JP2020519293A5 - - Google Patents
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- Publication number
- JP2020519293A5 JP2020519293A5 JP2019562424A JP2019562424A JP2020519293A5 JP 2020519293 A5 JP2020519293 A5 JP 2020519293A5 JP 2019562424 A JP2019562424 A JP 2019562424A JP 2019562424 A JP2019562424 A JP 2019562424A JP 2020519293 A5 JP2020519293 A5 JP 2020519293A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence identity
- mtcr
- cell receptor
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 31
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 3
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108700031361 Brachyury Proteins 0.000 description 23
- 229920001184 polypeptide Polymers 0.000 description 23
- 102000004196 processed proteins & peptides Human genes 0.000 description 23
- 108090000765 processed proteins & peptides Proteins 0.000 description 23
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762505406P | 2017-05-12 | 2017-05-12 | |
| US62/505,406 | 2017-05-12 | ||
| US201762609614P | 2017-12-22 | 2017-12-22 | |
| US62/609,614 | 2017-12-22 | ||
| US201862625051P | 2018-02-01 | 2018-02-01 | |
| US62/625,051 | 2018-02-01 | ||
| PCT/US2018/030637 WO2018208553A1 (en) | 2017-05-12 | 2018-05-02 | Human alpha fetoprotein-specific t cell receptors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519293A JP2020519293A (ja) | 2020-07-02 |
| JP2020519293A5 true JP2020519293A5 (enExample) | 2021-06-10 |
| JP7169298B2 JP7169298B2 (ja) | 2022-11-10 |
Family
ID=64095949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019562424A Active JP7169298B2 (ja) | 2017-05-12 | 2018-05-02 | ヒトアルファフェトタンパク質特異的ｔ細胞受容体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11041011B2 (enExample) |
| EP (1) | EP3622074A4 (enExample) |
| JP (1) | JP7169298B2 (enExample) |
| KR (1) | KR20200006985A (enExample) |
| CN (1) | CN110662760A (enExample) |
| AU (1) | AU2018266562A1 (enExample) |
| SG (1) | SG11201909751TA (enExample) |
| WO (1) | WO2018208553A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200006985A (ko) | 2017-05-12 | 2020-01-21 | 오거스타 유니버시티 리서치 인스티튜트, 인크. | 인간 알파 태아단백-특이적 t 세포 수용체 및 이의 용도 |
| CN110776562B (zh) * | 2018-07-30 | 2022-06-17 | 香雪生命科学技术（广东）有限公司 | 一种识别afp抗原的t细胞受体 |
| CN113072636B (zh) * | 2020-01-06 | 2024-05-28 | 香雪生命科学技术（广东）有限公司 | 一种识别afp的t细胞受体及其编码序列 |
| CN113321725B (zh) * | 2020-02-28 | 2024-06-11 | 香雪生命科学技术（广东）有限公司 | 一种识别afp的t细胞受体 |
| CN113684258B (zh) * | 2020-05-18 | 2024-08-20 | 上海赛比曼生物科技有限公司 | 用于检测鼠源tcr转基因拷贝数的试剂盒及方法 |
| CN115181177A (zh) * | 2021-04-02 | 2022-10-14 | 香雪生命科学技术（广东）有限公司 | 针对afp的t细胞受体 |
| US20240279318A1 (en) * | 2021-05-31 | 2024-08-22 | Nanjing Legend Biotech Co., Ltd. | Antibodies targeting afp peptide/mhc complexes and uses thereof |
| CN114121142B (zh) * | 2021-09-02 | 2023-10-31 | 四川大学华西医院 | 一种新型基因修饰增强型ny-eso-1特异型tcr-t模型构建方法及应用 |
| CN114853880B (zh) * | 2022-04-24 | 2023-11-10 | 中国科学院微生物研究所 | Wt1抗原特异性t细胞受体及其抗肿瘤用途 |
| WO2024159087A1 (en) * | 2023-01-26 | 2024-08-02 | Dana-Farber Cancer Institute, Inc. | Developing a car-engager platform to enhance the functionality and/or persistence of car t cells |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2975607B2 (ja) | 1989-03-16 | 1999-11-10 | 三洋電機株式会社 | Ａｆｃ回路 |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| EP0656946B2 (en) | 1992-08-21 | 2010-03-31 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| DE69427974T2 (de) | 1993-04-29 | 2001-12-06 | Unilever N.V., Rotterdam | Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae |
| GB9325182D0 (en) | 1993-12-08 | 1994-02-09 | T Cell Sciences Inc | Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions |
| WO2007131092A2 (en) | 2006-05-03 | 2007-11-15 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Chimeric t cell receptors and related materials and methods of use |
| EP1878744A1 (en) | 2006-07-13 | 2008-01-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them |
| US8105831B2 (en) * | 2007-03-09 | 2012-01-31 | University Of Washington | Parvoviral production of HLA homozygous cells |
| EP2504358B1 (en) | 2009-11-24 | 2016-10-19 | ChronTech Pharma AB | T cell receptors specific for immunodominant ctl epitopes of hcv |
| EP2618835B1 (en) * | 2010-09-20 | 2017-07-05 | BioNTech Cell & Gene Therapies GmbH | Antigen-specific t cell receptors and t cell epitopes |
| GB201313377D0 (en) * | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| ES2761280T3 (es) | 2013-09-12 | 2020-05-19 | Icahn School Med Mount Sinai | Métodos de producción de animales transgénicos con receptores de células T que son específicos de una proteína fluorescente |
| CN104087592B (zh) * | 2014-05-13 | 2016-01-27 | 天津医科大学总医院 | Afp158-166特异性tcr基因及其转基因t细胞及体外增殖方法及用途 |
| PL3223850T3 (pl) * | 2014-11-26 | 2020-08-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Receptory limfocytów t przeciwko zmutowanemu kras |
| CN105802909B (zh) | 2014-12-31 | 2021-01-01 | 中国医学科学院基础医学研究所 | 具有her2特异性tcr的t细胞制备物及其用途 |
| KR20200006985A (ko) | 2017-05-12 | 2020-01-21 | 오거스타 유니버시티 리서치 인스티튜트, 인크. | 인간 알파 태아단백-특이적 t 세포 수용체 및 이의 용도 |
-
2018
- 2018-05-02 KR KR1020197035091A patent/KR20200006985A/ko not_active Ceased
- 2018-05-02 WO PCT/US2018/030637 patent/WO2018208553A1/en not_active Ceased
- 2018-05-02 AU AU2018266562A patent/AU2018266562A1/en not_active Abandoned
- 2018-05-02 SG SG11201909751T patent/SG11201909751TA/en unknown
- 2018-05-02 EP EP18799369.6A patent/EP3622074A4/en active Pending
- 2018-05-02 JP JP2019562424A patent/JP7169298B2/ja active Active
- 2018-05-02 CN CN201880030341.XA patent/CN110662760A/zh active Pending
- 2018-05-02 US US15/969,211 patent/US11041011B2/en active Active
-
2021
- 2021-06-21 US US17/353,409 patent/US12173045B2/en active Active