|
FR2564319A1
(fr)
|
1984-05-21 |
1985-11-22 |
Inst Nat Sante Rech Med |
Nouvelles compositions de liposomes dotees d'une action specifique vis-a-vis de la proliferation de cellules donnees
|
|
US4584375A
(en)
|
1984-08-21 |
1986-04-22 |
Rensselaer Polytechnic Institute |
Fluorine-containing antifolates incapable of polyglutamate formation
|
|
KR0162654B1
(ko)
|
1989-12-11 |
1998-11-16 |
알렌 제이. 시니스갤리 |
N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
|
|
CA2057635A1
(en)
|
1990-12-14 |
1992-06-15 |
Hiroshi Akimoto |
Condensed heterocyclic compounds, their production and use
|
|
JP3202999B2
(ja)
|
1991-01-31 |
2001-08-27 |
協和醗酵工業株式会社 |
肝移行性リポソーム製剤
|
|
US5646253A
(en)
|
1994-03-08 |
1997-07-08 |
Memorial Sloan-Kettering Cancer Center |
Recombinant human anti-LK26 antibodies
|
|
US5416211A
(en)
|
1992-09-25 |
1995-05-16 |
Eli Lilly And Company |
Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
|
|
US6569432B1
(en)
|
1995-02-24 |
2003-05-27 |
Sloan-Kettering Institute For Cancer Research |
Prostate-specific membrane antigen and uses thereof
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
WO1997027764A1
(en)
|
1996-01-31 |
1997-08-07 |
South Alabama Medical Science Foundation |
Food and vitamin preparations containing the natural isomer of reduced folates
|
|
US20020168761A1
(en)
|
2000-01-24 |
2002-11-14 |
Gour Barbara J. |
Peptidomimetic modulators of cell adhesion
|
|
US20030073640A1
(en)
|
1997-07-23 |
2003-04-17 |
Ribozyme Pharmaceuticals, Inc. |
Novel compositions for the delivery of negatively charged molecules
|
|
ZA987550B
(en)
|
1997-09-26 |
2000-02-21 |
Lilly Co Eli |
Processes and intermediates useful to make antifolates.
|
|
US6262262B1
(en)
|
1997-09-26 |
2001-07-17 |
Eli Lilly And Company |
Processes and intermediates useful to make antifolates
|
|
US5912251A
(en)
|
1998-01-17 |
1999-06-15 |
Nair; Madhavan G. |
Metabolically inert anti-inflammatory and anti-tumor antifolates
|
|
US20050031679A1
(en)
|
1998-03-27 |
2005-02-10 |
Clemens Unger |
Method for producing liposomal formulations of active ingredients
|
|
CN1239545C
(zh)
|
1998-07-09 |
2006-02-01 |
罗狄亚化学公司 |
水溶性或水可分散性接枝共聚物
|
|
US6066732A
(en)
|
1998-08-21 |
2000-05-23 |
The Trustees Of Princeton University |
Process for the preparation of pyrrolo[2,3-d]pyrimidines
|
|
WO2001005405A1
(en)
|
1999-07-16 |
2001-01-25 |
The General Hospital Corporation |
Folylpolyglutamyl synthetase gene transfer to enhance antifolate drug sensitivity
|
|
AU6890800A
(en)
|
1999-08-23 |
2001-03-19 |
Eli Lilly And Company |
A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
|
|
CA2400155C
(en)
|
2000-02-25 |
2009-09-15 |
Eli Lilly And Company |
A novel crystalline form of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and process therefor
|
|
CN1095472C
(zh)
|
2000-04-17 |
2002-12-04 |
上海复康医药科技发展有限公司 |
叶酸－多聚糖复合物，其制备方法和以该复合物为活性成分的药物组合物
|
|
EP1286661A2
(en)
|
2000-06-09 |
2003-03-05 |
OSI Pharmaceuticals, Inc. |
Liposomal benzoquinazoline thymidylate synthase inhibitor formulations
|
|
JP5102928B2
(ja)
|
2000-06-30 |
2012-12-19 |
イーライ リリー アンド カンパニー |
新規な葉酸代謝拮抗薬の組み合わせ療法
|
|
JP2004501955A
(ja)
|
2000-06-30 |
2004-01-22 |
アイネックス ファーマシューティカルズ コーポレイション |
リポソーム抗新生物薬剤およびその使用
|
|
AU2003211103A1
(en)
|
2002-02-13 |
2003-09-04 |
Northeastern University |
Intracellular delivery of therapeutic agents
|
|
CH696628A5
(de)
|
2002-02-26 |
2007-08-31 |
Eprova Ag |
Verwendung von Folaten zur Herstellung einer Zubereitung geeignet zur Vorbeugung und Behandlung von Entzündungen und entzündungsassoziierter Krankheiten, im Speziellen zur Beeinflussung der
|
|
US7563590B2
(en)
*
|
2002-08-30 |
2009-07-21 |
Cypress Bioscience Inc. |
Methods of quantifying methotrexate metabolites
|
|
US6921667B2
(en)
|
2003-03-07 |
2005-07-26 |
Prometheus Laboratories, Inc. |
Methods for direct detection of individual methotrexate metabolites
|
|
US20040265368A1
(en)
|
2003-04-02 |
2004-12-30 |
Lawrence Mayer |
Combination compositions of camptothecins and fluoropyrimidines
|
|
AU2005206163B2
(en)
|
2004-01-14 |
2011-06-30 |
Gilead Sciences, Inc. |
Lipid-based dispersions useful for drug delivery
|
|
EP3101034A1
(en)
|
2004-02-12 |
2016-12-07 |
Morphotek, Inc. |
Monoclonal antibodies that specifically bind to folate receptor alpha
|
|
US7612071B2
(en)
|
2004-03-12 |
2009-11-03 |
Syntrix Biosystems, Inc. |
Compositions and methods employing aminopterin
|
|
US20080260812A1
(en)
|
2004-04-26 |
2008-10-23 |
Takami Matsuyama C/O Kagoshima University |
Therapeutic Medicine Containing Monoclonal Antibody Against Folate Receptor Beta (Fr-Beta)
|
|
LT3173073T
(lt)
|
2004-05-03 |
2025-01-10 |
Ipsen Biopharm Ltd. |
Liposomos, skirtos vaistų pristatymui
|
|
US7695908B2
(en)
|
2004-06-15 |
2010-04-13 |
Prometheus Laboratories Inc. |
Methods for predicting methotrexate polyglutamate levels using pharmacogenetics
|
|
JP2008512490A
(ja)
|
2004-09-08 |
2008-04-24 |
チェルシー・セラピューティクス，インコーポレイテッド |
異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤
|
|
JPWO2006035876A1
(ja)
|
2004-09-29 |
2008-05-15 |
興和株式会社 |
関節リウマチの予防及び／又は治療薬
|
|
US8126089B2
(en)
|
2004-09-30 |
2012-02-28 |
Alcatel Lucent |
Method and apparatus for providing frame synchronization in a digital communication system that supports multiple modulation formats
|
|
US20100266709A1
(en)
|
2004-12-16 |
2010-10-21 |
Hicks Terry Lee |
Compositions and Methods for Treating Burns
|
|
WO2006074416A1
(en)
|
2005-01-07 |
2006-07-13 |
Health Research Inc. |
5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
|
|
WO2007086881A2
(en)
|
2005-02-14 |
2007-08-02 |
Sirna Therapeutics, Inc. |
Cationic lipids and formulated molecular compositions containing them
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
|
GB2424837B
(en)
|
2005-04-06 |
2010-10-06 |
Cilag Ag Int |
Injection device
|
|
AU2005335876A1
(en)
|
2005-08-24 |
2007-03-01 |
Protherics Medicines Development Limited |
Cleavage of antifolate compounds
|
|
EP1962796A2
(en)
|
2005-12-08 |
2008-09-03 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Methods for affecting liposome composition by ultrasound irradiation
|
|
WO2007098089A2
(en)
|
2006-02-17 |
2007-08-30 |
Novacea, Inc. |
Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
|
|
US9265746B2
(en)
|
2006-05-31 |
2016-02-23 |
Merck & Cie |
Method for cell-specific targeting
|
|
US7994180B2
(en)
|
2006-08-14 |
2011-08-09 |
Sicor Inc. |
Processes for preparing intermediates of pemetrexed
|
|
JP2008543975A
(ja)
|
2006-08-14 |
2008-12-04 |
シコール インコーポレイティド |
高度に純粋なペメトレキセド二酸およびその調製方法
|
|
WO2008030818A2
(en)
|
2006-09-05 |
2008-03-13 |
Mebiopharm Co., Ltd. |
Novel liposome compositions
|
|
GB2453011B
(en)
|
2006-12-29 |
2010-06-23 |
Tracon Pharmaceuticals Inc |
Antifolate agent compositions in the treatment of cancer
|
|
RU2423114C2
(ru)
|
2006-12-29 |
2011-07-10 |
Тракон Фармасьютикалз, Инк. |
Комбинации антифолатного агента в лечении рака
|
|
JP2010516694A
(ja)
|
2007-01-19 |
2010-05-20 |
チェルシー・セラピューティクス，インコーポレイテッド |
新規な伝統的葉酸拮抗剤
|
|
CA2689042A1
(en)
|
2007-02-16 |
2008-08-28 |
Merck & Co., Inc. |
Compositions and methods for potentiated activity of biologicaly active molecules
|
|
BRPI0807939A2
(pt)
|
2007-04-03 |
2014-07-01 |
Reddys Lab Ltd Dr |
Formas sólidas de pemetrexed
|
|
CN101977620B
(zh)
|
2008-03-18 |
2014-05-07 |
英国技术集团国际有限公司 |
用于治疗类风湿性关节炎或急性骨髓性白血病的环戊二烯并[g]喹唑啉衍生物
|
|
GB0811360D0
(en)
|
2008-06-20 |
2008-07-30 |
Imp Innovations Ltd |
Methods
|
|
WO2010021865A1
(en)
|
2008-08-18 |
2010-02-25 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
|
WO2010080724A1
(en)
|
2009-01-12 |
2010-07-15 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
|
EP2437596B1
(en)
|
2009-06-03 |
2017-05-03 |
Ex-Tek, LLC |
Skin treatment compositions
|
|
WO2011000107A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
TW201118098A
(en)
|
2009-08-13 |
2011-06-01 |
Reddy S Lab Liimited Dr |
Processes for preparing pemetrexed
|
|
ES2579936T3
(es)
|
2009-08-20 |
2016-08-17 |
Sirna Therapeutics, Inc. |
Nuevos lípidos catiónicos con diversos grupos de cabeza para el suministro oligonucleotídico
|
|
EP2485770A4
(en)
|
2009-10-08 |
2013-04-10 |
Merck Sharp & Dohme |
Novel cationic lipids with short lipid chains for oligonucleotide delivery
|
|
EP2525781A1
(en)
|
2010-01-22 |
2012-11-28 |
Schering Corporation |
Novel cationic lipids for oligonucleotide delivery
|
|
TWI622402B
(zh)
|
2010-02-24 |
2018-05-01 |
免疫遺傳股份有限公司 |
葉酸受體１抗體類和免疫共軛物類及彼等之用途
|
|
CN102917690B
(zh)
|
2010-03-19 |
2016-08-24 |
麻省理工学院 |
脂质囊泡组合物和使用方法
|
|
US9770414B2
(en)
|
2010-05-13 |
2017-09-26 |
Pacira Pharmaceuticals, Inc. |
Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent
|
|
EP2394640A1
(en)
|
2010-05-21 |
2011-12-14 |
MediGene AG |
Improved liposomal formulations of lipophilic compounds
|
|
US8802863B2
(en)
|
2010-05-24 |
2014-08-12 |
Sirna Therapeutics, Inc. |
Amino alcohol cationic lipids for oligonucleotide delivery
|
|
CA2800693A1
(en)
|
2010-05-28 |
2011-12-01 |
Purdue Research Foundation |
Delivery of therapeutic agents to inflamed tissues using folate-targeted agents
|
|
DK2575767T3
(en)
|
2010-06-04 |
2017-03-13 |
Sirna Therapeutics Inc |
HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES
|
|
IT1401677B1
(it)
|
2010-07-22 |
2013-08-02 |
Chemi Spa |
Nuovo processo per la sintesi di pemetrexed sale disodico
|
|
KR101761388B1
(ko)
|
2010-07-30 |
2017-07-25 |
큐어백 아게 |
트랜스펙션 및 면역 자극을 위한 이황화-크로스링크된 양이온 성분 및 핵산의 복합체
|
|
WO2012033987A2
(en)
|
2010-09-09 |
2012-03-15 |
Purdue Research Foundation |
Anti-human folate receptor beta antibodies and methods of use
|
|
WO2012037068A1
(en)
|
2010-09-13 |
2012-03-22 |
De Novo Diagnostics, Inc. |
Methods for monitoring methotrexate therapy
|
|
CA2809858C
(en)
|
2010-09-20 |
2019-11-12 |
Sirna Therapeutics, Inc. |
Novel low molecular weight cationic lipids for oligonucleotide delivery
|
|
CA2811430A1
(en)
|
2010-09-30 |
2012-04-05 |
Merck Sharp & Dohme Corp. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
EP3485913A1
(en)
|
2010-10-21 |
2019-05-22 |
Sirna Therapeutics, Inc. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
WO2012056285A1
(en)
|
2010-10-25 |
2012-05-03 |
Fresenius Kabi Oncology Ltd. |
An improved process for the preparation of pemetrexed
|
|
WO2012061469A2
(en)
|
2010-11-02 |
2012-05-10 |
Sicor Inc. |
Crystalline forms of pralatrexate
|
|
WO2012061259A2
(en)
|
2010-11-05 |
2012-05-10 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
|
|
MX343607B
(es)
|
2010-11-05 |
2016-11-11 |
Morphotek Inc |
Receptor alfa de folato como marcador de diagnóstico y pronóstico para cánceres que expresan receptor alfa de folato.
|
|
WO2012078708A1
(en)
*
|
2010-12-07 |
2012-06-14 |
Chelsea Therapeutics, Inc. |
Combination comprising methotrexate and an antifolate compound
|
|
WO2012118806A2
(en)
|
2011-02-28 |
2012-09-07 |
The Regents Of The University Of California |
Compositions and methods for detecting and treating cancer
|
|
PL226015B1
(pl)
|
2011-03-03 |
2017-06-30 |
Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną |
Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
|
|
WO2012121682A2
(en)
|
2011-03-10 |
2012-09-13 |
National Science And Technology Development Agency |
Anti-folate antimalarials with dual-binding modes and their preparation
|
|
US8673914B2
(en)
|
2011-03-28 |
2014-03-18 |
St. John's University |
Use of phosphodiesterase inhibitors for treating multidrug resistance
|
|
EP2508894A1
(en)
|
2011-04-05 |
2012-10-10 |
Receptomon LLC |
Method for monitoring gene expression of translation and Integral/Secretory protein synthesis by magnetic resonance spectroscopy (MRS)
|
|
ES2795110T3
(es)
|
2011-06-08 |
2020-11-20 |
Translate Bio Inc |
Lípidos escindibles
|
|
US8183227B1
(en)
|
2011-07-07 |
2012-05-22 |
Chemo S. A. France |
Compositions, kits and methods for nutrition supplementation
|
|
RS61235B1
(sr)
|
2011-07-13 |
2021-01-29 |
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd |
Lipozomi koji ko-inkapsuliraju bisfosfonat i amfipatički agens
|
|
SI2731972T1
(en)
|
2011-07-15 |
2018-04-30 |
Eisai R&D Management Co., Ltd. |
Anti-folate receptor alpha antibodies and uses thereof
|
|
US20130122096A1
(en)
|
2011-11-14 |
2013-05-16 |
Silenseed Ltd. |
Compositions for drug delivery and methods of manufacturing and using same
|
|
JPWO2014003137A1
(ja)
|
2012-06-27 |
2016-06-02 |
旭化成メディカル株式会社 |
高アフィニティー抗体、及びその製造方法
|
|
WO2014016740A2
(en)
|
2012-07-23 |
2014-01-30 |
Fresenius Kabi Oncology Ltd. |
Improved process for the preparation of pralatrexate
|
|
ITRM20120398A1
(it)
|
2012-08-08 |
2014-02-09 |
Berlin Chemie Ag |
Procedimento di sintesi pemetrexed e suo sale di lisina.
|
|
WO2014046630A1
(en)
|
2012-09-19 |
2014-03-27 |
Keskin, Dilek |
Tumor targeted liposomal drug delivery system
|
|
US20140120157A1
(en)
|
2012-09-19 |
2014-05-01 |
Georgetown University |
Targeted liposomes
|
|
US9207238B2
(en)
|
2012-12-07 |
2015-12-08 |
Kyowa Hakko Kirin Co., Ltd. |
Anti-FOLR1 antibody
|
|
CN103040748B
(zh)
|
2012-12-18 |
2014-07-02 |
海南圣欣医药科技有限公司 |
一种培美曲塞二钠脂质体注射剂
|
|
US9192609B2
(en)
|
2013-04-17 |
2015-11-24 |
Hedgepath Pharmaceuticals, Inc. |
Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
|
|
SG11201509043RA
(en)
|
2013-05-14 |
2015-12-30 |
Immunogen Inc |
Anti-folr1 immunoconjugate dosing regimens
|
|
MA40428A
(fr)
*
|
2014-08-14 |
2016-02-18 |
L E A F Holdings Group Llc |
Médicament à affinité encapsulé dans un liposome
|
|
JOP20170004B1
(ar)
|
2016-01-15 |
2022-09-15 |
Lilly Co Eli |
الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
|
|
WO2017189961A1
(en)
|
2016-04-29 |
2017-11-02 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors
|
|
WO2018031968A1
(en)
|
2016-08-12 |
2018-02-15 |
L.E.A.F. Holdings Group Llc |
Alpha and gamma-d polyglutamated antifolates and uses thereof
|
|
WO2018031980A1
(en)
|
2016-08-12 |
2018-02-15 |
L.E.A.F. Holdings Group Llc |
Polyglutamated antifolates and uses thereof
|
|
CN121177507A
(zh)
|
2016-08-12 |
2025-12-23 |
L.E.A.F.控股集团公司 |
α和γ-D聚谷氨酸化抗叶酸剂及其用途
|
|
ES3062820T3
(en)
|
2017-11-08 |
2026-04-14 |
L E A F Holdings Group Llc |
Platinum complexes and uses thereof
|
|
EP3749314A4
(en)
|
2018-02-07 |
2022-02-23 |
L.E.A.F Holdings Group LLC |
ALPHA-POLYGLUTAMATE METHOTREXATE AND ITS USES
|
|
WO2019157145A1
(en)
|
2018-02-07 |
2019-08-15 |
L.E.A.F. Holdings Group Llc |
Gamma polyglutamated pemetrexed and uses thereof
|
|
WO2019157121A1
(en)
|
2018-02-07 |
2019-08-15 |
L.E.A.F. Holdings Group Llc |
Alpha polyglutamated lometrexol and uses thereof
|
|
EP3749319A4
(en)
|
2018-02-07 |
2022-06-22 |
L.E.A.F Holdings Group LLC |
TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES
|
|
EP3749321A4
(en)
|
2018-02-07 |
2022-03-09 |
L.E.A.F Holdings Group LLC |
Gamma polyglutamated antifolates and uses thereof
|
|
JP7491572B2
(ja)
|
2018-02-07 |
2024-05-28 |
エル．イー．エー．エフ． ホールディングス グループ エルエルシー |
アルファポリグルタミン酸化ペメトレキセドおよびその使用
|
|
CN111867593A
(zh)
|
2018-02-07 |
2020-10-30 |
L.E.A.F.控股集团公司 |
α聚谷氨酸化抗叶酸剂及其用途
|
|
WO2019157129A1
(en)
|
2018-02-07 |
2019-08-15 |
L.E.A.F. Holdings Group Llc |
Alpha polyglutamated pralatrexate and uses thereof
|
|
US12310966B2
(en)
|
2018-02-07 |
2025-05-27 |
L.E.A.F. Holdings Group Llc |
Alpha polyglutamated aminopterin and uses thereof
|
|
CA3090389A1
(en)
|
2018-02-07 |
2019-08-15 |
L.E.A.F. Holdings Group Llc |
Alpha polyglutamated raltitrexed and uses thereof
|
|
EP3749318A4
(en)
|
2018-02-07 |
2022-07-06 |
L.E.A.F Holdings Group LLC |
GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES
|
|
CA3090753A1
(en)
|
2018-02-14 |
2019-08-22 |
L.E.A.F. Holdings Group Llc |
Gamma polyglutamated pralatrexate and uses thereof
|
|
JP7462950B2
(ja)
|
2018-02-14 |
2024-04-08 |
エル．イー．エー．エフ． ホールディングス グループ エルエルシー |
ガンマポリグルタミン酸化メトトレキセートおよびその使用
|
|
US12350271B2
(en)
|
2018-02-14 |
2025-07-08 |
L.E.A.F. Holdings Group Llc |
Gamma polyglutamated aminopterin and uses thereof
|
|
WO2019160734A1
(en)
|
2018-02-14 |
2019-08-22 |
L.E.A.F. Holdings Group Llc |
Gamma polyglutamated lometrexol and uses thereof
|
|
WO2019160735A1
(en)
|
2018-02-14 |
2019-08-22 |
L.E.A.F. Holdings Group Llc |
Gamma polyglutamated tetrahydrofolates and uses thereof
|
|
US20230000997A1
(en)
|
2019-08-06 |
2023-01-05 |
L.E.A.F. Holdings Group Llc |
Processes of preparing polyglutamated antifolates and uses of their compositions
|