JP2021152063A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021152063A5 JP2021152063A5 JP2021103836A JP2021103836A JP2021152063A5 JP 2021152063 A5 JP2021152063 A5 JP 2021152063A5 JP 2021103836 A JP2021103836 A JP 2021103836A JP 2021103836 A JP2021103836 A JP 2021103836A JP 2021152063 A5 JP2021152063 A5 JP 2021152063A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- cancer
- formula
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 18
- 239000012453 solvate Substances 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 17
- -1 N-methylpyrrolyl Chemical group 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 229910052717 sulfur Inorganic materials 0.000 claims 11
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- DYSJMQABFPKAQM-UHFFFAOYSA-M 1-benzothiophene-2-carboxylate Chemical compound C1=CC=C2SC(C(=O)[O-])=CC2=C1 DYSJMQABFPKAQM-UHFFFAOYSA-M 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- ALBYIUDWACNRRB-UHFFFAOYSA-N hexanamide Chemical compound CCCCCC(N)=O ALBYIUDWACNRRB-UHFFFAOYSA-N 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1514928.9A GB201514928D0 (en) | 2015-08-21 | 2015-08-21 | PDD compounds |
| GB1514928.9 | 2015-08-21 | ||
| JP2018509597A JP6903635B2 (ja) | 2015-08-21 | 2016-08-19 | 抗増殖活性を有するピペリジノベンゾジアゼピン化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509597A Division JP6903635B2 (ja) | 2015-08-21 | 2016-08-19 | 抗増殖活性を有するピペリジノベンゾジアゼピン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021152063A JP2021152063A (ja) | 2021-09-30 |
| JP2021152063A5 true JP2021152063A5 (https=) | 2021-11-11 |
Family
ID=54292043
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509597A Active JP6903635B2 (ja) | 2015-08-21 | 2016-08-19 | 抗増殖活性を有するピペリジノベンゾジアゼピン化合物 |
| JP2021103836A Ceased JP2021152063A (ja) | 2015-08-21 | 2021-06-23 | 抗増殖活性を有するピペリジノベンゾジアゼピン化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509597A Active JP6903635B2 (ja) | 2015-08-21 | 2016-08-19 | 抗増殖活性を有するピペリジノベンゾジアゼピン化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10975072B2 (https=) |
| EP (2) | EP3337795B1 (https=) |
| JP (2) | JP6903635B2 (https=) |
| KR (1) | KR102710425B1 (https=) |
| CN (2) | CN108602803A (https=) |
| AU (1) | AU2016313228B2 (https=) |
| CA (1) | CA2996406A1 (https=) |
| DK (1) | DK3337795T3 (https=) |
| EA (1) | EA201890539A1 (https=) |
| GB (1) | GB201514928D0 (https=) |
| IL (1) | IL257650B (https=) |
| MX (1) | MX395406B (https=) |
| WO (1) | WO2017032983A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| GB201514928D0 (en) * | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| US20180339985A1 (en) * | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| TW201808936A (zh) | 2016-05-18 | 2018-03-16 | 美商梅爾莎納醫療公司 | 吡咯并苯并二氮呯類及其共軛物 |
| CN109641910A (zh) * | 2016-06-24 | 2019-04-16 | 梅尔莎纳医疗公司 | 吡咯并苯二氮*及其缀合物 |
| WO2019104289A1 (en) | 2017-11-27 | 2019-05-31 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| GB201814281D0 (en) * | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| EP4548932A1 (en) | 2022-06-30 | 2025-05-07 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| WO2024127333A1 (en) * | 2022-12-14 | 2024-06-20 | Pheon Therapeutics Ltd | Cytotoxic compounds |
| AU2023393382A1 (en) | 2022-12-14 | 2025-06-19 | Pheon Therapeutics Ltd | Cytotoxic compounds |
| WO2025262641A1 (en) | 2024-06-19 | 2025-12-26 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5841878A (ja) * | 1981-09-07 | 1983-03-11 | Fujisawa Pharmaceut Co Ltd | ベンゾジアゼピン誘導体、その製法およびそれを有効成分として含有する抗がん剤 |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5366972A (en) | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| US5418229A (en) | 1990-01-06 | 1995-05-23 | Alker; David | Muscarinic receptor antagonists |
| WO1993013777A1 (en) | 1992-01-21 | 1993-07-22 | Merck & Co., Inc. | Method of using m1-selective antimuscarinic pyridobenzodiazepinones in axial myopia therapy |
| EP0693070B1 (en) | 1993-04-05 | 2002-07-24 | Pharmaceutical Discovery Corporation | PYRIDO[2,3-b](1,4)BENZODIAZEPINONES AS M2 RECEPTOR LIGAND FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
| WO1996038422A1 (en) | 1995-05-31 | 1996-12-05 | Yamanouchi Pharmaceutical Co., Ltd. | Fused benzodiazepinone derivatives and medicinal composition of the same |
| US5650409A (en) | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US6864250B1 (en) | 1997-08-22 | 2005-03-08 | Kaken Pharmaceutical Co., Ltd. | N-acylated lipophilic amino acid derivatives |
| DE69925133T2 (de) | 1998-08-27 | 2006-01-19 | Spirogen Ltd., Ryde | Pyrrolobenzodiazepine |
| US6608193B2 (en) | 2001-12-21 | 2003-08-19 | The Procter & Gamble Company | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds |
| ATE361289T1 (de) | 2002-08-05 | 2007-05-15 | Lilly Co Eli | Piperazinsubstituierte arylbenzodiazepine |
| GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| US7456169B2 (en) | 2003-02-27 | 2008-11-25 | Abbott Laboratories Inc. | Heterocyclic kinase inhibitors |
| AU2003223107A1 (en) | 2003-03-31 | 2004-10-25 | Council Of Scentific And Industrial Research | Pyrene-linked pyrrolo (2,1-c) (1,4) benzodiazepine derivatives useful as anticancer agents |
| GB0308335D0 (en) | 2003-04-10 | 2003-05-14 | Novartis Ag | Organic compounds |
| GB0404578D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| EP1750706B1 (en) | 2004-06-01 | 2016-10-05 | University Of Virginia Patent Foundation | Dual small molecule inhibitors of cancer and angiogenesis |
| US8466144B2 (en) | 2004-07-16 | 2013-06-18 | Proteosys Ag | Muscarinic antagonists with parp and sir modulating activity as cytoprotective agents |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| IT1362675B (it) | 2005-03-15 | 2009-06-25 | Menarini Internat Operations Luxembourg Sa | N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche |
| US8637664B2 (en) | 2005-10-05 | 2014-01-28 | Spirogen Sarl | Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease |
| US20090318412A1 (en) | 2006-07-11 | 2009-12-24 | Takahiro Matsumoto | Tricyclic heterocyclic compound and use thereof |
| CA2660799C (en) * | 2006-08-14 | 2013-03-19 | Council Of Scientific & Industrial Research | Pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation thereof |
| CL2008001334A1 (es) | 2007-05-08 | 2008-09-22 | Genentech Inc | Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer. |
| NZ584514A (en) | 2007-10-19 | 2012-07-27 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| JP2009263283A (ja) | 2008-04-25 | 2009-11-12 | Toray Ind Inc | Ｃ型肝炎ウイルス阻害剤 |
| WO2009153589A1 (en) | 2008-06-17 | 2009-12-23 | Astrazeneca Ab | Pyridine compounds |
| GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| US20110263574A1 (en) | 2009-01-13 | 2011-10-27 | Proteosys Ag | Pirenzepine as otoprotective agent |
| RU2683325C2 (ru) * | 2009-02-05 | 2019-03-28 | Иммьюноджен, Инк. | Новые производные бензодиазепина |
| CN102482292B (zh) | 2009-04-23 | 2017-07-18 | Abbvie 公司 | 5‑ht受体的调节剂和其使用方法 |
| DE102009033392A1 (de) | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
| CU20090172A7 (es) | 2009-10-09 | 2011-10-05 | Ct De Investigación Y Desarrollo De Medicamentos | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
| WO2011117882A1 (en) | 2010-03-22 | 2011-09-29 | Council Of Scientific & Industrial Research | Pyrrolo[2,l-c][l,4]benzodiazepine-benzothiazole or benzoxazole conjugates linked through piperazine moiety and process for the preparation thereof |
| WO2012061019A2 (en) | 2010-10-25 | 2012-05-10 | Merck Sharp & Dohme Corp. | Tricyclic mglur5 receptor modulators |
| JP5826863B2 (ja) | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| US9006233B2 (en) | 2011-04-28 | 2015-04-14 | Uwm Research Foundation, Inc. | Gabaergic receptor subtype selective ligands and their uses |
| ES2623042T3 (es) * | 2012-04-30 | 2017-07-10 | Medimmune Limited | Pirrolobenzodiacepinas |
| EP3041846B1 (en) * | 2013-09-02 | 2018-11-07 | Hangzhou Dac Biotech Co., Ltd | Novel cytotoxic agents for conjugation of drugs to cell binding molecule |
| SG11201604784XA (en) | 2013-12-13 | 2016-07-28 | Genentech Inc | Anti-cd33 antibodies and immunoconjugates |
| GB201407816D0 (en) | 2014-05-02 | 2014-06-18 | King S College London | Pyrrolobenzodiazepine Compounds |
| LT3191135T (lt) | 2014-09-12 | 2020-11-25 | Genentech, Inc. | Anti-her2 antikūnai ir imunokonjugatai |
| CN107428747A (zh) | 2014-11-25 | 2017-12-01 | 拜耳制药股份公司 | 取代的吡啶并苯并二氮杂*酮衍生物及其用途 |
| US10508108B2 (en) | 2014-12-05 | 2019-12-17 | Merck Sharp & Dohme Corp. | Tricyclic compounds as inhibitors of mutant IDH enzymes |
| EP3226688B1 (en) | 2014-12-05 | 2020-07-01 | Merck Sharp & Dohme Corp. | Tricyclic compounds as inhibitors of mutant idh enzymes |
| BR112017014937A2 (pt) | 2015-01-14 | 2018-03-13 | Bristol-Myers Squibb Company | dímeros de benzodiazepina ligados em ponte a heteroarileno, conjugados dos mesmos, e métodos de preparação e uso |
| US9504694B2 (en) | 2015-03-19 | 2016-11-29 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepines |
| GB201510010D0 (en) * | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| GB201514928D0 (en) * | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| EP3371191B1 (en) | 2015-10-29 | 2020-08-26 | Merck Sharp & Dohme Corp. | Novel tricyclic compounds as inhibitors of mutant idh enzymes |
| TW201808936A (zh) | 2016-05-18 | 2018-03-16 | 美商梅爾莎納醫療公司 | 吡咯并苯并二氮呯類及其共軛物 |
| CN109641910A (zh) | 2016-06-24 | 2019-04-16 | 梅尔莎纳医疗公司 | 吡咯并苯二氮*及其缀合物 |
| WO2018053552A2 (en) | 2016-09-19 | 2018-03-22 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepines |
| US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
-
2015
- 2015-08-21 GB GBGB1514928.9A patent/GB201514928D0/en not_active Ceased
-
2016
- 2016-08-19 AU AU2016313228A patent/AU2016313228B2/en active Active
- 2016-08-19 CA CA2996406A patent/CA2996406A1/en not_active Abandoned
- 2016-08-19 CN CN201680060201.8A patent/CN108602803A/zh active Pending
- 2016-08-19 KR KR1020187007849A patent/KR102710425B1/ko active Active
- 2016-08-19 JP JP2018509597A patent/JP6903635B2/ja active Active
- 2016-08-19 EP EP16756759.3A patent/EP3337795B1/en active Active
- 2016-08-19 EP EP22178645.2A patent/EP4086251A1/en active Pending
- 2016-08-19 EA EA201890539A patent/EA201890539A1/ru unknown
- 2016-08-19 DK DK16756759.3T patent/DK3337795T3/da active
- 2016-08-19 CN CN202210543524.XA patent/CN114907345B/zh active Active
- 2016-08-19 MX MX2018002242A patent/MX395406B/es unknown
- 2016-08-19 WO PCT/GB2016/052565 patent/WO2017032983A1/en not_active Ceased
-
2018
- 2018-02-21 US US15/901,714 patent/US10975072B2/en active Active
- 2018-02-21 IL IL257650A patent/IL257650B/en unknown
-
2021
- 2021-06-23 JP JP2021103836A patent/JP2021152063A/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021152063A5 (https=) | ||
| JP2018525405A5 (https=) | ||
| ES2525429T3 (es) | Inhibidores de la proteína tirosina fosfatasa humana y métodos de uso | |
| JP6865254B2 (ja) | 眼疾患を処置するための組成物、製剤、および方法 | |
| ES2726946T3 (es) | Derivados de benzosulfonamida, composiciones de los mismos y su uso en la prevención de la metástasis de las células cancerosas | |
| ES2534392T3 (es) | Inhibidores de la proteína tirosina fosfatasa humana y métodos de uso | |
| ES2799582T3 (es) | Proceso para la síntesis de un inhibidor de indoleamina 2,3-dioxigenasa | |
| ES2399314T3 (es) | Gamma lactamas sustituidas como agentes terapeúticos | |
| JP2003500367A5 (https=) | ||
| JP2006509749A5 (https=) | ||
| RU2007109073A (ru) | Ингибиторы для атф-зависимого фермента на основе тиазола | |
| CN116457344A (zh) | 低分子量蛋白质降解剂及其应用 | |
| JP2026501617A (ja) | Ｎ－ハロアルキル置換カンプトテシン誘導体の抗体複合薬物 | |
| JP2010505865A5 (https=) | ||
| JP2010512355A (ja) | 癌の処置のためのジフェニルオキシ−インドール−２−オン化合物のプロドラッグ | |
| RU2004104329A (ru) | Ацилсемикарбазиды как ингибиторы циклинзависимой киназы, полезные в качестве противораковых и противопролиферативных агентов | |
| RU2002130247A (ru) | Производные оксадиазола, обладающие противоопухолевым действием | |
| JP2005519885A5 (https=) | ||
| KR20170117407A (ko) | 항종양 활성을 갖는 화합물 | |
| RU2006130686A (ru) | Новые пиперидины в качестве модуляторов хемокинов (ccr) | |
| US20070129327A1 (en) | Blood flow promoters for cauda equina tissues | |
| CN105246483A (zh) | 用于γ-谷氨酰循环调节的方法和组合物 | |
| RU2007125659A (ru) | Фенилпиперазиновые производные с сочетанием свойств неполного агонизма к рецепторам дофамина-d2 и ингибирования повторного поглощения серотонина | |
| CA2635093A1 (en) | Derivatives of sulindac, use thereof and preparation thereof | |
| JP2003516994A5 (https=) |