JP2021512922A5 - - Google Patents

Info

Publication number
JP2021512922A5
JP2021512922A5 JP2020542875A JP2020542875A JP2021512922A5 JP 2021512922 A5 JP2021512922 A5 JP 2021512922A5 JP 2020542875 A JP2020542875 A JP 2020542875A JP 2020542875 A JP2020542875 A JP 2020542875A JP 2021512922 A5 JP2021512922 A5 JP 2021512922A5
Authority
JP
Japan
Prior art keywords
compound
methyl
mixtures
compound according
hydrogen
Prior art date
Application number
JP2020542875A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021512922A (ja
JPWO2019155468A5 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IL2019/050151 external-priority patent/WO2019155468A1/en
Publication of JP2021512922A publication Critical patent/JP2021512922A/ja
Publication of JPWO2019155468A5 publication Critical patent/JPWO2019155468A5/ja
Publication of JP2021512922A5 publication Critical patent/JP2021512922A5/ja
Pending legal-status Critical Current

Links

JP2020542875A 2018-02-08 2019-02-07 ヘテロアリール化合物、それらの医薬組成物、及びそれら治療的使用 Pending JP2021512922A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862627908P 2018-02-08 2018-02-08
US201862627921P 2018-02-08 2018-02-08
US62/627,908 2018-02-08
US62/627,921 2018-02-08
PCT/IL2019/050151 WO2019155468A1 (en) 2018-02-08 2019-02-07 Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use

Publications (3)

Publication Number Publication Date
JP2021512922A JP2021512922A (ja) 2021-05-20
JPWO2019155468A5 JPWO2019155468A5 (https=) 2022-02-17
JP2021512922A5 true JP2021512922A5 (https=) 2022-02-17

Family

ID=65635772

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020542875A Pending JP2021512922A (ja) 2018-02-08 2019-02-07 ヘテロアリール化合物、それらの医薬組成物、及びそれら治療的使用

Country Status (11)

Country Link
US (2) US20200383984A1 (https=)
EP (1) EP3749666A1 (https=)
JP (1) JP2021512922A (https=)
KR (1) KR20200130287A (https=)
CN (1) CN111971280A (https=)
AU (1) AU2019219678A1 (https=)
BR (1) BR112020016064A2 (https=)
CA (1) CA3090063A1 (https=)
IL (1) IL276290A (https=)
MX (1) MX2020008375A (https=)
WO (1) WO2019155468A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX384172B (es) 2015-08-04 2025-03-14 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Derivados de pirazol pirimidina y sus usos.
IL288547B2 (en) * 2019-06-03 2025-10-01 Biotheryx Inc Non-hygroscopic crystalline pyrazole compound salts, pharmaceutical preparations thereof and use thereof
US20230047732A1 (en) * 2020-01-13 2023-02-16 Biotheryx, Inc. Pyrazolylpyrimidines and use thereof
WO2022204220A1 (en) * 2021-03-24 2022-09-29 Biotheryx, Inc. Pyrazolylpyrimidines for treating malignant solid tumor
US11752151B2 (en) * 2021-07-12 2023-09-12 Buddhist Tzu Chi Medical Foundation Method for enhancing hair growth
US20230053307A1 (en) * 2021-07-19 2023-02-16 Buddhist Tzu Chi Medical Foundation Method for preventing or treating skin disorders and conditions
CN119255980A (zh) * 2022-06-01 2025-01-03 西姆莱斯股份公司 具有环丙基结构的香料

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637809A (en) 1968-07-05 1972-01-25 Ciba Geigy Corp Antioxidants
US3698123A (en) 1971-12-06 1972-10-17 Carl R Heldt Structural toys
US3917899A (en) 1972-08-04 1975-11-04 Michael J Oliver Plate for adjustably mounting electrical receptacle
US3846770A (en) 1973-07-11 1974-11-05 Us Navy Serial access memory using magnetic domains in thin film strips
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
DE2839461C2 (de) 1978-09-11 1987-01-15 Bergwerksverband Gmbh, 4300 Essen Formmassen aus thermoplastischen Kunststoffen und Rückständen der Kohlehydrierung
US4328246A (en) 1979-08-14 1982-05-04 Joseph Gold Anti Walker 256 carcinoma agent and combination thereof
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US5762756A (en) 1994-11-21 1998-06-09 The Black Clawson Company Methods and apparatus for pulping and deinking
US6069696A (en) 1995-06-08 2000-05-30 Psc Scanning, Inc. Object recognition system and method
US6576139B1 (en) 1996-07-30 2003-06-10 Kenneth C. Hou Process for purifying photoresist composition employing a filter sheet
DE19630939C1 (de) 1996-07-31 1997-12-11 Siemens Ag Kontaktfeder
KR100218318B1 (ko) 1996-10-01 1999-09-01 문정환 주파수 변환장치
US7274662B1 (en) 1998-08-04 2007-09-25 At&T Corp. Method for performing segmented resource reservation
US6062668A (en) 1996-12-12 2000-05-16 Hitachi Koki Imaging Solutions, Inc. Drop detector for ink jet apparatus
US6364667B1 (en) 1997-03-14 2002-04-02 Relational Technologies Llp Techniques for mastering a body of knowledge by writing questions about the body of knowledge
US6073643A (en) 1998-09-14 2000-06-13 Patent Category Corp. Adjustable collapsible panels
MXPA02001565A (es) * 1999-08-13 2005-07-14 Vertex Pharma Inhibidores de cinasas c-jun n-terminal (jnk) y de otras cinasas proteicas.
DE20019821U1 (de) 1999-12-09 2001-06-07 BRAND GMBH + CO KG, 97877 Wertheim Dosiereinrichtung für Flüssigkeiten
JP2003520658A (ja) 2000-01-27 2003-07-08 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 脊柱の幾何学的データを抽出する方法及びシステム
AU782084B2 (en) 2000-08-15 2005-06-30 Baker Hughes Incorporated Self lubricating swage
AP2001002264A0 (en) 2000-08-30 2001-09-30 Pfizer Prod Inc Sustained release formulations for growth hormone secretagogues.
MXPA03002200A (es) 2000-09-13 2007-10-02 Interdigital Tech Corp Intercalador de modem fdd de tercera generacion.
WO2002028911A2 (en) 2000-10-02 2002-04-11 The University Of Akron Synthesis and characterization of nanocomposites by emulsion polymerization
US7113943B2 (en) 2000-12-06 2006-09-26 Content Analyst Company, Llc Method for document comparison and selection
US7120761B2 (en) 2000-12-20 2006-10-10 Fujitsu Limited Multi-port memory based on DRAM core
JP4007767B2 (ja) 2001-01-18 2007-11-14 日本碍子株式会社 圧電/電歪デバイスおよびその製造方法
US6709874B2 (en) 2001-01-24 2004-03-23 Infineon Technologies Ag Method of manufacturing a metal cap layer for preventing damascene conductive lines from oxidation
US6980946B2 (en) 2001-03-15 2005-12-27 Microsoft Corporation Method for hybrid processing of software instructions of an emulated computer system
WO2002077657A1 (en) 2001-03-22 2002-10-03 Fujitsu Limited Magnetoresistive spin-valve sensor and magnetic storage apparatus
JP4124607B2 (ja) 2001-04-06 2008-07-23 ヤマウチ株式会社 ピンチローラおよびピンチローラ装置
US6840774B2 (en) 2001-05-07 2005-01-11 Jack W. Fretwell, Jr. System to teach, measure and rate learner knowledge of basic mathematics facts
US6798220B1 (en) 2001-06-27 2004-09-28 Timothy H. Flanigan Moisture/mold detector
WO2003004492A1 (en) * 2001-07-03 2003-01-16 Vertex Pharmaceuticals Incorporated Isoxazolyl-pyrimidines as inhibitors of src and lck protein kinases
US6891474B1 (en) 2001-08-01 2005-05-10 Tagsense, Inc. Electromagnetic identification label for anti-counterfeiting, authentication, and tamper-protection
US7345559B2 (en) 2001-09-13 2008-03-18 General Electric Company High field open MRI magnet isolation system and method
US6965468B2 (en) 2003-07-03 2005-11-15 Reflectivity, Inc Micromirror array having reduced gap between adjacent micromirrors of the micromirror array
US7039976B2 (en) 2002-04-09 2006-05-09 Maytag Corporation Braking control system for a washing machine
US6739477B1 (en) 2002-04-12 2004-05-25 Floro Pascual Golf ball dispenser
US7048737B2 (en) 2002-06-11 2006-05-23 Bioplate, Inc. Cranial bone flap fixation system and method
WO2004001741A1 (en) 2002-06-21 2003-12-31 Seagate Technology Llc Fluid dynamic bearing asymmetry pressure feedback
CA2496197A1 (en) * 2002-08-20 2004-03-04 Neurogen Corporation 5-substituted-2-arylpyrazines as modulators of crf receptors
DE10240053A1 (de) 2002-08-30 2004-03-11 Robert Bosch Gmbh Brückenzünder-Zündelement
US6739108B2 (en) 2002-09-30 2004-05-25 Allpax Products, Inc. Fragile container handling system for retort/sterilization processes
JP2004158619A (ja) 2002-11-06 2004-06-03 Matsushita Electric Ind Co Ltd 電子デバイスおよびその製造方法
US6712069B1 (en) 2002-11-20 2004-03-30 William L. Spangler Solar energy collection and storage system
US7139876B2 (en) 2003-01-16 2006-11-21 Ip-First, Llc Microprocessor and apparatus for performing fast speculative pop operation from a stack memory cache
ITBO20030105A1 (it) 2003-02-28 2004-09-01 Fasco Spa Pistola pneumatica per elementi di fissaggio.
CN100425492C (zh) 2003-03-19 2008-10-15 日本精工株式会社 电动转向装置以及其中使用的树脂齿轮
US7248373B2 (en) 2003-03-21 2007-07-24 Durr Systems, Inc Workpiece configuration detection system and method
US6867376B2 (en) 2003-04-17 2005-03-15 Bellsouth Intellectual Property Corporation Glow rods with externally mountable anchoring members and related methods
US7069377B2 (en) 2003-05-08 2006-06-27 Micron Technology, Inc. Scratch control memory array in a flash memory device
FR2854693B1 (fr) 2003-05-09 2005-07-01 Siemens Vdo Automotive Procede de determination de l'energie d'un signal de cliquetis pour moteur a combustion interne
EP1658083B1 (en) 2003-06-19 2007-08-08 BODOR, Nicholas S. Enhancement of activity and/or duration of action of selected anti-inflammatory steroids
US6993866B1 (en) 2003-06-25 2006-02-07 James Strange Fishing bait rig attachment apparatus with rotating rattle
US6922367B2 (en) 2003-07-09 2005-07-26 Micron Technology, Inc. Data strobe synchronization circuit and method for double data rate, multi-bit writes
JP4183181B2 (ja) 2003-08-07 2008-11-19 株式会社小松製作所 異物除去装置
DE102004027446B4 (de) 2004-06-04 2007-08-23 Jungheinrich Aktiengesellschaft Vorrichtung zur Unterstützung des Ein- und Ausstapelns bei einem Stapler
US7197360B1 (en) 2005-01-12 2007-03-27 Pacesetter, Inc. Methods and systems for using an inductor to increase capacitor reformation efficiency in an implantable cardiac device (ICD)
US7377471B1 (en) 2005-06-06 2008-05-27 Compton Harry L Method and system for opening and securing a railroad frog
US7271369B2 (en) 2005-08-26 2007-09-18 Aem, Inc. Multilayer positive temperature coefficient device and method of making the same
WO2007129195A2 (en) * 2006-05-04 2007-11-15 Pfizer Products Inc. 4-pyrimidine-5-amino-pyrazole compounds
JP4666514B2 (ja) 2006-07-20 2011-04-06 リンテック株式会社 シート剥離装置及び剥離方法
US7799600B2 (en) 2007-05-31 2010-09-21 Chien-Min Sung Doped diamond LED devices and associated methods
US7689648B2 (en) 2007-06-27 2010-03-30 Microsoft Corporation Dynamic peer network extension bridge
PE20121066A1 (es) * 2009-06-19 2012-09-13 Abbvie Inc Derivados de diazahomoadamantano y metodos para usarlos
US9458156B2 (en) * 2014-12-23 2016-10-04 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
HK1246273B (en) * 2014-12-01 2019-12-06 恒翼生物医药(上海)股份有限公司 Substituted pyridines as bromodomain inhibitors
HK1245247A1 (zh) * 2014-12-17 2018-08-24 恒翼生物医药科技(上海)有限公司 溴结构域的抑制剂
JP2016193861A (ja) * 2015-03-31 2016-11-17 国立大学法人山梨大学 マスト細胞活性化を抑制するための医薬組成物
MX384172B (es) * 2015-08-04 2025-03-14 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Derivados de pirazol pirimidina y sus usos.
WO2017021970A1 (en) 2015-08-06 2017-02-09 Tower-Sec Ltd Means and methods for regulating can communication
CN109748915B (zh) * 2015-12-09 2021-03-26 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
JP6799752B2 (ja) * 2016-10-13 2020-12-16 パナソニックIpマネジメント株式会社 光ディスク装置、光ディスク読み出し方法
TW201837027A (zh) * 2017-02-01 2018-10-16 以色列商以色列耶路撒冷希伯來大學伊索研究發展有限公司 吡唑衍生物及其用途

Similar Documents

Publication Publication Date Title
JP2021512922A5 (https=)
ES2755772T3 (es) Pirimidinil y piridinilpirrolopiridinonas sustituidas, proceso para su preparación y su uso como inhibidores de cinasas
TW202513571A (zh) 吡啶并[4,3-d]嘧啶化合物
JP6666147B2 (ja) 環状エーテルピラゾール−4−イル−ヘテロシクリル−カルボキサミド化合物と使用方法
JP5997763B2 (ja) タンパク質キナーゼ阻害剤としての大環状化合物
RU2441005C2 (ru) Новые пиразолопиримидины как ингибиторы циклинзависимых киназ
CN111989332A (zh) 作为cdk抑制剂的大环化合物、其制备方法及其在医药上的应用
ES2973661T3 (es) Compuestos de cetona bicíclica y procedimientos de uso de los mismos
CN107548391A (zh) 嘧啶或吡啶类化合物、其制备方法和医药用途
IL282916B1 (en) Fused cyclic chemical compounds and their uses in the treatment of ras-mediated diorders
JP2016525135A5 (https=)
JP2020503303A5 (https=)
JP2020007311A5 (https=)
JP2019527230A5 (https=)
US20210128723A1 (en) Combination of atr kinase inhibitors and pd-1/pd-l1 inhibitors
JP2014193925A5 (https=)
RU2016118753A (ru) Производные пиридилкетона, способ их получения и их фармацевтическое применение
JP2018516917A5 (https=)
JP2018507877A5 (https=)
AU2015345054A1 (en) 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
WO2016096709A1 (en) Heterocyclic derivatives modulating activity of certain protein kinases
FI3546462T3 (fi) Uusi oksoisokinoliinijohdannainen
EP3219329A1 (en) Combinations of copanlisib
KR20180013851A (ko) 치환된 2,3-디히드로이미다조[1,2-c]퀴나졸린-함유 조합물
CN111601797A (zh) 苯并哌啶或杂芳基并哌啶类衍生物、其制备方法及其在医药上的应用