JP2021504319A - 接着性可塑剤−ポリマーマトリックスに基づく経皮治療システム - Google Patents
接着性可塑剤−ポリマーマトリックスに基づく経皮治療システム Download PDFInfo
- Publication number
- JP2021504319A JP2021504319A JP2020527938A JP2020527938A JP2021504319A JP 2021504319 A JP2021504319 A JP 2021504319A JP 2020527938 A JP2020527938 A JP 2020527938A JP 2020527938 A JP2020527938 A JP 2020527938A JP 2021504319 A JP2021504319 A JP 2021504319A
- Authority
- JP
- Japan
- Prior art keywords
- treatment system
- active substance
- transdermal
- polymer
- adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
a) 有機溶媒および/または水に基づく溶媒、少なくとも1種の本質的に非接着性のポリマー、および少なくとも1種の可塑剤を含む懸濁液中に、少なくとも1種の薬学的に活性な物質を懸濁する工程;
b) a)から得られた懸濁液を、活性物質不透過性の裏張り層に適用する工程;および
c) 溶媒を除去する工程
を含む上で規定された経皮治療システムを製造する方法にも関する。
Claims (13)
- 活性物質不透過性の裏張り層および活性物質不透過性の裏張り層の片側のポリマー層を含む経皮治療システムであって、ポリマーマトリックスは、少なくとも1種の薬学的に活性な物質、少なくとも1種の本質的に非接着性のポリマー、および少なくとも1種の可塑剤を含む経皮治療システムであって、該ポリマーマトリックスは本質的に接着性のポリマーを含まないことを特徴とする、前記経皮治療システム。
- 活性物質不透過性の裏張り層が所在していない、ポリマーマトリックスの片側に、追加の接着性層を含まないことを特徴とする、請求項1に記載の経皮治療システム。
- 本質的に接着性のポリマーは水溶性ポリマーを含むことを特徴とする、請求項1または2に記載の経皮治療システム。
- 本質的に非接着性のポリマーは、ポリビニルカプロラクタム/ポリ酢酸ビニル/ポリエチレングリコールコポリマー、セラック、ビニルピロリドン/酢酸ビニルコポリマー、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロースおよび/またはポリビニルピロリドンを含むことを特徴とする、請求項1〜3のいずれか1項に記載の経皮治療システム。
- 少なくとも1種の可塑剤は、グリセリンおよび/またはポリエチレングリコール、特にポリエチレングリコール200を含む、請求項1〜4のいずれか1項に記載の経皮治療システム。
- マトリックス層中における少なくとも1種の本質的に非接着性のポリマーの量は、マトリックス層の合計重量に対して約50〜90wt%である、請求項1〜5のいずれか1項に記載の経皮治療システム。
- マトリックス層中における少なくとも1種の可塑剤の量は、マトリックス層の合計重量に対して約5〜50wt%である、請求項1〜6のいずれか1項に記載の経皮治療システム。
- 少なくとも1種の薬学的に活性な物質は、イデベノン、オキシブチニン、リオシグアト、ロチゴチン、アピキサバン、ケタミン、アレンドロネートおよび/またはフェンタニルからなる群から選択されることを特徴とする、請求項1〜7のいずれか1項に記載の経皮治療システム。
- 少なくとも1種の薬学的に活性な物質の量は、マトリックス層の合計重量に対して約1〜20wt%であることを特徴とする、請求項1〜8のいずれか1項に記載の経皮治療システム。
- 染料、乳化剤、浸透向上剤、pH調節剤、湿潤剤、保存剤および/または抗酸化剤を含む群から選択される少なくとも1種の補助剤を、各場合。好ましくは、マトリックス層の合計重量に対して0.01〜20wt%の量で含むことを特徴とする、請求項1〜9のいずれか1項に記載の経皮治療システム。
- 請求項1〜10のいずれか1項に記載の経皮治療システムを製造する方法であって:
a) 有機溶媒および/または水をベースとする溶媒、少なくとも1種の本質的に非接着性のポリマー、および少なくとも1種の可塑剤を含む溶液または懸濁液中に、少なくとも1種の薬学的に活性な物質を溶解または懸濁する工程;
b) a)から得られた溶液または懸濁液を、活性物質不透過性の裏張り層に適用する工程;および
c) 溶媒を除去する工程
を含む、前記方法。 - 請求項11に記載の方法により得ることが可能な経皮治療システム。
- 請求項1〜10または12のいずれか1項に記載の経皮治療システムの、医薬品としての使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102017127433.2A DE102017127433A1 (de) | 2017-11-21 | 2017-11-21 | TTS auf Basis von klebenden Weichmacher-Polymer-Matrices |
DE102017127433.2 | 2017-11-21 | ||
PCT/EP2018/082090 WO2019110306A1 (de) | 2017-11-21 | 2018-11-21 | Transdermales therapeutisches system auf basis von klebenden weichmacher-polymer-matrices |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021504319A true JP2021504319A (ja) | 2021-02-15 |
JP7050921B2 JP7050921B2 (ja) | 2022-04-08 |
Family
ID=64572311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020527938A Active JP7050921B2 (ja) | 2017-11-21 | 2018-11-21 | 接着性可塑剤-ポリマーマトリックスに基づく経皮治療システム |
Country Status (8)
Country | Link |
---|---|
US (1) | US11304912B2 (ja) |
EP (1) | EP3713549A1 (ja) |
JP (1) | JP7050921B2 (ja) |
CN (1) | CN111372575B (ja) |
BR (1) | BR112020009593A2 (ja) |
CA (1) | CA3083252C (ja) |
DE (1) | DE102017127433A1 (ja) |
WO (1) | WO2019110306A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115715770B (zh) * | 2021-08-24 | 2024-01-26 | 新领医药技术(深圳)有限公司 | 阿哌沙班透皮贴剂及其制备方法 |
US11833138B1 (en) | 2023-01-30 | 2023-12-05 | Tap Pharmaceuticals Ag | Liquid pharmaceutical formulations of apixaban |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002008351A1 (de) * | 2000-07-24 | 2002-01-31 | Lts Lohmann Therapie-Systeme Ag | Medizinische haftkleber mit einem gehalt an disaccharid-polyestern |
WO2008108209A1 (ja) * | 2007-03-01 | 2008-09-12 | Cosmed Pharmaceutical Co., Ltd. | 経皮吸収製剤、その製造方法及び経皮吸収方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692462A (en) * | 1985-03-18 | 1987-09-08 | Menley & James Laboratories, Ltd. | Compositions and method of controlling transdermal penetration of topical and systemic agents |
DE4002281A1 (de) | 1990-01-26 | 1991-08-01 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit dem wirkstoff tulobuterol |
DE4237453C1 (ja) | 1992-11-06 | 1993-08-19 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
FR2732223B1 (fr) * | 1995-03-30 | 1997-06-13 | Sanofi Sa | Composition pharmaceutique pour administration transdermique |
DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
IL135258A0 (en) * | 1997-09-26 | 2001-05-20 | Noven Pharma | Bioadhesive compositions and methods for topical administration of active agents |
SE9904750D0 (sv) | 1999-12-23 | 1999-12-23 | Pharmacia & Upjohn Ab | New formulation, use and method |
US20030082225A1 (en) | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
US20030175328A1 (en) * | 2002-03-06 | 2003-09-18 | Adi Shefer | Patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients into the skin |
US20030175333A1 (en) * | 2002-03-06 | 2003-09-18 | Adi Shefer | Invisible patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin |
CN100409843C (zh) | 2003-06-20 | 2008-08-13 | 帝国制药株式会社 | 包含妥洛特罗的贴剂 |
DE102005010255A1 (de) * | 2005-03-07 | 2006-09-14 | Lts Lohmann Therapie-Systeme Ag | Faserfreies transdermales therapeutisches System und Verfahren zu seiner Herstellung |
US20100100124A1 (en) * | 2005-05-05 | 2010-04-22 | Tyco Healthcare Group Lp | Bioabsorbable surgical composition |
DE102006026060B4 (de) * | 2006-01-12 | 2013-01-31 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme |
US8414910B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
DE102006054731B4 (de) * | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
DE102006054733A1 (de) * | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit |
US20100158990A1 (en) | 2006-12-27 | 2010-06-24 | Abielle Pharmaceuticals, Inc | Transdermal method and patch for corticosteroid administration |
US20080226698A1 (en) * | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
WO2009005814A2 (en) * | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
US20090297591A1 (en) * | 2008-05-30 | 2009-12-03 | Orient Pharma Co., Ltd. | Compositions And Methods For The Transdermal Delivery Of Pharmaceutical Compounds |
DE102009056746A1 (de) * | 2009-12-04 | 2011-06-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung von Peptiden |
CN101836949A (zh) * | 2010-02-11 | 2010-09-22 | 上海现代药物制剂工程研究中心有限公司 | 含有止吐活性药物的透皮凝胶制剂及制备方法 |
PT2468274E (pt) * | 2010-12-14 | 2015-09-21 | Acino Ag | Sistema terapêutico transdérmico para a administração de uma substância ativa |
EP2667861A4 (en) | 2011-01-26 | 2014-07-16 | Csi Gmbh | TRANSDERMAL PROLONGED RELEASE PATCHES ASSOCIATING A BETA-AGONIST AND ANTICHOLINERGIC AND METHODS OF USE |
-
2017
- 2017-11-21 DE DE102017127433.2A patent/DE102017127433A1/de active Pending
-
2018
- 2018-11-21 BR BR112020009593-1A patent/BR112020009593A2/pt active Search and Examination
- 2018-11-21 JP JP2020527938A patent/JP7050921B2/ja active Active
- 2018-11-21 EP EP18812087.7A patent/EP3713549A1/de active Pending
- 2018-11-21 CN CN201880075282.8A patent/CN111372575B/zh active Active
- 2018-11-21 CA CA3083252A patent/CA3083252C/en active Active
- 2018-11-21 WO PCT/EP2018/082090 patent/WO2019110306A1/de unknown
- 2018-11-21 US US16/765,800 patent/US11304912B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002008351A1 (de) * | 2000-07-24 | 2002-01-31 | Lts Lohmann Therapie-Systeme Ag | Medizinische haftkleber mit einem gehalt an disaccharid-polyestern |
WO2008108209A1 (ja) * | 2007-03-01 | 2008-09-12 | Cosmed Pharmaceutical Co., Ltd. | 経皮吸収製剤、その製造方法及び経皮吸収方法 |
Also Published As
Publication number | Publication date |
---|---|
CA3083252A1 (en) | 2019-06-13 |
CN111372575A (zh) | 2020-07-03 |
JP7050921B2 (ja) | 2022-04-08 |
DE102017127433A1 (de) | 2019-05-23 |
US11304912B2 (en) | 2022-04-19 |
US20200281867A1 (en) | 2020-09-10 |
CN111372575B (zh) | 2023-12-01 |
CA3083252C (en) | 2023-01-10 |
EP3713549A1 (de) | 2020-09-30 |
WO2019110306A1 (de) | 2019-06-13 |
BR112020009593A2 (pt) | 2020-10-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2695217C2 (ru) | Композиции, включающие электрогидродинамически полученные волокна, для нанесения заданных доз активного вещества на кожу или слизистую оболочку | |
JP5850889B2 (ja) | 薬物の皮膚送達のための接着性外皮形成製剤とそれを使用する方法 | |
RU2449766C2 (ru) | Композиция для чрескожной доставки лекарственного средства | |
KR101737960B1 (ko) | 외용 의약 조성물 | |
ES2762460T3 (es) | Composiciones y métodos de administración dérmica | |
US9295655B2 (en) | Fentanyl transdermal patch | |
JP2016520638A5 (ja) | ||
CA2667477C (en) | Transdermal delivery of ketoprofen polar derivatives | |
JP2020055822A (ja) | 経皮送達システムにおける活性薬剤の放出を調節するための方法 | |
WO2007120868A2 (en) | Bioavailability enhancement of lipophilic drug by use solvent system | |
ES2504065T3 (es) | Composición estable de rasagilina | |
HUT64227A (en) | Process for the production of the preparatives containing ergolin-derivatives that can be used transdermally | |
EP3188714A1 (en) | Microstructure array, methods of making, and methods of use | |
TWI415636B (zh) | Bisoprolol transdermal device | |
JP2017519837A (ja) | 経皮送達システム | |
JP2005002009A (ja) | フェンタニル含有口腔粘膜貼付剤 | |
US11633367B2 (en) | Transdermal delivery system containing rotigotine | |
JP2020019788A (ja) | 界面介在物を含む経皮送達システム | |
JP7050921B2 (ja) | 接着性可塑剤-ポリマーマトリックスに基づく経皮治療システム | |
JP2005506297A (ja) | ペルゴリドの経皮送達 | |
KR102307852B1 (ko) | 약물의 경피 흡수 촉진용 조성물 및 패치 제제 | |
JP2003515555A (ja) | 同一有効成分を含有する貯留部と基質部を備えた経皮投与部材 | |
KR20140006729A (ko) | 로티고틴 함유 경피흡수제제 | |
JP2007520480A (ja) | 少なくとも一つの脂肪酸を含むジヒドロピリジンタイプのカルシウムアンタゴニスト用の経皮的デリバリー器具 | |
JP2000026285A (ja) | 貼付剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200716 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200716 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210727 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211020 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220308 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220329 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7050921 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |