JP2021531038A - ストレス顆粒集合を調節するためのシステム及び方法 - Google Patents

ストレス顆粒集合を調節するためのシステム及び方法 Download PDF

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JP2021531038A
JP2021531038A JP2021523576A JP2021523576A JP2021531038A JP 2021531038 A JP2021531038 A JP 2021531038A JP 2021523576 A JP2021523576 A JP 2021523576A JP 2021523576 A JP2021523576 A JP 2021523576A JP 2021531038 A JP2021531038 A JP 2021531038A
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protein
protein construct
ntf2
construct
stress
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JPWO2020014588A5 (https=
JP2021531038A5 (https=
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ブラングウィン，クリフ
ドレイク，ヴィクトリア
サンダース，デヴィッド
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ザ、トラスティーズ オブ プリンストン ユニバーシティ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
    • C12Y306/04012—DNA helicase (3.6.4.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
    • C12Y306/04013—RNA helicase (3.6.4.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2021523576A 2018-07-13 2019-07-12 ストレス顆粒集合を調節するためのシステム及び方法 Pending JP2021531038A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862697691P 2018-07-13 2018-07-13
US62/697,691 2018-07-13
US201862719751P 2018-08-20 2018-08-20
US62/719,751 2018-08-20
PCT/US2019/041564 WO2020014588A1 (en) 2018-07-13 2019-07-12 System and method for modulating stress granule assembly

Publications (3)

Publication Number Publication Date
JP2021531038A true JP2021531038A (ja) 2021-11-18
JPWO2020014588A5 JPWO2020014588A5 (https=) 2022-12-06
JP2021531038A5 JP2021531038A5 (https=) 2022-12-06

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JP2021523576A Pending JP2021531038A (ja) 2018-07-13 2019-07-12 ストレス顆粒集合を調節するためのシステム及び方法

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US (1) US12195768B2 (https=)
EP (1) EP3820494A4 (https=)
JP (1) JP2021531038A (https=)
CN (1) CN112423781A (https=)
WO (1) WO2020014588A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3820494A4 (en) 2018-07-13 2022-07-13 The Trustees of Princeton University System and method for modulating stress granule assembly
CN113135987B (zh) * 2021-06-10 2022-07-12 浙江师范大学 一类来源于Caprin1的活性肽及其应用
CN113214361B (zh) * 2021-06-10 2022-06-10 浙江师范大学 一类包含fgdf基序的应激颗粒抑制剂及其应用
WO2023174838A1 (en) * 2022-03-14 2023-09-21 F. Hoffmann-La Roche Ag Modulators of the g3bp2-tau interaction for the treatment of tau associated diseases
EP4269424A1 (en) * 2022-04-25 2023-11-01 Københavns Universitet Novel antiviral compounds and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514912A (ja) * 2001-08-23 2005-05-26 ザ ユニバーシティ オブ クイーンズランド 乳がんに関連する核酸およびポリペプチドならびにその使用
WO2007132555A1 (ja) * 2006-05-11 2007-11-22 The University Of Tokyo 細胞膜透過性ペプチドと細胞内におけるその使用
JP2016535600A (ja) * 2013-10-28 2016-11-17 キューピッド ペプチド カンパニー リミテッド 細胞輸送
JP2020520947A (ja) * 2017-05-24 2020-07-16 オーファザイム エー／エス 熱ショックタンパク質誘導因子および前頭側頭障害

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
EP2804598B1 (en) * 2012-01-17 2019-05-15 Kyoto University Prophylactic and therapeutic drug for amyotrophic lateral sclerosis and method of screening therefor
JP6340366B2 (ja) * 2012-07-31 2018-06-06 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 運動ニューロン疾患を診断および処置する方法
JP2019500899A (ja) * 2015-11-23 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
US20190085034A1 (en) 2016-03-16 2019-03-21 Tarveda Therapeutics, Inc. Antibody mimic conjugates and particles
US10668128B2 (en) * 2017-02-15 2020-06-02 University Of South Carolina Targeting G3BP proteins to accelerate nerve regeneration
US10526380B2 (en) * 2017-10-26 2020-01-07 St. Jude Children's Research Hospital Fusion protein and nucleic acid molecule for light-dependent stress granule assembly
EP3820494A4 (en) 2018-07-13 2022-07-13 The Trustees of Princeton University System and method for modulating stress granule assembly

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514912A (ja) * 2001-08-23 2005-05-26 ザ ユニバーシティ オブ クイーンズランド 乳がんに関連する核酸およびポリペプチドならびにその使用
WO2007132555A1 (ja) * 2006-05-11 2007-11-22 The University Of Tokyo 細胞膜透過性ペプチドと細胞内におけるその使用
JP2016535600A (ja) * 2013-10-28 2016-11-17 キューピッド ペプチド カンパニー リミテッド 細胞輸送
JP2020520947A (ja) * 2017-05-24 2020-07-16 オーファザイム エー／エス 熱ショックタンパク質誘導因子および前頭側頭障害

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER SCIENCE, vol. 103, no. 10, JPN6022055826, 2012, pages 1848 - 1856, ISSN: 0005259754 *
PLOS ONE, vol. 8, no. 12, JPN6022055825, 2013, pages 80947, ISSN: 0005259753 *
PLOS PATHOGENS, vol. 11, no. 2, JPN6022055827, 2015, pages 1004659, ISSN: 0005259752 *

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Publication number Publication date
EP3820494A1 (en) 2021-05-19
WO2020014588A1 (en) 2020-01-16
CN112423781A (zh) 2021-02-26
US12195768B2 (en) 2025-01-14
EP3820494A4 (en) 2022-07-13
US20210269780A1 (en) 2021-09-02

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