JP2021535126A5 - - Google Patents
Info
- Publication number
- JP2021535126A5 JP2021535126A5 JP2021510174A JP2021510174A JP2021535126A5 JP 2021535126 A5 JP2021535126 A5 JP 2021535126A5 JP 2021510174 A JP2021510174 A JP 2021510174A JP 2021510174 A JP2021510174 A JP 2021510174A JP 2021535126 A5 JP2021535126 A5 JP 2021535126A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- inhibitors
- composition according
- pharmaceutically acceptable
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726172P | 2018-08-31 | 2018-08-31 | |
| US62/726,172 | 2018-08-31 | ||
| US201962883860P | 2019-08-07 | 2019-08-07 | |
| US62/883,860 | 2019-08-07 | ||
| PCT/IB2019/057259 WO2020044266A1 (en) | 2018-08-31 | 2019-08-28 | Combinations for treatment of nash/nafld and related diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535126A JP2021535126A (ja) | 2021-12-16 |
| JP2021535126A5 true JP2021535126A5 (enExample) | 2022-02-22 |
| JP7161605B2 JP7161605B2 (ja) | 2022-10-26 |
Family
ID=68165623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510174A Active JP7161605B2 (ja) | 2018-08-31 | 2019-08-28 | Nash/nafldおよび関連疾患の治療のための組合せ |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11254660B2 (enExample) |
| EP (1) | EP3843740A1 (enExample) |
| JP (1) | JP7161605B2 (enExample) |
| KR (1) | KR102614808B1 (enExample) |
| CN (1) | CN112955147A (enExample) |
| AU (1) | AU2019329884B2 (enExample) |
| BR (1) | BR112021003039A2 (enExample) |
| CA (1) | CA3110601C (enExample) |
| CL (1) | CL2021000491A1 (enExample) |
| CO (1) | CO2021002230A2 (enExample) |
| CR (1) | CR20210110A (enExample) |
| DO (1) | DOP2021000036A (enExample) |
| EC (1) | ECSP21012501A (enExample) |
| IL (1) | IL281093B2 (enExample) |
| MA (1) | MA53496A (enExample) |
| MX (1) | MX2021002428A (enExample) |
| PH (1) | PH12021550339A1 (enExample) |
| PY (1) | PY1972032A (enExample) |
| SG (1) | SG11202101503RA (enExample) |
| TW (1) | TWI718644B (enExample) |
| UY (1) | UY38351A (enExample) |
| WO (1) | WO2020044266A1 (enExample) |
| ZA (1) | ZA202101090B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| EA202191432A1 (ru) | 2018-11-22 | 2021-10-14 | Цилу Регор Терапьютикс Инк. | Агонисты glp-1r и их применения |
| WO2020142365A1 (en) * | 2018-12-31 | 2020-07-09 | Christos Mantzoros | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
| WO2020150473A2 (en) | 2019-01-18 | 2020-07-23 | Dogma Therapeutics, Inc. | Pcsk9 inhibitors and methods of use thereof |
| BR112021013924A2 (pt) | 2019-01-18 | 2021-09-21 | Astrazeneca Ab | Inibidores de pcsk9 e métodos de uso do mesmo |
| AU2020256647B2 (en) | 2019-04-12 | 2025-07-31 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
| PT4097099T (pt) | 2020-02-07 | 2024-07-19 | Gasherbrum Bio Inc | Agonistas heterocíclicos de glp-1 |
| JP2022058085A (ja) * | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ2阻害剤とアセチル-CoAカルボキシラーゼ阻害剤との組合せ |
| JP2021134211A (ja) * | 2020-02-24 | 2021-09-13 | ファイザー・インク | Nafld/nashおよび関連疾患の処置のための組合せ |
| IL296100A (en) * | 2020-03-11 | 2022-11-01 | Dong A St Co Ltd | A medicinal preparation for the prevention or treatment of non-alcoholic steatohepatitis |
| WO2021211959A2 (en) * | 2020-04-18 | 2021-10-21 | Inipharm, Inc. | Methods and compositions for treating drug induced steatohepatitis |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| WO2021219019A1 (en) | 2020-04-29 | 2021-11-04 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN117645601A (zh) * | 2020-06-10 | 2024-03-05 | 重庆康丁医药技术有限公司 | 一种具有心血管益处的glp-1小分子 |
| CN113816948B (zh) * | 2020-06-19 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 稠合咪唑类衍生物、其制备方法及其在医药上的应用 |
| PE20231181A1 (es) | 2020-08-06 | 2023-08-11 | Gasherbrum Bio Inc | Agonistas del glp-1 heterociclicos |
| JP2023538408A (ja) * | 2020-08-21 | 2023-09-07 | ターンズ・ファーマシューティカルズ・インコーポレイテッド | Glp-1r作動薬としての化合物 |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| CN112635049A (zh) * | 2020-12-23 | 2021-04-09 | 无锡市第二人民医院 | 一种研究HSD17B13 rs72613567基因变异和肾功能损伤之间关系的方法 |
| SI4408840T1 (sl) | 2021-09-27 | 2025-12-31 | Terns Pharmaceuticals, Inc. | Benzimidazolne karboksilne kisline kot agonisti GLP-1R |
| US12024507B2 (en) | 2021-10-25 | 2024-07-02 | Terns Pharmaceuticals, Inc. | Compounds as GLP-1R agonists |
| AU2023224854A1 (en) | 2022-02-23 | 2024-10-03 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| EP4490155A1 (en) | 2022-03-09 | 2025-01-15 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| US20250250269A1 (en) | 2022-04-14 | 2025-08-07 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| CN121002014A (zh) | 2022-12-15 | 2025-11-21 | 加舒布鲁姆生物公司 | 具有glp-1激动剂活性的化合物的盐和固体形式 |
| PE20252787A1 (es) | 2023-04-07 | 2025-12-22 | Terns Pharmaceuticals Inc | Combinacion que comprende un agonista de thr-beta y un agonista de glp-1r para su uso en el tratamiento de un trastorno hepatico o una enfermedad cardiometabolica |
| EP4731212A1 (en) * | 2023-06-20 | 2026-04-29 | Sagimet Biosciences Inc. | Combination therapies of fasn inhibitors with thyroid hormone receptor agonists |
| WO2025080818A1 (en) * | 2023-10-10 | 2025-04-17 | Sagimet Biosciences Inc. | Combinations of fasn inhibitors and glp-1 agonists for liver diseases |
| CN118787746B (zh) * | 2024-07-01 | 2025-09-16 | 安徽省立医院(中国科学技术大学附属第一医院) | 脂肪酸合成酶抑制剂在预防及治疗药物性肝损伤中的应用 |
| CN120698959B (zh) * | 2025-05-29 | 2026-01-23 | 河北医科大学 | 一种达格列净-依折麦布共无定形物及其制备方法和应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1146866A (en) | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| EP0028489B1 (en) | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
| DE3438830A1 (de) | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
| ES2111065T5 (es) | 1991-04-16 | 2005-06-16 | Nippon Shinyaku Company, Limited | Procedimiento para producir una dispersion solida. |
| US5340591A (en) | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
| JP3265680B2 (ja) | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| DE19504832A1 (de) | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| PT901786E (pt) | 1997-08-11 | 2007-08-07 | Pfizer Prod Inc | Disperções farmacêuticas sólidas com biodisponibilidade melhorada |
| ID26984A (id) | 1998-07-06 | 2001-02-22 | Bristol Myers Squibb Co | Senyawa-senyawa sulfonamida sebagai antagonis reseptor angiotensin endotelin ganda |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| CA2439152C (en) | 2001-02-28 | 2008-06-17 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| WO2003072197A1 (en) | 2002-02-27 | 2003-09-04 | Pfizer Products Inc. | Acc inhibitors |
| EA011086B9 (ru) | 2004-05-12 | 2012-08-30 | Пфайзер Продактс Инк. | Производные пролина и их применение в качестве ингибиторов дипептидилпептидазы iv |
| GEP20094723B (en) | 2004-05-25 | 2009-07-10 | Pfizer Prod Inc | Tetraazabenzo [e] azulene derivatives and analogs thereof |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| EP2010520B1 (en) | 2006-04-20 | 2012-09-12 | Pfizer Products Inc. | Heterobicyclic amides for the prevention and treatment of glucokinase-mediated diseases |
| WO2008065508A1 (en) | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Spiroketone acetyl-coa carboxylase inhibitors |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| EP2297164A1 (en) | 2008-05-28 | 2011-03-23 | Pfizer Inc. | Pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| JP5435592B2 (ja) | 2008-05-28 | 2014-03-05 | ファイザー・インク | ピラゾロスピロケトンアセチルCoAカルボキシラーゼ阻害剤 |
| CA2729581A1 (en) | 2008-07-29 | 2010-02-04 | Pfizer Inc. | Fluorinated heteroaryls |
| ES2380408T3 (es) | 2008-08-28 | 2012-05-11 | Pfizer Inc. | Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol |
| TW201038580A (en) | 2009-02-02 | 2010-11-01 | Pfizer | 4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl derivatives |
| WO2010103437A1 (en) | 2009-03-11 | 2010-09-16 | Pfizer Inc. | Benzofuranyl derivatives used as glucokinase inhibitors |
| EP2406230A1 (en) | 2009-03-11 | 2012-01-18 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
| CA2754523A1 (en) | 2009-03-20 | 2010-09-23 | Pfizer Inc. | 3-oxa-7-azabicyclo[3.3.1]nonanes |
| EP2427448A1 (en) | 2009-05-08 | 2012-03-14 | Pfizer Inc. | Gpr 119 modulators |
| CA2759843A1 (en) | 2009-05-08 | 2010-11-10 | Pfizer Inc. | Gpr 119 modulators |
| GEP20135907B (en) | 2009-06-05 | 2013-08-12 | Pfizer | L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators |
| WO2011005611A1 (en) | 2009-07-09 | 2011-01-13 | Merck Sharp & Dohme Corp. | Neuromedin u receptor agonists and uses thereof |
| CH702192A1 (de) | 2009-11-04 | 2011-05-13 | New Dent Ag | Keramisches Implantat. |
| DK2621493T3 (en) * | 2010-09-30 | 2016-10-24 | Pfizer | N1 PYRAZOLOSPIROKETON-ACETYL-CoA carboxylase INHIBITORS |
| CU24152B1 (es) | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr |
| MX2017008844A (es) | 2015-01-09 | 2018-03-14 | Gilead Apollo Llc | Terapia de combinacion con inhibidor de acetil-coa carboxilasa (acc) para el tratamiento de enfermedad de higado graso no alcoholico. |
| TN2018000198A1 (en) | 2015-12-29 | 2019-10-04 | Pfizer | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors |
| AR109179A1 (es) * | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| CN106271089B (zh) | 2016-09-30 | 2019-01-25 | 英诺激光科技股份有限公司 | 一种激光薄膜刻蚀装置及方法 |
| WO2018109607A1 (en) | 2016-12-16 | 2018-06-21 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
| EP3713942B8 (en) | 2017-11-21 | 2023-04-12 | Pfizer Inc. | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid |
-
2019
- 2019-08-28 JP JP2021510174A patent/JP7161605B2/ja active Active
- 2019-08-28 CA CA3110601A patent/CA3110601C/en active Active
- 2019-08-28 IL IL281093A patent/IL281093B2/en unknown
- 2019-08-28 AU AU2019329884A patent/AU2019329884B2/en active Active
- 2019-08-28 CN CN201980071389.XA patent/CN112955147A/zh active Pending
- 2019-08-28 MX MX2021002428A patent/MX2021002428A/es unknown
- 2019-08-28 CR CR20210110A patent/CR20210110A/es unknown
- 2019-08-28 MA MA053496A patent/MA53496A/fr unknown
- 2019-08-28 BR BR112021003039-5A patent/BR112021003039A2/pt unknown
- 2019-08-28 KR KR1020217009415A patent/KR102614808B1/ko active Active
- 2019-08-28 EP EP19783644.8A patent/EP3843740A1/en active Pending
- 2019-08-28 SG SG11202101503RA patent/SG11202101503RA/en unknown
- 2019-08-28 WO PCT/IB2019/057259 patent/WO2020044266A1/en not_active Ceased
- 2019-08-28 TW TW108130771A patent/TWI718644B/zh active
- 2019-08-28 US US16/553,818 patent/US11254660B2/en active Active
- 2019-08-29 UY UY0001038351A patent/UY38351A/es not_active Application Discontinuation
- 2019-08-30 PY PY201901972032A patent/PY1972032A/es unknown
-
2021
- 2021-02-17 PH PH12021550339A patent/PH12021550339A1/en unknown
- 2021-02-17 ZA ZA2021/01090A patent/ZA202101090B/en unknown
- 2021-02-23 CO CONC2021/0002230A patent/CO2021002230A2/es unknown
- 2021-02-23 EC ECSENADI202112501A patent/ECSP21012501A/es unknown
- 2021-02-25 DO DO2021000036A patent/DOP2021000036A/es unknown
- 2021-02-26 CL CL2021000491A patent/CL2021000491A1/es unknown
- 2021-10-11 US US17/498,256 patent/US12247022B2/en active Active
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