JP2019532041A5 - - Google Patents
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- Publication number
- JP2019532041A5 JP2019532041A5 JP2019512835A JP2019512835A JP2019532041A5 JP 2019532041 A5 JP2019532041 A5 JP 2019532041A5 JP 2019512835 A JP2019512835 A JP 2019512835A JP 2019512835 A JP2019512835 A JP 2019512835A JP 2019532041 A5 JP2019532041 A5 JP 2019532041A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- substituted
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023007868A JP2023055766A (ja) | 2016-09-01 | 2023-01-23 | アルケンホスホンアミデートまたはアルキンホスホンアミデートとの化学選択的チオールコンジュゲーション |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16001917.0 | 2016-09-01 | ||
| EP16001917 | 2016-09-01 | ||
| PCT/EP2017/071937 WO2018041985A1 (en) | 2016-09-01 | 2017-09-01 | Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023007868A Division JP2023055766A (ja) | 2016-09-01 | 2023-01-23 | アルケンホスホンアミデートまたはアルキンホスホンアミデートとの化学選択的チオールコンジュゲーション |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532041A JP2019532041A (ja) | 2019-11-07 |
| JP2019532041A5 true JP2019532041A5 (https=) | 2020-10-01 |
| JP7217225B2 JP7217225B2 (ja) | 2023-02-02 |
Family
ID=56888890
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512835A Active JP7217225B2 (ja) | 2016-09-01 | 2017-09-01 | アルケンホスホンアミデートまたはアルキンホスホンアミデートとの化学選択的チオールコンジュゲーション |
| JP2023007868A Pending JP2023055766A (ja) | 2016-09-01 | 2023-01-23 | アルケンホスホンアミデートまたはアルキンホスホンアミデートとの化学選択的チオールコンジュゲーション |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023007868A Pending JP2023055766A (ja) | 2016-09-01 | 2023-01-23 | アルケンホスホンアミデートまたはアルキンホスホンアミデートとの化学選択的チオールコンジュゲーション |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US11161873B2 (https=) |
| EP (1) | EP3506949A1 (https=) |
| JP (2) | JP7217225B2 (https=) |
| CN (2) | CN117903297A (https=) |
| AU (1) | AU2017320913B2 (https=) |
| WO (1) | WO2018041985A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102772724B1 (ko) | 2018-03-07 | 2025-02-24 | 포슝스베르분드 베를린 에.베. | 알켄 또는 알킨-포스포노티올레이트 및 -포스포네이트로의 화학선택적 티올-접합 |
| CN109666044B (zh) * | 2018-07-04 | 2021-03-05 | 浙江大学 | 基于[2.2]对环芳烷骨架的有机磷化合物及其中间体和制备方法与用途 |
| EP4065112A4 (en) * | 2019-11-22 | 2023-12-27 | The Regents of the University of California | Taspase1 inhibitors and uses thereof |
| US20230250461A1 (en) * | 2020-06-26 | 2023-08-10 | Yale University | Compositions and Methods for Selective Detection and/or Inhibition of Bacterial Pathogens in Microbial Communities |
| US20250269046A1 (en) | 2021-02-26 | 2025-08-28 | Forschungsverbund Berlin E.V. | Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives |
| EP4326335A1 (en) | 2021-04-23 | 2024-02-28 | Forschungsverbund Berlin E.V. | Thiol-conjugation with unsaturated phosphorus(v) compounds |
| WO2023083900A1 (en) | 2021-11-09 | 2023-05-19 | Tubulis Gmbh | Conjugates comprising a phosphorus (v) and a drug moiety |
| ES3001145T1 (es) | 2021-11-09 | 2025-03-04 | Tubulis Gmbh | Conjugados que comprenden un fosforo (v) y un resto de camptotecina |
| WO2023105087A1 (en) | 2021-12-10 | 2023-06-15 | Tubulis Gmbh | Novel flt3 antibodies and antibody-drug-conjugates based thereon, therapeutic methods and uses thereof in combination with tyrosine kinase inhibitors |
| EP4543893A1 (en) | 2022-06-27 | 2025-04-30 | Evexta Bio | N-substituted indole derivatives and conjugates for the treatment of cancer |
| PE20251849A1 (es) | 2022-10-18 | 2025-07-22 | Tubulis Gmbh | Novedosos anticuerpo anti-tpbg y conjugados-anticuerpo-droga basados en el mismo, metodos terapeuticos y usos de los mismos |
| JP2025536308A (ja) | 2022-10-18 | 2025-11-05 | テューブリス ゲーエムベーハー | 新規なＮａＰｉ２ｂ抗体を有する新規な抗体－薬物コンジュゲート、治療的方法、ならびにそれらの使用 |
| IL320284A (en) | 2022-10-18 | 2025-06-01 | Tubulis Gmbh | Novel anti-napi2b antibodies and antibody-drug-conjugates based thereon, therapeutic methods and uses thereof |
| EP4637832A1 (en) | 2022-12-22 | 2025-10-29 | Tubulis GmbH | Conjugates comprising a phosphorus(v) moiety and a drug |
| AU2024332412A1 (en) | 2023-09-01 | 2026-03-12 | Tubulis Gmbh | Methods of preparing phosphonamidate compounds |
| WO2025146313A1 (en) | 2024-01-04 | 2025-07-10 | Deutsches Krebsforschungszentrum | Phosphinites as reductive disulfide rebridging agents |
| US12521446B2 (en) | 2024-02-27 | 2026-01-13 | Bristol-Myers Squibb Company | Anti-CEACAM5 antibody drug conjugates |
| CN119391070A (zh) * | 2024-11-28 | 2025-02-07 | 宁波卡倍亿新材料科技有限公司 | 一种新能源汽车耐高温阻燃电缆料及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2535174A (en) | 1949-04-07 | 1950-12-26 | Us Rubber Co | Mercaptoethanephosphonates |
| DE2024250A1 (de) | 1970-05-19 | 1971-12-02 | Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt | Antimikrobielle grenzflächenaktive Mittel |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| US9023834B2 (en) | 2008-11-13 | 2015-05-05 | Taigen Biotechnology Co., Ltd. | Lyophilization formulation |
| CN102058547A (zh) * | 2009-11-12 | 2011-05-18 | 太景生物科技股份有限公司 | 冻干制剂 |
| EP3564259A3 (en) * | 2012-11-09 | 2020-02-12 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| WO2015057063A1 (en) | 2013-10-14 | 2015-04-23 | Synaffix B.V. | Modified glycoprotein, protein-conjugate and process for the preparation thereof |
| CA2948082A1 (en) | 2014-05-09 | 2015-11-12 | Bayer Pharma Aktiengesellschaft | Method for targeted conjugation of peptides and proteins by paired c2 bridging of cysteine amino acids |
-
2017
- 2017-09-01 AU AU2017320913A patent/AU2017320913B2/en active Active
- 2017-09-01 EP EP17772314.5A patent/EP3506949A1/en active Pending
- 2017-09-01 US US16/328,199 patent/US11161873B2/en active Active
- 2017-09-01 CN CN202311230447.3A patent/CN117903297A/zh active Pending
- 2017-09-01 CN CN201780053946.6A patent/CN109689112B/zh active Active
- 2017-09-01 JP JP2019512835A patent/JP7217225B2/ja active Active
- 2017-09-01 WO PCT/EP2017/071937 patent/WO2018041985A1/en not_active Ceased
-
2021
- 2021-08-30 US US17/460,791 patent/US11746124B2/en active Active
-
2023
- 2023-01-23 JP JP2023007868A patent/JP2023055766A/ja active Pending
- 2023-07-10 US US18/349,727 patent/US12171837B2/en active Active
-
2024
- 2024-11-26 US US18/960,256 patent/US20250090672A1/en active Pending
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