JP2021518400A5 - - Google Patents
Info
- Publication number
- JP2021518400A5 JP2021518400A5 JP2020550712A JP2020550712A JP2021518400A5 JP 2021518400 A5 JP2021518400 A5 JP 2021518400A5 JP 2020550712 A JP2020550712 A JP 2020550712A JP 2020550712 A JP2020550712 A JP 2020550712A JP 2021518400 A5 JP2021518400 A5 JP 2021518400A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- hydrogen
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862647227P | 2018-03-23 | 2018-03-23 | |
| US62/647,227 | 2018-03-23 | ||
| US201962821831P | 2019-03-21 | 2019-03-21 | |
| US62/821,831 | 2019-03-21 | ||
| PCT/IB2019/052364 WO2019180683A1 (en) | 2018-03-23 | 2019-03-22 | Sting modulator compounds with sulfamate linkages, and methods of making and using |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021518400A JP2021518400A (ja) | 2021-08-02 |
| JP2021518400A5 true JP2021518400A5 (https=) | 2022-03-29 |
| JP7337086B2 JP7337086B2 (ja) | 2023-09-01 |
Family
ID=66397323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550712A Active JP7337086B2 (ja) | 2018-03-23 | 2019-03-22 | スルファメート結合を有するｓｔｉｎｇモジュレーター化合物、及び製造及び使用の方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20210015915A1 (https=) |
| EP (2) | EP4242212A3 (https=) |
| JP (1) | JP7337086B2 (https=) |
| WO (1) | WO2019180683A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| KR20200098511A (ko) | 2017-11-10 | 2020-08-20 | 다케다 야쿠힌 고교 가부시키가이샤 | Sting 조절제 화합물, 및 제조 및 사용 방법 |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
| IL302390A (en) | 2020-11-09 | 2023-06-01 | Takeda Pharmaceuticals Co | Drug antibody conjugates |
| KR20230106665A (ko) * | 2020-11-11 | 2023-07-13 | 바이오젠 엠에이 인코포레이티드 | 올리고뉴클레오티드, 시약, 및 그의 제조 방법 |
| CN119119063A (zh) | 2021-05-12 | 2024-12-13 | 勃林格殷格翰国际有限公司 | 作为cGAS抑制剂的具有N-连接环状取代基的吡啶衍生物 |
| AU2023376006A1 (en) * | 2022-11-09 | 2025-03-13 | Boehringer Ingelheim International Gmbh | Cyclic pyridine derivatives as cgas inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016538344A (ja) | 2013-11-19 | 2016-12-08 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 癌処置としてのｓｔｉｎｇアゴニストの使用 |
| WO2015074145A1 (en) * | 2013-11-22 | 2015-05-28 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| CR20160564A (es) | 2014-06-04 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos como moduladores de sting |
| BR112016030787B1 (pt) | 2014-07-01 | 2022-12-20 | Takeda Pharmaceutical Company Limited | Entidade química, composição farmacêutica e seu uso |
| EP3546473B1 (en) * | 2014-12-16 | 2025-12-10 | Kayla Therapeutics | Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction |
| WO2016096577A1 (en) | 2014-12-16 | 2016-06-23 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EA035817B1 (ru) | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| KR102222186B1 (ko) | 2015-08-13 | 2021-03-03 | 머크 샤프 앤드 돔 코포레이션 | Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 |
| JP2018534295A (ja) | 2015-10-28 | 2018-11-22 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達を活性化するための組成物および方法 |
| CN107849084B (zh) | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
| US20180369268A1 (en) | 2015-12-16 | 2018-12-27 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production |
| KR102789862B1 (ko) | 2016-01-11 | 2025-04-03 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드 |
| US10723756B2 (en) | 2016-01-11 | 2020-07-28 | Innate Tumor Immunity Inc. | Cyclic dinucleotides for treating conditions associated with STING activity such as cancer |
| NZ746112A (en) * | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| CN111712509A (zh) * | 2017-12-15 | 2020-09-25 | 詹森生物科技公司 | 作为sting激动剂的环状二核苷酸 |
-
2019
- 2019-03-22 WO PCT/IB2019/052364 patent/WO2019180683A1/en not_active Ceased
- 2019-03-22 EP EP23162945.2A patent/EP4242212A3/en active Pending
- 2019-03-22 US US17/040,083 patent/US20210015915A1/en not_active Abandoned
- 2019-03-22 EP EP19721764.9A patent/EP3768685A1/en not_active Withdrawn
- 2019-03-22 JP JP2020550712A patent/JP7337086B2/ja active Active
-
2024
- 2024-12-23 US US18/999,908 patent/US20250262298A1/en active Pending
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