JPWO2019155468A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019155468A5 JPWO2019155468A5 JP2020542875A JP2020542875A JPWO2019155468A5 JP WO2019155468 A5 JPWO2019155468 A5 JP WO2019155468A5 JP 2020542875 A JP2020542875 A JP 2020542875A JP 2020542875 A JP2020542875 A JP 2020542875A JP WO2019155468 A5 JPWO2019155468 A5 JP WO2019155468A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- aspects
- methyl
- hydrogen
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 96
- -1 bicyclo [2.2.1] heptyl Chemical group 0.000 description 80
- 239000000203 mixture Substances 0.000 description 59
- 229910052739 hydrogen Inorganic materials 0.000 description 43
- 239000001257 hydrogen Substances 0.000 description 43
- 125000000623 heterocyclic group Chemical group 0.000 description 36
- 238000000034 method Methods 0.000 description 35
- 125000000217 alkyl group Chemical group 0.000 description 34
- 125000001424 substituent group Chemical group 0.000 description 33
- 125000001072 heteroaryl group Chemical group 0.000 description 28
- 125000003118 aryl group Chemical group 0.000 description 25
- 125000003710 aryl alkyl group Chemical group 0.000 description 23
- 150000002431 hydrogen Chemical class 0.000 description 23
- 150000001345 alkine derivatives Chemical class 0.000 description 21
- 239000008194 pharmaceutical composition Substances 0.000 description 21
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 description 20
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 20
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 20
- 229910052805 deuterium Inorganic materials 0.000 description 20
- 239000000651 prodrug Substances 0.000 description 20
- 229940002612 prodrug Drugs 0.000 description 20
- 150000003839 salts Chemical class 0.000 description 20
- 239000012453 solvate Substances 0.000 description 19
- 239000000126 substance Substances 0.000 description 19
- 150000004677 hydrates Chemical class 0.000 description 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 16
- 125000004433 nitrogen atom Chemical group N* 0.000 description 12
- 125000004093 cyano group Chemical group *C#N 0.000 description 9
- 125000004419 alkynylene group Chemical group 0.000 description 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 125000004474 heteroalkylene group Chemical group 0.000 description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 8
- 125000002947 alkylene group Chemical group 0.000 description 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 6
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 6
- 125000005843 halogen group Chemical group 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 4
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 4
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 4
- 125000004450 alkenylene group Chemical group 0.000 description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 description 4
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 4
- 102000008122 Casein Kinase I Human genes 0.000 description 3
- 108010049812 Casein Kinase I Proteins 0.000 description 3
- 102000013702 Cyclin-Dependent Kinase 9 Human genes 0.000 description 3
- 108010025461 Cyclin-Dependent Kinase 9 Proteins 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- 125000003566 oxetanyl group Chemical group 0.000 description 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 125000005981 pentynyl group Chemical group 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 125000003226 pyrazolyl group Chemical group 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 102000045959 Interleukin-1 Receptor-Like 1 Human genes 0.000 description 1
- 108700003107 Interleukin-1 Receptor-Like 1 Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010057644 Testis cancer Diseases 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000006207 intravenous dosage form Substances 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862627908P | 2018-02-08 | 2018-02-08 | |
| US201862627921P | 2018-02-08 | 2018-02-08 | |
| US62/627,908 | 2018-02-08 | ||
| US62/627,921 | 2018-02-08 | ||
| PCT/IL2019/050151 WO2019155468A1 (en) | 2018-02-08 | 2019-02-07 | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021512922A JP2021512922A (ja) | 2021-05-20 |
| JPWO2019155468A5 true JPWO2019155468A5 (https=) | 2022-02-17 |
| JP2021512922A5 JP2021512922A5 (https=) | 2022-02-17 |
Family
ID=65635772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020542875A Pending JP2021512922A (ja) | 2018-02-08 | 2019-02-07 | ヘテロアリール化合物、それらの医薬組成物、及びそれら治療的使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20200383984A1 (https=) |
| EP (1) | EP3749666A1 (https=) |
| JP (1) | JP2021512922A (https=) |
| KR (1) | KR20200130287A (https=) |
| CN (1) | CN111971280A (https=) |
| AU (1) | AU2019219678A1 (https=) |
| BR (1) | BR112020016064A2 (https=) |
| CA (1) | CA3090063A1 (https=) |
| IL (1) | IL276290A (https=) |
| MX (1) | MX2020008375A (https=) |
| WO (1) | WO2019155468A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX384172B (es) | 2015-08-04 | 2025-03-14 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Derivados de pirazol pirimidina y sus usos. |
| IL288547B2 (en) * | 2019-06-03 | 2025-10-01 | Biotheryx Inc | Non-hygroscopic crystalline pyrazole compound salts, pharmaceutical preparations thereof and use thereof |
| US20230047732A1 (en) * | 2020-01-13 | 2023-02-16 | Biotheryx, Inc. | Pyrazolylpyrimidines and use thereof |
| WO2022204220A1 (en) * | 2021-03-24 | 2022-09-29 | Biotheryx, Inc. | Pyrazolylpyrimidines for treating malignant solid tumor |
| US11752151B2 (en) * | 2021-07-12 | 2023-09-12 | Buddhist Tzu Chi Medical Foundation | Method for enhancing hair growth |
| US20230053307A1 (en) * | 2021-07-19 | 2023-02-16 | Buddhist Tzu Chi Medical Foundation | Method for preventing or treating skin disorders and conditions |
| CN119255980A (zh) * | 2022-06-01 | 2025-01-03 | 西姆莱斯股份公司 | 具有环丙基结构的香料 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3637809A (en) | 1968-07-05 | 1972-01-25 | Ciba Geigy Corp | Antioxidants |
| US3698123A (en) | 1971-12-06 | 1972-10-17 | Carl R Heldt | Structural toys |
| US3917899A (en) | 1972-08-04 | 1975-11-04 | Michael J Oliver | Plate for adjustably mounting electrical receptacle |
| US3846770A (en) | 1973-07-11 | 1974-11-05 | Us Navy | Serial access memory using magnetic domains in thin film strips |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| DE2839461C2 (de) | 1978-09-11 | 1987-01-15 | Bergwerksverband Gmbh, 4300 Essen | Formmassen aus thermoplastischen Kunststoffen und Rückständen der Kohlehydrierung |
| US4328246A (en) | 1979-08-14 | 1982-05-04 | Joseph Gold | Anti Walker 256 carcinoma agent and combination thereof |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US5762756A (en) | 1994-11-21 | 1998-06-09 | The Black Clawson Company | Methods and apparatus for pulping and deinking |
| US6069696A (en) | 1995-06-08 | 2000-05-30 | Psc Scanning, Inc. | Object recognition system and method |
| US6576139B1 (en) | 1996-07-30 | 2003-06-10 | Kenneth C. Hou | Process for purifying photoresist composition employing a filter sheet |
| DE19630939C1 (de) | 1996-07-31 | 1997-12-11 | Siemens Ag | Kontaktfeder |
| KR100218318B1 (ko) | 1996-10-01 | 1999-09-01 | 문정환 | 주파수 변환장치 |
| US7274662B1 (en) | 1998-08-04 | 2007-09-25 | At&T Corp. | Method for performing segmented resource reservation |
| US6062668A (en) | 1996-12-12 | 2000-05-16 | Hitachi Koki Imaging Solutions, Inc. | Drop detector for ink jet apparatus |
| US6364667B1 (en) | 1997-03-14 | 2002-04-02 | Relational Technologies Llp | Techniques for mastering a body of knowledge by writing questions about the body of knowledge |
| US6073643A (en) | 1998-09-14 | 2000-06-13 | Patent Category Corp. | Adjustable collapsible panels |
| MXPA02001565A (es) * | 1999-08-13 | 2005-07-14 | Vertex Pharma | Inhibidores de cinasas c-jun n-terminal (jnk) y de otras cinasas proteicas. |
| DE20019821U1 (de) | 1999-12-09 | 2001-06-07 | BRAND GMBH + CO KG, 97877 Wertheim | Dosiereinrichtung für Flüssigkeiten |
| JP2003520658A (ja) | 2000-01-27 | 2003-07-08 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 脊柱の幾何学的データを抽出する方法及びシステム |
| AU782084B2 (en) | 2000-08-15 | 2005-06-30 | Baker Hughes Incorporated | Self lubricating swage |
| AP2001002264A0 (en) | 2000-08-30 | 2001-09-30 | Pfizer Prod Inc | Sustained release formulations for growth hormone secretagogues. |
| MXPA03002200A (es) | 2000-09-13 | 2007-10-02 | Interdigital Tech Corp | Intercalador de modem fdd de tercera generacion. |
| WO2002028911A2 (en) | 2000-10-02 | 2002-04-11 | The University Of Akron | Synthesis and characterization of nanocomposites by emulsion polymerization |
| US7113943B2 (en) | 2000-12-06 | 2006-09-26 | Content Analyst Company, Llc | Method for document comparison and selection |
| US7120761B2 (en) | 2000-12-20 | 2006-10-10 | Fujitsu Limited | Multi-port memory based on DRAM core |
| JP4007767B2 (ja) | 2001-01-18 | 2007-11-14 | 日本碍子株式会社 | 圧電／電歪デバイスおよびその製造方法 |
| US6709874B2 (en) | 2001-01-24 | 2004-03-23 | Infineon Technologies Ag | Method of manufacturing a metal cap layer for preventing damascene conductive lines from oxidation |
| US6980946B2 (en) | 2001-03-15 | 2005-12-27 | Microsoft Corporation | Method for hybrid processing of software instructions of an emulated computer system |
| WO2002077657A1 (en) | 2001-03-22 | 2002-10-03 | Fujitsu Limited | Magnetoresistive spin-valve sensor and magnetic storage apparatus |
| JP4124607B2 (ja) | 2001-04-06 | 2008-07-23 | ヤマウチ株式会社 | ピンチローラおよびピンチローラ装置 |
| US6840774B2 (en) | 2001-05-07 | 2005-01-11 | Jack W. Fretwell, Jr. | System to teach, measure and rate learner knowledge of basic mathematics facts |
| US6798220B1 (en) | 2001-06-27 | 2004-09-28 | Timothy H. Flanigan | Moisture/mold detector |
| WO2003004492A1 (en) * | 2001-07-03 | 2003-01-16 | Vertex Pharmaceuticals Incorporated | Isoxazolyl-pyrimidines as inhibitors of src and lck protein kinases |
| US6891474B1 (en) | 2001-08-01 | 2005-05-10 | Tagsense, Inc. | Electromagnetic identification label for anti-counterfeiting, authentication, and tamper-protection |
| US7345559B2 (en) | 2001-09-13 | 2008-03-18 | General Electric Company | High field open MRI magnet isolation system and method |
| US6965468B2 (en) | 2003-07-03 | 2005-11-15 | Reflectivity, Inc | Micromirror array having reduced gap between adjacent micromirrors of the micromirror array |
| US7039976B2 (en) | 2002-04-09 | 2006-05-09 | Maytag Corporation | Braking control system for a washing machine |
| US6739477B1 (en) | 2002-04-12 | 2004-05-25 | Floro Pascual | Golf ball dispenser |
| US7048737B2 (en) | 2002-06-11 | 2006-05-23 | Bioplate, Inc. | Cranial bone flap fixation system and method |
| WO2004001741A1 (en) | 2002-06-21 | 2003-12-31 | Seagate Technology Llc | Fluid dynamic bearing asymmetry pressure feedback |
| CA2496197A1 (en) * | 2002-08-20 | 2004-03-04 | Neurogen Corporation | 5-substituted-2-arylpyrazines as modulators of crf receptors |
| DE10240053A1 (de) | 2002-08-30 | 2004-03-11 | Robert Bosch Gmbh | Brückenzünder-Zündelement |
| US6739108B2 (en) | 2002-09-30 | 2004-05-25 | Allpax Products, Inc. | Fragile container handling system for retort/sterilization processes |
| JP2004158619A (ja) | 2002-11-06 | 2004-06-03 | Matsushita Electric Ind Co Ltd | 電子デバイスおよびその製造方法 |
| US6712069B1 (en) | 2002-11-20 | 2004-03-30 | William L. Spangler | Solar energy collection and storage system |
| US7139876B2 (en) | 2003-01-16 | 2006-11-21 | Ip-First, Llc | Microprocessor and apparatus for performing fast speculative pop operation from a stack memory cache |
| ITBO20030105A1 (it) | 2003-02-28 | 2004-09-01 | Fasco Spa | Pistola pneumatica per elementi di fissaggio. |
| CN100425492C (zh) | 2003-03-19 | 2008-10-15 | 日本精工株式会社 | 电动转向装置以及其中使用的树脂齿轮 |
| US7248373B2 (en) | 2003-03-21 | 2007-07-24 | Durr Systems, Inc | Workpiece configuration detection system and method |
| US6867376B2 (en) | 2003-04-17 | 2005-03-15 | Bellsouth Intellectual Property Corporation | Glow rods with externally mountable anchoring members and related methods |
| US7069377B2 (en) | 2003-05-08 | 2006-06-27 | Micron Technology, Inc. | Scratch control memory array in a flash memory device |
| FR2854693B1 (fr) | 2003-05-09 | 2005-07-01 | Siemens Vdo Automotive | Procede de determination de l'energie d'un signal de cliquetis pour moteur a combustion interne |
| EP1658083B1 (en) | 2003-06-19 | 2007-08-08 | BODOR, Nicholas S. | Enhancement of activity and/or duration of action of selected anti-inflammatory steroids |
| US6993866B1 (en) | 2003-06-25 | 2006-02-07 | James Strange | Fishing bait rig attachment apparatus with rotating rattle |
| US6922367B2 (en) | 2003-07-09 | 2005-07-26 | Micron Technology, Inc. | Data strobe synchronization circuit and method for double data rate, multi-bit writes |
| JP4183181B2 (ja) | 2003-08-07 | 2008-11-19 | 株式会社小松製作所 | 異物除去装置 |
| DE102004027446B4 (de) | 2004-06-04 | 2007-08-23 | Jungheinrich Aktiengesellschaft | Vorrichtung zur Unterstützung des Ein- und Ausstapelns bei einem Stapler |
| US7197360B1 (en) | 2005-01-12 | 2007-03-27 | Pacesetter, Inc. | Methods and systems for using an inductor to increase capacitor reformation efficiency in an implantable cardiac device (ICD) |
| US7377471B1 (en) | 2005-06-06 | 2008-05-27 | Compton Harry L | Method and system for opening and securing a railroad frog |
| US7271369B2 (en) | 2005-08-26 | 2007-09-18 | Aem, Inc. | Multilayer positive temperature coefficient device and method of making the same |
| WO2007129195A2 (en) * | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| JP4666514B2 (ja) | 2006-07-20 | 2011-04-06 | リンテック株式会社 | シート剥離装置及び剥離方法 |
| US7799600B2 (en) | 2007-05-31 | 2010-09-21 | Chien-Min Sung | Doped diamond LED devices and associated methods |
| US7689648B2 (en) | 2007-06-27 | 2010-03-30 | Microsoft Corporation | Dynamic peer network extension bridge |
| PE20121066A1 (es) * | 2009-06-19 | 2012-09-13 | Abbvie Inc | Derivados de diazahomoadamantano y metodos para usarlos |
| US9458156B2 (en) * | 2014-12-23 | 2016-10-04 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| HK1246273B (en) * | 2014-12-01 | 2019-12-06 | 恒翼生物医药(上海)股份有限公司 | Substituted pyridines as bromodomain inhibitors |
| HK1245247A1 (zh) * | 2014-12-17 | 2018-08-24 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
| JP2016193861A (ja) * | 2015-03-31 | 2016-11-17 | 国立大学法人山梨大学 | マスト細胞活性化を抑制するための医薬組成物 |
| MX384172B (es) * | 2015-08-04 | 2025-03-14 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Derivados de pirazol pirimidina y sus usos. |
| WO2017021970A1 (en) | 2015-08-06 | 2017-02-09 | Tower-Sec Ltd | Means and methods for regulating can communication |
| CN109748915B (zh) * | 2015-12-09 | 2021-03-26 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
| JP6799752B2 (ja) * | 2016-10-13 | 2020-12-16 | パナソニックＩｐマネジメント株式会社 | 光ディスク装置、光ディスク読み出し方法 |
| TW201837027A (zh) * | 2017-02-01 | 2018-10-16 | 以色列商以色列耶路撒冷希伯來大學伊索研究發展有限公司 | 吡唑衍生物及其用途 |
-
2019
- 2019-02-07 WO PCT/IL2019/050151 patent/WO2019155468A1/en not_active Ceased
- 2019-02-07 MX MX2020008375A patent/MX2020008375A/es unknown
- 2019-02-07 JP JP2020542875A patent/JP2021512922A/ja active Pending
- 2019-02-07 EP EP19708681.2A patent/EP3749666A1/en not_active Withdrawn
- 2019-02-07 AU AU2019219678A patent/AU2019219678A1/en not_active Abandoned
- 2019-02-07 CN CN201980019508.7A patent/CN111971280A/zh active Pending
- 2019-02-07 BR BR112020016064-4A patent/BR112020016064A2/pt not_active IP Right Cessation
- 2019-02-07 CA CA3090063A patent/CA3090063A1/en active Pending
- 2019-02-07 US US16/968,273 patent/US20200383984A1/en not_active Abandoned
- 2019-02-07 KR KR1020207025808A patent/KR20200130287A/ko not_active Ceased
-
2020
- 2020-07-26 IL IL276290A patent/IL276290A/en unknown
-
2023
- 2023-01-25 US US18/159,176 patent/US12138265B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021512922A5 (https=) | ||
| ES3029140T3 (en) | Substituted aminothiazoles as dgkzeta inhibitors for immune activation | |
| CA2984259C (en) | Combinations of inhibitors of irak4 with inhibitors of btk | |
| CN111170991B (zh) | 抗增殖化合物及其合成方法 | |
| TW202513571A (zh) | 吡啶并[4,3-d]嘧啶化合物 | |
| TWI784255B (zh) | 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途 | |
| JP6666147B2 (ja) | 環状エーテルピラゾール−４−イル−ヘテロシクリル−カルボキサミド化合物と使用方法 | |
| CN105492439B (zh) | 作为溴结构域抑制剂的取代的双环化合物 | |
| JP2021524484A5 (https=) | ||
| JP2026506002A (ja) | Ｓｏｓ１阻害剤及び抗がん薬を含む、がんの処置のための医薬組成物 | |
| JPWO2020012334A5 (https=) | ||
| WO2022235558A1 (en) | Aryl 3-oxopiperazine carboxamides and heteroaryl 3-oxopiperazine carboxamides as nav1.8 inhibitors | |
| JP2023538304A (ja) | 化合物、組成物及び方法 | |
| CN107735401B (zh) | 取代二氢吡咯并吡唑衍生物 | |
| JP7362600B2 (ja) | Ｒｉｐ１キナーゼ阻害剤として使用するための二環式化合物 | |
| EP4237418B1 (en) | Pyrimidine compounds, compositions, and medicinal applications thereof | |
| WO2017157792A1 (en) | Combinations of copanlisib | |
| EP3888652A1 (en) | Heterocyclic compound | |
| JPWO2019155468A5 (https=) | ||
| CN108699085A (zh) | 皮质抑素类似物及其用途 | |
| CN106573927B (zh) | 氧杂环庚烷-2-基-吡唑-4-基-杂环基-甲酰胺化合物和使用方法 | |
| AU2016296997B2 (en) | Chlorobenzene substituted azaaryl compounds | |
| CA3086714A1 (en) | Heterocycle compounds as tyro3, axl and mertk (tam) family of receptor tyrosine kinase inhibitors | |
| ES2666335T3 (es) | Forma polimórfica de Icotinib y usos de la misma | |
| HK40130280A (zh) | 作为sos1抑制剂的唑基吡啶哒嗪酮酰胺 |