BR112020016064A2 - Compostos de heteroarila, composições farmacêuticas dos mesmos e seu uso terapêutico - Google Patents
Compostos de heteroarila, composições farmacêuticas dos mesmos e seu uso terapêutico Download PDFInfo
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- BR112020016064A2 BR112020016064A2 BR112020016064-4A BR112020016064A BR112020016064A2 BR 112020016064 A2 BR112020016064 A2 BR 112020016064A2 BR 112020016064 A BR112020016064 A BR 112020016064A BR 112020016064 A2 BR112020016064 A2 BR 112020016064A2
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
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| US201862627908P | 2018-02-08 | 2018-02-08 | |
| US201862627921P | 2018-02-08 | 2018-02-08 | |
| US62/627,908 | 2018-02-08 | ||
| US62/627,921 | 2018-02-08 | ||
| PCT/IL2019/050151 WO2019155468A1 (en) | 2018-02-08 | 2019-02-07 | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use |
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| BR112020016064A2 true BR112020016064A2 (pt) | 2020-12-08 |
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|---|---|
| US (2) | US20200383984A1 (https=) |
| EP (1) | EP3749666A1 (https=) |
| JP (1) | JP2021512922A (https=) |
| KR (1) | KR20200130287A (https=) |
| CN (1) | CN111971280A (https=) |
| AU (1) | AU2019219678A1 (https=) |
| BR (1) | BR112020016064A2 (https=) |
| CA (1) | CA3090063A1 (https=) |
| IL (1) | IL276290A (https=) |
| MX (1) | MX2020008375A (https=) |
| WO (1) | WO2019155468A1 (https=) |
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| MX384172B (es) | 2015-08-04 | 2025-03-14 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Derivados de pirazol pirimidina y sus usos. |
| IL288547B2 (en) * | 2019-06-03 | 2025-10-01 | Biotheryx Inc | Non-hygroscopic crystalline pyrazole compound salts, pharmaceutical preparations thereof and use thereof |
| US20230047732A1 (en) * | 2020-01-13 | 2023-02-16 | Biotheryx, Inc. | Pyrazolylpyrimidines and use thereof |
| WO2022204220A1 (en) * | 2021-03-24 | 2022-09-29 | Biotheryx, Inc. | Pyrazolylpyrimidines for treating malignant solid tumor |
| US11752151B2 (en) * | 2021-07-12 | 2023-09-12 | Buddhist Tzu Chi Medical Foundation | Method for enhancing hair growth |
| US20230053307A1 (en) * | 2021-07-19 | 2023-02-16 | Buddhist Tzu Chi Medical Foundation | Method for preventing or treating skin disorders and conditions |
| CN119255980A (zh) * | 2022-06-01 | 2025-01-03 | 西姆莱斯股份公司 | 具有环丙基结构的香料 |
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| US3698123A (en) | 1971-12-06 | 1972-10-17 | Carl R Heldt | Structural toys |
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| DE2839461C2 (de) | 1978-09-11 | 1987-01-15 | Bergwerksverband Gmbh, 4300 Essen | Formmassen aus thermoplastischen Kunststoffen und Rückständen der Kohlehydrierung |
| US4328246A (en) | 1979-08-14 | 1982-05-04 | Joseph Gold | Anti Walker 256 carcinoma agent and combination thereof |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US5762756A (en) | 1994-11-21 | 1998-06-09 | The Black Clawson Company | Methods and apparatus for pulping and deinking |
| US6069696A (en) | 1995-06-08 | 2000-05-30 | Psc Scanning, Inc. | Object recognition system and method |
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| US6062668A (en) | 1996-12-12 | 2000-05-16 | Hitachi Koki Imaging Solutions, Inc. | Drop detector for ink jet apparatus |
| US6364667B1 (en) | 1997-03-14 | 2002-04-02 | Relational Technologies Llp | Techniques for mastering a body of knowledge by writing questions about the body of knowledge |
| US6073643A (en) | 1998-09-14 | 2000-06-13 | Patent Category Corp. | Adjustable collapsible panels |
| MXPA02001565A (es) * | 1999-08-13 | 2005-07-14 | Vertex Pharma | Inhibidores de cinasas c-jun n-terminal (jnk) y de otras cinasas proteicas. |
| DE20019821U1 (de) | 1999-12-09 | 2001-06-07 | BRAND GMBH + CO KG, 97877 Wertheim | Dosiereinrichtung für Flüssigkeiten |
| JP2003520658A (ja) | 2000-01-27 | 2003-07-08 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 脊柱の幾何学的データを抽出する方法及びシステム |
| AU782084B2 (en) | 2000-08-15 | 2005-06-30 | Baker Hughes Incorporated | Self lubricating swage |
| AP2001002264A0 (en) | 2000-08-30 | 2001-09-30 | Pfizer Prod Inc | Sustained release formulations for growth hormone secretagogues. |
| MXPA03002200A (es) | 2000-09-13 | 2007-10-02 | Interdigital Tech Corp | Intercalador de modem fdd de tercera generacion. |
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2019
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- 2019-02-07 MX MX2020008375A patent/MX2020008375A/es unknown
- 2019-02-07 JP JP2020542875A patent/JP2021512922A/ja active Pending
- 2019-02-07 EP EP19708681.2A patent/EP3749666A1/en not_active Withdrawn
- 2019-02-07 AU AU2019219678A patent/AU2019219678A1/en not_active Abandoned
- 2019-02-07 CN CN201980019508.7A patent/CN111971280A/zh active Pending
- 2019-02-07 BR BR112020016064-4A patent/BR112020016064A2/pt not_active IP Right Cessation
- 2019-02-07 CA CA3090063A patent/CA3090063A1/en active Pending
- 2019-02-07 US US16/968,273 patent/US20200383984A1/en not_active Abandoned
- 2019-02-07 KR KR1020207025808A patent/KR20200130287A/ko not_active Ceased
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2020
- 2020-07-26 IL IL276290A patent/IL276290A/en unknown
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2023
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| MX2020008375A (es) | 2020-09-25 |
| US12138265B2 (en) | 2024-11-12 |
| IL276290A (en) | 2020-09-30 |
| CA3090063A1 (en) | 2019-08-15 |
| US20230233562A1 (en) | 2023-07-27 |
| EP3749666A1 (en) | 2020-12-16 |
| JP2021512922A (ja) | 2021-05-20 |
| WO2019155468A1 (en) | 2019-08-15 |
| US20200383984A1 (en) | 2020-12-10 |
| CN111971280A (zh) | 2020-11-20 |
| AU2019219678A1 (en) | 2020-08-27 |
| KR20200130287A (ko) | 2020-11-18 |
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