JP2021501754A5 - - Google Patents
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- Publication number
- JP2021501754A5 JP2021501754A5 JP2020524155A JP2020524155A JP2021501754A5 JP 2021501754 A5 JP2021501754 A5 JP 2021501754A5 JP 2020524155 A JP2020524155 A JP 2020524155A JP 2020524155 A JP2020524155 A JP 2020524155A JP 2021501754 A5 JP2021501754 A5 JP 2021501754A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- integrin ligand
- alkyl
- αvβ6 integrin
- epithelial cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims description 68
- 102000006495 integrins Human genes 0.000 claims description 61
- 108010044426 integrins Proteins 0.000 claims description 61
- 210000002919 epithelial cell Anatomy 0.000 claims description 26
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 24
- 125000005647 linker group Chemical group 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 21
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 108091034117 Oligonucleotide Proteins 0.000 claims description 12
- 239000002243 precursor Substances 0.000 claims description 12
- 108091030071 RNAI Proteins 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 230000009368 gene silencing by RNA Effects 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 125000004429 atom Chemical group 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 6
- 125000000732 arylene group Chemical group 0.000 claims description 6
- 125000005549 heteroarylene group Chemical group 0.000 claims description 6
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 4
- 210000002383 alveolar type I cell Anatomy 0.000 claims description 4
- 210000002588 alveolar type II cell Anatomy 0.000 claims description 4
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims description 4
- 210000000013 bile duct Anatomy 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims description 4
- 230000002500 effect on skin Effects 0.000 claims description 4
- 210000001703 glandular epithelial cell Anatomy 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 230000000968 intestinal effect Effects 0.000 claims description 4
- 230000003248 secreting effect Effects 0.000 claims description 4
- 125000005717 substituted cycloalkylene group Chemical group 0.000 claims description 4
- 210000002175 goblet cell Anatomy 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 2
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims description 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims description 2
- SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical compound N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 claims description 2
- 108091023037 Aptamer Proteins 0.000 claims description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims description 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 2
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims description 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 150000001540 azides Chemical class 0.000 claims description 2
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 2
- 125000001047 cyclobutenyl group Chemical group C1(=CCC1)* 0.000 claims description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 claims description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 2
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 229920000768 polyamine Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 150000003536 tetrazoles Chemical class 0.000 claims description 2
- 229930192474 thiophene Natural products 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023060316A JP7758699B2 (ja) | 2017-11-01 | 2023-04-03 | インテグリンリガンドおよびその使用 |
| JP2025107419A JP2025129221A (ja) | 2017-11-01 | 2025-06-25 | インテグリンリガンドおよびその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762580398P | 2017-11-01 | 2017-11-01 | |
| US62/580,398 | 2017-11-01 | ||
| US201862646739P | 2018-03-22 | 2018-03-22 | |
| US62/646,739 | 2018-03-22 | ||
| US201862679549P | 2018-06-01 | 2018-06-01 | |
| US62/679,549 | 2018-06-01 | ||
| PCT/US2018/058471 WO2019089765A1 (en) | 2017-11-01 | 2018-10-31 | Integrin ligands and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023060316A Division JP7758699B2 (ja) | 2017-11-01 | 2023-04-03 | インテグリンリガンドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501754A JP2021501754A (ja) | 2021-01-21 |
| JP2021501754A5 true JP2021501754A5 (enExample) | 2021-12-09 |
| JP7445594B2 JP7445594B2 (ja) | 2024-03-07 |
Family
ID=66332633
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524155A Active JP7445594B2 (ja) | 2017-11-01 | 2018-10-31 | インテグリンリガンドおよびその使用 |
| JP2023060316A Active JP7758699B2 (ja) | 2017-11-01 | 2023-04-03 | インテグリンリガンドおよびその使用 |
| JP2025107419A Pending JP2025129221A (ja) | 2017-11-01 | 2025-06-25 | インテグリンリガンドおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023060316A Active JP7758699B2 (ja) | 2017-11-01 | 2023-04-03 | インテグリンリガンドおよびその使用 |
| JP2025107419A Pending JP2025129221A (ja) | 2017-11-01 | 2025-06-25 | インテグリンリガンドおよびその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11597701B2 (enExample) |
| EP (1) | EP3703700A4 (enExample) |
| JP (3) | JP7445594B2 (enExample) |
| KR (2) | KR102762143B1 (enExample) |
| CN (1) | CN111526880A (enExample) |
| AU (2) | AU2018359515B2 (enExample) |
| BR (1) | BR112020006901A2 (enExample) |
| CA (1) | CA3079402A1 (enExample) |
| CL (1) | CL2020001125A1 (enExample) |
| CR (1) | CR20200178A (enExample) |
| EC (1) | ECSP20028090A (enExample) |
| IL (1) | IL274300B2 (enExample) |
| JO (1) | JOP20200102A1 (enExample) |
| MX (2) | MX2020004554A (enExample) |
| MY (1) | MY208467A (enExample) |
| PE (1) | PE20200938A1 (enExample) |
| PH (1) | PH12020550263A1 (enExample) |
| SA (1) | SA520411899B1 (enExample) |
| SG (1) | SG11202002967SA (enExample) |
| TN (1) | TN2020000059A1 (enExample) |
| TW (2) | TW202434560A (enExample) |
| UA (1) | UA128250C2 (enExample) |
| WO (1) | WO2019089765A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020526192A (ja) | 2017-07-06 | 2020-08-31 | アローヘッド ファーマシューティカルズ インコーポレイテッド | アルファ−ＥＮａＣの発現を阻害するためのＲＮＡｉ剤、および使用方法 |
| US12065458B2 (en) | 2018-02-17 | 2024-08-20 | Arrowhead Pharmaceuticals, Inc. | Trialkyne linking agents and methods of use |
| CN114058623B (zh) * | 2020-08-06 | 2023-12-12 | 中国科学院化学研究所 | 一种核酸适体识别并结合整合素α3亚基及其相关功能 |
| KR20230066400A (ko) * | 2020-09-11 | 2023-05-15 | 애로우헤드 파마슈티컬스 인코포레이티드 | 인테그린 표적화 리간드 및 그의 용도 |
| WO2022056266A2 (en) * | 2020-09-11 | 2022-03-17 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of dux4, compositions thereof, and methods of use |
| MX2023002854A (es) * | 2020-09-11 | 2023-04-03 | Arrowhead Pharmaceuticals Inc | Plataformas de suministro al musculo esqueletico y metodos de uso. |
| KR20230167082A (ko) | 2021-04-08 | 2023-12-07 | 애로우헤드 파마슈티컬스 인코포레이티드 | 진행성 당화 최종 산물에 대한 수용체의 발현을 억제하기 위한 RNAi 작용제, 그의 조성물, 및 사용 방법 |
| AU2022280863A1 (en) * | 2021-05-28 | 2023-11-30 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of mucin 5ac (muc5ac), compositions thereof, and methods of use |
| CA3235224A1 (en) * | 2021-10-22 | 2023-04-27 | Anthony Nicholas | Rnai agents for inhibiting expression of matrix metalloproteinase 7(mmp7), compositions thereof, and methods of use |
| AU2023399039A1 (en) * | 2022-12-14 | 2025-05-22 | Alnylam Pharmaceuticals, Inc. | ALPHA-V BETA-6(ανβ6) INTEGRIN LIGANDS FOR EXTRAHEPATIC DELIVERY |
| TW202503060A (zh) * | 2023-06-13 | 2025-01-16 | 大陸商上海拓界生物醫藥科技有限公司 | 靶向ＭＭＰ７的ｓｉＲＮＡ、ｓｉＲＮＡ綴合物及其醫藥用途 |
| WO2024260259A1 (zh) * | 2023-06-19 | 2024-12-26 | 广东众生睿创生物科技有限公司 | 一种整合素配体及其用途 |
| WO2025128462A1 (en) | 2023-12-12 | 2025-06-19 | Eli Lilly And Company | Novel therapeutic delivery moieties and uses thereof |
| WO2025130549A1 (zh) * | 2023-12-22 | 2025-06-26 | 北京炫景瑞医药科技有限公司 | 一种靶向整合素αvβ6的配体、缀合物、组合物以及它们的用途 |
| WO2025152967A1 (zh) * | 2024-01-15 | 2025-07-24 | 武汉人福创新药物研发中心有限公司 | 靶向αvβ6的化合物及其用途 |
| WO2025152969A1 (zh) * | 2024-01-15 | 2025-07-24 | 武汉人福创新药物研发中心有限公司 | 靶向化合物及其用途 |
| WO2025180458A1 (zh) * | 2024-03-01 | 2025-09-04 | 长春金赛药业有限责任公司 | 整联蛋白配体及其用途 |
| WO2025252118A1 (zh) * | 2024-06-06 | 2025-12-11 | 苏州瑞博生物技术股份有限公司 | 整联蛋白αvβ6特异性配体化合物、缀合物、药物组合物及其用途 |
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| DE19831710A1 (de) | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | Diacylhydrazinderivate |
| KR20010093303A (ko) | 1999-02-20 | 2001-10-27 | 플레믹 크리스티안 | β-알라닌 유도체 |
| DE19929410A1 (de) | 1999-06-26 | 2000-12-28 | Merck Patent Gmbh | Inhibitoren des Integrins avß6 |
| DE10028402A1 (de) | 2000-06-13 | 2001-12-20 | Merck Patent Gmbh | Pyridin-2-yl-aminoalkycarbonylglycyl-beta-alanin und Derivate |
| DE10112771A1 (de) | 2001-03-16 | 2002-09-26 | Merck Patent Gmbh | Inhibitoren des Integrins alpha¶v¶beta¶6¶ |
| JP5192234B2 (ja) | 2004-08-10 | 2013-05-08 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 化学修飾オリゴヌクレオチド |
| GB0520068D0 (en) | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
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| WO2008030158A1 (en) | 2006-09-04 | 2008-03-13 | Astrazeneca Ab | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
| AR066984A1 (es) | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
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| US8858913B2 (en) | 2012-08-27 | 2014-10-14 | Preeti Misra | Multimeric peptidomimetic fibrosis specific dual-modality probes |
| EP2913064A1 (en) * | 2014-02-26 | 2015-09-02 | celares GmbH | Branched drug-linker conjugates for the coupling to biological targeting molecules |
| JP6789823B2 (ja) | 2014-04-15 | 2020-11-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 両末端ｐｅｇ化インテグリン結合性ペプチドおよびその使用方法 |
| WO2015179823A2 (en) | 2014-05-23 | 2015-11-26 | The California Institute For Biomedical Research | Lung localized inhibitors of alpha(v)beta 6 |
| CN107635550B (zh) | 2015-03-17 | 2021-12-24 | 箭头药业股份有限公司 | 改良的含二硫化物的炔烃交联剂 |
| BR112017025698A2 (pt) * | 2015-05-29 | 2018-08-14 | Arrowhead Pharmaceuticals Inc | composições e métodos para inibir a expressão do gene de hif2alfa |
| JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
-
2018
- 2018-10-31 IL IL274300A patent/IL274300B2/en unknown
- 2018-10-31 JO JOP/2020/0102A patent/JOP20200102A1/ar unknown
- 2018-10-31 TN TNP/2020/000059A patent/TN2020000059A1/en unknown
- 2018-10-31 EP EP18873120.2A patent/EP3703700A4/en active Pending
- 2018-10-31 CR CR20200178A patent/CR20200178A/es unknown
- 2018-10-31 UA UAA202003246A patent/UA128250C2/uk unknown
- 2018-10-31 AU AU2018359515A patent/AU2018359515B2/en active Active
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