JP2021500373A5 - - Google Patents
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- JP2021500373A5 JP2021500373A5 JP2020523010A JP2020523010A JP2021500373A5 JP 2021500373 A5 JP2021500373 A5 JP 2021500373A5 JP 2020523010 A JP2020523010 A JP 2020523010A JP 2020523010 A JP2020523010 A JP 2020523010A JP 2021500373 A5 JP2021500373 A5 JP 2021500373A5
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- 0 CS(C)N(CCNCC(O)=O)CCN(CCNCC(*)=O)CC(O)=O Chemical compound CS(C)N(CCNCC(O)=O)CCN(CCNCC(*)=O)CC(O)=O 0.000 description 2
- IXUWMUYNSXVWAS-UHFFFAOYSA-N NC(CCC(C(O)=O)NCCN(CCN(CCNCC(O)=O)CC(O)=O)CC(O)=O)=O Chemical compound NC(CCC(C(O)=O)NCCN(CCN(CCNCC(O)=O)CC(O)=O)CC(O)=O)=O IXUWMUYNSXVWAS-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024078640A JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762575607P | 2017-10-23 | 2017-10-23 | |
| US62/575,607 | 2017-10-23 | ||
| PCT/US2018/057086 WO2019083990A2 (en) | 2017-10-23 | 2018-10-23 | IMAGING AND RADIATION THERAPY AGENTS TARGETING α-FIBROBLAST ACTIVATION PROTEIN α (FAP-α) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024078640A Division JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500373A JP2021500373A (ja) | 2021-01-07 |
| JP2021500373A5 true JP2021500373A5 (https=) | 2021-12-02 |
Family
ID=66247306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523010A Pending JP2021500373A (ja) | 2017-10-23 | 2018-10-23 | 線維芽細胞活性化タンパク質α（ＦＡＰ−α）を標的とする撮像剤および放射線療法用薬剤 |
| JP2024078640A Pending JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024078640A Pending JP2024109682A (ja) | 2017-10-23 | 2024-05-14 | 線維芽細胞活性化タンパク質α（ＦＡＰ－α）を標的とする撮像剤および放射線療法用薬剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20200330624A1 (https=) |
| EP (1) | EP3700580A4 (https=) |
| JP (2) | JP2021500373A (https=) |
| KR (2) | KR20240162157A (https=) |
| CN (2) | CN116617420A (https=) |
| AU (2) | AU2018355222B2 (https=) |
| BR (1) | BR112020008011A2 (https=) |
| CA (1) | CA3088138A1 (https=) |
| EA (1) | EA202090776A1 (https=) |
| IL (1) | IL274088A (https=) |
| MX (2) | MX2020004807A (https=) |
| WO (1) | WO2019083990A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116474108A (zh) * | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| EA202090776A1 (ru) * | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| US11780821B2 (en) | 2017-12-15 | 2023-10-10 | Praxis Biotech LLC | Inhibitors of fibroblast activation protein |
| EP3749663A1 (en) * | 2018-02-06 | 2020-12-16 | Universität Heidelberg | Fap inhibitor |
| US11426472B2 (en) | 2018-10-17 | 2022-08-30 | Purdue Research Foundation | Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis |
| US11504364B2 (en) | 2018-12-21 | 2022-11-22 | Praxis Biotech LLC | Inhibitors of fibroblast activation protein |
| FI3997103T3 (fi) * | 2019-07-08 | 2025-02-03 | 3B Pharmaceuticals Gmbh | Fibroblastien aktivaatioproteiinin ligandia käsittäviä yhdisteitä ja niiden käyttö |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| JP7801207B2 (ja) * | 2019-07-08 | 2026-01-16 | ３ベー ファーマシューティカルズ ゲーエムベーハー | 線維芽細胞活性化タンパク質リガンドを含む化合物およびその使用 |
| CN114901315B (zh) * | 2019-09-17 | 2025-04-29 | 普渡研究基金会 | 癌症和其他纤维化和炎性疾病的成纤维细胞活化蛋白(fap)靶向的成像和治疗 |
| EP4096677A4 (en) * | 2020-01-31 | 2024-02-28 | Purdue Research Foundation | Fibroblast activation protein (fap) - targeted antifibrotic therapy |
| EP4019507A1 (en) | 2020-02-12 | 2022-06-29 | Philochem AG | Fibroblast activation protein ligands for targeted delivery applications |
| CN115943312A (zh) | 2020-05-07 | 2023-04-07 | 法国居里学院 | 免疫抑制性成纤维细胞群体的生物标志物antxr1及其在预测对免疫疗法的反应中的用途 |
| WO2021234181A1 (en) * | 2020-05-22 | 2021-11-25 | Universität Heidelberg | Use of fap inhibitor in a method of diagnosis |
| CN112138175A (zh) * | 2020-09-01 | 2020-12-29 | 上海市质子重离子临床技术研发中心 | 一种放射性核素99mTc标记FAPI的化合物的制备方法 |
| CN114790194B (zh) * | 2020-12-21 | 2024-03-26 | 苏州药明博锐生物科技有限公司 | 成纤维细胞活化蛋白抑制剂 |
| EP4050018A1 (en) * | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| IL303925A (en) * | 2021-01-07 | 2023-08-01 | 3B Pharmaceuticals Gmbh | Compounds comprising a fibroblast activation protein ligand and use thereof |
| WO2022170732A1 (zh) * | 2021-02-10 | 2022-08-18 | 上海蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| EP4043452A1 (en) | 2021-02-12 | 2022-08-17 | Philochem AG | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| CA3207999A1 (en) | 2021-02-12 | 2022-08-18 | Samuele CAZZAMALLI | Bivalent fibroblast activation protein ligands for targeted delivery applications |
| CN113105432B (zh) * | 2021-03-30 | 2022-03-04 | 上海交通大学医学院附属仁济医院 | 一种碳-11（11c）放射性药物及其制备方法和应用 |
| WO2022212958A1 (en) * | 2021-04-02 | 2022-10-06 | The Johns Hopkins University | Heterobivalent and homobivalent agents targeting fibroblast activation protein alpha and/or prostate-specific membrane antigen |
| CN113277989B (zh) * | 2021-04-27 | 2022-05-31 | 中南大学湘雅医院 | 一种68Ga标记的分子探针、制备方法及其应用 |
| US12599683B2 (en) | 2021-05-19 | 2026-04-14 | Ferronova Pty Ltd | Mapping nanoparticles |
| CN113527266A (zh) * | 2021-06-23 | 2021-10-22 | 上海健康医学院 | 一种靶向fap的双氧水响应的前药及其制备方法与应用 |
| GB202109922D0 (en) | 2021-07-09 | 2021-08-25 | Blue Earth Diagnostics Ltd | Radiotracers and therapeutics binding to fibroblast activation protein (fap) |
| EP4122499A1 (en) * | 2021-07-23 | 2023-01-25 | 3B Pharmaceuticals GmbH | Fibroblast activation protein inhibitors and use thereof |
| TW202320805A (zh) * | 2021-08-18 | 2023-06-01 | 美商杜夫特學院信託管理公司 | 用於pet造影之選擇性靶向纖維母細胞活化蛋白之放射性氟標誌試劑 |
| CN113880810B (zh) * | 2021-09-24 | 2023-02-28 | 厦门大学 | 一种核素标记的配合物及其制备方法和应用 |
| KR20240093543A (ko) | 2021-10-04 | 2024-06-24 | 필로켐 아게 | 방사성 표지된 섬유모세포 활성화 단백질 리간드 |
| TW202317541A (zh) | 2021-10-28 | 2023-05-01 | 行政院原子能委員會核能研究所 | 一種靶向成纖維細胞活化蛋白之化合物或其鹽，其製備方法及其用途 |
| WO2023081301A1 (en) * | 2021-11-05 | 2023-05-11 | On Target Laboratories, LLC | Fibroblast activation protein targeted dyes their related uses |
| US20250177582A1 (en) | 2022-01-30 | 2025-06-05 | Philochem Ag | High-affinity ligands of fibroblast activation protein for targeted delivery applications |
| AU2023223808A1 (en) * | 2022-02-22 | 2024-09-19 | Osaka University | RADIOLABELED FAPα-AFFINITY COMPOUND AND USE THEREOF |
| CN119072472A (zh) * | 2022-04-21 | 2024-12-03 | 上海先通生物科技有限公司 | Fap抑制剂 |
| WO2023222558A1 (en) | 2022-05-14 | 2023-11-23 | Zounek Alexis Nikolai | Precursor and theranostic radiotracer with improved tumor retention |
| CN115304582B (zh) * | 2022-07-20 | 2023-05-12 | 北京法伯新天医药科技有限公司 | FAP-α特异性肿瘤诊断显像剂 |
| WO2024026072A1 (en) * | 2022-07-28 | 2024-02-01 | Ratio Therapeutics, Inc. | Fibroblast activation protein-targeted compositions and methods of use thereof |
| CN115368342B (zh) * | 2022-08-24 | 2024-01-23 | 西南医科大学附属医院 | 成纤维细胞活性蛋白抑制剂、其放射性核素标记物及制备方法和应用 |
| CA3266566A1 (en) | 2022-09-06 | 2024-03-14 | Philochem Ag | MULTIVALENT FIBROBLAST ACTIVATING PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS |
| EP4342890A1 (en) * | 2022-09-21 | 2024-03-27 | Erasmus University Rotterdam Medical Center | Platform and scaffold for fap targeting agents |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| KR20250073273A (ko) * | 2022-09-23 | 2025-05-27 | 누클리디움 아게 | 고순도 구리 방사성 의약 조성물 및 이의 진단 및 치료 용도 |
| WO2024078592A1 (zh) * | 2022-10-14 | 2024-04-18 | 无锡诺宇医药科技有限公司 | 靶向成纤维细胞活化蛋白的药物及其应用 |
| IL322552A (en) * | 2023-02-10 | 2025-10-01 | Chengdu New Radiomedicine Tech Co Ltd | Polypeptide compound and its use |
| CN120957982A (zh) * | 2023-05-08 | 2025-11-14 | 江苏恒瑞医药股份有限公司 | 靶向成纤维细胞活化蛋白的配体 |
| IL326074A (en) * | 2023-07-28 | 2026-03-01 | Ratio Therapeutics Inc | Fibroblast activation protein-targeting compositions and methods of using them |
| CN117164557A (zh) * | 2023-08-30 | 2023-12-05 | 上海交通大学医学院附属仁济医院 | 靶向成纤维细胞激活蛋白的放射性药物标记前体及其放射性标记化合物与应用 |
| WO2025046043A1 (en) | 2023-08-31 | 2025-03-06 | Stichting Radboud Universitair Medisch Centrum | Endometriosis tracer |
| WO2025063849A2 (en) | 2023-09-21 | 2025-03-27 | Erasmus University Medical Center Rotterdam | Dimeric fap targeting agents |
| US20250186630A1 (en) * | 2023-12-12 | 2025-06-12 | Viewpoint Molecular Targeting, Inc. | Fibroblast activation protein targeting peptides |
| WO2025125335A1 (en) | 2023-12-13 | 2025-06-19 | Radiovaxx Gmbh | Cytotoxic or radiopharmaceutical compound with sulfur fluoride exchange group |
| WO2025125621A1 (en) | 2023-12-14 | 2025-06-19 | Radiovaxx Gmbh | Cancer-associated protein-targeted strong or covalently binding precursor compounds and radiotracers |
| WO2025146433A1 (en) | 2024-01-05 | 2025-07-10 | Radiovaxx Gmbh | Precursor and theranostic radiotracer with prolonged tumor retention |
| CN118063689B (zh) * | 2024-01-26 | 2025-01-28 | 锐康九域(厦门)医药科技有限公司 | 成纤维细胞激活蛋白-α响应水解致电荷翻转的聚合物-药物偶联物及其制备方法和应用 |
| WO2025250709A1 (en) * | 2024-05-28 | 2025-12-04 | Actithera, Inc. | Bifunctional compounds for cancer treatment |
| CN118271393B (zh) * | 2024-05-31 | 2024-09-03 | 中国药科大学 | 一种靶向fap的二聚化合物及其探针和应用 |
| WO2026007968A1 (zh) * | 2024-07-01 | 2026-01-08 | 杭州景嘉航生物医药科技有限公司 | 一种靶向结合成纤维细胞活化蛋白的化合物及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399869B2 (en) * | 2005-05-19 | 2008-07-15 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| ES2700234T3 (es) * | 2007-06-26 | 2019-02-14 | Univ Johns Hopkins | Inhibidores marcados del antígeno de membrana específico de la próstata (PSMA), evaluación biológica y uso como agentes para la obtención de imágenes |
| PT2318366T (pt) * | 2008-08-01 | 2017-08-02 | Univ Johns Hopkins | Agentes de ligação a psma e suas utilizações |
| WO2010036814A1 (en) * | 2008-09-25 | 2010-04-01 | Molecular Insight Pharmaceuticals, Inc. | Selective seprase inhibitors |
| WO2016149188A1 (en) * | 2015-03-13 | 2016-09-22 | The Johns Hopkins University | 68Ga-LABELED NOTA-CHELATED PSMA-TARGETED IMAGING AND THERAPEUTIC AGENTS |
| US9056841B2 (en) * | 2009-03-19 | 2015-06-16 | The Johns Hopkins University | PSMA-targeting compounds and uses thereof |
| WO2013107820A1 (en) * | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| US20150320892A1 (en) * | 2012-06-29 | 2015-11-12 | Ge Healthcare Limited | Imaging fibrosis |
| CN104955484B (zh) * | 2012-08-15 | 2019-01-15 | 文森医学公司 | 用于前列腺癌成像的前列腺特异性抗原药剂及其使用方法 |
| GB2538023A (en) * | 2014-02-03 | 2016-11-02 | Philochem Ag | Targeted drug conjugates |
| WO2016065142A2 (en) | 2014-10-22 | 2016-04-28 | The Johns Hopkins University | New scaffolds and multifunctional intermediates for imaging psma and cancer therapy |
| WO2016196628A1 (en) * | 2015-06-01 | 2016-12-08 | The Johns Hopkins University | Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase ix and uses thereof |
| CN116474108A (zh) | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| EA202090776A1 (ru) * | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| EP3749663A1 (en) | 2018-02-06 | 2020-12-16 | Universität Heidelberg | Fap inhibitor |
-
2018
- 2018-10-23 EA EA202090776A patent/EA202090776A1/ru unknown
- 2018-10-23 CN CN202310498227.2A patent/CN116617420A/zh active Pending
- 2018-10-23 BR BR112020008011-0A patent/BR112020008011A2/pt unknown
- 2018-10-23 CN CN201880083520.XA patent/CN111511408A/zh active Pending
- 2018-10-23 WO PCT/US2018/057086 patent/WO2019083990A2/en not_active Ceased
- 2018-10-23 KR KR1020247035948A patent/KR20240162157A/ko active Pending
- 2018-10-23 EP EP18871298.8A patent/EP3700580A4/en active Pending
- 2018-10-23 US US16/758,182 patent/US20200330624A1/en active Pending
- 2018-10-23 MX MX2020004807A patent/MX2020004807A/es unknown
- 2018-10-23 CA CA3088138A patent/CA3088138A1/en active Pending
- 2018-10-23 JP JP2020523010A patent/JP2021500373A/ja active Pending
- 2018-10-23 KR KR1020207013693A patent/KR102764076B1/ko active Active
- 2018-10-23 AU AU2018355222A patent/AU2018355222B2/en active Active
-
2020
- 2020-04-20 IL IL274088A patent/IL274088A/en unknown
- 2020-07-13 MX MX2023013164A patent/MX2023013164A/es unknown
-
2023
- 2023-07-18 US US18/354,282 patent/US11938201B2/en active Active
-
2024
- 2024-02-23 US US18/585,905 patent/US12115233B2/en active Active
- 2024-05-14 JP JP2024078640A patent/JP2024109682A/ja active Pending
- 2024-05-16 AU AU2024203249A patent/AU2024203249A1/en active Pending
- 2024-12-20 US US18/990,863 patent/US20250186628A1/en active Pending
-
2025
- 2025-04-07 US US19/172,114 patent/US20250235565A1/en active Pending
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