inc. | Lipid compositions and their uses for intratumoral polynucleotide delivery |
| PL3458074T3 (pl) | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| SI3458083T1 (sl) * | 2016-05-18 | 2023-03-31 | Modernatx, Inc. | Polinukleotidi, ki kodirajo interlevkin-12 (IL12) in njihova uporaba |
| CN118108847A (zh) * | 2016-08-07 | 2024-05-31 | 诺华股份有限公司 | mRNA介导的免疫方法 |
| CA3040337A1 (en) * | 2016-10-26 | 2018-05-03 | Curevac Ag | Lipid nanoparticle mrna vaccines |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| CA3103528A1 (en) * | 2018-06-19 | 2019-12-26 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mrna and long nucleic acids |
| WO2020051223A1 (en) | 2018-09-04 | 2020-03-12 | The Board Of Regents Of The University Of Texas System | Compositions and methods for organ specific delivery of nucleic acids |
| EP3846857A4 (en) | 2018-09-04 | 2022-10-12 | The Board Of Regents Of The University Of Texas System | COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS |
-
2019
- 2019-09-04 WO PCT/US2019/049565 patent/WO2020051223A1/en not_active Ceased
- 2019-09-04 GB GB2104777.4A patent/GB2592505B/en active Active
- 2019-09-04 JP JP2021536681A patent/JP7425066B2/ja active Active
- 2019-09-04 CN CN201980070622.2A patent/CN112996519B/zh active Active
- 2019-09-04 GB GB2219703.2A patent/GB2617430B/en active Active
- 2019-09-04 CN CN202510183613.1A patent/CN120093931A/zh active Pending
- 2019-09-04 GB GB2111271.9A patent/GB2606038B/en active Active
- 2019-09-04 EP EP19857774.4A patent/EP3846822A4/en active Pending
- 2019-09-04 AU AU2019336679A patent/AU2019336679B2/en active Active
- 2019-09-04 CA CA3111484A patent/CA3111484A1/en active Pending
-
2021
- 2021-03-04 US US17/191,895 patent/US11229609B2/en active Active
- 2021-09-13 US US17/473,863 patent/US11304911B2/en active Active
-
2022
- 2022-01-10 US US17/572,615 patent/US11590085B2/en active Active
- 2022-04-01 US US17/711,911 patent/US11510880B2/en active Active
- 2022-06-14 US US17/839,699 patent/US11648209B2/en active Active
- 2022-09-04 US US17/929,704 patent/US11648210B2/en active Active
-
2023
- 2023-11-07 JP JP2023189771A patent/JP7815196B2/ja active Active
- 2023-12-11 US US18/534,974 patent/US12133924B2/en active Active
-
2024
- 2024-02-28 US US18/590,737 patent/US20240245620A1/en not_active Abandoned
-
2025
- 2025-01-16 US US19/025,939 patent/US20250228788A1/en not_active Abandoned
- 2025-08-29 AU AU2025223878A patent/AU2025223878A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021535227A5 (enExample) | ||
| JP2021535226A5 (enExample) | ||
| JP2024016183A5 (enExample) | ||
| GB2592505A (en) | Compositions and methods for organ specific delivery of nucleic acids | |
| US20240083842A1 (en) | Lipocationic dendrimers and uses thereof | |
| US11464870B2 (en) | Lipid nanoparticles for in-vivo drug delivery, and uses thereof | |
| JP2025175052A5 (enExample) | ||
| JP4951338B2 (ja) | 脂質に封入された干渉rna | |
| US9220779B2 (en) | Carrier for negatively charged drugs comprising a cationic lipid and a preparation method thereof | |
| US20250249123A1 (en) | Lipids and compositions thereof | |
| US20210330600A1 (en) | Nanoparticle compositions for efficient nucleic acid delivery and methods of making and using the same | |
| US9730893B2 (en) | Lipid assemblies comprising anionic lysolipids and use thereof | |
| US10933081B2 (en) | Myostatin iRNA compositions and methods of use thereof | |
| US20240197636A1 (en) | Tissue-specific nucleic acid delivery by mixed cationic lipid particles | |
| ES2561812T3 (es) | Composición para inhibir la expresión de un gen diana | |
| JP2025541727A (ja) | 新規のポリグリセロールコンジュゲート脂質及びそれを含む脂質ナノ粒子組成物 | |
| US20250064741A1 (en) | Methods for enhanced nucleic acid delivery | |
| ES2698565B2 (es) | Procedimiento para la elaboración de nanopartículas lipídicas, y nanopartículas lipídicas con los macrófagos cerebrales como células diana | |
| CN118105357B (zh) | 一种鞘内递送制剂及其用途 | |
| US20250066787A1 (en) | Composition for Administration of Double-Stranded Oligonucleotide Structures Using Ultrasonic Nebulizer for Prevention or Treatment of Respiratory Viral Infection Including COVID-19, Pulmonary Fibrosis Caused by Viral Infection, or Respiratory Diseases | |
| JP2025540076A (ja) | 核酸、イオン化可能な脂質、ステロール、脂質アンカーポリマー、及びヘルパー脂質を含む脂質ナノ粒子、それらの使用 | |
| TW202449155A (zh) | 用於肌肉萎縮症之外顯子跳躍寡聚物 | |
| JP2022552993A (ja) | 血液脳関門透過能を有するペプチド核酸複合体及びこれを含む組成物 | |
| US20230190653A1 (en) | Method for reducing off-target uptake or accumulation of agents | |
| RU2799045C1 (ru) | Липидные наночастицы для доставки лекарственного средства in vivo и их применение |