JP2021531234A5 - - Google Patents
Info
- Publication number
- JP2021531234A5 JP2021531234A5 JP2020555323A JP2020555323A JP2021531234A5 JP 2021531234 A5 JP2021531234 A5 JP 2021531234A5 JP 2020555323 A JP2020555323 A JP 2020555323A JP 2020555323 A JP2020555323 A JP 2020555323A JP 2021531234 A5 JP2021531234 A5 JP 2021531234A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- substituted
- alkyl
- heterocyclyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023174330A JP7700193B2 (ja) | 2018-04-12 | 2023-10-06 | ヒトインテグリンα４β７のアンタゴニスト |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862656742P | 2018-04-12 | 2018-04-12 | |
| US62/656,742 | 2018-04-12 | ||
| PCT/US2019/027141 WO2019200202A1 (en) | 2018-04-12 | 2019-04-12 | Antagonists of human integrin (alpha4)(beta7) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023174330A Division JP7700193B2 (ja) | 2018-04-12 | 2023-10-06 | ヒトインテグリンα４β７のアンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021531234A JP2021531234A (ja) | 2021-11-18 |
| JP2021531234A5 true JP2021531234A5 (enExample) | 2022-04-20 |
| JP7365358B2 JP7365358B2 (ja) | 2023-10-19 |
Family
ID=68161020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555323A Active JP7365358B2 (ja) | 2018-04-12 | 2019-04-12 | ヒトインテグリンα４β７のアンタゴニスト |
| JP2023174330A Active JP7700193B2 (ja) | 2018-04-12 | 2023-10-06 | ヒトインテグリンα４β７のアンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023174330A Active JP7700193B2 (ja) | 2018-04-12 | 2023-10-06 | ヒトインテグリンα４β７のアンタゴニスト |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10759756B2 (enExample) |
| EP (1) | EP3773573B1 (enExample) |
| JP (2) | JP7365358B2 (enExample) |
| CN (1) | CN112312910A (enExample) |
| AR (1) | AR114489A1 (enExample) |
| MA (1) | MA52249A (enExample) |
| TW (2) | TW202528300A (enExample) |
| WO (1) | WO2019200202A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3773573B1 (en) * | 2018-04-12 | 2026-03-18 | Morphic Therapeutic, Inc. | Antagonists of human integrin (alpha4)(beta7) |
| EP3873605B1 (en) | 2018-10-30 | 2024-10-23 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
| FI3873884T3 (fi) | 2018-10-30 | 2025-02-24 | Gilead Sciences Inc | 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| ES3013256T3 (en) | 2018-10-30 | 2025-04-11 | Gilead Sciences Inc | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| WO2021030438A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| TWI775182B (zh) | 2019-10-16 | 2022-08-21 | 美商莫菲克醫療股份有限公司 | 抑制人類整合素αβ |
| IL302906A (en) * | 2020-11-20 | 2023-07-01 | Denali Therapeutics Inc | Compounds, compositions, and methods |
| US20250195485A1 (en) * | 2021-12-27 | 2025-06-19 | Xizang Haisco Pharmaceutical Co., Ltd. | Propionic acid derivative and medical use thereof |
| KR20250061759A (ko) * | 2022-09-09 | 2025-05-08 | 시젱 하이스코 파마수티칼 씨오., 엘티디. | 프로피온산 유도체 및 이의 의약에서의 응용 |
| JP2025542171A (ja) * | 2022-12-22 | 2025-12-25 | シンセラ， インコーポレイテッド | アルファ４ベータ７インテグリンアンタゴニスト及びその使用 |
| AU2024226489A1 (en) * | 2023-02-21 | 2025-10-02 | C4X Discovery Limited | Macrocyclic alpha4beta7 integrin inhibitors |
| WO2025026955A1 (en) * | 2023-07-28 | 2025-02-06 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| WO2025059417A1 (en) * | 2023-09-15 | 2025-03-20 | Morphic Therapeutic, Inc. | INHIBITING HUMAN INTEGRIN α4β7 |
| WO2025176107A1 (zh) * | 2024-02-20 | 2025-08-28 | 西藏海思科制药有限公司 | 一种吡啶酮衍生物及其在医药上的应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| AU681396B2 (en) * | 1993-03-31 | 1997-08-28 | G.D. Searle & Co. | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors |
| DE4427979A1 (de) * | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
| DK0730590T3 (da) | 1993-11-24 | 2001-03-19 | Du Pont Pharm Co | Isoxazolin og isozazol fibrinogenreceptorantagonister |
| US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| DE19622489A1 (de) * | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| US5981546A (en) * | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
| WO1998016547A1 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
| CA2268270A1 (en) | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Heterocyclic derivatives as factor xa inhibitors |
| DE19751251A1 (de) * | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
| US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| DE19821483A1 (de) * | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| AU4584199A (en) * | 1998-06-29 | 2000-01-17 | Du Pont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as iib/iiia antagonists |
| GB9826174D0 (en) * | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| RU2255933C9 (ru) * | 1999-05-07 | 2005-11-20 | Тексэс Байотекнолоджи Копэрейшн | ПРОИЗВОДНЫЕ ПРОПИОНОВОЙ КИСЛОТЫ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СЕЛЕКТИВНОГО ИНГИБИРОВАНИЯ СВЯЗЫВАНИЯ α4β1 ИНТЕГРИНА |
| US6723711B2 (en) * | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| ES2288871T3 (es) | 1999-09-24 | 2008-02-01 | Genentech, Inc. | Derivados de tirosina. |
| DE10041423A1 (de) | 2000-08-23 | 2002-03-07 | Merck Patent Gmbh | Biphenylderivate |
| DE10111876A1 (de) * | 2001-03-10 | 2002-09-19 | Aventis Pharma Gmbh | Bis(trifluormethyl)hydantoine als Zwischenprodukte für pharmazeutische Wirkstoffe |
| DE10154280A1 (de) | 2001-11-05 | 2003-05-15 | Wilex Ag | Antagonisten für alpha¶4¶-Integrine |
| DK1485127T3 (da) | 2002-02-25 | 2011-10-03 | Elan Pharm Inc | Anvendelse af midler til behandling af inflammation |
| WO2006026759A2 (en) | 2004-09-03 | 2006-03-09 | Genentech, Inc. | Humanized anti-beta7 antagonists and uses therefor |
| EP1863940B1 (en) | 2005-03-03 | 2012-06-06 | Seedlings Life Science Ventures, LLC. | Method of risk management for patients undergoing natalizumab treatment |
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| EA013080B1 (ru) | 2005-06-09 | 2010-02-26 | Юсб Фарма С.А. | 2,6-хинолинильные производные, способы их получения и их применение |
| US20070207141A1 (en) | 2006-02-28 | 2007-09-06 | Ivan Lieberburg | Methods of treating inflammatory and autoimmune diseases with natalizumab |
| US20100272680A1 (en) | 2009-02-09 | 2010-10-28 | Subramanian Baskaran | Piperidinyl Cyclic Amido Antiviral Agents |
| RU2016127812A (ru) | 2011-03-31 | 2018-12-06 | Дженентек, Инк. | Способы введения антагонистов интегрина бета7 |
| PL2903691T3 (pl) | 2012-10-05 | 2019-10-31 | Hoffmann La Roche | Sposoby diagnozowania i leczenia nieswoistego zapalenia jelit |
| WO2015148809A1 (en) | 2014-03-27 | 2015-10-01 | Genentech, Inc. | Methods for diagnosing and treating inflammatory bowel disease |
| WO2016011940A1 (zh) | 2014-07-25 | 2016-01-28 | 江苏恒瑞医药股份有限公司 | 氮茚-酰胺类衍生物、其制备方法及其在医药上的应用 |
| HK1244229A1 (zh) | 2015-02-26 | 2018-08-03 | F. Hoffmann-La Roche Ag | 治疗CROHN病的整联蛋白β7拮抗剂和方法 |
| US10246451B2 (en) | 2017-04-26 | 2019-04-02 | Aviara Pharmaceuticals, Inc. | Propionic acid derivatives and methods of use thereof |
| EP3773573B1 (en) | 2018-04-12 | 2026-03-18 | Morphic Therapeutic, Inc. | Antagonists of human integrin (alpha4)(beta7) |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
| ES3013256T3 (en) | 2018-10-30 | 2025-04-11 | Gilead Sciences Inc | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| EP3873605B1 (en) | 2018-10-30 | 2024-10-23 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
| FI3873884T3 (fi) | 2018-10-30 | 2025-02-24 | Gilead Sciences Inc | 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa |
| TWI775182B (zh) | 2019-10-16 | 2022-08-21 | 美商莫菲克醫療股份有限公司 | 抑制人類整合素αβ |
-
2019
- 2019-04-12 EP EP19785592.7A patent/EP3773573B1/en active Active
- 2019-04-12 AR ARP190100980A patent/AR114489A1/es unknown
- 2019-04-12 CN CN201980033206.5A patent/CN112312910A/zh active Pending
- 2019-04-12 TW TW113137058A patent/TW202528300A/zh unknown
- 2019-04-12 WO PCT/US2019/027141 patent/WO2019200202A1/en not_active Ceased
- 2019-04-12 US US16/382,512 patent/US10759756B2/en active Active
- 2019-04-12 TW TW108112877A patent/TWI856956B/zh active
- 2019-04-12 MA MA052249A patent/MA52249A/fr unknown
- 2019-04-12 JP JP2020555323A patent/JP7365358B2/ja active Active
-
2020
- 2020-07-27 US US16/939,812 patent/US11174228B2/en active Active
-
2021
- 2021-11-12 US US17/525,479 patent/US20220340529A1/en not_active Abandoned
-
2023
- 2023-10-06 JP JP2023174330A patent/JP7700193B2/ja active Active
- 2023-12-22 US US18/394,421 patent/US12221416B2/en active Active
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