JP2021516959A5 - - Google Patents
Info
- Publication number
- JP2021516959A5 JP2021516959A5 JP2020546359A JP2020546359A JP2021516959A5 JP 2021516959 A5 JP2021516959 A5 JP 2021516959A5 JP 2020546359 A JP2020546359 A JP 2020546359A JP 2020546359 A JP2020546359 A JP 2020546359A JP 2021516959 A5 JP2021516959 A5 JP 2021516959A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- protein
- compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18160384 | 2018-03-07 | ||
| EP18160384.6 | 2018-03-07 | ||
| PCT/EP2019/055509 WO2019170710A2 (en) | 2018-03-07 | 2019-03-06 | Chemoselective thiol-conjugation with alkene or alkyne-phosphonothiolates and -phosphonates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021516959A JP2021516959A (ja) | 2021-07-15 |
| JP2021516959A5 true JP2021516959A5 (https=) | 2022-03-09 |
| JP7429191B2 JP7429191B2 (ja) | 2024-02-07 |
Family
ID=61691626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546359A Active JP7429191B2 (ja) | 2018-03-07 | 2019-03-06 | アルケンホスホノチオレートまたはアルキンホスホノチオレートおよびアルケンホスホネートまたはアルキンホスホネートとの化学選択的チオールコンジュゲーション |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12453779B2 (https=) |
| EP (1) | EP3762423A2 (https=) |
| JP (1) | JP7429191B2 (https=) |
| KR (1) | KR102772724B1 (https=) |
| CN (2) | CN112088168B (https=) |
| AU (1) | AU2019232602B2 (https=) |
| BR (1) | BR112020018093A2 (https=) |
| CA (1) | CA3092286A1 (https=) |
| IL (1) | IL276981B2 (https=) |
| SG (1) | SG11202008186RA (https=) |
| WO (1) | WO2019170710A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250269046A1 (en) | 2021-02-26 | 2025-08-28 | Forschungsverbund Berlin E.V. | Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives |
| EP4326335A1 (en) | 2021-04-23 | 2024-02-28 | Forschungsverbund Berlin E.V. | Thiol-conjugation with unsaturated phosphorus(v) compounds |
| ES3001145T1 (es) | 2021-11-09 | 2025-03-04 | Tubulis Gmbh | Conjugados que comprenden un fosforo (v) y un resto de camptotecina |
| WO2023083900A1 (en) | 2021-11-09 | 2023-05-19 | Tubulis Gmbh | Conjugates comprising a phosphorus (v) and a drug moiety |
| JP2025506650A (ja) * | 2022-02-17 | 2025-03-13 | レボロ バイオセラピューティクス リミテッド | シャペロニン６０．１由来のペプチドを作製する方法 |
| EP4543893A1 (en) | 2022-06-27 | 2025-04-30 | Evexta Bio | N-substituted indole derivatives and conjugates for the treatment of cancer |
| JP2025536308A (ja) | 2022-10-18 | 2025-11-05 | テューブリス ゲーエムベーハー | 新規なＮａＰｉ２ｂ抗体を有する新規な抗体－薬物コンジュゲート、治療的方法、ならびにそれらの使用 |
| PE20251849A1 (es) | 2022-10-18 | 2025-07-22 | Tubulis Gmbh | Novedosos anticuerpo anti-tpbg y conjugados-anticuerpo-droga basados en el mismo, metodos terapeuticos y usos de los mismos |
| EP4637832A1 (en) | 2022-12-22 | 2025-10-29 | Tubulis GmbH | Conjugates comprising a phosphorus(v) moiety and a drug |
| AU2024332412A1 (en) | 2023-09-01 | 2026-03-12 | Tubulis Gmbh | Methods of preparing phosphonamidate compounds |
| US12521446B2 (en) | 2024-02-27 | 2026-01-13 | Bristol-Myers Squibb Company | Anti-CEACAM5 antibody drug conjugates |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2535174A (en) | 1949-04-07 | 1950-12-26 | Us Rubber Co | Mercaptoethanephosphonates |
| GB1346045A (en) | 1955-11-03 | 1974-02-06 | Aviat Minister Of | Manufacture of organic phosphorus compounds |
| DE1064512B (de) | 1958-03-26 | 1959-09-03 | Bayer Ag | Verfahren zur Herstellung von beta-Alkylmercaptovinylphosphon-saeurethiolestern |
| CH410942A (de) | 1957-06-05 | 1966-04-15 | Bayer Ag | Verfahren zur Herstellung von Phosphonsäurethiolestern |
| DE1072245B (de) * | 1957-06-24 | 1959-12-31 | Farbenfabriken Bayer Aktiengesellschaft, Leverkusen-Bayerwerk | Verfahren zur Herstellung von Phosphonsäure-O-alkyl-thiolestern |
| US3014943A (en) * | 1957-06-24 | 1961-12-26 | Bayer Ag | Phosphonic acid esters |
| US3223754A (en) * | 1959-12-04 | 1965-12-14 | Bayer Ag | Alkyl mercapto alkyl esters of substituted phosphonic acids |
| US3121662A (en) * | 1960-03-09 | 1964-02-18 | Bayer Ag | (thiono)-thiolphosphonic and-thiolphosphinic acid esters and a process for their production |
| NL262130A (https=) | 1960-03-09 | |||
| GB917085A (en) | 1960-12-08 | 1963-01-30 | Bayer Ag | Phosphonic and thiophosphonic acid esters |
| US3904710A (en) | 1971-08-19 | 1975-09-09 | Exxon Research Engineering Co | Pesticidal O,S{40 -dialkyl S-phenylthioalkyl dithiophosphates and preparation thereof |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| WO2009051025A1 (ja) * | 2007-10-18 | 2009-04-23 | Katayama Chemical Industries Co., Ltd. | 含リン化合物と含イオウ化合物の触媒 |
| ES2955183T3 (es) | 2011-03-11 | 2023-11-29 | Gore & Ass | Mejoras para las entidades biológicas inmovilizadas |
| CA2948082A1 (en) | 2014-05-09 | 2015-11-12 | Bayer Pharma Aktiengesellschaft | Method for targeted conjugation of peptides and proteins by paired c2 bridging of cysteine amino acids |
| AU2017320913B2 (en) * | 2016-09-01 | 2024-08-15 | Forschungsverbund Berlin E.V. | Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates |
-
2019
- 2019-03-06 KR KR1020207028795A patent/KR102772724B1/ko active Active
- 2019-03-06 CN CN201980030827.8A patent/CN112088168B/zh active Active
- 2019-03-06 CN CN202510097610.6A patent/CN120098033A/zh active Pending
- 2019-03-06 BR BR112020018093-9A patent/BR112020018093A2/pt unknown
- 2019-03-06 IL IL276981A patent/IL276981B2/en unknown
- 2019-03-06 US US16/977,680 patent/US12453779B2/en active Active
- 2019-03-06 CA CA3092286A patent/CA3092286A1/en active Pending
- 2019-03-06 JP JP2020546359A patent/JP7429191B2/ja active Active
- 2019-03-06 AU AU2019232602A patent/AU2019232602B2/en active Active
- 2019-03-06 EP EP19713707.8A patent/EP3762423A2/en active Pending
- 2019-03-06 WO PCT/EP2019/055509 patent/WO2019170710A2/en not_active Ceased
- 2019-03-06 SG SG11202008186RA patent/SG11202008186RA/en unknown
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