JP2021517171A5 - - Google Patents
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- Publication number
- JP2021517171A5 JP2021517171A5 JP2021502678A JP2021502678A JP2021517171A5 JP 2021517171 A5 JP2021517171 A5 JP 2021517171A5 JP 2021502678 A JP2021502678 A JP 2021502678A JP 2021502678 A JP2021502678 A JP 2021502678A JP 2021517171 A5 JP2021517171 A5 JP 2021517171A5
- Authority
- JP
- Japan
- Prior art keywords
- benzaldehyde
- water
- propoxy
- mmol
- hexane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- SBJTXITWIGRBID-UHFFFAOYSA-N 3,4-bis(3-phenylpropoxy)benzaldehyde Chemical compound C=1C=CC=CC=1CCCOC1=CC(C=O)=CC=C1OCCCC1=CC=CC=C1 SBJTXITWIGRBID-UHFFFAOYSA-N 0.000 description 2
- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-dihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- PCYGLFXKCBFGPC-UHFFFAOYSA-N 3,4-Dihydroxy hydroxymethyl benzene Natural products OCC1=CC=C(O)C(O)=C1 PCYGLFXKCBFGPC-UHFFFAOYSA-N 0.000 description 1
- XMZQWZJMTBCUFT-UHFFFAOYSA-N 3-bromopropylbenzene Chemical compound BrCCCC1=CC=CC=C1 XMZQWZJMTBCUFT-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862648381P | 2018-03-26 | 2018-03-26 | |
| US62/648,381 | 2018-03-26 | ||
| PCT/KR2019/003514 WO2019190172A1 (ko) | 2018-03-26 | 2019-03-26 | 신규한 화합물 및 이를 포함하는 비만 또는 대사증후군의 예방 또는 치료용 약학적 조성물 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021517171A JP2021517171A (ja) | 2021-07-15 |
| JP2021517171A5 true JP2021517171A5 (https=) | 2021-08-26 |
| JP7029213B2 JP7029213B2 (ja) | 2022-03-03 |
Family
ID=68060316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502678A Active JP7029213B2 (ja) | 2018-03-26 | 2019-03-26 | 新規な化合物およびこれを含む肥満または代謝症候群の予防または治療用薬学的組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12065394B2 (https=) |
| EP (1) | EP3778555A4 (https=) |
| JP (1) | JP7029213B2 (https=) |
| KR (1) | KR102054399B1 (https=) |
| CN (1) | CN112105598B (https=) |
| AU (1) | AU2019243133B2 (https=) |
| TW (1) | TWI717712B (https=) |
| WO (1) | WO2019190172A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019183600A1 (en) | 2018-03-23 | 2019-09-26 | The Regents Of The University Of California | Methods and compounds for targeted autophagy |
| US12383624B2 (en) | 2018-07-24 | 2025-08-12 | Seoul National University R&Db Foundation | Cargo delivery system and composition comprising the same |
| AU2019312065A1 (en) | 2018-07-24 | 2021-02-18 | Protech Co., Ltd. | Novel autophagy-targeting chimera (AUTOTAC) compound, and composition for preventing, alleviating, or treating diseases through target protein degradation comprising same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0641766B1 (en) | 1991-10-04 | 1998-11-11 | Taisho Pharmaceutical Co. Ltd | Alkoxyphenylalkylamine derivative |
| NO179246C (no) | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| JP3421702B2 (ja) | 1993-03-26 | 2003-06-30 | 大正製薬株式会社 | シグマ受容体拮抗薬 |
| US6586433B2 (en) | 1999-09-23 | 2003-07-01 | Pharmacia Corporation | Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
| CA2658098A1 (en) | 2006-07-19 | 2008-01-24 | Osurf | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
| US9580382B2 (en) * | 2011-08-08 | 2017-02-28 | Id4Pharma, Llc | p62-ZZ chemical inhibitor |
| KR101594168B1 (ko) * | 2013-10-02 | 2016-02-15 | 서울대학교산학협력단 | p62의 ZZ 영역에 의해 매개되는 자가포식 조절 방법 및 그 용도 |
| CN107848932B (zh) | 2015-06-11 | 2025-09-02 | 解向群 | p62-ZZ化学抑制剂 |
| KR101731908B1 (ko) | 2015-08-18 | 2017-05-11 | 서울대학교산학협력단 | p62 ZZ 도메인에 결합하는 리간드 또는 아르기닌화된 BiP에 의해 매개되는 오토파지 활성을 통한 신경변성 질환 예방 및 치료 |
-
2019
- 2019-03-26 US US17/041,960 patent/US12065394B2/en active Active
- 2019-03-26 AU AU2019243133A patent/AU2019243133B2/en active Active
- 2019-03-26 CN CN201980022495.9A patent/CN112105598B/zh active Active
- 2019-03-26 TW TW108110541A patent/TWI717712B/zh active
- 2019-03-26 EP EP19774785.0A patent/EP3778555A4/en active Pending
- 2019-03-26 JP JP2021502678A patent/JP7029213B2/ja active Active
- 2019-03-26 KR KR1020190034615A patent/KR102054399B1/ko active Active
- 2019-03-26 WO PCT/KR2019/003514 patent/WO2019190172A1/ko not_active Ceased
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