JP2021510677A - がんを治療するための選択的parp1阻害剤 - Google Patents
がんを治療するための選択的parp1阻害剤 Download PDFInfo
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- JP2021510677A JP2021510677A JP2020534949A JP2020534949A JP2021510677A JP 2021510677 A JP2021510677 A JP 2021510677A JP 2020534949 A JP2020534949 A JP 2020534949A JP 2020534949 A JP2020534949 A JP 2020534949A JP 2021510677 A JP2021510677 A JP 2021510677A
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Abstract
Description
の化合物又はその薬学的に許容できる塩及び/若しくは溶媒和物である。上記の化合物の原子は、その同位体に置換されてもよく、その化合物が依然として式の範囲内にあることは認識し得る。例えば、上記の構造のうちの1つにある水素は、重水素に置換されてもよく、そのような化合物は、適切な式の範囲内にあるであろう。
PARP阻害剤アッセイは、直接蛍光法に基づく反応生成物形成の濃度測定である。アッセイ試薬は、市販キットとして販売されている(http://www.merckmillipore.com/GB/en/product/PARP1−Enzyme−Activity−Assay、MM_NF−17−10149参照)。PARP阻害を測定するためには、すべての種類の阻害剤(競合的な、不競合的な、及び非競合的な(アロステリック)(後者は、ジンクフィンガー阻害剤の作用方式を示す))の特定、阻害能(Ki)の直接計算、及びin vivoモデリングが可能となるように、NAD+基質濃度をKm(ミカエリス定数)に設定するべきである(Michael G.Acker、Douglas S.Auld.、Considerations for the design and reporting of enzyme assays in high−throughput screening applications、Perspectives in Science (2014年)1巻、56〜73頁及びその中で引用されている文献を参照)。文献で報告されている他のすべてのPARP阻害剤アッセイ(及び市販で入手可能なPARP阻害剤アッセイを含む)は、測定用にNAD+を大幅に変換してNAD+を標識するか、又は(仮に含んでいたとしても)極めて低い濃度のNAD+を含むだけであり、競合的な動態が典型的にならないようにする。
1.0%阻害のコントロールは、阻害剤のない反応試料を含有し、
2.PARP1/2/3活性の100%阻害のコントロールは、β−NADのない反応試料を含有し、且つ
3.DNA依存の活性の100%阻害のコントロールは、DNAのない反応試料を含有した。
PARP1/2/3総活性を、コントロール(1)とコントロール(2)間の差として算出した。DNA非依存性の活性を、コントロール(1)とコントロール(3)間の差として算出した。DNA依存性の活性を、PARP1/2/3総活性とDNA非依存性の活性の差として算出した。図1に示される通り、約80%のPARP1活性は、DNA依存性である。しかしながら、潜在的に、PARP1活性の最大30%がDNA非依存性となり得る。
コントロールにしたがって阻害値を百分率に変換した。DNA依存性の活性の阻害のみがみとめられたので、コントロール(1)及びコントロール(3)を、PARP1のケースに使用し、結果を図2に示している。PARP2/3総活性の阻害(DNA依存性及びDNA非依存性の反応の双方)がみとめられたので、コントロール(1)及びコントロール(2)をPARP2/3のケースに使用した。図3及び図4は、それぞれ金チオリンゴ酸塩及び金チオグルコースの異なる濃度に対するPARP1及びPARP2の阻害百分率を示す。
PARP2を阻害することが骨粗鬆症の重大な危険因子であることを証明するために、実施例1に記載のPARP阻害剤アッセイを使用してPARP2特異的阻害剤を最初に特定した。PARP阻害剤アッセイを使用して、ミノサイクリンが特異的PARP2阻害剤であり、PARP2を2.8μMのIC50で阻害し、PARP1を204.5μMのIC50で阻害することを発明者らは見出した、図6参照。ミノサイクリンに対するPARP2の選択要因がPARP1と比べて70倍を超えていることに注目されるであろう。
金チオリンゴ酸ナトリウム及び金チオグルコースがPARP1を阻害するがPARP2/3を阻害しない理由は、DNA修復のPARP1の活性化に必須のステップである、PARP1の1種又は複数のジンクフィンガードメインとDNAとの結合を、金チオリンゴ酸ナトリウム及び金チオグルコースが阻害するからであると発明者らは考えている。Zn2+イオンが放出され、Au+イオンに置換されると、立体構造の変化があると考えられる。結果として得られる「ゴールドフィンガー」ドメインは、DNAに結合しないため、SSBは修復されない。したがって、がん細胞を死なせることを目的とする合成致死機構は、維持される。
Claims (25)
- 骨粗鬆症に罹患している若しくは骨粗鬆症のリスクのある被験者又は長期療法を必要とする被験者のがんの治療、改善、又は予防における使用のための、ポリ(ADP−リボース)ポリメラーゼ1(PARP1)へのDNA結合の選択的阻害剤又はその薬学的に許容できる塩若しくは溶媒和物。
- DNA結合以外のPARP1の他の機能を阻害しない、請求項1に記載の使用のための選択的阻害剤。
- PARP1の他の機能が,DNA損傷に非依存性の酸化ストレスに対する細胞応答におけるPARP1の役割,並びに/又は細胞の代謝制御と代謝活性、カルシウムシグナリングと石灰化、及びアポトーシスにおけるPARP1の役割を含む、請求項2に記載の使用のための選択的阻害剤。
- PARP1のNAD+結合部位を阻害も遮断もしない、請求項1〜3のいずれか一項に記載の使用のための選択的阻害剤。
- PARP1のジンクフィンガーの阻害剤である、請求項1〜4のいずれか一項に記載の使用のための選択的阻害剤。
- 被験者が、閉経後の女性、45歳までに子宮摘出をしている女性、過度の運動若しくは過度の食事制限の結果6ヵ月間より長く無月経である女性、又は性腺機能低下症に罹患している男性である、請求項1〜5のいずれか一項に記載の使用のための選択的阻害剤。
- 被験者がリューマチ性関節炎に罹患している、請求項1〜6のいずれか一項に記載の使用のための選択的阻害剤。
- がんが固形腫瘍又は固形がんである、請求項1〜7のいずれか一項に記載の使用のための選択的阻害剤。
- がんが、血液がん、腸がん、脳がん、乳がん、子宮頸がん、子宮内膜がん、胃がん、肝臓がん、肺がん、卵巣がん、膵臓がん、前立腺がん、又は皮膚がんである、請求項1〜8のいずれか一項に記載の使用のための選択的阻害剤。
- がんが、乳がん、前立腺がん、骨髄腫、又は子宮頸がんである、請求項9に記載の使用のための選択的阻害剤。
- 長期療法が維持療法である、請求項1〜10のいずれか一項に記載の使用のための選択的阻害剤。
- PARP2及び/又はPARP3の阻害剤ではない、請求項1〜11のいずれか一項に記載の使用のための選択的阻害剤。
- 金錯体である、請求項1〜12のいずれか一項に記載の使用のための選択的阻害剤。
- 金(I)錯体である、請求項13に記載の使用のための選択的阻害剤。
- 水溶性高分子錯体である、請求項1〜14のいずれか一項に記載の使用のための選択的阻害剤。
- 前記化合物が式I又は式IIの化合物である、請求項16に記載の使用のための選択的阻害剤。
- 金チオリンゴ酸ナトリウム、金チオリンゴ酸カリウム、又は金チオリンゴ酸カルシウムである、請求項17に記載の使用のための選択的阻害剤。
- DNAを損傷する薬剤と組み合わせて使用される、請求項1〜20のいずれか一項に記載の使用のための選択的阻害剤。
- 毛細血管拡張性失調症変異及びrad3関連プロテインキナーゼ(ATR)阻害剤、チェックポイント阻害剤、血管内皮増殖因子(VEGF)阻害剤、又はwee1阻害剤と組み合わせて使用される、請求項21に記載の使用のための選択的阻害剤。
- 前記チェックポイント阻害剤が、プログラム細胞死タンパク質1(PD−1)阻害剤、プログラム細胞死リガンド1(PD−L1)阻害剤、又は細胞障害性T−リンパ球関連タンパク質4(CTLA−4)阻害剤である、請求項22に記載の使用のための選択的阻害剤。
- 骨粗鬆症に罹患している若しくは骨粗鬆症のリスクのある被験者又は長期療法を必要とする被験者のがんを治療するための医薬組成物であって、請求項1〜19のいずれか一項に定義された、PARP1へのDNA結合の選択的阻害剤又はその薬学的に許容できる塩若しくは溶媒和物、及び薬学的に許容できる賦形剤を含む、医薬組成物。
- 請求項24に記載の前記組成物を製造する方法であって、請求項1〜19のいずれか一項に定義された、PARP1へのDNA結合の選択的阻害剤又はその薬学的に許容できる塩若しくは溶媒和物の治療有効量、及び薬学的に許容できる賦形剤を接触させるステップを含む、方法。
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Title |
---|
JACQUES, A. ET AL.: "Reactivity of Cys4 zinc finger domains with gold(III) complexes: insights into the formation of "gol", INORGANIC CHEMISTRY, vol. 54, no. 8, JPN6022026327, 2015, pages 4104 - 4113, XP055577691, ISSN: 0004959537, DOI: 10.1021/acs.inorgchem.5b00360 * |
平沢 晃 ほか: "産婦人科臨床における遺伝性乳癌卵巣癌の位置づけ", 家族性腫瘍, vol. 第1巻,第2号, JPN6022026328, 2011, pages 48 - 51, ISSN: 0004959539 * |
竹内 聡, 杉山 徹: "固形がん薬物療法における維持療法の最新の知見 進行卵巣がんにおける維持療法 —分子標的薬の立場より—", 癌と化学療法, vol. 第41巻, 第8号, JPN6023000208, 2014, pages 937 - 943, ISSN: 0004959538 * |
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