JP2015517577A5 - - Google Patents

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Publication number
JP2015517577A5
JP2015517577A5 JP2015514140A JP2015514140A JP2015517577A5 JP 2015517577 A5 JP2015517577 A5 JP 2015517577A5 JP 2015514140 A JP2015514140 A JP 2015514140A JP 2015514140 A JP2015514140 A JP 2015514140A JP 2015517577 A5 JP2015517577 A5 JP 2015517577A5
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JP
Japan
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aryl
het
nhr
cycloalkyl
independently
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JP2015514140A
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English (en)
Japanese (ja)
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JP2015517577A (ja
JP6653573B2 (ja
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Priority claimed from PCT/US2013/042148 external-priority patent/WO2013177241A1/en
Publication of JP2015517577A publication Critical patent/JP2015517577A/ja
Publication of JP2015517577A5 publication Critical patent/JP2015517577A5/ja
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Publication of JP6653573B2 publication Critical patent/JP6653573B2/ja
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JP2015514140A 2012-05-22 2013-05-22 シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法 Active JP6653573B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261650039P 2012-05-22 2012-05-22
US61/650,039 2012-05-22
US201361757876P 2013-01-29 2013-01-29
US61/757,876 2013-01-29
PCT/US2013/042148 WO2013177241A1 (en) 2012-05-22 2013-05-22 Method for synthesizing cycloalkanyl(b}indoles, cycloalkanyl(b) benzofurans, cycloalkanyl(b)benzothiophenes, compounds and methods of use

Publications (3)

Publication Number Publication Date
JP2015517577A JP2015517577A (ja) 2015-06-22
JP2015517577A5 true JP2015517577A5 (https=) 2016-07-07
JP6653573B2 JP6653573B2 (ja) 2020-02-26

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ID=49624309

Family Applications (1)

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JP2015514140A Active JP6653573B2 (ja) 2012-05-22 2013-05-22 シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法

Country Status (4)

Country Link
US (1) US9598365B2 (https=)
EP (1) EP2887804B1 (https=)
JP (1) JP6653573B2 (https=)
WO (1) WO2013177241A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3230279A1 (en) 2014-12-10 2017-10-18 Massachusetts Institute of Technology Fused 1,3-azole derivatives useful for the treatment of proliferative diseases
US10526287B2 (en) 2015-04-23 2020-01-07 Constellation Pharmaceuticals, Inc. LSD1 inhibitors and uses thereof
CA3001065A1 (en) 2015-10-14 2017-04-20 Xiaoxi WEI Compositions and methods for reducing ice crystal formation
KR20180107261A (ko) 2016-02-16 2018-10-01 메사추세츠 인스티튜트 오브 테크놀로지 Myc 조정제로서의 MAX 결합제 및 그의 용도
TWI753037B (zh) 2016-10-26 2022-01-21 美商星座製藥公司 Lsd1抑制劑及其用途
US11633379B2 (en) 2017-01-04 2023-04-25 Trustees Of Dartmouth College Methods of inhibiting PCSK9
JP2023532888A (ja) * 2020-06-27 2023-08-01 クレセンタ バイオサイエンシズ 細胞代謝を調節する化合物の組成及び使用方法
US12138243B2 (en) 2021-12-31 2024-11-12 Crescenta Biosciences Antiviral use of FABP4 modulating compounds
CN120590310B (zh) * 2025-08-07 2025-10-28 昆明医科大学 一种吲哚-3-芳基酮衍生物及其制备方法和应用
CN121102205B (zh) * 2025-11-17 2026-02-17 昆明医科大学 一种吲哚-3-芳基酮衍生物在制备治疗或预防金黄色葡萄球菌引起的感染性疾病的药物中的用途

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3696118A (en) * 1970-04-22 1972-10-03 Marcel K Eberle SPIRO NORBORNANE 6,9-METHANOCYCLOHEPT(b)INDOLES
US3931288A (en) * 1972-03-13 1976-01-06 Hoffmann-La Roche Inc. Alkyl esters of 4-chlorophenoxy-4-oxo-cycloalkyl-carboxylic acid
US4755505A (en) * 1987-08-18 1988-07-05 American Home Products Corporation 1-[2-(dialkylamino)alkyl]-4,5-dihydro-4-(aryl)-1-benzazocine-2,6(1H,3H)-diones as anti-arrhythmic agents
EP1184373A4 (en) 1999-04-20 2004-10-20 Meiji Seika Kaisha TRICYCLIC CONNECTIONS
EP1330457B1 (en) * 2000-11-03 2004-10-20 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
AU2003231509A1 (en) 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Compound exhibiting pgd 2 receptor antagonism
WO2004063156A1 (en) 2003-01-08 2004-07-29 Biovitrum Ab Novel indole derivates as fabp-4 inhibitors
WO2004069831A1 (en) * 2003-02-10 2004-08-19 Glenmark Pharmaceuticals Ltd. Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation
ES2314446T3 (es) 2003-06-10 2009-03-16 Smithkline Beecham Corporation Derivados de tetrahidrocarbazol y su uso farmaceutico.
ES2320663T3 (es) 2003-08-26 2009-05-27 Smithkline Beecham Corporation Nuevos indoles cicloalquil(b) condensados.
WO2005094833A1 (en) 2004-03-31 2005-10-13 Council Of Scientific And Industrial Research Novel n-substituted dihydrobenzothiepino, dihydrobenzoxepino and tetrahydro benzocyclohepta indoles as selective estrogen receptor modulators
AU2005300030B2 (en) 2004-09-20 2012-01-12 Janssen Pharmaceutica N.V. Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
US7338973B2 (en) 2004-09-20 2008-03-04 Janssen Pharmaceutica N.V. Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
EP1817295B1 (en) 2004-11-18 2012-11-07 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
JP2008520674A (ja) 2004-11-22 2008-06-19 スミスクライン ビーチャム コーポレーション Ｈｃｖインヒビター
EP1824476A2 (en) 2004-11-22 2007-08-29 SmithKline Beecham Corporation Tetrahydrocarbazole derivatives for treating flaviridae viruses
EP1919920B1 (en) 2005-08-12 2011-05-18 Genentech, Inc. Pentacyclic kinase inhibitors
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
AU2007284537B2 (en) 2006-08-17 2012-04-12 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
CL2009000725A1 (es) 2008-03-24 2009-05-29 Medivation Technologies Inc Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico.
WO2010036998A2 (en) 2008-09-29 2010-04-01 Abbott Laboratories Indole and indoline derivatives and methods of use thereof
WO2010054382A1 (en) 2008-11-10 2010-05-14 Elixir Pharmaceuticals, Inc. Compounds, compositions, and methods for treating malaria or leishmaniasis
JP5497284B2 (ja) * 2008-12-08 2014-05-21 ユー・ディー・シー アイルランド リミテッド 白色有機電界発光素子
DK2410844T3 (en) 2009-03-27 2016-07-04 Merck Sharp & Dohme Inhibitors of hepatitis C virus replication
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8575186B2 (en) 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
WO2011084433A2 (en) 2009-12-17 2011-07-14 Abbott Laboratories Aza-bridged ring-fused indoles and indolines
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
WO2012054526A2 (en) * 2010-10-19 2012-04-26 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies

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