CN116617420A - 靶向成纤维细胞活化蛋白α的化合物、药物组合物及用途 - Google Patents

靶向成纤维细胞活化蛋白α的化合物、药物组合物及用途 Download PDF

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Publication number
CN116617420A
CN116617420A CN202310498227.2A CN202310498227A CN116617420A CN 116617420 A CN116617420 A CN 116617420A CN 202310498227 A CN202310498227 A CN 202310498227A CN 116617420 A CN116617420 A CN 116617420A
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group
alkyl
fap
activation protein
fibroblast activation
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Chinese (zh)
Inventor
杨兴
斯里达尔•尼玛加达
史蒂文•罗韦
斯蒂芬妮•斯莱尼亚
马丁·G·庞培
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Johns Hopkins University
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Johns Hopkins University
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Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CN116617420A publication Critical patent/CN116617420A/zh
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    • A—HUMAN NECESSITIES
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
CN202310498227.2A 2017-10-23 2018-10-23 靶向成纤维细胞活化蛋白α的化合物、药物组合物及用途 Pending CN116617420A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762575607P 2017-10-23 2017-10-23
US62/575,607 2017-10-23
PCT/US2018/057086 WO2019083990A2 (en) 2017-10-23 2018-10-23 IMAGING AND RADIATION THERAPY AGENTS TARGETING α-FIBROBLAST ACTIVATION PROTEIN α (FAP-α)
CN201880083520.XA CN111511408A (zh) 2017-10-23 2018-10-23 靶向成纤维细胞活化蛋白-α(FAP-α)的成像剂及放射治疗剂

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CN201880083520.XA Division CN111511408A (zh) 2017-10-23 2018-10-23 靶向成纤维细胞活化蛋白-α(FAP-α)的成像剂及放射治疗剂

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CN116617420A true CN116617420A (zh) 2023-08-22

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CN202310498227.2A Pending CN116617420A (zh) 2017-10-23 2018-10-23 靶向成纤维细胞活化蛋白α的化合物、药物组合物及用途
CN201880083520.XA Pending CN111511408A (zh) 2017-10-23 2018-10-23 靶向成纤维细胞活化蛋白-α(FAP-α)的成像剂及放射治疗剂

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US (5) US20200330624A1 (https=)
EP (1) EP3700580A4 (https=)
JP (2) JP2021500373A (https=)
KR (2) KR20240162157A (https=)
CN (2) CN116617420A (https=)
AU (2) AU2018355222B2 (https=)
BR (1) BR112020008011A2 (https=)
CA (1) CA3088138A1 (https=)
EA (1) EA202090776A1 (https=)
IL (1) IL274088A (https=)
MX (2) MX2020004807A (https=)
WO (1) WO2019083990A2 (https=)

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