JP2021527828A5 - - Google Patents
Info
- Publication number
- JP2021527828A5 JP2021527828A5 JP2020571476A JP2020571476A JP2021527828A5 JP 2021527828 A5 JP2021527828 A5 JP 2021527828A5 JP 2020571476 A JP2020571476 A JP 2020571476A JP 2020571476 A JP2020571476 A JP 2020571476A JP 2021527828 A5 JP2021527828 A5 JP 2021527828A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- laser
- less
- ionization
- charged particle
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024077914A JP2024119808A (ja) | 2018-06-18 | 2024-05-13 | 高解像度イメージング装置および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862686341P | 2018-06-18 | 2018-06-18 | |
| US62/686,341 | 2018-06-18 | ||
| US201962792759P | 2019-01-15 | 2019-01-15 | |
| US62/792,759 | 2019-01-15 | ||
| PCT/US2019/037644 WO2019246033A1 (en) | 2018-06-18 | 2019-06-18 | High resolution imaging apparatus and method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024077914A Division JP2024119808A (ja) | 2018-06-18 | 2024-05-13 | 高解像度イメージング装置および方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021527828A JP2021527828A (ja) | 2021-10-14 |
| JPWO2019246033A5 JPWO2019246033A5 (https=) | 2022-06-27 |
| JP2021527828A5 true JP2021527828A5 (https=) | 2022-06-27 |
| JP7489333B2 JP7489333B2 (ja) | 2024-05-23 |
Family
ID=68983080
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020571476A Active JP7489333B2 (ja) | 2018-06-18 | 2019-06-18 | 高解像度イメージング装置および方法 |
| JP2024077914A Pending JP2024119808A (ja) | 2018-06-18 | 2024-05-13 | 高解像度イメージング装置および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024077914A Pending JP2024119808A (ja) | 2018-06-18 | 2024-05-13 | 高解像度イメージング装置および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US11264221B2 (https=) |
| EP (1) | EP3807922A4 (https=) |
| JP (2) | JP7489333B2 (https=) |
| CN (2) | CN113678227B (https=) |
| CA (1) | CA3104126A1 (https=) |
| WO (1) | WO2019246033A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11264221B2 (en) | 2018-06-18 | 2022-03-01 | Fluidigm Canada Inc. | High resolution imaging apparatus and method |
| US20210391161A1 (en) * | 2019-01-15 | 2021-12-16 | Fluidigm Canada Inc. | Direct ionization in imaging mass spectrometry operation |
| WO2020159088A1 (ko) * | 2019-01-29 | 2020-08-06 | 한국표준과학연구원 | Ldi-ms를 이용한 혈액 내 유기물 측정 방법 및 이를 위한 장치 |
| US20210183632A1 (en) * | 2019-04-11 | 2021-06-17 | Exum Instruments | Mass spectrometry of samples including coaxial desorption/ablation and image capture |
| US11164734B2 (en) * | 2019-04-11 | 2021-11-02 | Exum Instruments | Laser desorption, ablation, and ionization system for mass spectrometry analysis of samples including organic and inorganic materials |
| NL2023384B1 (en) * | 2019-06-26 | 2021-02-01 | Confocal Nl B V | Re-scan microscope system and method |
| DE102019005364B3 (de) * | 2019-07-31 | 2020-10-08 | Carl Zeiss Multisem Gmbh | System-Kombination eines Teilchenstrahlsystem und eines lichtoptischen Systems mit kollinearer Strahlführung sowie Verwendung der System-Kombination |
| CN111161998B (zh) * | 2020-02-10 | 2025-06-17 | 浙江迪谱诊断技术有限公司 | 一种激光同轴离子激发装置 |
| JP7471575B2 (ja) * | 2020-04-23 | 2024-04-22 | 株式会社Sumco | 試料導入装置、誘導結合プラズマ分析装置および分析方法 |
| CN115843386B (zh) * | 2020-05-27 | 2025-05-13 | 株式会社岛津制作所 | 质量分析方法以及质量分析装置 |
| US11796721B2 (en) * | 2020-06-09 | 2023-10-24 | IonQ, Inc. | Parabolic Cassegrain-type reflector for ablation loading |
| US12013521B2 (en) * | 2020-06-29 | 2024-06-18 | Mgi Tech Co., Ltd. | Systems and methods for optical scanning and imaging through a fluid medium for nucleic acid sequencing |
| GB2628478A (en) | 2020-10-29 | 2024-09-25 | Ambergen Inc | Novel photocleavable mass-tags for multiplexed mass spectrometric imaging of tissues using biomolecular probes |
| WO2022103843A1 (en) * | 2020-11-11 | 2022-05-19 | George Mason Research Foundation, Inc. | Laser capture microdissection visualization chemistry |
| EP4260360A4 (en) * | 2020-12-08 | 2024-05-22 | SHINE Technologies, LLC | ISOTHERMAL ION SOURCE WITH AUXILIARY HEATING ELEMENTS |
| EP3958035A1 (en) * | 2021-02-02 | 2022-02-23 | Leica Microsystems CMS GmbH | Lens assembly for microscopic imaging and corresponding microscope and imaging method |
| EP4047346A1 (en) * | 2021-02-19 | 2022-08-24 | Sartorius BioAnalytical Instruments, Inc. | Flow cytometry evaluation with fluid sample monitoring beads having size-sensitive fluorescent hydrogel |
| DE102021105327B3 (de) * | 2021-03-05 | 2022-05-12 | Bruker Daltonics GmbH & Co. KG | Desorptions-Ionenquelle mit Postdesorptions-Ionisierung in Transmissionsgeometrie |
| EP4308647A4 (en) * | 2021-03-15 | 2025-01-22 | The Governing Council Of The University Of Toronto | METAL-MARKED POLYMER MICROBEADS WITH MARKING LEVEL CONTROL |
| CN117501408A (zh) * | 2021-04-14 | 2024-02-02 | 吉米亚分析公司 | 为icp-ms生成高产率负离子的系统 |
| WO2022222100A1 (zh) * | 2021-04-22 | 2022-10-27 | 北京航空航天大学 | 利用皮秒电脉冲的磁动力学测试系统 |
| DE102021112503B4 (de) * | 2021-05-12 | 2025-03-27 | Carl Zeiss Microscopy Gmbh | Teilchenstrahlvorrichtung mit einer Ablenkeinheit |
| GB2607713B (en) | 2021-05-26 | 2023-09-20 | Thermo Fisher Scient Bremen Gmbh | Systems and methods for imaging and ablating a sample |
| CN113504173B (zh) * | 2021-06-29 | 2022-09-20 | 中国科学院长春光学精密机械与物理研究所 | 一种euv多层膜光学元件的综合测试装置及其测试方法 |
| US11893786B1 (en) * | 2021-08-17 | 2024-02-06 | Amazon Technologies, Inc. | Scan-free barcode reading |
| CN116432694B (zh) * | 2021-12-30 | 2025-10-31 | 浙江舜宇智能光学技术有限公司 | 基于消除tof多路径的神经网络模型的压缩方法和装置 |
| CN114359251B (zh) * | 2022-01-11 | 2025-06-03 | 招商局重庆交通科研设计院有限公司 | 一种混凝土表面破损的自动识别方法 |
| CN114509493B (zh) * | 2022-02-28 | 2025-07-08 | 中国科学院地球化学研究所 | La-icp-ms动态变形束斑的测试方法与设备 |
| CN114674809B (zh) * | 2022-03-23 | 2025-04-01 | 中国科学院合肥物质科学研究院 | 具有自动对焦与微区成像功能的libs分析装置及应用 |
| CN114839979A (zh) * | 2022-04-22 | 2022-08-02 | 新疆大学 | 一种基于srp的多机器人羽流寻源相对导航策略 |
| TWI799345B (zh) * | 2022-09-01 | 2023-04-11 | 國立清華大學 | 反射掃描式同調光繞射顯影方法及系統 |
| WO2024061773A1 (en) * | 2022-09-23 | 2024-03-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Electron beam apparatus and method for generating a pulsed electron beam and applications thereof |
| DE102022131740B4 (de) | 2022-11-30 | 2026-02-12 | Bruker Daltonics GmbH & Co. KG | Verfahren zum Desorbieren und Ionisieren von Probenmaterial |
| WO2024177957A1 (en) * | 2023-02-20 | 2024-08-29 | The Brigham And Women’S Hospital, Inc. | System and method for mass spectrometry analysis, imaging and quantitation of metals |
| CN121586551A (zh) * | 2023-04-11 | 2026-02-27 | 阿瓦瓦公司 | 用于激光处理设备的运动跟踪和模糊补偿 |
| WO2025014690A2 (en) * | 2023-07-07 | 2025-01-16 | Trustees Of Boston University | Widefield interferometric defocus-enhanced (wide) mid- infrared (mir) photothermal microscopy |
| CN116973154A (zh) * | 2023-07-18 | 2023-10-31 | 西湖大学 | 新的用于生物样品的膨胀蛋白组学分析的方法 |
| CN117169792B (zh) * | 2023-08-30 | 2024-05-14 | 华中科技大学 | 一种基于磁纳米粒子磁化响应的透射式高分辨率成像方法 |
| CN117405763A (zh) * | 2023-09-28 | 2024-01-16 | 中国地质大学(武汉) | 一种单颗粒的元素与同位素分析系统与方法 |
| US20250163571A1 (en) * | 2023-11-17 | 2025-05-22 | Fei Company | Carbon containing precursors for beam-induced deposition |
| CN117538135B (zh) * | 2024-01-09 | 2024-03-15 | 成都艾立本科技有限公司 | 基于纳米结构的气溶胶libs检测复合薄膜及检测方法 |
| CN119149872B (zh) * | 2024-11-20 | 2025-02-18 | 中国科学技术大学 | 一种用于激发激光等离子体光源的激光参数确定方法 |
| CN121253561B (zh) * | 2025-12-08 | 2026-04-17 | 山东大学 | 分析Zn掺杂KDP晶体表面飞秒激光诱导损伤行为的方法 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988879A (en) * | 1987-02-24 | 1991-01-29 | The Board Of Trustees Of The Leland Stanford Junior College | Apparatus and method for laser desorption of molecules for quantitation |
| US5225326A (en) | 1988-08-31 | 1993-07-06 | Research Development Foundation | One step in situ hybridization assay |
| JPH039259A (ja) | 1989-06-06 | 1991-01-17 | Nippon Telegr & Teleph Corp <Ntt> | 高繰り返しレーザ励起質量分折装置 |
| JPH0378955A (ja) | 1989-08-21 | 1991-04-04 | Hitachi Ltd | 固体表面検査方法および装置 |
| JP3155570B2 (ja) * | 1991-09-20 | 2001-04-09 | 株式会社日立製作所 | 収束イオンビーム質量分析方法及び収束イオンビーム質量分析複合装置 |
| JPH05225950A (ja) * | 1992-02-10 | 1993-09-03 | Hitachi Ltd | 質量分析計 |
| JP3140577B2 (ja) * | 1992-10-07 | 2001-03-05 | 日本電信電話株式会社 | レーザイオン化中性粒子質量分析装置 |
| JP2526412B2 (ja) * | 1994-03-31 | 1996-08-21 | 工業技術院長 | 連続断面像を得るための顕微鏡用生体試料の作成方法 |
| JPH07294459A (ja) * | 1994-04-21 | 1995-11-10 | Nippon Steel Corp | スパッタ中性粒子質量分析方法 |
| US6229142B1 (en) | 1998-01-23 | 2001-05-08 | Micromass Limited | Time of flight mass spectrometer and detector therefor |
| JP2000162164A (ja) * | 1998-11-26 | 2000-06-16 | Hitachi Ltd | 共鳴レーザイオン化中性粒子質量分析装置および分析方法 |
| JP3683156B2 (ja) * | 2000-03-09 | 2005-08-17 | トヨタ自動車株式会社 | 固体物質の表面分析方法 |
| JP2002116184A (ja) * | 2000-10-10 | 2002-04-19 | Hitachi Ltd | 半導体デバイス異物分析装置およびシステム |
| AU2002349241A1 (en) * | 2001-12-14 | 2003-06-30 | Mds Inc., D.B.A. Mds Sciex | Method of chemical of ionization at reduced pressures |
| US7576928B2 (en) | 2003-10-31 | 2009-08-18 | Hamamatsu Photonics K.K. | Solid immersion lens holder |
| JP4587960B2 (ja) * | 2004-02-16 | 2010-11-24 | オリンパス株式会社 | 液浸対物レンズ及び液浸媒質の保持機構 |
| US7994474B2 (en) * | 2004-02-23 | 2011-08-09 | Andreas Hieke | Laser desorption ionization ion source with charge injection |
| US20100090101A1 (en) * | 2004-06-04 | 2010-04-15 | Ionwerks, Inc. | Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues |
| EP2752874A1 (en) | 2004-06-07 | 2014-07-09 | Fluidigm Corporation | Method and apparatus for imaging a device under temperature control |
| WO2006090138A2 (en) | 2005-02-25 | 2006-08-31 | Micromass Uk Limited | Mass spectrometer |
| US20100092972A1 (en) | 2007-03-16 | 2010-04-15 | Human Genetic Signatures Pty Ltd. | Assay for gene expression |
| EP1975592A1 (en) | 2007-03-28 | 2008-10-01 | F. Hoffmann-la Roche AG | Sorption micro-array |
| US8384023B2 (en) * | 2009-01-23 | 2013-02-26 | Ionwerks, Inc. | Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces |
| EP2391877B1 (en) * | 2009-02-02 | 2019-05-15 | Light Matter Interaction Inc. | Soft ablative desorption method and system |
| GB201002447D0 (en) | 2010-02-12 | 2010-03-31 | Micromass Ltd | Mass spectrometer |
| JP2011233248A (ja) | 2010-04-23 | 2011-11-17 | Tokyo Institute Of Technology | レーザイオン化質量分析装置 |
| US9212390B2 (en) | 2010-04-30 | 2015-12-15 | Exiqon A/S | In situ hybridization method and buffer |
| US8723108B1 (en) | 2012-10-19 | 2014-05-13 | Agilent Technologies, Inc. | Transient level data acquisition and peak correction for time-of-flight mass spectrometry |
| JP2016505833A (ja) | 2012-12-14 | 2016-02-25 | マイクロマス ユーケー リミテッド | 飛行時間型msのadcデータの飛行ごとの補正 |
| KR102244494B1 (ko) * | 2013-02-09 | 2021-04-27 | 엘레멘탈 사이언티픽 레이저스 엘엘씨 | 챔버 내 유체 핸들링 시스템 및 이를 사용하여 유체를 핸들링하는 방법들 |
| KR20150114963A (ko) | 2013-02-14 | 2015-10-13 | 일렉트로 싸이언티픽 인더스트리이즈 인코포레이티드 | 조성 분석 시스템을 위한 레이저 어블레이션 셀 및 토치 시스템 |
| SG11201507853QA (en) | 2013-03-22 | 2015-10-29 | Eth Zuerich | Laser ablation cell |
| US9589779B2 (en) * | 2013-04-17 | 2017-03-07 | Fluidigm Canada Inc. | Sample analysis for mass cytometry |
| DE102013208959A1 (de) | 2013-05-15 | 2014-11-20 | Carl Zeiss Microscopy Gmbh | Vorrichtung zur massenselektiven Bestimmung eines Ions |
| JP2015087237A (ja) | 2013-10-30 | 2015-05-07 | キヤノン株式会社 | 質量分布計測方法及び質量分布計測装置 |
| US10309879B2 (en) | 2014-02-21 | 2019-06-04 | Massachusetts Institute Of Technology | Expansion microscopy |
| GB201403625D0 (en) * | 2014-02-28 | 2014-04-16 | Asrepresented By The Sec Dep Of Health And Human Services The | Multiplexed imaging of tissue samples by mass cytometry |
| JP6316041B2 (ja) | 2014-03-18 | 2018-04-25 | 株式会社東芝 | スパッタ中性粒子質量分析装置 |
| US20150279645A1 (en) | 2014-03-27 | 2015-10-01 | Kabushiki Kaisha Toshiba | Mass spectroscope and mass spectrometry |
| WO2016090356A1 (en) | 2014-12-05 | 2016-06-09 | Fluidigm Canada Inc. | Mass cytometry imaging |
| CN104697967B (zh) * | 2015-03-17 | 2017-07-11 | 北京理工大学 | 高空间分辨激光双轴共焦光谱‑质谱显微成像方法与装置 |
| CA2981496C (en) * | 2015-04-23 | 2023-09-05 | The Board Of Trustees Of The Leland Stanford Junior University | Method for multiplexed sample analysis by photoionizing secondary sputtered neutrals |
| US20170023482A1 (en) * | 2015-07-20 | 2017-01-26 | United States Of America, As Represented By The Secretary Of Commerce | Simultaneous plural color broadband coherent anti-stokes raman scattering microscope and imaging |
| CN105572216A (zh) * | 2015-12-30 | 2016-05-11 | 大连民族大学 | 一种新型飞行时间二次离子质谱 |
| US20170253918A1 (en) | 2016-03-01 | 2017-09-07 | Expansion Technologies | Combining protein barcoding with expansion microscopy for in-situ, spatially-resolved proteomics |
| US20170276578A1 (en) | 2016-03-22 | 2017-09-28 | University Of Washington | Expansion microscopy methods and kits |
| WO2018026910A1 (en) * | 2016-08-02 | 2018-02-08 | Fluidigm Canada Inc. | Sample imaging apparatus and method |
| GB2556074A (en) * | 2016-11-17 | 2018-05-23 | Micromass Ltd | Axial atmospheric pressure photo-ionization imaging source and inlet device |
| CN108133879B (zh) * | 2017-12-21 | 2020-04-03 | 厦门大学 | 用于微纳尺度形貌及化学信息同时原位获得的近场离子源 |
| US11264221B2 (en) | 2018-06-18 | 2022-03-01 | Fluidigm Canada Inc. | High resolution imaging apparatus and method |
| CN112970092B (zh) * | 2018-09-10 | 2025-08-19 | 富鲁达加拿大公司 | 高速调制样本成像设备和方法 |
-
2019
- 2019-06-18 US US17/253,538 patent/US11264221B2/en active Active
- 2019-06-18 WO PCT/US2019/037644 patent/WO2019246033A1/en not_active Ceased
- 2019-06-18 CN CN201980053879.7A patent/CN113678227B/zh active Active
- 2019-06-18 CA CA3104126A patent/CA3104126A1/en active Pending
- 2019-06-18 CN CN202411568895.9A patent/CN119480607A/zh active Pending
- 2019-06-18 EP EP19822117.8A patent/EP3807922A4/en active Pending
- 2019-06-18 JP JP2020571476A patent/JP7489333B2/ja active Active
-
2022
- 2022-01-21 US US17/580,917 patent/US11967496B2/en active Active
-
2024
- 2024-03-20 US US18/610,570 patent/US12278098B2/en active Active
- 2024-05-13 JP JP2024077914A patent/JP2024119808A/ja active Pending
-
2025
- 2025-03-13 US US19/078,618 patent/US20250246420A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021527828A5 (https=) | ||
| JPWO2019246033A5 (https=) | ||
| US20120314214A1 (en) | Laser Induced Breakdown Spectroscopy Having Enhanced Signal-to-Noise Ratio | |
| KR102151765B1 (ko) | 레이저 생성 플라즈마 극자외 광원용 타겟 | |
| US7931850B2 (en) | Nanometer-scale ablation using focused, coherent extreme ultraviolet/soft x-ray light | |
| Pfotenhauer et al. | Spectral shaping of laser generated proton beams | |
| JP2016522887A5 (https=) | ||
| Cristoforetti et al. | Effect of laser parameters on plasma shielding in single and double pulse configurations during the ablation of an aluminium target | |
| EP2313230A2 (en) | Method and apparatus for laser machining | |
| CN104142316A (zh) | 结合预烧蚀和再加热的三脉冲libs探测系统 | |
| Henyk et al. | Laser-induced ion emission from dielectrics | |
| Nicolussi et al. | Surface analysis by SNMS: Femtosecond laser postionization of sputtered and laser desorbed atoms | |
| Batool et al. | Time of flight measurements of energy and density of laser induced Mg plasma ions and investigation of ablated surface morphology | |
| Caridi et al. | Investigations on low temperature laser-generated plasmas | |
| Shaim et al. | Aluminum multicharged ion generation from femtosecond laser plasma | |
| Rusby et al. | Escaping electrons from intense laser-solid interactions as a function of laser spot size | |
| JP4286164B2 (ja) | レーザ加工モニタリングシステム | |
| Deuzeman | Generation and interactions of energetic tin ions | |
| JP2015179572A (ja) | スパッタ中性粒子質量分析装置 | |
| Brajdic et al. | In situ measurement of plasma and shock wave properties inside laser-drilled metal holes | |
| JP2007057432A (ja) | イオンの抽出方法およびその装置 | |
| CN204086140U (zh) | 一种结合预烧蚀和再加热的三脉冲libs探测系统 | |
| Hedwig et al. | Confinement effect in enhancing shock wave plasma generation at low pressure by TEA CO2 laser bombardment on quartz sample | |
| WO2008038642A1 (fr) | Procédé d'analyse d'échantillon et appareil d'analyse | |
| WO2005074003A1 (ja) | レーザ分析装置及び方法 |