JP2021514618A5 - - Google Patents
Info
- Publication number
- JP2021514618A5 JP2021514618A5 JP2020543995A JP2020543995A JP2021514618A5 JP 2021514618 A5 JP2021514618 A5 JP 2021514618A5 JP 2020543995 A JP2020543995 A JP 2020543995A JP 2020543995 A JP2020543995 A JP 2020543995A JP 2021514618 A5 JP2021514618 A5 JP 2021514618A5
- Authority
- JP
- Japan
- Prior art keywords
- igm
- antibody
- variant
- amino acid
- constant region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023183845A JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862637186P | 2018-03-01 | 2018-03-01 | |
| US62/637,186 | 2018-03-01 | ||
| PCT/US2019/020374 WO2019169314A1 (en) | 2018-03-01 | 2019-03-01 | IgM Fc AND J-CHAIN MUTATIONS THAT AFFECT IgM SERUM HALF-LIFE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023183845A Division JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021514618A JP2021514618A (ja) | 2021-06-17 |
| JP2021514618A5 true JP2021514618A5 (enExample) | 2022-03-07 |
| JP7376490B2 JP7376490B2 (ja) | 2023-11-08 |
Family
ID=67805543
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543995A Active JP7376490B2 (ja) | 2018-03-01 | 2019-03-01 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
| JP2023183845A Pending JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023183845A Pending JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10899835B2 (enExample) |
| EP (1) | EP3758752A4 (enExample) |
| JP (2) | JP7376490B2 (enExample) |
| KR (1) | KR102745232B1 (enExample) |
| CN (1) | CN111787951B (enExample) |
| AU (2) | AU2019227984A1 (enExample) |
| BR (1) | BR112020017296A2 (enExample) |
| IL (1) | IL276590A (enExample) |
| MX (1) | MX2020009069A (enExample) |
| SG (1) | SG11202008343YA (enExample) |
| WO (1) | WO2019169314A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3105250B1 (en) | 2014-02-10 | 2020-08-05 | IGM Biosciences, Inc. | Iga multi-specific binding molecules |
| PL3560954T3 (pl) | 2014-04-03 | 2021-12-13 | Igm Biosciences, Inc. | Zmodyfikowany łańcuch J |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| EP3957738A1 (en) | 2015-03-04 | 2022-02-23 | IGM Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| CN107847591B (zh) | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
| EP3355913B1 (en) | 2015-09-30 | 2024-10-30 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| SG11201809336QA (en) | 2016-05-09 | 2018-11-29 | Igm Biosciences Inc | Anti-pd-l1 antibodies |
| MX2019011986A (es) | 2017-04-07 | 2019-11-07 | Igm Biosciences Inc | Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas. |
| MX2020009069A (es) | 2018-03-01 | 2020-10-08 | Igm Biosciences Inc | Mutaciones de fc de igm y de la cadena j que afectan la semivida de igm en suero. |
| JP2022544405A (ja) | 2019-08-15 | 2022-10-18 | アイジーエム バイオサイエンシズ インコーポレイテッド | 免疫刺激性多量体型結合分子 |
| KR20220045030A (ko) * | 2019-08-17 | 2022-04-12 | 아이쥐엠 바이오사이언스 인코포레이티드 | 다량체성 이중특이적 항-cd123 결합 분자 및 이의 용도 |
| AU2020351205A1 (en) * | 2019-09-19 | 2022-04-14 | Igm Biosciences, Inc. | Multimeric antibodies with enhanced selectivity for cells with high target density |
| CN110669134A (zh) * | 2019-10-15 | 2020-01-10 | 广东菲鹏生物有限公司 | IgM-FC片段、IgM-FC抗体及制备方法和应用 |
| BR112022013071A2 (pt) * | 2020-01-06 | 2022-09-20 | Igm Biosciences Inc | Moléculas de ligação multiméricas altamente sialiladas |
| EP4139362A2 (en) | 2020-04-22 | 2023-03-01 | IGM Biosciences Inc. | Pd-1 agonist multimeric binding molecules |
| JP2023526224A (ja) * | 2020-05-12 | 2023-06-21 | アイジーエム バイオサイエンシズ インコーポレイテッド | がんを治療するための、がん治療薬との組合せでの多量体抗ｄｒ５結合分子の使用 |
| US20220033851A1 (en) * | 2020-08-03 | 2022-02-03 | Roger B. Swartz | mRNA, episomal and genomic integrated lentiviral and gammaretroviral vector expression of dimeric immunoglobulin A and polymeric immunoglobulin A to Enable Mucosal and Hematological Based Immunity/Protection via Gene Therapy for Allergens, viruses, HIV, bacteria, pneumonia, infections, pathology associated proteins, systemic pathologies, cancer, toxins and unnatural viruses. CAR engineered and non-CAR engineered immune cell expression of dimeric immunoglobulin A and polymeric immunoglobulin A. |
| WO2022080912A1 (ko) * | 2020-10-16 | 2022-04-21 | 주식회사 아이엠바이오로직스 | IgM 영역을 이용한 융합단백질 플랫폼 |
| US20240076392A1 (en) * | 2021-02-17 | 2024-03-07 | Igm Biosciences, Inc. | Anti-cd123 binding molecules and uses thereof |
| EP4403569A4 (en) * | 2021-09-13 | 2025-10-29 | Shenyang Eye Industry Tech Institute Ltd | Humanized Monoclonal Antibody Against Periostin, Method of Preparation Thereof and Its Use |
| WO2023064766A1 (en) * | 2021-10-11 | 2023-04-20 | Igm Biosciences, Inc. | Lateral flow device and uses thereof |
| US20250326844A1 (en) | 2022-04-07 | 2025-10-23 | Repertoire Immune Medicines, Inc. | T cell receptor multimers and uses thereof |
| AU2023253516A1 (en) * | 2022-04-15 | 2024-11-21 | Imbiologics Corp. | Fusion protein platform with improved half-life |
| CN121405820A (zh) * | 2025-12-29 | 2026-01-27 | 江苏谱新生物医药有限公司 | 一种病毒包膜嵌合受体及其相关生物材料和应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US6045774A (en) * | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
| EP1015493A1 (en) * | 1997-01-10 | 2000-07-05 | EPIcyte Pharmaceutical, Inc. | Novel epithelial tissue targeting agent |
| US20050129616A1 (en) | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US20040248299A1 (en) | 2002-12-27 | 2004-12-09 | Sumedha Jayasena | RNA interference |
| US20050014932A1 (en) | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
| DK1814913T3 (en) | 2004-11-05 | 2015-09-28 | Univ Leland Stanford Junior | ANTIBODY-INDUCED CELL membrane damage. |
| BRPI0611445A2 (pt) * | 2005-05-09 | 2010-09-08 | Glycart Biotechnology Ag | molécula de ligação a antìgeno glicomanipulada, polinucleotìdeo, polipeptìdeo, vetor, célula hospedeira, método para produção, uso e composição farmacêutica |
| US20110130324A1 (en) | 2008-07-14 | 2011-06-02 | Uchicago Argonne, Llc | Methods for systematic control of protein stability |
| JP5898082B2 (ja) * | 2009-10-07 | 2016-04-06 | マクロジェニクス，インコーポレーテッド | フコシル化程度の変更により改良されたエフェクター機能を示すＦｃ領域含有ポリペプチドおよびその使用法 |
| WO2013120012A2 (en) | 2012-02-08 | 2013-08-15 | Igm Biosciences Inc. | Cdim binding proteins and uses thereof |
| MX367668B (es) | 2013-03-15 | 2019-08-30 | Dana Farber Cancer Inst Inc | Anticuerpos neutralizadores de flavivirus y métodos de uso de los mismos. |
| CA2922830A1 (en) | 2013-09-05 | 2015-04-16 | Igm Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| EP3105250B1 (en) | 2014-02-10 | 2020-08-05 | IGM Biosciences, Inc. | Iga multi-specific binding molecules |
| PL3560954T3 (pl) | 2014-04-03 | 2021-12-13 | Igm Biosciences, Inc. | Zmodyfikowany łańcuch J |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| EP3957738A1 (en) | 2015-03-04 | 2022-02-23 | IGM Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| CN107847591B (zh) | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
| CN108025322B (zh) * | 2015-07-09 | 2021-04-13 | 分配技术有限公司 | 用于流体的剂量分配的系统和制造方法 |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| EP3355913B1 (en) * | 2015-09-30 | 2024-10-30 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| SG11201809336QA (en) | 2016-05-09 | 2018-11-29 | Igm Biosciences Inc | Anti-pd-l1 antibodies |
| JP2019530640A (ja) | 2016-07-20 | 2019-10-24 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多量体ｏｘ４０結合分子及びその使用 |
| AU2017299608A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric CD137/4-1BB binding molecules and uses thereof |
| MX2019000799A (es) | 2016-07-20 | 2019-06-03 | Igm Biosciences Inc | Moleculas de union a gitr multimericas y usos de las mismas. |
| EP3496536A4 (en) | 2016-07-20 | 2020-02-12 | IGM Biosciences, Inc. | MULTIMERE CD40-BINDING MOLECULES AND USES THEREOF |
| MX2019011986A (es) | 2017-04-07 | 2019-11-07 | Igm Biosciences Inc | Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas. |
| EP3759229A4 (en) | 2018-02-26 | 2021-12-29 | IGM Biosciences Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| MX2020009069A (es) | 2018-03-01 | 2020-10-08 | Igm Biosciences Inc | Mutaciones de fc de igm y de la cadena j que afectan la semivida de igm en suero. |
| US20210380701A1 (en) * | 2018-10-23 | 2021-12-09 | Igm Biosciences, Inc. | MULTIVALENT IgM- AND IgA-Fc-BASED BINDING MOLECULES |
| US20220106398A1 (en) * | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
-
2019
- 2019-03-01 MX MX2020009069A patent/MX2020009069A/es unknown
- 2019-03-01 WO PCT/US2019/020374 patent/WO2019169314A1/en not_active Ceased
- 2019-03-01 BR BR112020017296-0A patent/BR112020017296A2/pt unknown
- 2019-03-01 KR KR1020207023441A patent/KR102745232B1/ko active Active
- 2019-03-01 CN CN201980016388.5A patent/CN111787951B/zh active Active
- 2019-03-01 JP JP2020543995A patent/JP7376490B2/ja active Active
- 2019-03-01 EP EP19760662.7A patent/EP3758752A4/en active Pending
- 2019-03-01 AU AU2019227984A patent/AU2019227984A1/en not_active Abandoned
- 2019-03-01 SG SG11202008343YA patent/SG11202008343YA/en unknown
-
2020
- 2020-03-23 US US16/827,100 patent/US10899835B2/en active Active
- 2020-08-09 IL IL276590A patent/IL276590A/en unknown
- 2020-12-03 US US17/110,550 patent/US20210087273A1/en not_active Abandoned
-
2023
- 2023-10-26 JP JP2023183845A patent/JP2024016093A/ja active Pending
- 2023-12-29 US US18/400,974 patent/US20240124584A1/en active Pending
-
2025
- 2025-11-21 AU AU2025271120A patent/AU2025271120A1/en active Pending
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